# List of companies with in-house R&D in Minnesota

Tamtam tracks 146 companies with in-house R&D headquartered in Minnesota. This list ranks the 50 largest by number of employees on LinkedIn, led by Medtronic, Cargill and 3M. Their median headcount is 2,512. Half of them were founded in 1961 or later. The most common headquarters are Minneapolis (12), Eden Prairie (5) and Saint Paul (4).

These companies are the largest in-house R&D employers in Minnesota. They include major players in healthcare technology and food production, alongside significant firms in industrial machinery and chemical manufacturing. Companies like Medtronic, a healthcare technology firm, and Cargill, providing food and ingredients, lead the sector. Other notable companies are 3M, known for its science and technology applications, and Ecolab, a global provider of water, hygiene, and infection prevention solutions.

The data shows a strong concentration of headquarters in Minneapolis and Saint Paul, indicating these cities are key hubs for research and development activities in the state. The mix of industries represented, from medical equipment to agriculture, highlights a diverse R&D landscape.

🇺🇸 Minnesota · 50 companies · Updated Nov 11, 2026

| # | Company | Industry | Headquarters | Employees | Founded |
|---|---|---|---|---|---|
| 1 | [Medtronic](https://www.tamtam.ai/c/medtronic) (medtronic.com)<br>A healthcare technology company tackling challenging health issues worldwide with innovative solutions that significantly impact and improve lives | Medical Equipment Manufacturing | 🇺🇸 Minneapolis | 100,323 |  |
| 2 | [Cargill](https://www.tamtam.ai/c/cargill) (cargill.com)<br>A family company providing food, ingredients, solutions, and products in a sustainable way Partnering with producers and customers for a better future | Food and Beverage Manufacturing | 🇺🇸 Wayzata | 69,086 |  |
| 3 | [3M](https://www.tamtam.ai/c/3m) (3m.com)<br>A company using science and technology to improve people's lives, making the impossible possible | Industrial Machinery Manufacturing | 🇺🇸 Saint Paul | 63,807 | 1902 |
| 4 | [Ecolab](https://www.tamtam.ai/c/ecolab) (ecolab.com)<br>A global leader providing water, hygiene, and infection prevention solutions for various industries worldwide through comprehensive services and personalized insights | Chemical Manufacturing | 🇺🇸 Saint Paul | 48,879 |  |
| 5 | [Mayo Clinic](https://www.tamtam.ai/c/mayo-clinic) (mayoclinic.org)<br>A leading not-for-profit medical practice founded on values of patient-centered care, teamwork, professionalism, and excellence in healthcare services | Hospitals and Health Care | 🇺🇸 Rochester | 48,774 |  |
| 6 | [General Mills](https://www.tamtam.ai/c/general-mills) (generalmills.com)<br>The company is dedicated to creating beloved food products while prioritizing positive impact, learning, innovation, and growth through collaboration and leadership | Manufacturing | 🇺🇸 Minneapolis | 25,309 | 1928 |
| 7 | [Xcel Energy](https://www.tamtam.ai/c/xcel-energy) (xcelenergy.com)<br>providing reliable, resilient, and sustainable energy services to customers across eight states, focusing on excellent service and growth opportunities | Utilities | 🇺🇸 Minneapolis | 12,073 |  |
| 8 | [Polaris Inc.](https://www.tamtam.ai/c/polaris-inc) (polaris.com)<br>Global leader in Powersports, offering a diverse product lineup including off-road vehicles, motorcycles, snowmobiles, boats, and accessories, with a focus on innovation and outdoor experiences | Manufacturing | 🇺🇸 Medina | 9,228 | 1954 |
| 9 | [Essentia Health](https://www.tamtam.ai/c/essentia-health) (essentiahealth.org)<br>Integrated health system providing patient-centered care through hospitals, clinics, long-term care, pharmacies, ambulance services, and research in three states. | Hospitals and Health Care | 🇺🇸 Duluth | 8,194 |  |
| 10 | [Donaldson](https://www.tamtam.ai/c/donaldson) (donaldson.com)<br>Global provider of filtration technologies and high-quality filters for various industries worldwide, with a strong focus on solving complex contamination control challenges | Industrial Machinery Manufacturing | 🇺🇸 Bloomington | 8,011 | 1915 |
| 11 | [Land O'Lakes, Inc.](https://www.tamtam.ai/c/land-o-lakes-inc) (landolakesinc.com)<br>A farmer and retailer-owned cooperative committed to creating new market opportunities, championing farming's potential, and creating a better world for all | Food and Beverage Manufacturing | 🇺🇸 Arden Hills | 6,867 | 1921 |
| 12 | [The Toro Company](https://www.tamtam.ai/c/the-toro-company) (thetorocompany.com)<br>Portfolio of global brands providing innovative equipment and solutions for landscaping, construction, irrigation, and outdoor maintenance industries worldwide. | Machinery Manufacturing | 🇺🇸 Minneapolis | 6,275 |  |
| 13 | [Covidien (Medtronic Minimally Invasive Therapies Group)](https://www.tamtam.ai/c/covidien-medtronic-minimally-invasive-therapies-group) (medtronic.com)<br>A company acquired by Medtronic in 2015, focused on healthcare products Visit Medtronic's LinkedIn page for more information | Medical Equipment Manufacturing | 🇺🇸 Fridley | 6,168 | 2007 |
| 14 | [St. Jude Medical](https://www.tamtam.ai/c/st-jude-medical) (cardiovascular.abbott)<br>Global medical device manufacturer transforming treatment for epidemic diseases with cost-effective technologies, focusing on cardiac, cardiovascular, and neuromodulation products. | Medical Equipment Manufacturing | 🇺🇸 Saint Paul | 5,896 | 1976 |
| 15 | [H.B. Fuller](https://www.tamtam.ai/c/h-b-fuller) (hbfuller.com)<br>Global provider of adhesives, sealants, and specialty chemicals enhancing product quality and convenience across multiple industries worldwide. | Chemical Manufacturing | 🇺🇸 Vadnais Heights | 5,627 | 1887 |
| 16 | [Graco](https://www.tamtam.ai/c/graco) (graco.com)<br>A global leader in fluid handling systems and components, providing technology for fluid management in industrial and commercial settings through innovative products and distribution channels | Machinery Manufacturing | 🇺🇸 Minneapolis | 4,942 | 1926 |
| 17 | [Daikin Applied Americas](https://www.tamtam.ai/c/daikin-applied-americas) (daikinapplied.com)<br>Provides advanced HVAC systems focusing on air quality, energy efficiency, IoT integration, and next-generation compressors through global sales and service network. | Industrial Machinery Manufacturing | 🇺🇸 Minneapolis | 4,833 | 1924 |
| 18 | [nVent](https://www.tamtam.ai/c/nvent) (nvent.com)<br>Provides global electrical connection and protection solutions, designing, manufacturing, marketing, installing, and servicing high-performance products and solutions for sensitive equipment, buildings, and critical processes. | Appliances, Electrical, and Electronics Manufacturing | 🇺🇸 St. Louis Park | 4,056 | 2018 |
| 19 | [Sleep Number Corporation](https://www.tamtam.ai/c/sleep-number-corporation) (sleepnumber.com)<br>Company improves health and wellbeing through innovative sleep products, operating retail stores, distribution centers, and supporting diverse workforce nationwide. | Retail | 🇺🇸 Minneapolis | 3,632 | 1987 |
| 20 | [Marvin](https://www.tamtam.ai/c/marvin) (marvin.com)<br>A family-owned business offering a diverse portfolio of customizable window and door solutions for builders, architects, and homeowners worldwide | Wholesale Building Materials | 🇺🇸 Warroad | 3,375 | 1912 |
| 21 | [Arctic Wolf](https://www.tamtam.ai/c/arctic-wolf) (arcticwolf.com)<br>Provides security operations as a concierge service, offering 24x7 monitoring, detection, response, and ongoing risk management to strengthen security posture. | Computer and Network Security | 🇺🇸 Eden Prairie | 3,297 |  |
| 22 | [TENNANT SA](https://www.tamtam.ai/c/tennant-company) (tennantco.com)<br>A leader in the cleaning industry, developing innovative and sustainable solutions to address indoor and outdoor cleaning challenges globally | Manufacturing | 🇺🇸 Eden Prairie | 2,671 | 1870 |
| 23 | [Bio-Techne](https://www.tamtam.ai/c/bio-techne) (bio-techne.com)<br>A leading developer and manufacturer of high-quality purified proteins, reagent solutions, diagnostic products, and genomic tools for research and clinical use globally | Biotechnology Research | 🇺🇸 Minneapolis | 2,924 |  |
| 24 | [Starkey Hearing](https://www.tamtam.ai/c/starkey-hearing) (starkey.com)<br>Design, develop, manufacture, and distribute advanced digital hearing aids globally through multiple brands with evidence-based technology. | Medical Equipment Manufacturing | 🇺🇸 Eden Prairie | 2,527 | 1967 |
| 25 | [Thermo King](https://www.tamtam.ai/c/thermo-king) (thermoking.com)<br>Development and innovation of sustainable transport refrigeration and temperature control solutions aimed at improving customer quality of life. | Truck Transportation | 🇺🇸 Bloomington | 2,512 |  |
| 26 | [NMDP](https://www.tamtam.ai/c/nmdp) (nmdp.org)<br>A global non-profit leader in cell therapy, connecting researchers, donors, and clinicians to save lives by finding cures for blood cancers and disorders | Non-profit Organizations | 🇺🇸 Minneapolis | 2,382 | 1987 |
| 27 | [Perforce Software](https://www.tamtam.ai/c/perforce-software) (perforce.com)<br>Leader in digital product development, providing innovative solutions for faster and higher quality output through the power of Perforce technology | Software Development | 🇺🇸 Minneapolis | 2,028 | 1995 |
| 28 | [Cirrus](https://www.tamtam.ai/c/cirrus) (cirrusaircraft.com)<br>A global leader in personal aviation, known for best-selling piston aircraft, innovative single-engine jet, and pioneering safety systems | Airlines and Aviation | 🇺🇸 Duluth | 1,832 | 1984 |
| 29 | [HealthEast](https://www.tamtam.ai/c/healtheast) (fairview.org)<br>A leading nonprofit healthcare provider in Minnesota offering a full range of services including hospitals, clinics, senior care, rehabilitation, and home health services with compassion | Hospitals and Health Care | 🇺🇸 Minneapolis | 1,830 |  |
| 30 | [Winnebago Industries](https://www.tamtam.ai/c/winnebago-industries) (winnebagoind.com)<br>The company is a leading manufacturer of outdoor lifestyle products, providing innovative solutions for leisure travel and recreation activities with a focus on work-life balance | Manufacturing | 🇺🇸 Eden Prairie | 1,695 | 1958 |
| 31 | [MTS Systems Corporation](https://www.tamtam.ai/c/mts-systems-corporation) (mts.com)<br>A global supplier of test and simulation systems that partners with customers to innovate and revolutionize products across various industries | Mechanical Or Industrial Engineering | 🇺🇸 Eden Prairie | 1,687 |  |
| 32 | [Protolabs](https://www.tamtam.ai/c/protolabs) (protolabs.com)<br>Digital manufacturing resource providing injection molding, CNC machining, 3D printing, and sheet metal fabrication from prototyping to production. | Industrial Machinery Manufacturing | 🇺🇸 Maple Plain | 1,648 |  |
| 33 | [TSI Incorporated](https://www.tamtam.ai/c/tsi-incorporated) (tsi.com)<br>Global leader in precision measurement instruments for aerosol science, air flow, indoor air quality, fluid dynamics, and biohazard detection Headquarters in US with worldwide presence | Industrial Machinery Manufacturing | 🇺🇸 Shoreview | 1,559 | 1961 |
| 34 | [Hazelden Betty Ford Foundation](https://www.tamtam.ai/c/hazelden-betty-ford-foundation) (hazeldenbettyford.org)<br>A nonprofit treatment provider offering recovery solutions, addiction education, prevention programs, and advocacy for diverse communities nationwide Join the team today | Hospitals and Health Care | 🇺🇸 Center City | 1,458 | 1949 |
| 35 | [Kindeva Drug Delivery](https://www.tamtam.ai/c/kindeva-drug-delivery) (kindevadd.com)<br>CDMO advancing drug projects with expertise in injectable, inhalation, and dermal delivery, optimizing development and manufacturing for pharmaceutical companies. | Pharmaceutical Manufacturing | 🇺🇸 Woodbury | 1,369 | 2020 |
| 36 | [T.O. Plastics](https://www.tamtam.ai/c/t-o-plastics) (toplastics.com)<br>A company specializing in designing and producing custom packaging and products from thermoformed plastics for various industries, ensuring quality and customer satisfaction | Packaging and Containers Manufacturing | 🇺🇸 Clearwater | 1,352 | 1948 |
| 37 | [Inspire Medical Systems](https://www.tamtam.ai/c/inspire-medical-systems) (inspiresleep.com)<br>Develops a neurostimulation device for obstructive sleep apnea. This device stimulates airway muscles to reduce OSA severity and improve patient quality of life. | Medical Equipment Manufacturing | 🇺🇸 Golden Valley | 1,341 | 2007 |
| 38 | [Gillette Children's](https://www.tamtam.ai/c/gillette-children-s) (gillettechildrens.org)<br>Specializing in brain, bone, and movement conditions starting in childhood, we provide research, treatment, and technologies for children to thrive | Hospitals and Health Care | 🇺🇸 Saint Paul | 1,313 | 1897 |
| 39 | [Banner Engineering](https://www.tamtam.ai/c/banner-engineering) (bannerengineering.com)<br>Global leader in industrial automation with a wide range of sensors, vision sensors, LED lights, wireless, and safety products for various industries worldwide | Automation Machinery Manufacturing | 🇺🇸 Plymouth | 1,224 | 1966 |
| 40 | [Loram Maintenance of Way, Inc.](https://www.tamtam.ai/c/loram-maintenance-of-way-inc) (loram.com)<br>Specializes in railway maintenance services and equipment, with a focus on safety, expertise, environmental sustainability, and a vision to be a global leader in the industry | Railroad Equipment Manufacturing | 🇺🇸 Hamel | 1,124 | 1954 |
| 41 | [Heraeus Medevio](https://www.tamtam.ai/c/heraeus-medevio) (bit.ly)<br>Provides contract design, development, and manufacturing of medical devices globally, supporting companies from concept through product lifecycle with materials science expertise. | Medical Equipment Manufacturing | 🇺🇸 Minneapolis | 1,124 |  |
| 42 | [Cretex Medical](https://www.tamtam.ai/c/cretex-medical) (cretexmedical.com)<br>Specializing in medical device manufacturing and engineering, providing metal and plastic machining, injection molding, sterilization case design, custom instrument manufacturing, assembly, and packaging services | Medical Equipment Manufacturing | 🇺🇸 Elk River | 1,062 |  |
| 43 | [Federal Reserve Bank of Minneapolis](https://www.tamtam.ai/c/federal-reserve-bank-of-minneapolis) (minneapolisfed.org)<br>Support national monetary and financial system stability, uphold ethical standards, embrace diversity, and provide development opportunities for workforce excellence. | Banking | 🇺🇸 Minneapolis | 1,047 |  |
| 44 | [CPM](https://www.tamtam.ai/c/cpm) (onecpm.com)<br>The company innovates nutrition for both people and animals, produces renewable fuels, and contributes materials for a more sustainable world | Machinery Manufacturing | 🇺🇸 Blaine | 1,005 | 1883 |
| 45 | [Hearth & Home Technologies](https://www.tamtam.ai/c/hearth-and-home-technologies) (hearthnhome.com)<br>The company is a leading producer and installer of hearth products including fireplaces, inserts, stoves, and more, focused on making houses feel like homes | Manufacturing | 🇺🇸 Lakeville | 1,005 | 1996 |
| 46 | [Digi International](https://www.tamtam.ai/c/digi-international) (digi.com)<br>Provider of reliable IoT and M2M connectivity products, embedded modules, routers, gateways, cloud software, and professional services for critical communications. | Telecommunications | 🇺🇸 Hopkins | 978 | 1985 |
| 47 | [Teleflex Medical OEM](https://www.tamtam.ai/c/teleflex-medical-oem) (teleflexmedicaloem.com)<br>Design, prototype, and manufacture custom medical devices including catheters, tubing, sutures, and related components with in-house engineering and production. | Medical Equipment Manufacturing | 🇺🇸 Plymouth | 936 |  |
| 48 | [OATI](https://www.tamtam.ai/c/oati) (linktr.ee)<br>OATI is a pioneer in providing internet-based solutions for energy industry challenges, specializing in Smart Grid, Distributed Energy Resources, and more | Software Development | 🇺🇸 Bloomington | 936 | 1995 |
| 49 | [R&D Systems](https://www.tamtam.ai/c/r-and-d-systems) (rndsystems.com)<br>This company brings together various brands such as R&D Systems, Tocris, and Novus Biologicals to be a stronger scientific partner in helping customers achieve their research goals | Biotechnology Research | 🇺🇸 Minnneapolis | 863 | 1985 |
| 50 | [Hutchinson Technology Inc.](https://www.tamtam.ai/c/hutchinson-technology-inc) (hutchinson.tdk.com)<br>Specializing in close-tolerance products that blend chemical, mechanical, and electronic technologies, this company is a leader in the electronics industry worldwide | Appliances, Electrical, and Electronics Manufacturing | 🇺🇸 Hutchinson | 817 | 1965 |

## How this list is built

Every company on this list has a Tamtam company profile. The industry is the one the company gives on LinkedIn; categories such as SaaS or fintech are classified by Tamtam's AI from the company's website and LinkedIn page; and the headquarters city must match the company's own address. Companies are ranked by the number of employees on LinkedIn, and the list is refreshed every night. Classifications can be wrong, so treat the list as a starting point rather than an official ranking. Last updated Nov 11, 2026.

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Source: https://www.tamtam.ai/l/r-and-d-companies-minnesota