# 30 leading companies with in-house R&D in Clermont-Ferrand
Tamtam tracks 35 companies with in-house R&D headquartered in Clermont-Ferrand. This list ranks the 30 largest by number of employees on LinkedIn, led by Michelin, CHU de Clermont-Ferrand and centre jean perrin. Their median headcount is 44. Half of them were founded in 2000 or later.
Clermont-Ferrand's in-house R&D landscape is diverse, featuring large established groups, public institutions, and younger specialized firms. Michelin, founded in 1889, manufactures tires and components for various sectors, including mobility and healthcare. The CHU de Clermont-Ferrand, a university hospital, provides extensive care, teaching, and research. Atelier industriel de l'a茅ronautique de Clermont-Fd maintains French military aircraft, while BeYs offers digital trust solutions like electronic signatures.
A notable pattern is the strong presence of both traditional manufacturing and advanced biotechnology. AFYREN develops biobased compounds through fermentation, and CARBIOS focuses on enzyme-based plastic and textile biorecycling. The city also hosts significant public and semi-public research and development entities, reflecting a broad range of R&D activities from heavy industry to specialized scientific fields.
馃嚝馃嚪 Clermont-Ferrand 路 30 companies 路 Updated Nov 11, 2026
| # | Company | Industry | Headquarters | Employees | Founded |
|---|---|---|---|---|---|
| 1 | [Michelin](https://www.tamtam.ai/c/michelin) (michelin.com)
Manufactures high-quality tires, components, and composites for mobility, construction, aeronautics, low-carbon energies, and healthcare. Offers exceptional experiences through connected solutions, AI, and the MICHELIN Guide. | Motor Vehicle Manufacturing | 馃嚝馃嚪 Clermont-Ferrand | 56,897 | 1889 |
| 2 | [CHU de Clermont-Ferrand](https://www.tamtam.ai/c/chu-de-clermont-ferrand) (chu-clermontferrand.fr)
A university hospital with over 8000 employees in Clermont-Ferrand, providing care, prevention, teaching, and research services across multiple sites | Government Administration | 馃嚝馃嚪 Clermont-Ferrand | 2,531 | 1767 |
| 3 | [centre jean perrin](https://www.tamtam.ai/c/centre-jean-perrin) (cjp.fr)
Specialized cancer treatment, research, education, and training center serving 28,000 patients annually with equitable access and no extra fees. | Hospitals and Health Care | 馃嚝馃嚪 Clermont-Ferrand | 448 | 1973 |
| 4 | [UNIVERSITE D'AUVERGNE](https://www.tamtam.ai/c/universite-d-auvergne) (uca.fr)
provides student information, orientation, career insertion support, monitors academic success, conducts graduate follow-up surveys, and facilitates study reorientation | Higher Education | 馃嚝馃嚪 Clermont-Ferrand | 374 | 1976 |
| 5 | [Atelier industriel de l'a茅ronautique de Clermont-Fd](https://www.tamtam.ai/c/atelier-industriel-de-l-aeronautique-de-clermont-fd) (defense.gouv.fr)
State military aeronautical industrial service maintains French armed forces transport, fighter, training aircraft, and helicopters. Expert in industrial maintenance, modifications, repairs, and equipment maintenance. | Aviation and Aerospace Component Manufacturing | 馃嚝馃嚪 Clermont-Ferrand | 256 | 1939 |
| 6 | [MICHELIN Innovation Lab](https://www.tamtam.ai/c/michelin-innovation-lab) (michelin.com)
Innovation lab focused on exploring new territories and leveraging expertise beyond tires | Manufacturing | 馃嚝馃嚪 Clermont-Ferrand | 200 | |
| 7 | [NOREVA GROUPE](https://www.tamtam.ai/c/noreva-groupe) (noreva-laboratoires.com)
Development of high-tolerance dermatological skincare products addressing skin health holistically, suitable for all ages and skin conditions. | Personal Care Product Manufacturing | 馃嚝馃嚪 Clermont-Ferrand | 163 | 2000 |
| 8 | [BeYs](https://www.tamtam.ai/c/beys) (be-ys.com)
The company offers innovative digital trust solutions, including electronic signature, data archiving, and personal document management, ensuring security and compliance | IT Services and IT Consulting | 馃嚝馃嚪 Clermont-Ferrand | 153 | 2000 |
| 9 | [AFYREN](https://www.tamtam.ai/c/afyren) (afyren.com)
Develops biobased compounds via patented fermentation for diverse industries like food and cosmetics, focusing on low-carbon and zero-waste production. | Biotechnology Research | 馃嚝馃嚪 Clermont-Ferrand | 145 | 2012 |
| 10 | [MICHELIN Aircraft Tyre](https://www.tamtam.ai/c/michelin-aircraft-tyre) (aircraft.michelin.com)
Manufacturing bias and radial tires for military, commercial, regional, and general aviation markets. Essential for takeoff, landing, and taxiing aircraft. | Airlines and Aviation | 馃嚝馃嚪 Clermont-Ferrand | 139 | 2000 |
| 11 | [Babymoov Group](https://www.tamtam.ai/c/babymoov-group) (babymoov.com)
French company creating solutions for parents through 6 ranges: feeding, comfort, safety, caring, outdoor, playing. Products found in over 70 countries, lifetime warranty. | Manufacturing | 馃嚝馃嚪 Clermont-Ferrand | 129 | 1997 |
| 12 | [CARBIOS](https://www.tamtam.ai/c/carbios) (carbios.com)
Develops enzyme-based processes for plastic and textile biorecycling and biodegradation, promoting a circular economy with industrial-scale solutions supported by major brands. | Biotechnology Research | 馃嚝馃嚪 Clermont-Ferrand | 102 | 2011 |
| 13 | [AUBRILAM](https://www.tamtam.ai/c/aubrilam) (aubrilam.com)
Designs and manufactures outdoor furniture to enhance urban spaces, offering over 300 customizable products for various environments worldwide | Furniture and Home Furnishings Manufacturing | 馃嚝馃嚪 Clermont-Ferrand | 86 | 1978 |
| 14 | [SURGAR](https://www.tamtam.ai/c/surgar) (surgar-surgery.com)
Specializing in augmented reality for laparoscopic surgery on mobile organs, we aim to enhance precision and save lives through better surgery | Medical Equipment Manufacturing | 馃嚝馃嚪 Clermont-Ferrand | 46 | 2019 |
| 15 | [ADIV](https://www.tamtam.ai/c/adiv) (adiv.fr)
Bridge between academic research and meat industry needs, providing tailored R&D, audit, consulting, expertise, and training services. | Business Consulting and Services | 馃嚝馃嚪 Clermont-Ferrand | 44 | 1975 |
| 16 | [Trelleborg Oil & Marine](https://www.tamtam.ai/c/trelleborg-oil-and-marine) (trelleborg.com)
The company specializes in providing high-performing, innovative flexible hose solutions for oil and gas transfer applications, tailored to unique requirements | Industrial Machinery Manufacturing | 馃嚝馃嚪 Clermont-Ferrand | 38 | |
| 17 | [Alfa Informatique](https://www.tamtam.ai/c/alfa-informatique) (alfainfo.fr)
Since 1980, this company designs and develops management software tailored to the needs of healthcare, social, and medical sectors, becoming a leading French editor in this market | IT Services and IT Consulting | 馃嚝馃嚪 Clermont-Ferrand | 30 | |
| 18 | [Th茅a Pharma France](https://www.tamtam.ai/c/thea-pharma-france) (theapharma.fr)
Specializes in research, development, and commercialization of ophthalmology products with a strong presence across Europe and worldwide. | Pharmaceutical Manufacturing | 馃嚝馃嚪 Clermont-Ferrand | 27 | |
| 19 | [BBS Slama](https://www.tamtam.ai/c/bbs-slama) (bbs-logiciels.com)
Developing innovative calculation solutions for professionals in energy efficiency to accurately study thermal aspects of buildings, ensuring compliance with regulations and improving energy performance | Software Development | 馃嚝馃嚪 Clermont-Ferrand | 24 | 1985 |
| 20 | [SYLink Technologie](https://www.tamtam.ai/c/sylink-technologie) (sylink.fr)
SYLink Technologie offers AI-driven products for securing networks, IoT devices, and business data, simplifying cybersecurity with user-friendly interfaces and unique designs | Computer and Network Security | 馃嚝馃嚪 Clermont-Ferrand | 21 | 2017 |
| 21 | [CELIUM ENERGIES](https://www.tamtam.ai/c/celium-energies) (celium.pro)
Industrial project design and implementation in the Auvergne Rh么ne-Alpes region Specializing in heating, air conditioning, ventilation, industrial piping, dust removal, and fire protection systems | Construction | 馃嚝馃嚪 Clermont-Ferrand | 19 | 1872 |
| 22 | [Kalkin](https://www.tamtam.ai/c/kalkin) (kalkin.fr)
Specializing in digitalizing outdoor activities for tourism, the company offers 3D modeling solutions to showcase destinations and enhance visitor experiences | Software Development | 馃嚝馃嚪 Clermont-Ferrand | 12 | 2012 |
| 23 | [BIENESIS](https://www.tamtam.ai/c/bienesis) (bienesis.fr)
Development of innovative system protecting vineyards from climate hazards like frost, hail, diseases, reducing production losses and chemical runoff. | Climate Technology Product Manufacturing | 馃嚝馃嚪 Clermont-Ferrand | 11 | 2024 |
| 24 | [Punch Powertrain France - former APOJEE](https://www.tamtam.ai/c/punch-powertrain-france-former-apojee) (punchpowertrain.com)
High-technology supplier in power electronics & ignition/combustion fields for automotive, aerospace, and industrial sectors, offering innovative solutions for efficiency | Motor Vehicle Manufacturing | 馃嚝馃嚪 Clermont-Ferrand | 10 | 1999 |
| 25 | [Biotech Open Platform](https://www.tamtam.ai/c/biotech-open-platform) (biotechopenplatform.com)
Formed by Danone, Michelin, DMC, and Cr茅dit Agricole. Accelerates industrialization of precision fermentation for bio-based materials and ingredients, driving biotech innovation and scalable production. | Manufacturing | 馃嚝馃嚪 Clermont-Ferrand | 10 | 2024 |
| 26 | [BioUpp](https://www.tamtam.ai/c/bioupp) (bioupp.com)
Developed a patented innovation converting excess electricity into biogas by utilizing CO2, recognized by i-Lab and Women TechEU. | Renewable Energy Power Generation | 馃嚝馃嚪 Clermont-Ferrand | 9 | 2024 |
| 27 | [Qarboon (ex-Dense Fluid Degreasing)](https://www.tamtam.ai/c/qarboon-ex-dense-fluid-degreasing) (dense-fluid-degreasing.com)
A French company specializing in innovative and ecological cleaning machines utilizing supercritical CO2 for industrial cleaning, decontamination, sterilization, and extraction | Machinery Manufacturing | 馃嚝馃嚪 Clermont-Ferrand | 9 | 2012 |
| 28 | [ECHODIA](https://www.tamtam.ai/c/echodia) (echodia.fr)
Specialized in hearing assessment, the company develops and sells devices for auditory measurements in otorhinolaryngology and neuroscience fields, catering to healthcare professionals' needs | Medical Equipment Manufacturing | 馃嚝馃嚪 Clermont-Ferrand | 6 | 2009 |
| 29 | [CALNESIS](https://www.tamtam.ai/c/calnesis) (calnesis.com)
Independent laboratory specializing in Physical Chemistry, offering R&D studies, measurements, and analyses in various fields with customized measurement benches and software solutions | Business Consulting and Services | 馃嚝馃嚪 Clermont-Ferrand | 5 | 2015 |
| 30 | [Probionov](https://www.tamtam.ai/c/probionov) (probionov.com)
Specializing in innovative probiotic formulations, we develop products for gastroenterology, gynecology, and immune system defense, with a focus on pharmaceutical-grade research and development | Pharmaceutical Manufacturing | 馃嚝馃嚪 Clermont-Ferrand | 4 | 1955 |
## How this list is built
Every company on this list has a Tamtam company profile. The industry is the one the company gives on LinkedIn; categories such as SaaS or fintech are classified by Tamtam's AI from the company's website and LinkedIn page; and the headquarters city must match the company's own address. Companies are ranked by the number of employees on LinkedIn, and the list is refreshed every night. Classifications can be wrong, so treat the list as a starting point rather than an official ranking. Last updated Nov 11, 2026.
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Source: https://www.tamtam.ai/l/r-and-d-companies-clermont-ferrand