| # | Company | Employees |
|---|---|---|
| 1 | 57,548 | |
| 2 |
Aya Healthcareayahealthcare.com
A leading healthcare talent software and staffing company offering a wide range of labor services, powered by a comprehensive software suite |
24,463 |
| 3 |
Jack in the Boxjackinthebox.com
Operates quick-serve restaurants, offering diverse menu items like breakfast sandwiches, salads. Company pioneered many fast-food staples, with over 2000 locations. |
21,368 |
| 4 | 19,892 | |
| 5 |
LPL Financiallpl.com
Wealth management firm supporting financial advisors and institutions through investment solutions, fintech tools, practice management services, and custody of trillions in brokerage assets. |
14,788 |
| 6 |
The UPS Storetheupsstore.com
A nationwide network of retail centers offering shipping, printing, postal services, and more, with franchise opportunities available for qualifying entrepreneurs |
12,412 |
| 7 |
Scripps Healthcareers.scripps.org
Non-profit healthcare system providing acute hospitals, outpatient centers, home health, hospice, and advanced clinical research in San Diego. |
11,885 |
| 8 |
Sharp HealthCarecareers.sharp.com
Not-for-profit healthcare system offering acute, specialty hospitals, medical groups, and health plan with advanced, compassionate patient care services. |
11,594 |
| 9 |
General Atomicsga.com
Development of advanced technology solutions including unmanned aerial vehicles, research reactors, aircraft systems, MagLev transport, and fusion energy for global customers. |
11,213 |
| 10 |
UC San Diego Healthemployment.ucsd.edu
A leading academic health system in San Diego region, offering outstanding patient care, cutting-edge research, medical education, and community health programs |
10,962 |
| 11 |
Teradatateradata.com
The company specializes in providing a cloud analytics and data platform that empowers organizations with harmonized data and trusted AI/ML for confident decision-making and impactful results |
9,882 |
| 12 |
San Diego State Universitysdsu.edu
Top-ranked public research institution offering transformative experiences, international opportunities, diversity initiatives, and vibrant campus life for over 36,000 students |
9,764 |
| 13 |
Illuminaillumina.com
The company develops innovative technologies and assays for genetic analysis, enabling personalized medicine and advancing disease research, drug development, and molecular testing |
9,673 |
| 14 |
San Diego Unified School Districtlinktr.ee
A diverse and inclusive educational institution in San Diego with over 221 facilities, serving 132,000 students to prepare them for college and career success |
9,483 |
| 15 |
Resmedresmed.com.br
The company pioneers innovative medical devices and software platforms to treat chronic diseases, improve quality of life, and reduce healthcare costs globally |
9,180 |
| 16 |
County of San Diegosandiegocounty.gov
The company is dedicated to maintaining a skilled and diverse workforce to support County departments in delivering exceptional services to San Diego residents and visitors |
9,069 |
| 17 |
Dexcomdexcom.com
A leader in continuous glucose monitoring technology, empowering individuals with diabetes to control their health and pursue their dreams |
8,997 |
| 18 |
Solar Turbinessolarturbines.com
Manufacturer of industrial gas turbines, compressors, and generator sets used in oil, gas, and power generation projects globally. |
7,656 |
| 19 |
Call Center Services Internationalccsi.com
Specializing in establishing bilingual contact centers in Mexico with a focus on high-quality workforce, advanced infrastructure, and proximity to the US |
7,648 |
| 20 |
National Universitynu.edu
National University provides accessible education to working professionals, offering diverse degree programs and innovative formats to empower positive change in communities |
7,573 |
| 21 |
The City of San Diegosandiego.gov
Dedicated to improving the quality of life and fostering the economic base for citizens and businesses in San Diego through various platforms |
6,914 |
| 22 |
PriceSmartpricesmart.com
A membership-based retail company offering high-quality items at low prices across Central America, Colombia and the Caribbean, while supporting local communities through philanthropic initiatives |
6,108 |
| 23 |
Berkshire Hathaway HomeServices California Propertiesbhhscalifornia.com
A leading real estate firm in Southern California focused on finding dream homes for clients, offering a seamless transaction process and career opportunities |
5,934 |
| 24 |
Guild Mortgageguildmortgage.com
A leading independent mortgage provider, prioritizing customer service with commitment to on-time closings and tailored loan options for homebuyers |
5,337 |
| 25 |
Rady Children's Hospital-San Diegorchsd.org
Leading pediatric health care system with a 511-bed hospital, 40+ locations, and a focus on serving San Diego and surrounding counties Nonprofit organization relying on donations |
4,856 |
| 26 |
Digital Marketingdmnpco.com
Providing digital marketing strategies, social media marketing, SEO, and advertising services to small businesses and start-ups Consulting for online marketing analysis |
4,841 |
| 27 |
University of San Diegosandiego.edu
Private Catholic university offering liberal arts education focused on academic excellence, social justice, peace, and sustainability values. |
4,593 |
| 28 |
Qdoba Restaurant Corporationqdoba.com
A fast-casual Mexican restaurant chain with over 740 locations in the US and Canada, focusing on flavorful ingredients and a vibrant, inclusive work culture |
4,341 |
| 29 |
Vistage Worldwide, Inc.vistage.com
An executive coaching organization providing tailored solutions for CEOs, business owners, and key executives to solve complex issues and challenges |
3,493 |
| 30 |
CATERINGurbncatering.com
Award-winning restaurant group with full-service catering, custom pizza trucks, and personalized event menus for clients in Southern California Stress-free flawless catered experiences |
3,343 |
| 31 |
Encore Capital Groupencorecapital.com
Publicly traded company promoting employee wellness, professional growth, and consumer rights, recognized for leadership and healthy workplace initiatives. |
3,243 |
| 32 |
NAVWARnavwar.navy.mil
This company specializes in providing information warfare capabilities and services to support naval, joint, coalition, and national missions |
3,228 |
| 33 | 3,123 | |
| 34 |
Poway Unified School Districtpowayusd.com
A leading K-12 public education provider in northern San Diego County, operating a variety of schools serving over 36,000 students |
3,118 |
| 35 |
Cubic Corporationcubic.com
The company creates technology solutions in transportation to simplify daily journeys and defense capabilities to promote mission success and safety |
3,095 |
| 36 |
MNC Softwaremncsoftware.com
Forward-thinking company specializing in advanced monitoring and control software for broadcast, ground station, and infrastructure management with over 50 years of engineering experience |
3,080 |
| 37 |
Kratos Defense and Security Solutionskratosdefense.com
National security technologies spanning unmanned systems, hypersonics, satellite communications, cyber defense, and propulsion systems for rapid deployment to support various military domain missions. |
2,950 |
| 38 |
Club Demonstration Servicesclubdemo.com
Influencing purchase decisions by providing in-store marketing services to Costco and CPGs, driving sales through sensory experiences and product trials |
2,941 |
| 39 |
San Diego Gas & Electricsdge.com
provides clean, safe, and reliable energy to improve lives in San Diego and southern Orange counties with over 4,000 employees |
2,822 |
| 40 |
Kleinfelderkleinfelder.com
Engineering, science, and construction firm offering solutions for transportation, water, energy, and private infrastructure projects with a dedicated, cross-disciplinary team |
2,656 |
| 41 |
Cetera Financial Groupcetera.com
Network of independent retail financial firms providing technology, guidance, research, and collaborative platforms for financial professionals and investors. |
2,653 |
| 42 |
ACES (Comprehensive Educational Services)acesaba.com
Provide professional autism and special needs services including therapy, education, and support in homes, schools, and communities nationwide. |
2,611 |
| 43 |
CareFusionbd.com
Develops market-leading technologies and services for the health care industry; products improve cost and safety of patient care. |
2,600 |
| 44 |
Semprasempra.com
A leading energy infrastructure company helping to electrify and decarbonize major markets in North America through sustainable practices and operational excellence |
2,572 |
| 45 |
Cubic Transportation Systemscubic.com
A global leader in transportation systems, providing payment solutions and traveler tools for seamless journeys while revolutionizing the industry |
2,452 |
| 46 |
Neurocrine Biosciencesneurocrine.com
A neuroscience-focused biopharmaceutical company dedicated to discovering treatments for neurological, neuroendocrine, and neuropsychiatric disorders, providing hope for patients with limited options |
2,378 |
| 47 |
Power Digital Marketingpowerdigitalmarketing.com
Growth marketing firm utilizing proprietary technology to analyze digital ecosystems and develop custom data-driven playbooks for revenue growth and brand recognition worldwide. |
2,318 |
| 48 |
Midland Credit Managementencorecapital.com
A specialty finance provider offering debt recovery solutions to consumers, emphasizing empathy, collaboration, and respect to guide them towards financial recovery and empowerment |
2,266 |
| 49 |
Tandem Diabetes Caretandemdiabetes.com
A global diabetes technology company manufacturing and selling advanced automated insulin delivery systems to reduce the burden of diabetes management |
2,203 |
| 50 |
Cohu, Inc.cohu.com
A global supplier of semiconductor test equipment, handlers, MEMS modules, thermal systems, and automated test equipment, focusing on yield improvement and cost reduction for manufacturers |
2,084 |
| 51 |
San Diego Zoo Wildlife Alliancesandiegozoowildlifealliance.org
A nonprofit conservation leader inspiring passion for nature, working globally to conserve wildlife through innovation, partnerships, and education initiatives |
2,038 |
| 52 |
Ace Parkingaceparking.com
ACE PARKING offers personalized parking services for various industries, managing over 1,250 locations nationwide with a client-driven approach to maximize revenue potential |
1,995 |
| 53 |
MedImpact Healthcare Systems, Inc.medimpact.com
An independent pharmacy benefit manager focusing on promoting Lower Cost and Better Care through effective management of client pharmacy benefits |
1,973 |
| 54 |
Point Loma Nazarene Universitypointloma.edu
Liberal arts university in San Diego offering over 60 undergraduate programs, graduate program centers, and serving over 4,600 students since 1902 |
1,966 |
| 55 |
General Dynamics NASSCOjobs.nassco.com
A shipbuilding company with locations on the West and East Coasts specializing in ships for the US Navy and commercial markets, also providing repair services |
1,845 |
| 56 |
SOLV Energysolvenergy.com
Provider of solar services for utility, high-voltage substation, and energy storage markets in North America Focus on cleaner power and renewable energy initiatives |
1,772 |
| 57 |
Helix Electrichelixelectric.com
An award-winning electrical contractor with expertise in design-build projects, specializing in complex construction in various sectors across the United States |
1,756 |
| 58 |
EDF Renewables North Americaedf-re.com
Development and operation of wind, solar, and storage projects with onsite energy solutions for commercial and industrial customers. |
1,725 |
| 59 |
Host Healthcare, Inc.hosthealthcare.com
Travel healthcare staffing agency specializing in nursing, allied, and therapy jobs Award-winning team with top ratings and recognized as a top employer |
1,701 |
| 60 |
Interior Logic Group, Inc.interiorlogicgroup.com
National provider of design and finish solutions offering installation of flooring, cabinets, countertops, and window coverings for homebuilders, commercial, and multifamily customers. |
1,664 |
| 61 |
YMCA of San Diego Countyymcasd.org
The organization is committed to enhancing human life and empowering individuals to reach their full potential through holistic development |
1,632 |
| 62 | 1,569 | |
| 63 |
Kyocera International, Inc. (North America)americas.kyocera.com
A leading provider of high-tech products for consumers and businesses including fine ceramics, semiconductor components, communication equipment, consumer products, and more |
1,553 |
| 64 |
Fairfield Residentialfairfieldresidential.com
A leading multifamily real estate operator and investment manager with expertise in acquisition, development, property management, and creating vibrant communities nationwide |
1,541 |
| 65 | 1,537 | |
| 66 |
San Diego Community College Districtsdccd.edu
The company is a large community college district in California, offering a variety of programs to approximately 100,000 students annually |
1,529 |
| 67 |
American Council on Exercise (ACE Fitness)acefitness.org
A nonprofit organization certifying exercise professionals and health coaches, conducting research, convening experts, working with communities, and advocating for physical activity policies |
1,514 |
| 68 |
ClickUpclickup.com
It offers a comprehensive productivity platform combining project management, document collaboration, and AI, enhancing efficiency for millions of users globally. |
1,502 |
| 69 |
All Starall-star.com
A privately owned firm specializing in aerospace support, facilities maintenance, military housing, logistics, construction, and fleet maintenance for military, government, and commercial contracts |
1,501 |
| 70 |
Family Health Centers of San Diegofhcsd.org
Delivering comprehensive behavioral health and primary care services to diverse, underserved populations in San Diego County for over 50 years |
1,474 |
| 71 |
Corticacorticacare.com
Innovative healthcare company specializing in treating neurodevelopmental conditions by combining medical, therapeutic, and behavioral approaches for comprehensive care and family empowerment |
1,462 |
| 72 |
California Bank & Trustcalbanktrust.com
A leading California bank with over $12 billion in assets offering a wide range of financial services to businesses and individuals |
1,432 |
| 73 |
Axos Bankaxosbank.com
This company empowers consumers and businesses in managing their financial lives through banking, borrowing, investing, and planning with an exceptional team |
1,430 |
| 74 |
NuVasiveglobusmedical.com
A company focused on providing innovative musculoskeletal procedural solutions and enabling technologies to improve patient care worldwide Visit their website for more information |
1,409 |
| 75 |
Mitchell International, Inc.mitchell.com
This company provides smart technology solutions to auto insurance, collision repair, and workers' compensation markets, utilizing advanced technology for success |
1,407 |
| 76 |
Kyribakyriba.com
A company empowering CFOs to optimize liquidity, manage financial risk, and reduce costs through a SaaS platform with AI and automation |
1,397 |
| 77 |
Seismicseismic.com
Global enablement platform providing customer-facing teams with skills, content, tools, and insights to drive engagement and revenue growth. |
1,329 |
| 78 |
100%100percent.com
A San Diego-based brand producing premium goggles, eyewear, helmets, gloves, and sportswear for motocross, downhill slopes, and BMX racing to inspire a new generation of racers |
1,318 |
| 79 |
San Diego County Office of Educationsdcoe.net
Leading innovation in education, the company supports school districts with cost-effective resources, staff development, and services to ensure all students thrive |
1,300 |
| 80 |
San Diego County Sheriff's Officesdsheriff.gov
Leading law enforcement agency in San Diego County with 4,000 employees providing general law enforcement, detention, court services, and specialized regional services |
1,272 |
| 81 |
Naval Information Warfare Center Pacificniwcpacific.navy.mil
A technological support center for the US military branches, specializing in information warfare, cyber domain, autonomous unmanned systems, and communication technologies |
1,266 |
| 82 |
ICW Groupicwgroup.com
National multi-line property and casualty insurance company offering comprehensive coverage through multiple carriers to protect customers and support independent agents. |
1,242 |
| 83 |
Alliant Universityalliant.edu
A private university offering graduate programs in psychology, education, business management, and forensic studies with a focus on practical applications Operating in multiple locations |
1,239 |
| 84 |
San Ysidro Healthsyhealth.org
A non-profit organization providing high-quality, compassionate, accessible, and affordable healthcare services for families in San Diego County, serving over 145,000 patients |
1,235 |
| 85 |
UC San Diego School of Medicinemedschool.ucsd.edu
Dedicated to advancing understanding and treatment of human diseases through translational research, clinical care, and education for a healthier world |
1,201 |
| 86 |
Netradynenetradyne.com
Utilizing computer vision and edge computing for fleet safety solutions, analyzing data points to improve driver behavior, increase profitability, and enhance transparency. |
1,167 |
| 87 |
High Tech Highhightechhigh.org
This organization is a network of sixteen charter schools in San Diego County, focused on equity, personalization, authentic work, and collaborative design |
1,109 |
| 88 |
CONAM Management Corporationconam.com
Established in 1975, this San Diego-based firm specializes in managing, investing in, developing, and rehabilitating multifamily housing properties nationwide |
1,108 |
| 89 |
Mutual of Omaha Mortgagemutualmortgage.com
A trusted mortgage company with strong leadership, cutting-edge technology, and superior support for an easy and efficient loan process Proudly serving customers for over 100 years |
1,104 |
| 90 |
LifeWavelifewave.com
The company offers wellness products that enhance well-being, empower individuals, and provide opportunities for personal and professional growth |
1,100 |
| 91 |
Elevo Learningelevolearning.com
This organization provides in-school and out-of-school programs to support the well-being and academic success of students, partnering with districts across California |
1,080 |
| 92 |
Powur, PBCpowur.com
Empowering homeowners and advisors to thrive in the global shift to sustainable energy, accelerating the adoption of clean energy worldwide |
1,078 |
| 93 |
Pacifica Senior Livingpacificaseniorliving.com
Passionate division of Pacifica Companies delivering personalized care services to seniors across 13 states in over 90 communities with ample growth opportunities |
1,048 |
| 94 |
Acadia Pharmaceuticalsacadia.com
Develop and commercialize FDA-approved treatments for neurological disorders, focusing on underserved diseases like Parkinson's psychosis and Rett syndrome. |
1,010 |
| 95 |
Lytx, Inc.lytx.com
Global leader providing video-based fleet management solutions, leveraging video to enhance driver and fleet safety, efficiency, and profitability. Offers services from safety to fuel management, utilizing AI. |
1,006 |
| 96 |
Industryindustryrecruiterai.com
Revolutionizing recruitment for hospitality, retail, and grocery industries with expert hourly and skilled labor matchmaking, achieving placements in under 24 hours |
985 |
| 97 |
Sempra Infrastructuresemprainfrastructure.com
The company delivers energy in North America, committed to building future energy systems for a better world |
968 |
| 98 |
Art of Problem Solvingartofproblemsolving.com
Developing educational opportunities for top students worldwide in math and expanding into other subjects, with a focus on online learning |
967 |
| 99 |
NP Digitalnpdigital.com
Award-winning agency delivering paid and organic search, social media, content marketing, and conversion optimization services through proprietary platforms and expert talent globally. |
961 |
| 100 |
SeaWorld San Diegoseaworld.com
A leading entertainment company focused on nature conservation, education, zoological care, and expanding into media platforms and consumer products |
960 |
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How this list is built
Every company on this list has a Tamtam company profile. The industry is the one the company gives on LinkedIn; categories such as SaaS or fintech are classified by Tamtam's AI from the company's website and LinkedIn page; and the headquarters city must match the company's own address. Companies are ranked by the number of employees on LinkedIn, and the list is refreshed every night. Classifications can be wrong, so treat the list as a starting point rather than an official ranking. Last updated Oct 9, 2026.
More company lists in San Diego
- SaaS companies in San Diego 49
- Software Development companies in San Diego 40
- Biotechnology Research companies in San Diego 34
- IT Services and IT Consulting companies in San Diego 32
- Financial Services companies in San Diego 29
- Hospitals and Health Care companies in San Diego 28
The same list elsewhere in United States
- The largest companies in the United States 91,636
- The largest companies in New York 6,921
- The largest companies in San Francisco 2,031
- The largest companies in Houston 1,790
- The largest companies in Chicago 1,669
- The largest companies in Los Angeles 1,245
- The largest companies in Atlanta 1,146
- The largest companies in Washington 1,082
- The largest companies in Austin 1,076
- The largest companies in Dallas 1,036
- The largest companies in Boston 988
- The largest companies in Miami 879
- The largest companies in Denver 645
- The largest companies in Seattle 593
- The largest companies in Philadelphia 504
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