The companies listed are predominantly mid-sized to large firms specializing in medical device manufacturing and biotechnology research in Irvine. Most were founded between the 1970s and early 2000s, reflecting a mature industry presence.
Edwards Lifesciences develops structural heart technologies, while Masimo focuses on noninvasive patient monitoring. Glidewell Dental pioneers digital dentistry innovations, and Allergan Aesthetics, an AbbVie Company, markets leading aesthetic products. Toshiba, though primarily in electronics, also has a significant presence here, indicating a broader tech ecosystem.
| # | Company | Employees | |||
|---|---|---|---|---|---|
| 1 |
Edwards Lifesciencesedwards.com
Develops breakthrough structural heart technologies and medical devices for patients, partnering with clinicians to improve lives globally across over 100 countries. |
14,148 | |||
| 2 |
Toshibatoshiba.com
A global technology company focusing on energy, infrastructure, electronics, and digital solutions to create a sustainable future for generations to come |
8,787 | |||
| 3 |
Masimomasimo.com
Develops and manufactures innovative noninvasive patient monitoring technologies and sensors to improve clinical decision-making and patient safety worldwide. |
3,667 | |||
| 4 |
Allergan Aesthetics, an AbbVie Companyglobal.allerganaesthetics.com
Develop, manufacture, and market a portfolio of leading aesthetics products including facial injectables, body contouring, plastics, and skin care. |
2,456 | |||
| 5 |
Glidewell Dentalglidewelldental.com
Pioneering digital dentistry innovations, offering comprehensive, cost-effective clinical solutions, combining open digital workflows, AI-powered manufacturing, and vertically integrated operations to empower dental professionals. |
2,238 | |||
| 6 |
Advanced Sterilization Productsasp.com
Global leader providing advanced products, technologies, and workflows for medical sterilization and disinfection, dedicated to defending lives of patients and healthcare workers. |
1,532 | |||
| 7 |
Inari Medicalinarimedical.com
Treats venous and other diseases, offers innovative products and services in MedSurg, Neurotechnology, Orthopedics to improve patient and healthcare outcomes. |
688 | |||
| 8 |
Axonics, Inc.bostonscientific.com
Develops and sells medical devices to treat bladder and bowel dysfunction, including sacral neuromodulation systems and hydrogels for urinary incontinence. |
618 | |||
| 9 |
Nihon Kohden Americaus.nihonkohden.com
Manufacturer of patient monitoring, sleep assessment, neurology, and cardiology instruments focused on quality, innovation, and healthcare professional needs. |
566 | |||
| 10 |
InModeinmodemd.com
Develops, manufactures, markets radio-frequency platforms for minimally-invasive procedures, improving existing surgical methods in plastic surgery, gynecology, dermatology, ENT, ophthalmology. |
539 | |||
| 11 |
Rhevera Medicalendologix.com
Develops therapies for interventional treatment of vascular disease, preserving and restoring blood flow for complex cases like peripheral arterial disease and abdominal aortic aneurysms. |
505 | |||
| 12 |
Beta Bionicsbetabionics.com
Development and commercialization of advanced adaptive algorithm-based autonomous insulin delivery devices to improve diabetes treatment and patient quality of life. |
425 | |||
Want more companies than this list?This page shows the largest ones only. Connect to Tamtam to see every company that matches, filter by size, industry or growth, and reach their decision-makers. | |||||
| 13 |
Angel Alignerangelaligner.com
A global leader in clear aligner technology, driving innovation in orthodontic treatment with over 20 years of experience and a focus on research and digital solutions |
378 | |||
| 14 |
mdxhealthmdxhealth.com
Provides actionable molecular diagnostic information to personalize cancer diagnosis and treatment. Tests based on genetic, epigenetic, and molecular technologies for urologic cancers. |
322 | |||
| 15 |
CERENOVUS
A leader in neurovascular care, committed to changing the trajectory of stroke with a broad portfolio of devices for endovascular treatment |
317 | |||
| 16 |
Mentor Worldwide LLCmentorwwllc.com
A leading global brand specializing in breast aesthetics, developing innovative breast implants with a patient-first approach to empower women's self-esteem and quality of life |
225 | |||
| 17 |
Keystone Dental Groupkeystonedental.com
Oral healthcare company delivering breakthrough dental implant and biomaterial technologies, manufacturing premium cutting-edge implants and components through scientific R&D and advanced manufacturing. |
208 | |||
| 18 |
Acclarentproducts.integralife.com
A medical device company providing minimally invasive technologies for ENT surgeons to treat rhinosinusitis and Eustachian Tube Dysfunction, preserving nasal anatomy |
184 | |||
| 19 |
NeurOpticsneuroptics.com
Leader in NPi Pupillometry technology, providing innovative solutions for improved patient outcomes in various medical disciplines worldwide |
81 | |||
| 20 |
Keating Dental Labkeatingdentallab.com
Family-run, full-service dental laboratory providing high-quality dental restorations, including dentures, e.max, zirconia, and implant-supported restorations, with 5-star customer service and educational resources. |
73 | |||
| 21 |
LimFlow, Now Part of Strykerlimflow.com
LimFlow offers innovative medical technology for end-stage CLTI patients, restoring blood flow to prevent amputations and improve quality of life |
25 | |||
| 22 |
altaviz, llcaltaviz.com
Innovative company developing high-performance medical devices and instruments for various industries, focusing on enhancing patient care and safety |
22 | |||
| 23 |
11 Health11health.com
Medical wearables company revolutionizing chronic illness management and ostomy life through innovative technology and empathetic patient care |
9 | |||
| 24 |
Rebeccatech LLCnebulyft.com
Innovative medical solutions provider specializing in micro-devices, plasma technology, radio-frequency, and device integration for professional care givers |
7 | |||
| 25 |
Hio Medical Resource
Provider of top-tier medical supplies to healthcare providers, hospitals, retail brands, and white label partners, dedicated to precision, reliability, and excellence |
3 | |||
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How this list is built
Every company on this list has a Tamtam company profile. The industry is the one the company gives on LinkedIn; categories such as SaaS or fintech are classified by Tamtam's AI from the company's website and LinkedIn page; and the headquarters city must match the company's own address. Companies are ranked by the number of employees on LinkedIn, and the list is refreshed every night. Classifications can be wrong, so treat the list as a starting point rather than an official ranking. Last updated Nov 12, 2026.
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The same list elsewhere in United States
- Medical device companies in the United States 911
- Medical device companies in California 188
- Medical device companies in Massachusetts 78
- Medical device companies in Minnesota 55
- Medical device companies in Florida 49
- Medical device companies in New York State 43
- Medical device companies in Pennsylvania 41
- Medical device companies in Texas 37
- Medical device companies in Illinois 36
- Medical device companies in New Jersey 34
- Medical device companies in Ohio 27
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- Medical device companies in North Carolina 25