# The 27 largest companies with in-house R&D in Durham

Tamtam tracks 27 companies with in-house R&D headquartered in Durham. This list ranks all of them by number of employees on LinkedIn, led by IQVIA, Duke University and Duke University Health System. Their median headcount is 1,181. Half of them were founded in 1988 or later.

These Durham-based companies are predominantly large organizations specializing in healthcare, higher education, and technology. Many are significant employers, reflecting a focus on research and development. Key entities include IQVIA, which provides clinical research and healthcare intelligence; Duke University, a private research university; FHI 360, a nonprofit advancing global equity and well-being; and Avalara, offering an AI platform for global tax and compliance.

A notable characteristic is the strong presence of academic and healthcare institutions. Duke University, Duke University Health System, and Duke University Hospital collectively form a substantial cluster, indicating a deep integration of medical research, education, and patient care within the local economy.

🇺🇸 Durham · 27 companies · Updated Nov 11, 2026

| # | Company | Industry | Headquarters | Employees | Founded |
|---|---|---|---|---|---|
| 1 | [IQVIA](https://www.tamtam.ai/c/iqvia) (iqvia.com)<br>Provides clinical research, commercial insights, and healthcare intelligence to life sciences and healthcare industries, accelerating medical treatments for better patient outcomes. | Hospitals and Health Care | 🇺🇸 Durham | 80,633 | 1954 |
| 2 | [Duke University](https://www.tamtam.ai/c/duke-university) (duke.edu)<br>Private research university offering undergraduate, graduate, and professional education with strong emphasis on research and academic excellence. | Higher Education | 🇺🇸 Durham | 16,307 | 1924 |
| 3 | [Duke University Health System](https://www.tamtam.ai/c/duke-university-health-system) (dukehealth.org)<br>Academic health system focused on innovative research, education, evidence-based medicine, community health improvement, and eliminating health disparities globally and locally. | Hospitals and Health Care | 🇺🇸 Durham | 12,096 |  |
| 4 | [FHI 360](https://www.tamtam.ai/c/fhi-360) (fhi360.org)<br>Nonprofit organization advancing equity, health, and well-being worldwide through research, resources, and locally led, data-driven solutions. | International Trade and Development | 🇺🇸 Durham | 8,644 | 1971 |
| 5 | [University of New Hampshire](https://www.tamtam.ai/c/university-of-new-hampshire) (unh.edu)<br>Public research university offering undergraduate and graduate programs, engaging in teaching, research, creative expression, and community service. | Higher Education | 🇺🇸 Durham | 6,952 |  |
| 6 | [Avalara](https://www.tamtam.ai/c/avalara) (avalara.com)<br>Provides an agentic AI platform for global tax and compliance, automating calculations, return filings, and exemption certificate management for businesses worldwide. | Software Development | 🇺🇸 Durham | 5,649 | 2004 |
| 7 | [Duke University Hospital](https://www.tamtam.ai/c/duke-university-hospital)<br>A leading academic medical center known for exceptional care, groundbreaking research, and commitment to improving the health of individuals and communities | Hospitals and Health Care | 🇺🇸 Durham | 3,704 | 1925 |
| 8 | [Duke University School of Medicine](https://www.tamtam.ai/c/duke-university-school-of-medicine) (medschool.duke.edu)<br>Leading medical school with a focus on interdisciplinary collaboration, research, and innovation to improve human health locally and globally | Higher Education | 🇺🇸 Durham | 2,542 | 1930 |
| 9 | [Toshiba Global Commerce Solutions](https://www.tamtam.ai/c/toshiba-global-commerce-solutions) (commerce.toshiba.com)<br>Global leader in retail store technology, providing integrated in-store solutions that enhance customer engagement, transform the in-store experience, and accelerate digital transformation | Technology, Information and Internet | 🇺🇸 Durham | 2,537 | 2012 |
| 10 | [Wolfspeed](https://www.tamtam.ai/c/wolfspeed) (wolfspeed.com)<br>Global leader in Silicon Carbide technology for over 30 years, enabling breakthroughs in electric vehicles, 5G, renewable energy, aerospace, and defense industries | Semiconductor Manufacturing | 🇺🇸 Durham | 2,460 | 2015 |
| 11 | [KBI Biopharma](https://www.tamtam.ai/c/kbi-biopharma) (kbibiopharma.com)<br>Provides fully-integrated, accelerated drug development and biomanufacturing services to pharmaceutical and biotechnology companies globally with world-class analytical capabilities. | Biotechnology Research | 🇺🇸 Durham | 1,694 | 1996 |
| 12 | [Cree](https://www.tamtam.ai/c/cree) (wolfspeed.com)<br>Specializing in Silicon Carbide technology, we provide cutting-edge solutions and innovations Follow us at Wolfspeed, Inc for the latest updates | Semiconductor Manufacturing | 🇺🇸 Durham | 1,658 | 1987 |
| 13 | [JAGGAER](https://www.tamtam.ai/c/jaggaer) (jaggaer.com)<br>It provides enterprise procurement and supplier collaboration solutions, enhancing decision-making and automating processes for organizations globally, with proven expertise. | Software Development | 🇺🇸 Durham | 1,474 | 1995 |
| 14 | [Q² Solutions](https://www.tamtam.ai/c/q-solutions) (labs.iqvia.com)<br>Company undergoing rebranding and transition from Q² Solutions to IQVIA Laboratories, directing audience to new website and LinkedIn. | Pharmaceutical Manufacturing | 🇺🇸 Durham | 1,181 | 2015 |
| 15 | [Duke Clinical Research Institute](https://www.tamtam.ai/c/duke-clinical-research-institute) (dcri.org)<br>A global leader in clinical research, conducting groundbreaking trials, managing patient registries, and publishing impactful research to improve healthcare quality | Research Services | 🇺🇸 Durham | 1,009 | 1969 |
| 16 | [Duke University Pratt School of Engineering](https://www.tamtam.ai/c/duke-university-pratt-school-of-engineering) (pratt.duke.edu)<br>A top-ranked engineering school providing rigorous education, research, and societal impact to cultivate purposeful and impactful lives for students | Higher Education | 🇺🇸 Durham | 638 | 1939 |
| 17 | [SMT (SportsMEDIA Technology)](https://www.tamtam.ai/c/smt-sportsmedia-technology) (smt.com)<br>Provider of advanced technology and services for sports broadcasts, events, and entertainment, offering a wide range of innovative solutions to enhance productions | Technology, Information and Media | 🇺🇸 Durham | 636 | 1988 |
| 18 | [BioCryst Pharmaceuticals, Inc.](https://www.tamtam.ai/c/biocryst-pharmaceuticals-inc) (biocryst.com)<br>Development of oral small-molecule and protein therapeutics targeting hereditary angioedema and other rare, difficult-to-treat diseases worldwide. | Biotechnology Research | 🇺🇸 Durham | 613 | 1986 |
| 19 | [Duke Cancer Institute](https://www.tamtam.ai/c/duke-cancer-institute) (dukecancerinstitute.org)<br>A collaborative and innovative cancer institute at a renowned university and medical center, creating breakthroughs and transforming possibilities in cancer care | Hospitals and Health Care | 🇺🇸 Durham | 374 | 1973 |
| 20 | [MedPharm](https://www.tamtam.ai/c/medpharm) (medpharm.com)<br>Supports companies navigating the complexity of topical and transdermal drug development and manufacturing, from formulation and preclinical research to clinical trial supply and commercial manufacturing. | Pharmaceutical Manufacturing | 🇺🇸 Durham | 285 | 1999 |
| 21 | [Solystic](https://www.tamtam.ai/c/solystic) (solystic.com)<br>Provides end-to-end automation solutions for mail, express, parcels, e-commerce, and retail industries, focusing on sorting, distribution, and intralogistics processes. | Automation Machinery Manufacturing | 🇺🇸 Durham | 258 | 1950 |
| 22 | [The Duke Human Vaccine Institute](https://www.tamtam.ai/c/the-duke-human-vaccine-institute) (dhvi.duke.edu)<br>A leader in infectious disease research, DHVI focuses on developing vaccines, diagnostics, and therapeutics to address global health challenges and disparities | Research Services | 🇺🇸 Durham | 184 | 1990 |
| 23 | [Gilero, A Sanner Group Company](https://www.tamtam.ai/c/gilero-a-sanner-group-company) (gilero.com)<br>Offering end-to-end design, development, and manufacturing for medical devices and pharmaceutical products, specializing in a variety of areas for client needs | Medical Equipment Manufacturing | 🇺🇸 Durham | 154 |  |
| 24 | [Smart Wires Inc.](https://www.tamtam.ai/c/smart-wires-inc) (smartwires.com)<br>Global provider of grid enhancing technology and services helping utilities unlock capacity, solve critical issues, and create flexible, reliable, affordable power grids. | Appliances, Electrical, and Electronics Manufacturing | 🇺🇸 Durham | 95 | 2010 |
| 25 | [Sipcam Agro USA](https://www.tamtam.ai/c/sipcam-agro-usa) (sipcam.com)<br>A global leader in agrotechnology, specializing in the development, production, and marketing of plant protection products for agriculture, turfgrass, and ornamental markets | Agricultural Chemical Manufacturing | 🇺🇸 Durham | 61 | 1946 |
| 26 | [Nocturnal](https://www.tamtam.ai/c/nocturnal) (nocturnalpd.com)<br>A boutique firm specializing in accelerating medical device commercialization for class II and III devices through expertise, unique engagement model, and result-based pricing | Medical Equipment Manufacturing | 🇺🇸 Durham | 32 | 2011 |
| 27 | [StrideBio, Inc](https://www.tamtam.ai/c/stridebio-inc) (stridebio.com)<br>A gene therapy company creating innovative genetic medicines to treat rare diseases, improving AAV vectors for enhanced efficacy and manufacturability at scale | Biotechnology Research | 🇺🇸 Durham | 4 | 2015 |

## How this list is built

Every company on this list has a Tamtam company profile. The industry is the one the company gives on LinkedIn; categories such as SaaS or fintech are classified by Tamtam's AI from the company's website and LinkedIn page; and the headquarters city must match the company's own address. Companies are ranked by the number of employees on LinkedIn, and the list is refreshed every night. Classifications can be wrong, so treat the list as a starting point rather than an official ranking. Last updated Nov 11, 2026.

## More company lists in Durham

- [The largest companies in Durham](https://www.tamtam.ai/l/largest-companies-durham-united-states) (182)
- [Multinational companies in Durham](https://www.tamtam.ai/l/multinational-companies-durham) (37)

## The same list elsewhere in United States

- [Companies with in-house R&D in the United States](https://www.tamtam.ai/l/r-and-d-companies-united-states) (6,796)
- [Companies with in-house R&D in California](https://www.tamtam.ai/l/r-and-d-companies-california) (1,276)
- [Companies with in-house R&D in Texas](https://www.tamtam.ai/l/r-and-d-companies-texas) (442)
- [Companies with in-house R&D in New York State](https://www.tamtam.ai/l/r-and-d-companies-new-york-state) (419)
- [Companies with in-house R&D in Massachusetts](https://www.tamtam.ai/l/r-and-d-companies-massachusetts) (396)
- [Companies with in-house R&D in Illinois](https://www.tamtam.ai/l/r-and-d-companies-illinois) (322)
- [Companies with in-house R&D in Michigan](https://www.tamtam.ai/l/r-and-d-companies-michigan) (287)
- [Companies with in-house R&D in Ohio](https://www.tamtam.ai/l/r-and-d-companies-ohio) (277)
- [Companies with in-house R&D in Pennsylvania](https://www.tamtam.ai/l/r-and-d-companies-pennsylvania) (255)
- [Companies with in-house R&D in New Jersey](https://www.tamtam.ai/l/r-and-d-companies-new-jersey) (224)
- [Companies with in-house R&D in Florida](https://www.tamtam.ai/l/r-and-d-companies-florida) (221)
- [Companies with in-house R&D in Alabama](https://www.tamtam.ai/l/r-and-d-companies-alabama) (214)
- [Companies with in-house R&D in Georgia](https://www.tamtam.ai/l/r-and-d-companies-georgia) (173)
- [Companies with in-house R&D in Virginia](https://www.tamtam.ai/l/r-and-d-companies-virginia) (166)
- [Companies with in-house R&D in North Carolina](https://www.tamtam.ai/l/r-and-d-companies-north-carolina) (158)
- [Companies with in-house R&D in Wisconsin](https://www.tamtam.ai/l/r-and-d-companies-wisconsin) (154)
- [Companies with in-house R&D in Minnesota](https://www.tamtam.ai/l/r-and-d-companies-minnesota) (146)
- [Companies with in-house R&D in Washington State](https://www.tamtam.ai/l/r-and-d-companies-washington-state) (140)
- [Companies with in-house R&D in Colorado](https://www.tamtam.ai/l/r-and-d-companies-colorado) (113)
- [Companies with in-house R&D in Maryland](https://www.tamtam.ai/l/r-and-d-companies-maryland) (107)
- [Companies with in-house R&D in Indiana](https://www.tamtam.ai/l/r-and-d-companies-indiana) (104)
- [Companies with in-house R&D in New York](https://www.tamtam.ai/l/r-and-d-companies-new-york) (223)
- [Companies with in-house R&D in San Francisco](https://www.tamtam.ai/l/r-and-d-companies-san-francisco) (147)
- [Companies with in-house R&D in Houston](https://www.tamtam.ai/l/r-and-d-companies-houston) (129)

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Source: https://www.tamtam.ai/l/r-and-d-companies-durham