These California companies are primarily in biotechnology research, medical equipment manufacturing, and healthcare services. They range from established firms like Genentech, a science company finding solutions for difficult-to-treat conditions, and Edwards Lifesciences, which develops structural heart technologies, to newer companies like Lyra Health, providing AI-driven mental health benefits, and Clipboard, a platform connecting healthcare facilities with professionals for shifts. Many of these companies focus on developing innovative solutions in specialized medical fields.
The headquarters of these companies are spread across California, with notable clusters in the San Francisco Bay Area (South San Francisco, Hercules, Palo Alto) and Southern California (Irvine, San Diego, Los Angeles). This geographic distribution highlights a broad presence of healthtech innovation throughout the state. Several companies, such as Bio-Rad Laboratories, founded in 1952, and VSP Vision, founded in 1955, have long histories, while others like Envista Holdings Corporation (2019) are more recent.
| # | Company | Employees | |||
|---|---|---|---|---|---|
| 1 | 18,287 | ||||
| 2 |
Edwards Lifesciencesedwards.com
Develops breakthrough structural heart technologies and medical devices for patients, partnering with clinicians to improve lives globally across over 100 countries. |
14,148 | |||
| 3 |
VSP Visionvspvision.com
A global company dedicated to improving vision and providing healthcare solutions through innovative products, programs, and services, with a focus on diversity and charitable giving |
10,506 | |||
| 4 |
Bio-Rad Laboratoriesbio-rad.com
Development and supply of innovative products for life science research and medical diagnostics, enhancing discovery and clinical results worldwide. |
9,416 | |||
| 5 |
Resmedresmed.com.br
The company pioneers innovative medical devices and software platforms to treat chronic diseases, improve quality of life, and reduce healthcare costs globally |
9,180 | |||
| 6 |
Dexcomdexcom.com
A leader in continuous glucose monitoring technology, empowering individuals with diabetes to control their health and pursue their dreams |
8,997 | |||
| 7 |
Variancancercare.siemens-healthineers.com
Development and delivery of advanced imaging, radiation therapy, software, and services supporting the entire cancer care journey globally. |
8,395 | |||
| 8 |
Internet Brandsinternetbrands.com
An online media and technology company in Automotive, Health, Legal, and Home/Travel industries, providing web solutions, media websites, and web presence software products |
7,007 | |||
| 9 |
RadNetradnet.com
A leading provider of diagnostic imaging services with 370+ locations in core markets like California, offering services through a network of 9,000 employees |
5,667 | |||
| 10 |
Infinxinfinx.com
Innovative healthcare company offering scalable prior authorization and revenue cycle management solutions, using AI-driven software and billing specialists to optimize revenue capture |
5,195 | |||
| 11 |
BetterHelpbetterhelp.com
Provides online therapy sessions through video, voice, chat, and messaging with licensed therapists to support mental health improvement. |
4,101 | |||
| 12 |
Clipboardclipboardworks.com
Platform connecting healthcare facilities and schools with local professionals for unfilled shifts, improving care and offering flexible, higher-paying work. |
3,716 | |||
| 13 |
Episourceepisource.com
A leading provider of risk adjustment services, software, and solutions for health plans and provider groups, specializing in end-to-end solutions |
2,922 | |||
| 14 |
Lyra Healthlyrahealth.com
Provider of AI-driven mental health benefits and personalized support, connecting employees to exclusive providers and tools for recovery. |
2,872 | |||
| 15 |
Envista Holdings Corporationenvistaco.com
Partners with dental professionals, providing industry-leading products, solutions, and technology for diagnosing, treating, preventing dental conditions, and improving smile aesthetics globally. |
2,210 | |||
| 16 |
Personify Healthpersonifyhealth.com
A personalized health platform offering health plan administration, wellbeing solutions, and health navigation services to empower individuals and optimize investments for businesses |
2,139 | |||
| 17 |
hims & hersbit.ly
A multi-specialty telehealth platform connecting consumers to licensed healthcare professionals for various conditions like sexual health, hair care, mental health, and more |
2,022 | |||
| 18 | 1,884 | ||||
| 19 |
iRhythm Technologies, Inc.irhythm.com
A digital health company using wearable biosensors and data analytics to detect, predict, and prevent disease, with a focus on patient care and innovation |
1,874 | |||
| 20 |
Included Healthincludedhealth.com
Integrated virtual care and navigation company breaking down barriers to provide high-quality healthcare for all, offering personalized care guidance and access |
1,732 | |||
| 21 |
Hinge Healthhingehealth.com
AI-driven musculoskeletal care combining wearable technology and expert clinicians to deliver personalized, evidence-based treatment improving outcomes and reducing costs. |
1,665 | |||
| 22 |
Commurecommure.com
Innovative technologies enhancing healthcare workforce, solving industry challenges, and catalyzing a vibrant health ecosystem for hospitals and health systems |
1,577 | |||
| 23 |
Headspaceheadspace.com
provides evidence-based mental health support combining clinical care and technology to offer personalized, accessible lifelong mental health assistance worldwide |
1,560 | |||
| 24 |
艑URAouraring.com
A fast-growing startup based in Finland, Oura helps people track sleep and activity with their Oura Ring and app, empowering users to improve their health and well-being |
1,428 | |||
| 25 |
Doctor On Demandincludedhealth.com
Integrated virtual care and navigation to raise healthcare standards, providing high-quality, personalized care for all health needs and journey stages |
1,389 | |||
Want more companies than this list?This page shows the largest ones only. Connect to Tamtam to see every company that matches, filter by size, industry or growth, and reach their decision-makers. | |||||
| 26 |
Medelymedely.com
Medely is a healthcare labor marketplace connecting professionals with high-paying jobs and providing facilities with workforce management tools Join the team revolutionizing healthcare |
1,344 | |||
| 27 |
Advantmedadvantmed.com
A healthcare information management company offering solutions to optimize revenue and quality outcomes for health plans and Managed Care Organizations |
1,294 | |||
| 28 |
Honorhonorcare.com
This company revolutionizes in-home care for seniors by combining expertise in workforce management, technology, and personalized care, partnering with home care agencies nationwide |
1,193 | |||
| 29 |
Carbon Healthcarbonhealth.com
A tech-enabled healthcare company with a human-centered approach, aiming to break down traditional healthcare barriers and provide accessible personalized care |
1,090 | |||
| 30 |
GoodRxblocked.goodrx.com
The company is focused on providing affordable and convenient healthcare solutions for all Americans through technology, savings cards, and an app |
1,087 | |||
| 31 | 1,069 | ||||
| 32 |
Private Access, Inc.privateaccess.com
Developing web applications to solve privacy issues in medical research, facilitating secure sharing of confidential records & accelerating research with dynamic electronic consent management |
1,031 | |||
| 33 |
Solacesolace.health
A marketplace connecting individuals with health advocates to empower them in navigating and taking control of their personal health decisions |
1,008 | |||
| 34 |
Omada Healthomadahealth.com
Virtual-first healthcare provider offering personalized interventions for chronic conditions, using clinical protocols and behavior science to achieve long-term health improvements with evidence-based programs |
988 | |||
| 35 |
Ambry Geneticsambrygen.com
A leading clinical genomic diagnostic company with the largest genetic sequencing lab worldwide, offering precision medicine solutions and partnering with non-profit organizations |
977 | |||
| 36 |
Machinifymachinify.com
A healthcare software company uses machine learning and data analytics to improve outcomes and drive down costs in the industry |
937 | |||
| 37 |
Doximitydoximity.com
A digital platform connecting over 80% of US physicians, providing tools for collaboration, staying updated, managing careers, and conducting virtual patient visits |
914 | |||
| 38 |
Modern Healthmodernhealth.com
Global workforce mental health platform, employee benefit. Provides evidence-based coaching, therapy, group support, digital programs. Fast access to culturally responsive care. |
905 | |||
| 39 |
Trusted Healthtrustedhealth.com
A leading labor marketplace and workforce management platform for healthcare, connecting nurses to job opportunities and offering full employer-of-record services |
893 | |||
| 40 |
iSpace, Inc.ispace.com
A global services company specializing in IT, BPO, and healthcare solutions, driving innovation and delivering outcomes for Fortune 1000 clients |
893 | |||
| 41 |
Astrana Healthastranahealth.com
Technology-powered healthcare company enabling providers to deliver accessible, high-quality, and high-value care through an integrated platform for value-based arrangements |
892 | |||
| 42 |
Best Doctorsbestdoctors.com
A global expert medical service providing access to a network of top specialists for diagnosis, treatment plans, and healthcare cost reduction |
857 | |||
| 43 |
Equipequip.health
The company provides virtual care teams and gold-standard treatment at home for families seeking lasting recovery from eating disorders |
842 | |||
| 44 |
Heartflowheartflow.com
Advanced AI technology creating personalized 3D heart models from CT scans to improve diagnosis and treatment of coronary artery disease. |
841 | |||
| 45 |
CareDx, Inc.caredx.com
Innovative company specializing in non-invasive diagnostics for organ transplant patients, offering surveillance and pre-transplant solutions for kidney and heart transplants |
834 | |||
| 46 |
Collective Healthcollectivehealth.com
Integrated health benefits platform streamlining delivery, improving member experience, and reducing costs for employees and companies to navigate and pay for healthcare |
811 | |||
| 47 |
Transcarenttranscarent.com
Streamlines healthcare access with personalized app & on-demand care team Guides members to high-quality, affordable care while improving quality & reducing costs |
810 | |||
| 48 |
Santesanteapp.com
A Silicon Valley-based mHealth startup is revolutionizing healthcare technology Stay tuned for exciting updates! |
765 | |||
| 49 |
Twin Healthtwinhealth.com
The company combines medical science and digital twin technology to personalize care for chronic metabolic diseases through individualized guidance and support |
755 | |||
| 50 | 747 | ||||
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How this list is built
Every company on this list has a Tamtam company profile. The industry is the one the company gives on LinkedIn; categories such as SaaS or fintech are classified by Tamtam's AI from the company's website and LinkedIn page; and the headquarters city must match the company's own address. Companies are ranked by the number of employees on LinkedIn, and the list is refreshed every night. Classifications can be wrong, so treat the list as a starting point rather than an official ranking. Last updated Nov 12, 2026.
More company lists in California
- The largest companies in California 15,264
- Multinational companies in California 2,591
- SaaS companies in California 1,854
- Software Development companies in California 1,649
- AI companies in California 1,296
- Companies with in-house R&D in California 1,275
- Manufacturers in California 1,066
- Hardware manufacturers in California 985
- IT Services and IT Consulting companies in California 968
- Education providers in California 950
- Subscription businesses in California 939
- Venture capital and private equity firms in California 917
- Professional services firms in California 880
- Companies with a mobile app in California 827
- Retail chains in California 803
- IT services companies in California 796
- Venture Capital and Private Equity Principals companies in California 731
- Financial services firms in California 711
- Financial Services companies in California 642
- Healthcare providers in California 569
- AI-native companies in California 561
- Hospitals and Health Care companies in California 555
- Consulting firms in California 551
- Public sector organisations in California 535
The same list elsewhere in United States
- Healthtech companies in the United States 792
- Healthtech companies in New York State 101
- Healthtech companies in Texas 60
- Healthtech companies in Massachusetts 53
- Healthtech companies in Florida 47
- Healthtech companies in Pennsylvania 34
- Healthtech companies in Illinois 30
- Healthtech companies in New Jersey 26
- Healthtech companies in New York 91
- Healthtech companies in San Francisco 53