# List of companies with in-house R&D in South Carolina

Tamtam tracks 70 companies with in-house R&D headquartered in South Carolina. This list ranks the 50 largest by number of employees on LinkedIn, led by Medical University of South Carolina, University of South Carolina and Clemson University. Their median headcount is 719. Half of them were founded in 1964 or later. The most common headquarters are Greenville (7), Columbia (5) and Charleston (4).

These companies are primarily large institutions, including several universities and a medical center, alongside established manufacturing and technology firms. The list features major employers such as the Medical University of South Carolina, a public institution dedicated to healthcare education and research, and the University of South Carolina, a globally recognized research university. Sonoco, a manufacturer of packaging solutions, and Milliken & Company, a materials science leader, also represent significant manufacturing presence. The companies operate across diverse sectors including healthcare, education, packaging, chemicals, and industrial machinery.

A notable characteristic is the strong representation of higher education institutions, with the Medical University of South Carolina, the University of South Carolina, Clemson University, and Coastal Carolina University all appearing on the list. This indicates a significant concentration of R&D activity within academic and medical research environments in South Carolina, alongside a robust industrial base.

🇺🇸 South Carolina · 50 companies · Updated Nov 14, 2026

| # | Company | Industry | Headquarters | Employees | Founded |
|---|---|---|---|---|---|
| 1 | [Medical University of South Carolina](https://www.tamtam.ai/c/medical-university-of-south-carolina) (musc.edu)<br>Public institution focused on educating healthcare professionals, conducting biomedical research, and providing comprehensive healthcare services in South Carolina and beyond. | Hospitals and Health Care | 🇺🇸 Charleston | 15,845 | 1824 |
| 2 | [University of South Carolina](https://www.tamtam.ai/c/university-of-south-carolina) (sc.edu)<br>A globally recognized research university offering 324 degree programs, top-tier research, community engagement, and numerous nationally ranked programs in South Carolina | Higher Education | 🇺🇸 Columbia | 13,337 | 1801 |
| 3 | [Clemson University](https://www.tamtam.ai/c/clemson-university) (clemson.edu)<br>A historic university dedicated to academic excellence, research, and developing leaders with values of honesty, integrity, and respect | Higher Education | 🇺🇸 Clemson | 11,869 | 1889 |
| 4 | [Sonoco](https://www.tamtam.ai/c/sonoco) (sonoco.com)<br>A leading manufacturer of consumer, industrial, healthcare, and protective packaging, creating sustainable solutions for brands worldwide to enhance products and lives | Packaging and Containers Manufacturing | 🇺🇸 Hartsville | 10,850 |  |
| 5 | [MilliporeSigma](https://www.tamtam.ai/c/milliporesigma) (sigmaaldrich.com)<br>Provides scientists with state-of-the-art tools, services, and expertise for experiments and product development, impacting life and health globally. Offers broad portfolio and integrated services. | Biotechnology Research | 🇺🇸 Burlington | 10,484 | 1668 |
| 6 | [Diversey](https://www.tamtam.ai/c/diversey) (solenis.com)<br>provides cleaning, hygiene, and infection prevention solutions with advanced chemicals, digital technologies, and services for multiple industries | Chemical Manufacturing | 🇺🇸 Fort Mill | 10,357 | 1923 |
| 7 | [Milliken & Company](https://www.tamtam.ai/c/milliken-and-company) (milliken.com)<br>Global leader in materials science creating sustainable products and solutions across textiles, chemicals, flooring, and healthcare industries. | Industrial Machinery Manufacturing | 🇺🇸 Spartanburg | 4,191 | 1865 |
| 8 | [JTEKT North America Corporation](https://www.tamtam.ai/c/jtekt-north-america-corporation) (jtekt-na.com)<br>Development and manufacturing of steering systems, driveline components, and bearings for automotive, industrial, and energy sectors. | Motor Vehicle Parts Manufacturing | 🇺🇸 Greenville | 3,851 | 2006 |
| 9 | [AFL](https://www.tamtam.ai/c/afl) (aflglobal.com)<br>A global manufacturer offering end-to-end solutions in fiber optic technology for energy, service provider, enterprise, and industrial markets in over 130 countries | Telecommunications | 🇺🇸 Duncan | 3,658 |  |
| 10 | [Coastal Carolina University](https://www.tamtam.ai/c/coastal-carolina-university) (coastal.edu)<br>Public university offering over 100 undergraduate and 30 graduate programs, including Ph.D. degrees, with strong marine science focus and active student life. | Higher Education | 🇺🇸 Conway | 3,558 | 1954 |
| 11 | [3D Systems Corporation](https://www.tamtam.ai/c/3d-systems-corporation) (3dsystems.com)<br>Provides additive manufacturing solutions, including hardware, software, materials, and services, empowering customers to create products in healthcare and industrial markets. | Industrial Machinery Manufacturing | 🇺🇸 Rock Hill | 3,536 |  |
| 12 | [Blackbaud](https://www.tamtam.ai/c/blackbaud) (blackbaud.com)<br>Software provider focused on social impact, serving nonprofits, education, and socially responsible companies with essential solutions for fundraising, financial management, and more | Software Development | 🇺🇸 Charleston | 3,257 |  |
| 13 | [Savannah River Nuclear Solutions](https://www.tamtam.ai/c/savannah-river-nuclear-solutions) (savannahrivernuclearsolutions.com)<br>A company responsible for managing and operating the Department of Energy's Savannah River Site in South Carolina, working with Newport News Nuclear and Honeywell | Government Relations Services | 🇺🇸 Aiken | 3,126 | 2008 |
| 14 | [KYOCERA AVX Components Corporation](https://www.tamtam.ai/c/kyocera-avx-components-corporation) (kyocera-avx.com)<br>A global manufacturer of advanced electronic components for various industries, focused on technological innovation and building a better future through quality products | Appliances, Electrical, and Electronics Manufacturing | 🇺🇸 Fountain Inn | 3,005 | 1970 |
| 15 | [Phillips Medisize](https://www.tamtam.ai/c/phillips-medisize) (phillipsmedisize.com)<br>Designs and manufactures products for pharmaceutical, medtech, and in vitro diagnostic companies globally, focusing on patient-centric solutions. | Medical Equipment Manufacturing | 🇺🇸 Hudson | 2,893 | 1964 |
| 16 | [Zeus](https://www.tamtam.ai/c/zeus-orangeburg) (zeusinc.com)<br>Specializing in polymer extrusion and catheter design, this global company partners with various industries to deliver innovative solutions and enhance lives worldwide | Plastics Manufacturing | 🇺🇸 Orangeburg | 1,381 | 1966 |
| 17 | [AVX Corporation](https://www.tamtam.ai/c/avx-corporation) (kyocera-avx.com)<br>Manufacturer and supplier of advanced electronic components, including capacitors, inductors, filters, and various innovative sensor and antenna solutions, serving multiple global markets. | Appliances, Electrical, and Electronics Manufacturing | 🇺🇸 United States | 1,352 |  |
| 18 | [Delinea](https://www.tamtam.ai/c/delinea) (delinea.com)<br>Reduces identity-based risk by providing real-time, context-aware access controls for human, machine, and AI identities with unified enforcement and auditing. | Software Development | 🇺🇸 San Francisco | 1,341 | 2021 |
| 19 | [Sage Automotive Interiors](https://www.tamtam.ai/c/sage-automotive-interiors) (sageautomotiveinteriors.com)<br>A global supplier of specialty materials for automotive interiors, focusing on design, sustainability, and innovation for leading global automotive brands worldwide | Motor Vehicle Manufacturing | 🇺🇸 Greenville | 1,208 |  |
| 20 | [Ingevity](https://www.tamtam.ai/c/ingevity) (ingevity.com)<br>This company develops and manufactures solutions for purifying, protecting, and enhancing the world through specialty chemicals, biodegradable plastics, and activated carbon products | Chemical Manufacturing | 🇺🇸 North Charleston | 1,054 |  |
| 21 | [Wabtec Passenger Transit](https://www.tamtam.ai/c/wabtec-passenger-transit) (wabteccorp.com)<br>Global provider of pneumatic, electronic, and mechanical solutions for transit industry, specializing in braking equipment, controllers, couplers, and train-control systems | Railroad Equipment Manufacturing | 🇺🇸 Spartanburg | 924 | 1869 |
| 22 | [Savannah River National Laboratory](https://www.tamtam.ai/c/savannah-river-national-laboratory) (srnl.gov)<br>A multidisciplinary research center solving environmental and security challenges by applying science to global security, energy, and environmental cleanup | Research Services | 🇺🇸 Aiken | 865 | 1951 |
| 23 | [Chicago Pneumatic](https://www.tamtam.ai/c/chicago-pneumatic) (cp.com)<br>Design and manufacture construction, maintenance, and production tools and compressors tailored for specific industrial applications worldwide. | Industrial Machinery Manufacturing | 🇺🇸 Rock Hill | 837 | 1901 |
| 24 | [Coroplast Tape Corporation](https://www.tamtam.ai/c/coroplast-tape-corporation) (coroplast-tape.com)<br>Develops innovative adhesive tape products, specializing in special-purpose applications for a variety of industries, with a focus on driving success and strong relationships globally | Motor Vehicle Manufacturing | 🇺🇸 Rock Hill | 806 | 2014 |
| 25 | [Reliable Automatic Sprinkler Co., Inc.](https://www.tamtam.ai/c/reliable-automatic-sprinkler-co-inc) (reliablesprinkler.com)<br>Global manufacturer of fire protection products, specializing in innovative fire sprinklers, valves, and special systems Offers premier customer service worldwide | Wholesale Building Materials | 🇺🇸 Liberty | 719 | 1920 |
| 26 | [AGY](https://www.tamtam.ai/c/agy) (agy.com)<br>A global provider of high-performance composite solutions, specializing in high-strength and specialty glass yarns and rovings for various industries | Glass Product Manufacturing | 🇺🇸 Aiken | 675 |  |
| 27 | [AstenJohnson](https://www.tamtam.ai/c/astenjohnson) (astenjohnson.com)<br>Global manufacturer of pulp & paper machine clothing, filaments, technical fabrics, and nonwovens for various industries, prioritizing quality, innovation, and customer relationships | Paper and Forest Product Manufacturing | 🇺🇸 North Charleston | 661 | 1790 |
| 28 | [Nutramax Laboratories](https://www.tamtam.ai/c/nutramax-laboratories) (nutramaxlabs.com)<br>The company provides safe, effective products with high-quality ingredients and manufacturing standards for improved quality of life internationally | Manufacturing | 🇺🇸 Lancaster | 627 | 1992 |
| 29 | [Thorne](https://www.tamtam.ai/c/thorne) (thorne.com)<br>Innovative health solutions company focused on home testing, dietary education, and nutritional products, promoting good health through technology and expertise | Wellness and Fitness Services | 🇺🇸 Summerville | 557 |  |
| 30 | [Belimed](https://www.tamtam.ai/c/belimed) (belimed.com)<br>Supplier of sterilization, disinfection, and cleaning products and services for medical and surgical instruments with global presence and innovation focus. | Medical Equipment Manufacturing | 🇺🇸 Ladson | 551 | 1968 |
| 31 | [International Vitamin Corporation](https://www.tamtam.ai/c/international-vitamin-corporation) (ivcinc.com)<br>Production of high-quality dietary supplements, nutritional, prescription, and OTC products for leading U.S. retailers and global contract customers. | Manufacturing | 🇺🇸 Greenville | 543 |  |
| 32 | [Gelnex Gelatin](https://www.tamtam.ai/c/gelnex-gelatin) (darlingii.com)<br>A leading manufacturer of gelatin and collagen peptides, sourcing proteins from inspected animals and focusing on high quality, sustainability, and customer satisfaction | Food and Beverage Services | 🇺🇸 Ita | 528 | 1998 |
| 33 | [University of South Carolina School of Medicine](https://www.tamtam.ai/c/university-of-south-carolina-school-of-medicine) (sc.edu)<br>Established in 1974, USC SOM improves South Carolinians' health by training physicians, genetic counselors, nurse anesthetists, and biomedical scientists in a nurturing environment | Higher Education | 🇺🇸 Columbia | 477 | 1977 |
| 34 | [Technetics Group](https://www.tamtam.ai/c/technetics-group) (technetics.com)<br>Design and manufacture custom-engineered seals, components, and sub-systems for extreme applications in semiconductor, aerospace, nuclear, and life sciences industries. | Industrial Machinery Manufacturing | 🇺🇸 Columbia | 467 |  |
| 35 | [Precision Valve Corporation](https://www.tamtam.ai/c/precision-valve-corporation) (precisionglobal.com)<br>Innovates, designs, and manufactures dispensing solutions for personal, household, food, industrial, and pharmaceutical markets, including valves, actuators, and pumps. | Packaging and Containers Manufacturing | 🇺🇸 Greenville | 451 | 1949 |
| 36 | [Gulbrandsen Technologies](https://www.tamtam.ai/c/gulbrandsen-technologies) (gulbrandsentechnologies.com)<br>Manufacturer of low-cost chemical solutions for various industries with a focus on water treatment, personal care, pigments, and electronic etchants, prioritizing customer service | Chemical Manufacturing | 🇺🇸 Orangeburg | 443 | 1984 |
| 37 | [Milliken Chemical](https://www.tamtam.ai/c/milliken-chemical) (milliken.com)<br>Innovative solutions in plastics additives, colorants, silicones, and chemical intermediates for a sustainable future in various industries | Chemical Manufacturing | 🇺🇸 Spartanburg | 436 | 1865 |
| 38 | [FN America, LLC](https://www.tamtam.ai/c/fn-america-llc) (fnamerica.com)<br>Develops and manufactures high quality reliable firearms training and support services for global military law enforcement and commercial customers from US facilities | Defense and Space Manufacturing | 🇺🇸 Columbia | 383 | 1980 |
| 39 | [MUSC Children's Health](https://www.tamtam.ai/c/musc-children-s-health) (musckids.org)<br>Specializing in pediatric clinical care and research, providing comprehensive and compassionate services in over 27 specialty areas across South Carolina | Hospitals and Health Care | 🇺🇸 Charleston | 376 |  |
| 40 | [Wikoff](https://www.tamtam.ai/c/wikoff) (wikoff.com)<br>A company specializing in high quality, tailor-made inks for challenging printing needs, fostering a culture of employee ownership and providing unmatched service and support worldwide | Printing Services | 🇺🇸 Fort Mill | 368 | 1956 |
| 41 | [AIRSYS Global](https://www.tamtam.ai/c/airsys-global) (air-sys.com)<br>A global leader in energy-saving cooling technology for data centers, telecom, medical, and semiconductor industries, prioritizing environmental sustainability and technological advancement | Mechanical Or Industrial Engineering | 🇺🇸 Greer | 366 | 1995 |
| 42 | [Nutra Manufacturing](https://www.tamtam.ai/c/nutra-manufacturing) (ivcinc.com)<br>Leader in nutritional supplements, prioritizing truth in labeling, ingredient safety, and product potency Committed to helping customers improve their lives through quality products | Pharmaceutical Manufacturing | 🇺🇸 Greenville | 350 |  |
| 43 | [SixAxis, LLC](https://www.tamtam.ai/c/sixaxis-llc) (sixaxisllc.com)<br>Innovative manufacturing company offering loading rack, fall protection, and safety solutions worldwide through diverse brands and software innovations | Industrial Machinery Manufacturing | 🇺🇸 Andrews | 328 | 2002 |
| 44 | [The Ritedose Corporation](https://www.tamtam.ai/c/the-ritedose-corporation) (ritedose.com)<br>A leading manufacturer specializing in blow-fill-seal production of small fill volume pharmaceutical unit dose sterile and non-sterile liquids for inhalation, eyes, ears, and oral consumption | Pharmaceutical Manufacturing | 🇺🇸 Columbia | 323 | 1995 |
| 45 | [ORBIS Inc](https://www.tamtam.ai/c/orbis-inc) (orbisinc.net)<br>A Veteran Owned Small Business providing engineering, technical, and consulting services to the Department of Defense with headquarters in Charleston, SC | Defense and Space Manufacturing | 🇺🇸 Charleston | 302 | 2000 |
| 46 | [Alltrista Plastics LLC](https://www.tamtam.ai/c/alltrista-plastics-llc) (alltrista.com)<br>Innovative precision manufacturing company serving medical, consumer packaging, and industrial markets worldwide, focusing on design, engineering, and sustainable solutions Join us! | Plastics Manufacturing | 🇺🇸 Greer | 263 | 1973 |
| 47 | [Cornell Dubilier - Manufacturer of Power Capacitors](https://www.tamtam.ai/c/cornell-dubilier-manufacturer-of-power-capacitors) (cde.com)<br>Leading global supplier of capacitors, RF filters, and advanced medtech components for industrial applications in renewable energy, electric vehicles, and aerospace | Manufacturing | 🇺🇸 Liberty | 238 | 1933 |
| 48 | [Clayens US](https://www.tamtam.ai/c/clayens-us) (clayens.com)<br>Global leader in custom molding technologies, offering design, production, and program management services for various industries worldwide, specializing in various types of plastics | Plastics Manufacturing | 🇺🇸 Greenville | 227 | 1931 |
| 49 | [ITW Hartness](https://www.tamtam.ai/c/itw-hartness) (hartness.com)<br>A leading provider of secondary packaging solutions, specializing in accumulation and case packing technology for various markets worldwide | Machinery Manufacturing | 🇺🇸 Greenville | 225 | 1940 |
| 50 | [Sage Parts](https://www.tamtam.ai/c/sage-parts) (sageparts.com)<br>A leading provider of replacement parts for aviation ground support equipment, offering cost-saving solutions, fast delivery, extensive catalog, online ordering, and green alternatives | Aviation and Aerospace Component Manufacturing | 🇺🇸 Fountain Inn | 221 | 1969 |

## How this list is built

Every company on this list has a Tamtam company profile. The industry is the one the company gives on LinkedIn; categories such as SaaS or fintech are classified by Tamtam's AI from the company's website and LinkedIn page; and the headquarters city must match the company's own address. Companies are ranked by the number of employees on LinkedIn, and the list is refreshed every night. Classifications can be wrong, so treat the list as a starting point rather than an official ranking. Last updated Nov 14, 2026.

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Source: https://www.tamtam.ai/l/r-and-d-companies-south-carolina