The 100 largest companies in Cambridge (2026 list)

#	Company	Industry	Headquarters	Employees	Founded
1	Harvard University harvard.edu An institution dedicated to teaching, learning, and research, producing global leaders across disciplines since 1636 Maintains flagship social media channels	Higher Education	🇺🇸 Cambridge	34,940	n/a
2	Massachusetts Institute of Technology web.mit.edu A private research university in Cambridge, Massachusetts, advancing knowledge and educating students in science and technology-focused areas	Higher Education	🇺🇸 Cambridge	23,586	1861
3	HubSpot hubspot.com It provides a comprehensive CRM platform with marketing, sales, and service tools, fostering employee growth and a flexible workplace culture.	Software Development	🇺🇸 Cambridge	12,229	2006
4	Akamai Technologies akamai.com A global leader in internet infrastructure, Akamai powers and protects online experiences for billions of users daily through innovative solutions	Technology, Information and Internet	🇺🇸 Cambridge	10,647	n/a
5	Biogen biogen.com Company pioneers innovative science, delivering new medicines to transform patients' lives, with a global presence and focus on superior treatment outcomes.	Biotechnology Research	🇺🇸 Cambridge	7,724	n/a
6	Moderna modernatx.com Pioneering mRNA technology for new medicines to improve patient lives by providing real-time instructions for protein production in cells	Biotechnology Research	🇺🇸 Cambridge	6,906	2010
7	Cultural Care Au Pair culturalcare.com Connecting international au pairs with American families for childcare, cultural exchange, and enriching year-long experiences in the USA.	Individual and Family Services	🇺🇸 Cambridge	6,091	1989
8	Cambridge Health Alliance challiance.org Provides comprehensive health care through hospitals and specialty centers, serving over 140,000 patients in Boston's metro-north region.	Hospitals and Health Care	🇺🇸 Cambridge	3,680	1996
9	BeOne Medicines beonemedicines.com Developing innovative, affordable cancer treatments for hematology and solid tumors with a global team and collaborative approach.	Pharmaceutical Manufacturing	🇺🇸 Cambridge	3,350	2010
10	Broad Institute of MIT and Harvard broadinstitute.org Multidisciplinary teams collaborate across labs and programs to address complex biomedical challenges in human biology and disease worldwide.	Research Services	🇺🇸 Cambridge	3,204	2003
11	MIT Sloan School of Management mitsloan.mit.edu A leading management school in Cambridge, Massachusetts that focuses on inventing ideas with impact, discovering future challenges and opportunities	Higher Education	🇺🇸 Cambridge	3,132	n/a
12	Draper draper.com A nonprofit engineering innovation company advancing technologies for national security through collaboration with government, academia, and industry to solve complex challenges	Defense and Space Manufacturing	🇺🇸 Cambridge	2,932	n/a
13	Alnylam Pharmaceuticals alnylam.com A global biotech company pioneering RNAi therapeutics to treat rare genetic diseases, with a breakthrough product and a robust pipeline	Biotechnology Research	🇺🇸 Cambridge	2,883	2002
14	Harvard Law School hls.harvard.edu A prestigious center of legal education offering a rigorous curriculum, diverse faculty, extensive research programs, and a global network of alumni	Higher Education	🇺🇸 Cambridge	2,550	n/a
15	Aspire Institute aspireleaders.org A non-profit organization founded to empower low-income, first-generation college students worldwide through a fully funded leadership development program	Higher Education	🇺🇸 Cambridge	2,518	2017
16	MIT Technology Review technologyreview.com Independent media company providing analysis, features, and events explaining commercial, social, and political impacts of new technologies worldwide.	Book and Periodical Publishing	🇺🇸 Cambridge	2,029	n/a
17	BeiGene beonemedicines.com Global oncology company developing accessible and affordable cancer treatments through innovative research, collaborations, and commitment to improving medicine access for patients worldwide	Biotechnology Research	🇺🇸 Cambridge	1,967	2010
18	Mass General Hospital massgeneral.org A higher education company located in Cambridge, Massachusetts, United States, specializing in providing healthcare services and medical research at Mass General Hospital	Higher Education	🇺🇸 Cambridge	1,839	n/a
19	Hult International Business School hult.edu Offers undergraduate and postgraduate business programs across global campuses with a diverse student body from over 140 nationalities.	Higher Education	🇺🇸 Cambridge	1,804	n/a
20	Forrester forrester.com Provides research, consulting, and events to help leaders use customer-focused insights and data to drive growth and navigate change.	Research Services	🇺🇸 Cambridge	1,653	1983
21	Cytel cytel.com Global expertise in consulting, data-driven analytics, and software solutions for biotech and pharma companies to make confident, data-driven decisions in life sciences	Pharmaceutical Manufacturing	🇺🇸 Cambridge	1,625	1987
22	Takeda Oncology takedaoncology.com Global oncology business unit leveraging transformative medicines to treat hematologic cancers and solid tumors, driving innovation through partnerships and cutting-edge science	Pharmaceutical Manufacturing	🇺🇸 Cambridge	1,621	1993
23	Vinfen vinfen.org A dynamic organization providing comprehensive services for adolescents and adults with disabilities or life challenges in Massachusetts and Connecticut	Mental Health Care	🇺🇸 Cambridge	1,562	1977
24	Lesley University lesley.edu Dedicated to active learning, research, and artistic practice, fostering mentorship relationships to prepare graduates for shaping a more just world	Higher Education	🇺🇸 Cambridge	1,444	1909
25	Peak Support peaksupport.io A rapidly growing services provider offering exceptional customer support, sales operations, and business process outsourcing globally, focusing on helping high-growth companies succeed	Outsourcing and Offshoring Consulting	🇺🇸 Cambridge	1,240	2015
26	Harvard Kennedy School hks.harvard.edu This organization at Harvard Kennedy School aims to improve public policy, leadership, and global connections for a safer, freer, and more just society	Higher Education	🇺🇸 Cambridge	1,226	1936
27	Sarepta Therapeutics sarepta.com Development of precision genetic medicines targeting rare diseases with significant impact on patients' lives and futures.	Biotechnology Research	🇺🇸 Cambridge	1,160	n/a
28	Harvard Graduate School of Education gse.harvard.edu Dedicated to studying and improving education, believing it is crucial to society's health and future	Higher Education	🇺🇸 Cambridge	1,109	n/a
29	Hult Prize Foundation hultprize.org Inspiring young entrepreneurs worldwide to tackle global challenges by creating impactful startups aligned with UN Sustainable Development Goals	Non-profit Organizations	🇺🇸 Cambridge	1,087	n/a
30	MIT Computer Science and Artificial Intelligence Laboratory (CSAIL)csail.mit.edu Leading research in computer science and artificial intelligence, developing innovative technologies and fostering industry collaborations for future information technology advancements.	Higher Education	🇺🇸 Cambridge	999	2003
31	PCA pcadesign.com PCA is a prominent design firm in Greater Boston, offering architecture, planning, and interior design services with a focus on innovative and award-winning solutions	Architecture and Planning	🇺🇸 Cambridge	852	1982
32	ConcertAI concertai.com Innovative AI-powered SaaS data company specializing in healthcare, experiencing rapid growth as a leader in the industry	Biotechnology Research	🇺🇸 Cambridge	840	2018
33	Flagship Pioneering flagshippioneering.com Innovative biotechnology company creating platform companies for transformative human health and sustainability products, with over 100 ventures in its ecosystem	Biotechnology Research	🇺🇸 Cambridge	836	2000
34	MIT Media Lab media.mit.edu An interdisciplinary creative playground at the intersection of academic rigor and transformative technology, focused on positive societal impact	Higher Education	🇺🇸 Cambridge	801	1985
35	CapeStart capestart.com CapeStart provides AI innovation scaling services through data annotation, machine learning, and software development for various industries worldwide	IT Services and IT Consulting	🇺🇸 Cambridge	795	2013
36	Tatte Bakery & Cafe tattebakery.com A bakery founded in 2007, growing from farmers markets to brick-and-mortar cafes in multiple locations Emphasizing quality, creativity, and inclusivity in their team	Restaurants	🇺🇸 Cambridge	780	2007
37	SMMA smma.com A multidisciplinary design firm balancing architecture, engineering, interiors, and site design to provide creative and technical expertise since 1955	Architecture and Planning	🇺🇸 Cambridge	766	1955
38	Abdul Latif Jameel Poverty Action Lab (J-PAL)povertyactionlab.org Global network conducting randomized evaluations to improve poverty reduction programs, informing policy through scientific evidence and training.	Research Services	🇺🇸 Cambridge	760	2003
39	Blueprint Medicines blueprintmedicines.com Develop targeted medicines addressing allergy, inflammation, oncology, and hematology by focusing on root causes and advancing clinical programs.	Biotechnology Research	🇺🇸 Cambridge	722	2011
40	Harvard University Graduate School of Design gsd.harvard.edu A leading graduate school focused on educating professionals in architecture, landscape design, urban planning, and related disciplines to shape the 21st century built environment	Architecture and Planning	🇺🇸 Cambridge	681	n/a
41	ATS ats-business.com A global company with 30+ years of experience serving numerous clients, delivering exceptional results worth billions of dollars through best-in-class experts Visit https://wwwats-businesscom	Business Consulting and Services	🇺🇸 Cambridge	668	1980
42	Agios Pharmaceuticals agios.com Commercial-stage biopharmaceutical company focused on developing and delivering innovative medicines for rare diseases, rooted in hematology, reflecting patient priorities.	Pharmaceutical Manufacturing	🇺🇸 Cambridge	644	2008
43	MIT Professional Education professional.mit.edu This company provides specialized education programs taught by MIT faculty for science and engineering professionals worldwide to advance their careers and organizations	Higher Education	🇺🇸 Cambridge	625	n/a
44	Harvard John A. Paulson School of Engineering and Applied Sciences seas.harvard.edu SEAS conducts collaborative research and education at the intersection of engineering, applied sciences, and technology to address global challenges and serve society	Higher Education	🇺🇸 Cambridge	600	n/a
45	Beam Therapeutics beamtx.com Pioneering CRISPR base editing technology to develop precision genetic medicines for life-long cures, while fostering a community of fearless innovators	Biotechnology Research	🇺🇸 Cambridge	592	2017
46	Harvard Extension School extension.harvard.edu Provides continuing education at Harvard for over a century, offering affordable, open-enrollment courses, certificates, and degrees for adult, part-time learners.	Higher Education	🇺🇸 Cambridge	585	1910
47	Dorchester County Public Schools dcps.schoolspring.com The company's mission is to provide leadership for excellence in teaching and learning for all students, preparing them for college and careers	Primary and Secondary Education	🇺🇸 Cambridge	584	n/a
48	ZoomRx zoomrx.com A strategic healthcare consulting firm leveraging data, technology, and expertise to help shape therapy markets with collaboration, innovation, and deep analysis	Business Consulting and Services	🇺🇸 Cambridge	541	2009
49	iGEM igem.org This company educates and advances synthetic biology through competitions, events, and programs, bringing together industry professionals and future leaders in the field	Biotechnology Research	🇺🇸 Cambridge	533	2003
50	Vericel® Corporation vcel.com A leading provider of advanced cell therapies and specialty biologics for sports medicine and severe burn care markets Core values include integrity, teamwork, and innovation	Biotechnology Research	🇺🇸 Cambridge	520	1989
51	Cambridge Savings Bank cambridgesavings.com A full-service mutual bank in Massachusetts with over $6 billion in assets, offering individual and business banking services through branches and digital solutions	Banking	🇺🇸 Cambridge	520	1834
52	Center for Astrophysics \| Harvard & Smithsonian cfa.harvard.edu A collaborative research center between Harvard and the Smithsonian dedicated to advancing knowledge of the universe through astronomy and astrophysics	Research Services	🇺🇸 Cambridge	519	1973
53	MacPaw 🇺🇦macpaw.com Empowering 30 million MacOS/iOS users with technology through CleanMyMac and Setapp, offering innovative products for efficient device management	Software Development	🇺🇸 Cambridge	514	2009
54	Inari inari.com Utilizing new breeding technology and AI, the company designs nature-positive seeds for a sustainable global food system, enhancing crop productivity efficiently	Biotechnology Research	🇺🇸 Cambridge	510	2016
55	Malta Inc maltainc.com The company has developed a thermal energy storage system that can collect, store, and dispatch energy from various sources for extended periods	Renewable Energy Semiconductor Manufacturing	🇺🇸 Cambridge	509	2018
56	Intellia Therapeutics, Inc.intelliatx.com Leading genome editing company focusing on developing curative gene editing treatments using CRISPR/Cas9 technology to transform the lives of patients with severe diseases	Biotechnology Research	🇺🇸 Cambridge	495	2014
57	Harvard Project for Asian and International Relations (HPAIR)hpair.org Organizes student conferences in Asia-Pacific. Gathers students, academics, and leaders to discuss international issues, fostering global relationships and connecting talent with leaders.	International Affairs	🇺🇸 Cambridge	488	1991
58	EF Go Ahead Tours goaheadtours.com Specializing in group travel for a wide range of travelers, offering over 180 tours across 7 continents to help people experience the world	Travel Arrangements	🇺🇸 Cambridge	488	1990
59	Cambridge Mobile Telematics cmtelematics.com AI-driven platform identifying and reducing driving risks, partnering with insurers and automakers to prevent crashes and enhance road safety worldwide.	Software Development	🇺🇸 Cambridge	477	2010
60	BlueRock Therapeutics bluerocktx.com A leading engineered cell therapy company developing regenerative medicines for neurology, cardiology, and immunology indications through innovative cell+gene platform	Biotechnology Research	🇺🇸 Cambridge	474	2016
61	Quantori quantori.com Quantori accelerates drug discovery and patient outcomes through cutting-edge data engineering, machine learning, cloud expertise, and healthcare data optimization services	IT Services and IT Consulting	🇺🇸 Cambridge	473	2018
62	Cell Press cell.com Publisher of over 50 scientific journals across various disciplines, with a focus on editorial excellence, innovation, and advocacy to share inspiring science	Book and Periodical Publishing	🇺🇸 Cambridge	446	1986
63	EF High School Exchange Year efexchangeyear.org Facilitating cultural exchange by connecting high school students worldwide with American host families, creating lasting friendships and transformative experiences	Education Administration Programs	🇺🇸 Cambridge	442	1979
64	EverQuote everquote.com A fast-growing technology company in Cambridge simplifying, personalizing, and making insurance more affordable through data, technology, and knowledgeable advisors	Technology, Information and Internet	🇺🇸 Cambridge	432	2011
65	Newfire Global Partners newfireglobal.com An American IT service company delivering innovative software solutions across various industries globally with a focus on staff augmentation and advisory services	Software Development	🇺🇸 Cambridge	431	2016
66	U.S. DOT Volpe National Transportation Systems Center volpe.dot.gov A federally funded agency within the US Department of Transportation, providing innovative solutions and expertise to improve transportation systems nationwide	Research Services	🇺🇸 Cambridge	428	1970
67	Suno suno.com Platform enabling music creation for all skill levels, removing barriers and allowing users to create songs using imagination alone.	Technology, Information and Internet	🇺🇸 Cambridge	424	2022
68	Lumiere Education lumiere-education.com This company is passionate about training future researchers, having received over 5000 student applications to their programs	Education Administration Programs	🇺🇸 Cambridge	407	n/a
69	Whitehead Institute wi.mit.edu A leading nonprofit research institution collaborating with MIT, pioneering biomedical science through innovative research in cancer, immunology, genetics, and more	Research Services	🇺🇸 Cambridge	405	1982
70	BLK Capital Management, Corp blkcapitalmanagement.org A student-run hedge fund focused on educating members in active investment management, specializing in long/short equity with a global approach	Financial Services	🇺🇸 Cambridge	401	2017
71	Infinity Pharmaceuticals infi.com This company operates an alumni page designed to connect and engage with former members or employees	Pharmaceutical Manufacturing	🇺🇸 Cambridge	398	2001
72	TurnUp Activism turnup.us A non-profit organization mobilizing young activists through a mobile app, training programs, and civic technologies to increase youth voter turnout and combat voter suppression	Civic and Social Organizations	🇺🇸 Cambridge	391	2019
73	The Harvard Crimson thecrimson.com The Harvard Crimson is a daily college newspaper in Cambridge, MA, publishing news, sports, arts sections, with a rich journalistic history	Newspaper Publishing	🇺🇸 Cambridge	390	1873
74	Wave Life Sciences wavelifesciences.com Biotechnology company harnessing RNA medicines to develop treatments for various disorders, including rare diseases like Duchenne muscular dystrophy and prevalent conditions like obesity	Biotechnology Research	🇺🇸 Cambridge	386	2012
75	National Bureau of Economic Research nber.org A nonprofit research organization conducting nonpartisan economic research through a network of over 1,700 affiliated scholars, without making policy recommendations	Research Services	🇺🇸 Cambridge	375	1920
76	Buckingham Browne & Nichols School bbns.org An independent co-educational day school in Massachusetts, educating students from pre-kindergarten through twelfth grade, with top rankings and notable alumni achievements	Primary and Secondary Education	🇺🇸 Cambridge	373	1974
77	Aspire Leaders Program A global organization empowering first-generation college students to unlock their potential through education, mentorship, and connections to Harvard faculty	Higher Education	🇺🇸 Cambridge	369	2021
78	Independent Investor independentinvestor.us This company helps independent investors achieve market-beating returns by providing answers to tough investing questions using research by Valens Research	Financial Services	🇺🇸 Cambridge	367	n/a
79	XtalPi Inc.en.xtalpi.com A quantum physics-based, AI-powered drug R&D company revolutionizing drug discovery with integrated technology platform and support from renowned investors	Biotechnology Research	🇺🇸 Cambridge	349	2015
80	Cerevel Therapeutics cerevel.com Biopharmaceutical company developing therapies for central nervous system disorders, with a portfolio targeting Parkinson's, Alzheimer's, epilepsy, schizophrenia, and addiction	Pharmaceutical Manufacturing	🇺🇸 Cambridge	347	2018
81	First Line Software firstlinesoftware.com It offers software engineering, digital transformation, and advisory services globally, specializing in retail, healthcare IT, machine learning, and data management.	IT System Custom Software Development	🇺🇸 Cambridge	346	2010
82	CIC (Cambridge Innovation Center)cic.com Global leader in driving innovation at scale, managing workspace, labs, and event spaces, with bespoke programming and industry cluster development to advance innovation	Real Estate	🇺🇸 Cambridge	345	1999
83	Clover cloverfoodlab.com Restaurant chain focusing on local, organic, chemical-free food sourcing, promoting health and environmental sustainability in Boston area.	Restaurants	🇺🇸 Cambridge	343	2008
84	Cambridge-Isanti Schools c-ischools.org An educational institution in partnership with the community, the company aims to educate, empower, and inspire every student to reach their full potential	Primary and Secondary Education	🇺🇸 Cambridge	334	n/a
85	Global Worker Dialogue (GWD)workerdiaries.org Facilitating transparent communication to gather credible data and improve labor conditions in global value chains for responsible and sustainable practices	International Trade and Development	🇺🇸 Cambridge	331	2002
86	Scholar Rock scholarrock.com Biopharmaceutical company specializing in developing therapies targeting protein growth factors to treat serious diseases with high unmet need	Biotechnology Research	🇺🇸 Cambridge	330	2012
87	Healthworks healthworksfitness.com A leading women's fitness center in Boston, offering group classes, personal training, spa amenities, and community-focused initiatives through a non-profit fitness center	Wellness and Fitness Services	🇺🇸 Cambridge	329	1977
88	ReversingLabs reversinglabs.com Provides a cybersecurity platform for file and software security, verifying safe binaries, and offering insights into the software supply chain.	Computer and Network Security	🇺🇸 Cambridge	320	2009
89	Ragon Institute of Mass General Brigham, MIT, and Harvard ragoninstitute.org Leading collaborative research institute focused on developing an HIV/AIDS vaccine, fostering innovative partnerships, funding promising studies, and accelerating bench-to-bedside research for immunology advancements	Research Services	🇺🇸 Cambridge	319	2009
90	nference nference.com Leverages academic minds, researchers, and patient data to accelerate drug development, generate evidence, and improve clinical trials, offering comprehensive biological and clinical insights.	Biotechnology Research	🇺🇸 Cambridge	314	2013
91	Dr. Dental mydrdental.com Dr Dental provides convenient, affordable, and quality dental care with great service at multiple locations throughout Massachusetts and surrounding states	Hospitals and Health Care	🇺🇸 Cambridge	313	n/a
92	Nuvalent, Inc.nuvalent.com Precision oncology company developing targeted therapies for cancer patients, utilizing structure-based design to create innovative small molecules for improved outcomes and reduced side effects	Biotechnology Research	🇺🇸 Cambridge	308	2017
93	DeepHealth deephealth.com An AI-powered subsidiary focused on healthcare informatics, DeepHealth aims to enhance care delivery by leveraging advanced AI technologies and personalized workflows	Hospitals and Health Care	🇺🇸 Cambridge	307	n/a
94	solo.io solo.io Soloio specializes in cloud-native application networking, connecting, securing, and monitoring Kubernetes applications and APIs globally using open-source technologies	Software Development	🇺🇸 Cambridge	300	2017
95	Cartwheel cartwheel.org Rapid care access for students, stronger mental health programs for schools to support kids' well-being and joyful lives.	Mental Health Care	🇺🇸 Cambridge	249	2022
96	iGEM Competition competition.igem.org Annual synthetic biology competition for students to build genetically engineered systems using BioBricks, striving to make a positive impact on communities	Biotechnology Research	🇺🇸 Cambridge	210	2004
97	Wistia wistia.com It provides a video marketing platform for businesses to create, host, market, and measure video content effectively and collaboratively.	Software Development	🇺🇸 Cambridge	206	2006
98	Highland Capital Partners hcp.com venture capital firm investing over 3 billion dollars in more than 270 technology companies prioritizing entrepreneurs and innovation	Venture Capital and Private Equity Principals	🇺🇸 Cambridge	202	1987
99	Harvard Kenneth C. Griffin Graduate School of Arts and Sciences gsas.harvard.edu The Graduate School of Arts and Sciences fosters scholarship, innovation, and diverse communities across 58 fields of study, offering 5 years of funding to PhD candidates	Higher Education	🇺🇸 Cambridge	199	1872
100	Simera simera.me AI-powered platform for global remote hiring, vetting, onboarding, training, and managing professionals for businesses without upfront costs.	Software Development	🇺🇸 Cambridge	199	2021

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Every company on this list has a Tamtam company profile. The industry is the one the company gives on LinkedIn; categories such as SaaS or fintech are classified by Tamtam's AI from the company's website and LinkedIn page; and the headquarters city must match the company's own address. Companies are ranked by the number of employees on LinkedIn, and the list is refreshed every night. Classifications can be wrong, so treat the list as a starting point rather than an official ranking. Last updated Oct 24, 2026.

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The same list elsewhere in United States

The largest companies in the United States 91,669
The largest companies in California 12,813
The largest companies in New York State 10,485
The largest companies in Texas 8,086
The largest companies in Florida 4,945
The largest companies in Illinois 4,175
The largest companies in Pennsylvania 3,110
The largest companies in Massachusetts 3,093
The largest companies in Georgia 2,632
The largest companies in Ohio 2,618
The largest companies in New Jersey 2,569
The largest companies in Virginia 2,503
The largest companies in Michigan 2,346
The largest companies in North Carolina 2,174
The largest companies in Alabama 1,806
The largest companies in Washington State 1,785
The largest companies in Colorado 1,774
The largest companies in Minnesota 1,700
The largest companies in Maryland 1,527
The largest companies in Wisconsin 1,482
The largest companies in New York 6,920
The largest companies in San Francisco 2,030
The largest companies in Houston 1,791
The largest companies in Chicago 1,668