# Companies with in-house R&D headquartered in the Puy-de-Dôme department
Tamtam tracks 82 companies with in-house R&D headquartered in the Puy-de-Dôme department. This list ranks the 30 largest by number of employees on LinkedIn, led by Michelin, CHU de Clermont-Ferrand and centre jean perrin. Their median headcount is 145. Half of them were founded in 1978 or later. The most common headquarters are Clermont-Ferrand (13) and Aubière (2).
The Puy-de-Dôme department hosts a diverse array of companies with significant in-house R&D capabilities, ranging from large industrial groups to specialized firms. Key players include Michelin, a major manufacturer of tires and mobility solutions, CHU de Clermont-Ferrand, a large university hospital, and DÔMES PHARMA, which develops pet health solutions. Other notable companies are JOUBERT Group, specializing in technical textiles, and OMERIN Group, a global leader in wires and cables for extreme conditions.The companies in Puy-de-Dôme demonstrate a strong concentration in manufacturing, particularly in automotive, textiles, and specialized electronics. There is also a notable presence in healthcare and biotechnology, with institutions like Centre Jean Perrin focusing on cancer treatment and AFYREN developing biobased compounds. A significant cluster of these companies, including Michelin and CHU de Clermont-Ferrand, are headquartered in Clermont-Ferrand, highlighting its role as a regional economic hub.
🇫🇷 Puy-de-Dôme · 30 companies · Updated Nov 12, 2026
| # | Company | Industry | Headquarters | Employees | Founded |
|---|---|---|---|---|---|
| 1 | [Michelin](https://www.tamtam.ai/c/michelin) (michelin.com)
Manufactures high-quality tires, components, and composites for mobility, construction, aeronautics, low-carbon energies, and healthcare. Offers exceptional experiences through connected solutions, AI, and the MICHELIN Guide. | Motor Vehicle Manufacturing | 🇫🇷 Clermont-Ferrand | 56,897 | 1889 |
| 2 | [CHU de Clermont-Ferrand](https://www.tamtam.ai/c/chu-de-clermont-ferrand) (chu-clermontferrand.fr)
A university hospital with over 8000 employees in Clermont-Ferrand, providing care, prevention, teaching, and research services across multiple sites | Government Administration | 🇫🇷 Clermont-Ferrand | 2,531 | 1767 |
| 3 | [centre jean perrin](https://www.tamtam.ai/c/centre-jean-perrin) (cjp.fr)
Specialized cancer treatment, research, education, and training center serving 28,000 patients annually with equitable access and no extra fees. | Hospitals and Health Care | 🇫🇷 Clermont-Ferrand | 448 | 1973 |
| 4 | [UNIVERSITE D'AUVERGNE](https://www.tamtam.ai/c/universite-d-auvergne) (uca.fr)
provides student information, orientation, career insertion support, monitors academic success, conducts graduate follow-up surveys, and facilitates study reorientation | Higher Education | 🇫🇷 Clermont-Ferrand | 374 | 1976 |
| 5 | [JOUBERT Group](https://www.tamtam.ai/c/joubert-group) (joubert.fr)
Designing and manufacturing technical textile products like nets, straps, and automotive accessories for industrial, consumer, and original equipment applications across diverse sectors globally. | Textile Manufacturing | 🇫🇷 Ambert | 330 | 1928 |
| 6 | [Atelier industriel de l'aéronautique de Clermont-Fd](https://www.tamtam.ai/c/atelier-industriel-de-l-aeronautique-de-clermont-fd) (defense.gouv.fr)
State military aeronautical industrial service maintains French armed forces transport, fighter, training aircraft, and helicopters. Expert in industrial maintenance, modifications, repairs, and equipment maintenance. | Aviation and Aerospace Component Manufacturing | 🇫🇷 Clermont-Ferrand | 256 | 1939 |
| 7 | [DÔMES PHARMA](https://www.tamtam.ai/c/domes-pharma) (domespharma.com)
Develops, manufactures, and markets solutions for pet health and well-being, leveraging expertise across the entire medicine value chain and all distribution channels. | Pharmaceutical Manufacturing | 🇫🇷 Pont-du-Château | 239 | 1947 |
| 8 | [LIMAGRAIN INGREDIENTS](https://www.tamtam.ai/c/limagrain-ingredients) (limagrain-ingredients.com)
The company specializes in creating trustworthy nutritional products by innovating with grain to enhance well-balanced nutrition for healthy and enjoyable experiences | Food and Beverage Manufacturing | 🇫🇷 Riom | 236 | 2002 |
| 9 | [OMERIN Group](https://www.tamtam.ai/c/omerin-group) (omerin.com)
A global leader in manufacturing wires and cables for extreme temperatures and severe environments with a focus on medical devices and safety sectors | Appliances, Electrical, and Electronics Manufacturing | 🇫🇷 Ambert | 207 | 1959 |
| 10 | [MICHELIN Innovation Lab](https://www.tamtam.ai/c/michelin-innovation-lab) (michelin.com)
Innovation lab focused on exploring new territories and leveraging expertise beyond tires | Manufacturing | 🇫🇷 Clermont-Ferrand | 200 | |
| 11 | [SIGMA Clermont](https://www.tamtam.ai/c/sigma-clermont) (sigma-clermont.fr)
A school on the Clermont-Ferrand science campus offering specialized education in mechanical engineering and chemistry, with strong industry collaborations and cutting-edge research facilities | Higher Education | 🇫🇷 Aubière | 179 | 2016 |
| 12 | [NOREVA GROUPE](https://www.tamtam.ai/c/noreva-groupe) (noreva-laboratoires.com)
Development of high-tolerance dermatological skincare products addressing skin health holistically, suitable for all ages and skin conditions. | Personal Care Product Manufacturing | 🇫🇷 Clermont-Ferrand | 163 | 2000 |
| 13 | [AddUp](https://www.tamtam.ai/c/addup) (addupsolutions.com)
Designs and sells metal additive manufacturing machines, including powder bed fusion and directed energy deposition systems, offering comprehensive support for industrial production transitions. | Industrial Machinery Manufacturing | 🇫🇷 Cébazat | 162 | 2016 |
| 14 | [BeYs](https://www.tamtam.ai/c/beys) (be-ys.com)
The company offers innovative digital trust solutions, including electronic signature, data archiving, and personal document management, ensuring security and compliance | IT Services and IT Consulting | 🇫🇷 Clermont-Ferrand | 153 | 2000 |
| 15 | [AFYREN](https://www.tamtam.ai/c/afyren) (afyren.com)
Develops biobased compounds via patented fermentation for diverse industries like food and cosmetics, focusing on low-carbon and zero-waste production. | Biotechnology Research | 🇫🇷 Clermont-Ferrand | 145 | 2012 |
| 16 | [BIOCORP](https://www.tamtam.ai/c/biocorp) (biocorpsys.com)
A French company specializing in connected medical devices, focusing on innovating solutions for patients with diabetes and other diseases | Medical Equipment Manufacturing | 🇫🇷 Issoire | 144 | 2004 |
| 17 | [MICHELIN Aircraft Tyre](https://www.tamtam.ai/c/michelin-aircraft-tyre) (aircraft.michelin.com)
Manufacturing bias and radial tires for military, commercial, regional, and general aviation markets. Essential for takeoff, landing, and taxiing aircraft. | Airlines and Aviation | 🇫🇷 Clermont-Ferrand | 139 | 2000 |
| 18 | [Babymoov Group](https://www.tamtam.ai/c/babymoov-group) (babymoov.com)
French company creating solutions for parents through 6 ranges: feeding, comfort, safety, caring, outdoor, playing. Products found in over 70 countries, lifetime warranty. | Manufacturing | 🇫🇷 Clermont-Ferrand | 129 | 1997 |
| 19 | [CARBIOS](https://www.tamtam.ai/c/carbios) (carbios.com)
Develops enzyme-based processes for plastic and textile biorecycling and biodegradation, promoting a circular economy with industrial-scale solutions supported by major brands. | Biotechnology Research | 🇫🇷 Clermont-Ferrand | 102 | 2011 |
| 20 | [Sol Solution SAS](https://www.tamtam.ai/c/sol-solution-sas) (sol-solution.com)
Design, develop, and distribute geotechnical investigation and compaction equipment with strong focus on innovation and research. | Civil Engineering | 🇫🇷 Riom | 102 | 1992 |
| 21 | [COMPTE.R](https://www.tamtam.ai/c/compte-r) (compte-r.com)
Designs and manufactures wood and biomass thermal generators, leading renewable energy solutions with international presence across Europe and North America. | Industrial Machinery Manufacturing | 🇫🇷 Arlanc | 89 | 1890 |
| 22 | [AUBRILAM](https://www.tamtam.ai/c/aubrilam) (aubrilam.com)
Designs and manufactures outdoor furniture to enhance urban spaces, offering over 300 customizable products for various environments worldwide | Furniture and Home Furnishings Manufacturing | 🇫🇷 Clermont-Ferrand | 86 | 1978 |
| 23 | [GCK EMI](https://www.tamtam.ai/c/gck-emi) (gck-emi.com)
Design and production of advanced embedded electronics and electromechanical components for mobility, including control units, power electronics, and industrial assemblies. | Appliances, Electrical, and Electronics Manufacturing | 🇫🇷 Brassac-les-Mines | 83 | |
| 24 | [GCK](https://www.tamtam.ai/c/gck) (gck.co)
A sustainable energy ecosystem leading the green energy revolution through storage, supply, and e-mobility solutions in the industrial sector | Transportation Equipment Manufacturing | 🇫🇷 Lempdes | 77 | 2020 |
| 25 | [Top Clean Packaging Group](https://www.tamtam.ai/c/top-clean-packaging-group) (topcleanpackaging.com)
Manufacturing and supplying innovative packaging solutions using thermoforming, injection molding, assembly, and clean room packaging with ISO certifications. | Pharmaceutical Manufacturing | 🇫🇷 Peschadoires | 76 | 1927 |
| 26 | [VERDOT](https://www.tamtam.ai/c/verdot) (verdot-biotechnologies.com)
Design and supply of single-use and stainless steel purification systems for biopharmaceuticals, including chromatography and filtration solutions. | Biotechnology Research | 🇫🇷 Riom | 71 | 1950 |
| 27 | [CELTA - Groupe Rossmann](https://www.tamtam.ai/c/celta-groupe-rossmann) (rossmann.com)
Family-owned independent supplier of custom corrugated packaging solutions Offering a wide range of eco-friendly products, including unique packaging solutions for fragile items and long objects | Packaging and Containers Manufacturing | 🇫🇷 Courpiere | 69 | 1977 |
| 28 | [CIDECO](https://www.tamtam.ai/c/cideco) (cideco.tech)
The company specializes in diagnosing and rehabilitating buildings and structures, implementing IoT sensors for monitoring, creating 3D models, and promoting sustainable materials | Civil Engineering | 🇫🇷 Aubière | 61 | 2017 |
| 29 | [Issoire Aviation](https://www.tamtam.ai/c/issoire-aviation) (issoire-aviation.fr)
Design, manufacture, and certification of high-performance composite aerospace components and complete aircraft, including proprietary all-carbon planes and subcontracting services. | Aviation and Aerospace Component Manufacturing | 🇫🇷 Issoire | 57 | 1978 |
| 30 | [Brüggen France](https://www.tamtam.ai/c/bruggen-france) (brueggen.com)
European leader producing breakfast cereals for all ages, operating a major production site and R&D center in France. | Food and Beverage Manufacturing | 🇫🇷 Thiers | 55 | 1868 |
## How this list is built
Every company on this list has a Tamtam company profile. The industry is the one the company gives on LinkedIn; categories such as SaaS or fintech are classified by Tamtam's AI from the company's website and LinkedIn page; and the headquarters city must match the company's own address. Companies are ranked by the number of employees on LinkedIn, and the list is refreshed every night. Classifications can be wrong, so treat the list as a starting point rather than an official ranking. Last updated Nov 12, 2026.
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Source: https://www.tamtam.ai/l/r-and-d-companies-puy-de-dome