# 30 leading companies with in-house R&D in the Yonne department

Tamtam tracks 31 companies with in-house R&D headquartered in the Yonne department. This list ranks the 30 largest by number of employees on LinkedIn, led by EPNAK, AFM-Téléthon and Genethon. Their median headcount is 39. Half of them were founded in 1987 or later. The most common headquarters are Évry (15) and Auxerre (2).

These companies in the Yonne department are predominantly involved in specialized manufacturing and biotechnology research, alongside significant civic and social organizations. Notable companies include EPNAK, which supports individuals with disabilities, and AFM-Téléthon, a patient-led association fighting rare genetic diseases. Genethon is a nonprofit laboratory developing gene therapy treatments, while FRUEHAUF specializes in manufacturing trailers. PNEU LAURENT is a European leader in heavy truck tire retreading, and Guernet designs and distributes compressed air equipment.

A significant cluster of biotechnology research firms is present, with several companies based in Évry focusing on gene therapy, genomics, and industrial biotechnology. This concentration suggests a specialized scientific and industrial base within the region.

🇫🇷 Yonne · 30 companies · Updated Nov 11, 2026

| # | Company | Industry | Headquarters | Employees | Founded |
|---|---|---|---|---|---|
| 1 | [EPNAK](https://www.tamtam.ai/c/epnak) (epnak.org)<br>The company supports over 6000 people with disabilities in achieving full citizenship through inclusive services, focusing on education, employment, housing, and healthcare | Government Administration | 🇫🇷 Évry | 1,189 | 1887 |
| 2 | [AFM-Téléthon](https://www.tamtam.ai/c/afm-telethon) (afm-telethon.fr)<br>A parent and patient-led association fighting against rare and debilitating genetic diseases through research, patient support, and public awareness initiatives | Civic and Social Organizations | 🇫🇷 Évry | 702 | 1958 |
| 3 | [Genethon](https://www.tamtam.ai/c/genethon) (genethon.fr)<br>Nonprofit laboratory developing gene therapy treatments for rare genetic diseases including neuromuscular, immune, blood, liver, and vision disorders. | Biotechnology Research | 🇫🇷 Évry | 321 | 1990 |
| 4 | [TopSolid France](https://www.tamtam.ai/c/topsolid-france) (topsolid.com)<br>Creating ideas efficiently and effectively through fast-paced production processes | Software Development | 🇫🇷 Évry | 260 | 1984 |
| 5 | [FRUEHAUF](https://www.tamtam.ai/c/fruehauf) (fruehauf.com)<br>A French company specializing in manufacturing and marketing a wide range of trailers for transportation solutions, known for durability, innovation, and quality service | Truck Transportation | 🇫🇷 Auxerre | 256 | 1946 |
| 6 | [Yposkesi, an SK pharmteco company](https://www.tamtam.ai/c/yposkesi-an-sk-pharmteco-company) (skpharmteco.com)<br>Yposkesi is a leading CDMO in Europe specializing in gene therapy viral vector manufacturing for ATMPs, with a focus on innovation and quality | Biotechnology Research | 🇫🇷 Évry | 137 | 2016 |
| 7 | [Texcell](https://www.tamtam.ai/c/texcell) (texcell.com)<br>Texcell provides comprehensive support for biotech and pharma companies, offering services in virology, immunology, analytical labs, viral safety testing, and GMP cell banking | Pharmaceutical Manufacturing | 🇫🇷 Évry | 107 | 2003 |
| 8 | [PNEU LAURENT](https://www.tamtam.ai/c/pneu-laurent) (laurentretread.com)<br>European leader in heavy truck tire retreading, manufacturing premolded tread bands and offering products for civil engineering vehicles. | Motor Vehicle Manufacturing | 🇫🇷 Avallon | 80 | 1952 |
| 9 | [Guernet](https://www.tamtam.ai/c/guernet) (guernet.com)<br>Design and distribution of compressed air equipment, garage tools, mobile installations, and intervention vehicles with customer-focused technical support. | Machinery Manufacturing | 🇫🇷 Joigny | 69 | 1911 |
| 10 | [Abolis Biotechnologies](https://www.tamtam.ai/c/abolis-biotechnologies) (abolis.fr)<br>Develops tailor-made industrial solutions using microorganisms for various sectors, addressing challenges like renewable resources, supply chain security, and emissions reduction. | Biotechnology Research | 🇫🇷 Évry | 66 | 2014 |
| 11 | [CHARLATTE RESERVOIRS - Fayat group](https://www.tamtam.ai/c/charlatte-reservoirs-fayat-group) (fayat.com)<br>Design and supply bladder type surge vessels and compressor regulated vessels for water, wastewater, and sewage applications worldwide with in-house hydraulic analysis. | Industrial Machinery Manufacturing | 🇫🇷 Migennes | 61 | 1961 |
| 12 | [Conimast International](https://www.tamtam.ai/c/conimast-international) (conimast.fr)<br>Conimast, based in Saint-florentin, Yonne, operates a 110,000m² industrial site producing made in France lighting masts in-house, supporting local employment | Industrial Machinery Manufacturing | 🇫🇷 Saint-Florentin | 55 | 1987 |
| 13 | [CHAROT](https://www.tamtam.ai/c/charot) (charot.com)<br>This company specializes in HVAC engineering, offering a wide range of products, innovative solutions in thermal energy, and a commitment to sustainability and community involvement | Mechanical Or Industrial Engineering | 🇫🇷 Sens | 51 | 1932 |
| 14 | [IntegraGen](https://www.tamtam.ai/c/integragen) (integragen.com)<br>Specializes in genomics of cancer and rare genetic diseases, providing DNA sequencing services and genomic data interpretation software for research institutes. | Biotechnology Research | 🇫🇷 Évry | 44 |  |
| 15 | [ISOSTA](https://www.tamtam.ai/c/isosta) (isosta.com)<br>Design and manufacture of sandwich panels, facades, and joinery fillings providing aesthetic, technical, innovative, and durable solutions for construction professionals. | Wholesale Building Materials | 🇫🇷 Sens | 39 | 1966 |
| 16 | [MATREX \| Conveyors for industry and airport](https://www.tamtam.ai/c/matrex-conveyors-for-industry-and-airport) (matrex.fr)<br>A small business specializing in designing and manufacturing industrial handling solutions for baggage and various industries, located south of Paris | Industrial Machinery Manufacturing | 🇫🇷 Villeneuve-sur-Yonne | 35 | 1961 |
| 17 | [Global Bioenergies](https://www.tamtam.ai/c/global-bioenergies) (global-bioenergies.com)<br>Development of unique processes producing sustainable aviation fuels and cosmetic ingredients from renewable resources, certified and supported by major industry players. | Biotechnology Research | 🇫🇷 Évry | 34 | 2008 |
| 18 | [EFIRACK](https://www.tamtam.ai/c/efirack) (efirack.fr)<br>Specializing in designing solutions for datacenters, EFIRACK offers expertise in thermal corridors, server racks, cooling, security, and services, providing personalized installations for IT challenges | IT Services and IT Consulting | 🇫🇷 Migennes | 30 | 1991 |
| 19 | [Mistral Coolers](https://www.tamtam.ai/c/mistral-coolers) (mistralcoolers.com)<br>Manufacture and innovation of durable, ergonomic water coolers focused on hygiene, performance, and user-friendly design for European markets. | Retail Office Equipment | 🇫🇷 Évry | 28 | 1952 |
| 20 | [ERTOP](https://www.tamtam.ai/c/ertop) (ertop.fr)<br>Specializing in precision sheet metal fabrication, project management, and assembly, we offer innovative solutions from prototypes to large-scale production with a team of 50 professionals | Aviation and Aerospace Component Manufacturing | 🇫🇷 Joigny | 26 | 1984 |
| 21 | [TOPSOLID Corporate](https://www.tamtam.ai/c/topsolid-corporate) (topsolid.com)<br>Leading publisher of CAD/CAM software, offering fully integrated solutions for mechanical, sheet metal, and wood industries worldwide. | Software Development | 🇫🇷 Évry | 25 | 1984 |
| 22 | [Eurofeedback](https://www.tamtam.ai/c/eurofeedback) (eurofeedback.com)<br>Designing and manufacturing of electrical/electronic equipment for industrial, medical, and aesthetic sectors since 1989 in France | Appliances, Electrical, and Electronics Manufacturing | 🇫🇷 Évry | 20 | 1989 |
| 23 | [CAPPI](https://www.tamtam.ai/c/cappi) (cappi.fr)<br>Specializing in temperature-controlled packaging for pharmaceutical and food products, providing solutions for manufacturers, wholesalers, distributors, and the food industry in Europe | Packaging and Containers Manufacturing | 🇫🇷 Auxerre | 13 | 1996 |
| 24 | [Abcell-bio](https://www.tamtam.ai/c/abcell-bio) (abcell-bio.com)<br>A company with 10 years in stem cell research, offering expertise in cell culture, hematopoiesis, and vascular biology using various cell types and custom media | Biotechnology Research | 🇫🇷 Évry | 7 | 2006 |
| 25 | [RB3D](https://www.tamtam.ai/c/rb3d) (rb3d.com)<br>Offering solutions to reduce musculoskeletal risks in industry, agriculture, and logistics with manipulators, exoskeletons, and cobots to enhance efficiency and safety during manual tasks | Automation Machinery Manufacturing | 🇫🇷 Monéteau | 6 | 2001 |
| 26 | [Infodev](https://www.tamtam.ai/c/infodev) (infodev.fr)<br>A software company specializing in ERP solutions for industrial businesses, offering software for sales, purchasing, production, and tailored software development services | Software Development | 🇫🇷 Sens | 6 | 1983 |
| 27 | [NEED-Robotics](https://www.tamtam.ai/c/need-robotics) (needrobotics.net)<br>Specializing in robotics, mechatronics, and industrial automation, we provide innovative solutions tailored to market needs, based in France | Industrial Machinery Manufacturing | 🇫🇷 Sens | 6 | 2020 |
| 28 | [SE-Therapeutics](https://www.tamtam.ai/c/se-therapeutics) (setherapeutics.com)<br>Innovative technology for intracellular delivery of antibodies and gene editing RNPs to provide life-changing cures for cancer and neurodegenerative disorders | Biotechnology Research | 🇫🇷 Évry | 6 | 2022 |
| 29 | [EDE Innov](https://www.tamtam.ai/c/ede-innov) (ede-innov.com)<br>Specializing in designing and implementing custom machines, prototypes, and innovative products across various industries, with expertise in mechanics, electronics, sensors, and industrial computing | Research Services | 🇫🇷 Évry | 4 | 2011 |
| 30 | [IDC MEDICAL](https://www.tamtam.ai/c/idc-medical) (idc-medical.com)<br>A French company developing custom solutions based on identified medical issues, with a focus on high disinfection of medical devices | International Trade & Development | 🇫🇷 Saint-Fargeau | 2 | 2017 |

## How this list is built

Every company on this list has a Tamtam company profile. The industry is the one the company gives on LinkedIn; categories such as SaaS or fintech are classified by Tamtam's AI from the company's website and LinkedIn page; and the headquarters city must match the company's own address. Companies are ranked by the number of employees on LinkedIn, and the list is refreshed every night. Classifications can be wrong, so treat the list as a starting point rather than an official ranking. Last updated Nov 11, 2026.

## More company lists in the Yonne department

- [The largest companies in the Yonne department](https://www.tamtam.ai/l/largest-companies-yonne) (220)
- [Manufacturers in the Yonne department](https://www.tamtam.ai/l/manufacturers-yonne) (27)

## The same list elsewhere in France

- [Companies with in-house R&D in France](https://www.tamtam.ai/l/r-and-d-companies-france) (8,750)
- [Companies with in-house R&D in Île-de-France](https://www.tamtam.ai/l/r-and-d-companies-ile-de-france) (2,695)
- [Companies with in-house R&D in Auvergne-Rhône-Alpes](https://www.tamtam.ai/l/r-and-d-companies-auvergne-rhone-alpes) (1,460)
- [Companies with in-house R&D in Occitanie](https://www.tamtam.ai/l/r-and-d-companies-occitanie) (680)
- [Companies with in-house R&D in Grand Est](https://www.tamtam.ai/l/r-and-d-companies-grand-est) (640)
- [Companies with in-house R&D in Provence-Alpes-Côte d'Azur](https://www.tamtam.ai/l/r-and-d-companies-provence-alpes-cote-dazur) (613)
- [Companies with in-house R&D in Nouvelle-Aquitaine](https://www.tamtam.ai/l/r-and-d-companies-nouvelle-aquitaine) (566)
- [Companies with in-house R&D in the Hauts-de-Seine department](https://www.tamtam.ai/l/r-and-d-companies-hauts-de-seine) (510)
- [Companies with in-house R&D in the Rhône department](https://www.tamtam.ai/l/r-and-d-companies-rhone) (509)
- [Companies with in-house R&D in Pays de la Loire](https://www.tamtam.ai/l/r-and-d-companies-pays-de-la-loire) (480)
- [Companies with in-house R&D in Hauts-de-France](https://www.tamtam.ai/l/r-and-d-companies-hauts-de-france) (410)
- [Companies with in-house R&D in Brittany](https://www.tamtam.ai/l/r-and-d-companies-brittany) (366)
- [Companies with in-house R&D in the Haute-Garonne department](https://www.tamtam.ai/l/r-and-d-companies-haute-garonne) (323)
- [Companies with in-house R&D in the Bouches-du-Rhône department](https://www.tamtam.ai/l/r-and-d-companies-bouches-du-rhone) (321)
- [Companies with in-house R&D in the Isère department](https://www.tamtam.ai/l/r-and-d-companies-isere) (304)
- [Companies with in-house R&D in Bourgogne-Franche-Comté](https://www.tamtam.ai/l/r-and-d-companies-bourgogne-franche-comte) (261)
- [Companies with in-house R&D in the Nord department](https://www.tamtam.ai/l/r-and-d-companies-nord) (237)
- [Companies with in-house R&D in Normandy](https://www.tamtam.ai/l/r-and-d-companies-normandy) (227)
- [Companies with in-house R&D in the Gironde department](https://www.tamtam.ai/l/r-and-d-companies-gironde) (225)
- [Companies with in-house R&D in the Loire-Atlantique department](https://www.tamtam.ai/l/r-and-d-companies-loire-atlantique) (207)
- [Companies with in-house R&D in the Essonne department](https://www.tamtam.ai/l/r-and-d-companies-essonne) (198)
- [Companies with in-house R&D in Centre-Val de Loire](https://www.tamtam.ai/l/r-and-d-companies-centre-val-de-loire) (195)
- [Companies with in-house R&D in Paris](https://www.tamtam.ai/l/r-and-d-companies-paris) (1,249)
- [Companies with in-house R&D in Lyon](https://www.tamtam.ai/l/r-and-d-companies-lyon) (192)

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Source: https://www.tamtam.ai/l/r-and-d-companies-yonne