These Frankfurt-based companies with in-house R&D span diverse sectors, from motor vehicle manufacturing and IT services to chemical production and healthcare. The list includes established large groups alongside mid-sized firms. Companies like AUMOVIO provide advanced mobility solutions, while T-Systems International focuses on end-to-end IT solutions and digital transformation. In the chemical sector, allnex offers specialty polymers with a focus on sustainability, and INEOS Styrolution specializes in styrenics supply. Regnology delivers technology for regulatory reporting, and Emma – The Sleep Company develops advanced sleep technology products.
A notable pattern among these companies is the strong presence of the IT Services and IT Consulting industry, with T-Systems International and DB Systel GmbH both headquartered in Frankfurt and focusing on digital solutions. This indicates a concentration of expertise in information technology and digital transformation within the city.
| # | Company | Employees | |||
|---|---|---|---|---|---|
| 1 |
AUMOVIOaumovio.com
Provides innovative hardware, software, modern mobility solutions, and a wide range of mobility services, making future mobility safe, exciting, connected, and autonomous. |
20,389 | |||
| 2 |
T-Systems Internationalt-systems.com
Provides end-to-end IT solutions, cloud migration, and industry-specific digital transformation services with strong security and global presence. |
10,768 | |||
| 3 |
DB Systel GmbHdbsystel.de
The company focuses on digitalizing rail systems through innovative solutions and partnerships, aiming to meet customer needs and IT standards |
4,639 | |||
| 4 |
allnexallnex.com
A leading producer of specialty polymers focused on sustainability, offering advanced coating solutions for various industries through global innovation and responsive local support |
2,259 | |||
| 5 |
Regnologyregnology.net
Provides technology for regulatory, risk, tax, and finance reporting, helping clients achieve compliance and unlock insights across various financial sectors globally. |
2,015 | |||
| 6 |
INEOS Styrolutionineos.com
Global leader in styrenics supply, specializing in styrene monomer, polystyrene, ABS, and styrenic specialties for various industries, with world-class production facilities and 90+ years of experience |
1,978 | |||
| 7 |
Chemetallchemetall.com
Leading supplier of applied surface treatment technologies for metal, plastic, and glass substrates in industries like automotive, aerospace, and aluminum finishing |
1,728 | |||
| 8 |
Universitätsmedizin Frankfurtunimedizin-ffm-karriere.softgarden.io
A university hospital in Frankfurt with 7,500 employees, focusing on healthcare, research, and education Offering diverse career opportunities and promoting work-life balance |
1,379 | |||
| 9 |
Merz Therapeuticsmerztherapeutics.com
Development of innovative treatments and partnerships for movement disorders, neurodegenerative diseases, liver disease, improving patient quality of life globally. |
1,322 | |||
| 10 |
Emma – The Sleep Companyteam.emma-sleep.com
Development and promotion of advanced sleep technology products aimed at improving rest quality and supporting diverse, inclusive work culture. |
1,317 | |||
| 11 |
SAMSON GROUPsamsongroup.com
A leading manufacturer of control valves, butterfly valves, automation units, regulators, transmitters, and controllers for industrial processes, with a focus on innovation and digitization |
1,144 | |||
| 12 |
Nintendo of Europenintendo.com
A Japanese company creates popular video game franchises, hardware, and software products, aiming to provide unique entertainment experiences globally |
998 | |||
| 13 |
Deutsche WertpapierService Bank AGdwpbank.de
The company is a leading provider of securities services in Germany, servicing millions of accounts for various types of banks with cost-effective and risk-managing solutions |
882 | |||
| 14 |
Matrix42matrix42.com
An enterprise service management platform offering solutions for efficient processes, data security, and improved employee experience through IT services and automation |
630 | |||
| 15 |
SBS Ecoclean Groupecoclean-group.net
Innovative global leader in providing efficient and sustainable solutions for industrial parts cleaning, surface processing, and green hydrogen generation |
578 | |||
Want more companies than this list?This page shows the largest ones only. Connect to Tamtam to see every company that matches, filter by size, industry or growth, and reach their decision-makers. | |||||
| 16 |
Crytekcrytek.com
An independent videogame developer, publisher, and technology provider known for award-winning titles created with cutting-edge 3D game development solution CRYENGINE |
496 | |||
| 17 | 481 | ||||
| 18 |
SVOLT Energy Technology (Europe) GmbHsvolt.cn
Development and production of lithium battery materials, cells, modules, packs, management systems, and energy storage products globally. |
410 | |||
| 19 |
Casco Automotive Group - An Amphenol Companycascoauto.com
Provides innovative automotive power and sensor products with global production, enhancing vehicle comfort, safety, and power accessibility. |
396 | |||
| 20 |
CNGR Advanced Materialcngr.eu
A global supplier of energy materials for lithium batteries, focusing on technological innovation, energy efficiency, and sustainability through precursor production and recycling |
390 | |||
| 21 |
BioSpring GmbHbiospring.net
A global expert in oligonucleotide science and cGMP manufacturing, offering comprehensive support for drug development from preclinical to commercial stages |
333 | |||
| 22 |
Merz Groupmerz.com
Global family-owned company with six businesses focusing on aesthetics, therapeutics, lifecare, real estate, financial investments, and private markets. |
262 | |||
| 23 |
Merz Lifecaremerz-lifecare.com
Development and marketing of scientifically based, nature-inspired health, wellness, and beauty products focused on improving quality of life. |
256 | |||
| 24 |
Haltermann Carlesshaltermann-carless.com
A leading international supplier of high-value hydrocarbon-based specialty products and solvents, providing sustainable solutions for various industries with a focus on renewable resources |
222 | |||
| 25 |
Fraunhofer ITMPitmp.fraunhofer.de
Researching and developing innovative methods for early detection, diagnosis, and treatment of diseases related to impaired immune system functions |
196 | |||
| 26 |
WeylChem Group of Companiesweylchem.com
Custom manufacturing of fine chemicals, intermediates, and reagents with unique technologies serving diverse markets worldwide at various scales. |
170 | |||
| 27 |
Nord-Micro GmbHnordmicro.de
The company designs, manufactures, and maintains aviation equipment, collaborating with major aircraft manufacturers and serving over 500 airlines globally with innovative solutions |
135 | |||
| 28 |
Quoniam Asset Managementquoniam.com
Quantitative asset management firm providing data-driven investment solutions for institutional investors, managing equity, fixed income, and multi-asset strategies globally. |
132 | |||
| 29 |
Link11 GmbHlink11.com
Delivers cybersecurity solutions making the internet safer for businesses of all sizes, with state-of-the-art products in network security, web protection, and web performance. |
113 | |||
| 30 |
TVARITtvarit.com
Specialized Deep Tech company in Frankfurt, Germany, providing cutting-edge Industrial AI technology for sustainable, zero-waste manufacturing in the metal industry |
60 | |||
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How this list is built
Every company on this list has a Tamtam company profile. The industry is the one the company gives on LinkedIn; categories such as SaaS or fintech are classified by Tamtam's AI from the company's website and LinkedIn page; and the headquarters city must match the company's own address. Companies are ranked by the number of employees on LinkedIn, and the list is refreshed every night. Classifications can be wrong, so treat the list as a starting point rather than an official ranking. Last updated Nov 12, 2026.
More company lists in Frankfurt
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- Multinational companies in Frankfurt 178
- Financial services firms in Frankfurt 127
- Financial Services companies in Frankfurt 97
- Critical infrastructure operators in Frankfurt 77
- SaaS companies in Frankfurt 44
- Banking companies in Frankfurt 43
- Retail chains in Frankfurt 41
- Professional services firms in Frankfurt 36
- IT Services and IT Consulting companies in Frankfurt 31
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The same list elsewhere in Germany
- Companies with in-house R&D in Germany 2,450
- Companies with in-house R&D in Bavaria 529
- Companies with in-house R&D in Baden-Württemberg 520
- Companies with in-house R&D in North Rhine-Westphalia 455
- Companies with in-house R&D in Hesse 200
- Companies with in-house R&D in Lower Saxony 138
- Companies with in-house R&D in Rhineland-Palatinate 88
- Companies with in-house R&D in Schleswig-Holstein 52
- Companies with in-house R&D in Saxony 44
- Companies with in-house R&D in Berlin 165
- Companies with in-house R&D in Munich 148
- Companies with in-house R&D in Hamburg 84
- Companies with in-house R&D in Stuttgart 51
- Companies with in-house R&D in Cologne 35
- Companies with in-house R&D in Düsseldorf 30
- Companies with in-house R&D in Aachen 29
- Companies with in-house R&D in Bremen 25
- Companies with in-house R&D in Karlsruhe 25