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Top 54 venture-backed startups in Massachusetts

Tamtam tracks 54 venture-backed startups headquartered in Massachusetts. This list ranks all of them by number of employees on LinkedIn, led by Preply, Toast and Klaviyo. Their median headcount is 349. Half of them were founded in 2015 or later. The most common headquarters are Boston (26), Cambridge (7) and Burlington (4).

馃嚭馃嚫 Massachusetts54 companiesUpdated Nov 2, 2026
#CompanyIndustryHeadquarters EmployeesFounded
1
Preplypreply.com

The company connects learners with online tutors worldwide, offering live language classes with AI tools and learning materials for progress and engagement

Technology, Information and Internet 馃嚭馃嚫 Brookline 18,061 2012
2
Toastpos.toasttab.com

Toast empowers restaurants with cloud-based software and hardware to streamline operations, drive revenue, and enhance guest experience through POS, marketing, and HR solutions

Software Development 馃嚭馃嚫 Boston 7,762 2011
3
Klaviyoklaviyo.com

Unified customer platform empowering brands with ownership of consumer data to automate personalized email/SMS communications, foster customer relationships, and drive growth

Marketing Services 馃嚭馃嚫 Boston 2,902 2012
4
Semrushsemrush.com

A leading online visibility management platform offering a suite of marketing tools to help companies improve their online presence and results

Software Development 馃嚭馃嚫 Boston 2,357 2008
5
OutSystemsoutsystems.com

Provides an AI development platform for enterprises to rapidly build custom applications and AI agents while modernizing legacy core business systems.

Software Development 馃嚭馃嚫 Boston 2,228 2001
6
Devoted Healthdevoted.com

Dedicated to improving health and well-being for seniors through personalized care, advanced technology, and partnerships with top healthcare providers

Hospitals and Health Care 馃嚭馃嚫 Waltham 2,197 2017
7
Snyksnyk.io

Empowering organizations to build fast, stay secure, unleashing developer productivity, reducing business risk, accelerating secure software delivery, innovating without limits.

Computer and Network Security 馃嚭馃嚫 Boston 1,557 n/a
8
Auraaura.com

A mission-driven technology company focused on creating a safer internet for all, providing comprehensive digital security services trusted by millions worldwide

Software Development 馃嚭馃嚫 Boston 1,274 2017
9
Creatiocreatio.com

Provides an AI-native, no-code platform for CRM and workflow automation, enhancing customer and employee experiences and boosting team efficiency.

Software Development 馃嚭馃嚫 Boston 1,158 2014
10
Commonwealth Fusion Systemscfs.energy

A company specializing in commercial fusion energy, developing compact power plants using HTS magnet technology to combat climate change

Energy Technology 馃嚭馃嚫 Devens 1,089 2018
11
DataRobotdatarobot.com

Value-driven AI company accelerating AI impact with innovative AI lifecycle platform for organizations to build, operate, and govern AI landscapes confidently

Software Development 馃嚭馃嚫 Boston 881 2012
12
Gradiantgradiant.com

Provides advanced water and wastewater treatment solutions for critical industries, reducing water usage, reclaiming resources, and renewing wastewater into freshwater.

Environmental Services 馃嚭馃嚫 Woburn 859 2013
13
Dotmaticsdotmatics.com

Global leader in R&D scientific software connecting science, data, and decision-making with end-to-end solutions for research in biology, chemistry, and more Trusted by millions worldwide

Software Development 馃嚭馃嚫 Boston 639 2005
14
Salsifysalsify.com

Salsify's Product Experience Management platform helps brand manufacturers, distributors, and retailers succeed in digital commerce through PIM, Syndication, and Automation

Software Development 馃嚭馃嚫 Boston 583 2012
15
Inariinari.com

Utilizing new breeding technology and AI, the company designs nature-positive seeds for a sustainable global food system, enhancing crop productivity efficiently

Biotechnology Research 馃嚭馃嚫 Cambridge 510 2016
16
Malta Incmaltainc.com

The company has developed a thermal energy storage system that can collect, store, and dispatch energy from various sources for extended periods

Renewable Energy Semiconductor Manufacturing 馃嚭馃嚫 Cambridge 509 2018
17
Devodevo.com

Delivers a real-time security data platform, including data-powered threat detection, automated case management, autonomous investigations, and threat hunting, to enhance security operations.

Computer and Network Security 馃嚭馃嚫 Boston 500 2011
18
Cambridge Mobile Telematicscmtelematics.com

AI-driven platform identifying and reducing driving risks, partnering with insurers and automakers to prevent crashes and enhance road safety worldwide.

Software Development 馃嚭馃嚫 Cambridge 477 2010
19
BlueRock Therapeuticsbluerocktx.com

A leading engineered cell therapy company developing regenerative medicines for neurology, cardiology, and immunology indications through innovative cell+gene platform

Biotechnology Research 馃嚭馃嚫 Cambridge 474 2016
20
Aqua Securityaquasec.com

Pioneer in securing containerized cloud native applications from development to production, preventing and mitigating attacks in real time, integrating security from code to cloud.

Computer and Network Security 馃嚭馃嚫 Burlington 471 2015
21
Penterapentera.io

AI-powered Automated Security Validation for enterprise teams. Emulates real-world attacks across on-prem, cloud, and external environments to reveal exploitable vulnerabilities.

Computer and Network Security 馃嚭馃嚫 Burlington 469 2015
22
Showpadshowpad.com

It provides an AI-powered enablement operating system that integrates marketing and revenue teams to enhance sales training and content management.

Software Development 馃嚭馃嚫 Waltham 428 2011
23
Abacus Insightsabacusinsights.com

Abacus leverages healthcare data to improve patient care by breaking down silos and providing powerful insights through innovative technologies

Software Development 馃嚭馃嚫 Boston 409 2017
24
AVAeatwithava.com

An intelligent eating platform reshaping food and nutrition habits with top talent in nutrition science, technology, and behavioral coaching Currently in private beta

Wellness and Fitness Services 馃嚭馃嚫 Boston 359 2016
25
Lushalusha.com

Provides B2B data and sales intelligence for sales, marketing, recruiting, and RevOps teams to find contacts, enrich records, and track buying signals.

Software Development 馃嚭馃嚫 Boston 359 2016
26
LightForcelf.co

pioneers generative braces, creating individualized 3D-printed brackets for patients, uniting digital planning, advanced manufacturing, and algorithmic bonding for orthodontics.

Medical Equipment Manufacturing 馃嚭馃嚫 Wilmington 349 2015
27
XtalPi Inc.en.xtalpi.com

A quantum physics-based, AI-powered drug R&D company revolutionizing drug discovery with integrated technology platform and support from renowned investors

Biotechnology Research 馃嚭馃嚫 Cambridge 349 2015
28
Generate:Biomedicinesgeneratebiomedicines.com

Innovating in generative biology to develop innovative therapeutics that drive breakthroughs in the field

Biotechnology Research 馃嚭馃嚫 Somerville 335 n/a
29
Boston Metalbostonmetal.com

Revolutionizing steel production with carbon-free technology that is more efficient, cost-effective, and eco-friendly, using Molten Oxide Electrolysis (MOE)

Primary Metal Manufacturing 馃嚭馃嚫 Woburn 316 n/a
30
Zappizappi.io

A leading agile market research platform for brands to improve ads and products with faster, more affordable consumer insights

Software Development 馃嚭馃嚫 Boston 312 2013
31
Janajana.com

A mobile advertising company providing free internet in emerging markets by offsetting user data costs through strategic advertising campaigns

Advertising Services 馃嚭馃嚫 Boston 266 2009
32
Tomorrow.iotomorrow.io

Weather intelligence and climate adaptation platform using space technology and AI to help organizations predict impact, mitigate risk, and ensure operational resilience

Software Development 馃嚭馃嚫 Boston 228 2016
33
Allegoallego.com

It provides a comprehensive platform for sales, enablement, and marketing teams to enhance buyer engagement and accelerate sales cycles.

Software Development 馃嚭馃嚫 Waltham 208 2013
34
Intersections Inc.aura.com

A leading provider of digital threat protection services, offering identity risk management and privacy protection through innovative software and data monitoring solutions

IT Services and IT Consulting 馃嚭馃嚫 Burlington 196 2019
35
Immutaimmuta.com

This company enables organizations to securely access and protect their cloud data through sensitive data discovery, security controls, and data activity monitoring

Software Development 馃嚭馃嚫 Boston 195 2015
36
Parabilis Medicinesparabilismed.com

FogPharma is developing HeliconTM peptides, a new drug modality that combines monoclonal antibodies with small molecules for broad, efficient drug targeting

Biotechnology Research 馃嚭馃嚫 Cambridge 195 2016
37
GreenLight Biosciencesgreenlightbiosciences.com

Develop and commercialize environmentally friendly, easy-to-use crop protection solutions leveraging natural methods to support sustainable farming practices.

Biotechnology Research 馃嚭馃嚫 Medford 182 2008
38
FundGuardfundguard.com

Transforming investment operations with a cloud-native, AI-powered platform to reduce fees, offer new products, support sustainable investing, and grow assets efficiently

Financial Services 馃嚭馃嚫 Dedham 159 2018
39
AtScaleatscale.com

This company enables faster, data-driven decision-making with a semantic layer platform that simplifies and accelerates business intelligence and data science capabilities for enterprise customers

Software Development 馃嚭馃嚫 Boston 151 2013
40
Implicityimplicity.com

Provides a universal cardiac remote monitoring and research platform to hospitals and clinics, enhancing remote care for cardiac patients.

Hospitals and Health Care 馃嚭馃嚫 Cambridge 125 2016
41
Maven AGImavenagi.com

AI-powered platform transforming customer support experience through generative technology

Software Development 馃嚭馃嚫 Boston 114 2023
42
7AI7ai.com

AI-driven autonomous cybersecurity platform providing rapid, self-directed threat detection and response to protect against evolving cyber threats.

Computer and Network Security 馃嚭馃嚫 Boston 112 2024
43
Centaur.aicentaur.ai

Data labeling solution for healthcare AI with 50k+ labelers, gamified app for quality control, scalable methodology for high-quality labels in 24 hours

Software Development 馃嚭馃嚫 Boston 79 2017
44
Cometeercometeer.com

Revolutionizing the global coffee market with specialty coffee capsules delivered frozen, no machine required Outstanding quality, rave reviews, and innovative technology driving growth

Food and Beverage Manufacturing 馃嚭馃嚫 Gloucester 68 2015
45
GENOSKINgenoskin.com

Genoskin generates first-in-human clinical data using live human skin models to help de-risk drug development for researchers and companies

Biotechnology Research 馃嚭馃嚫 Salem 59 2011
46
Gutenberg Technologygutenberg-technology.com

This company helps businesses organize and share their knowledge through web and mobile apps for better collaboration and faster execution

Software Development 馃嚭馃嚫 Boston 55 2010
47
Tessianproofpoint.com

A leading cloud email security platform using machine learning to protect organizations against advanced threats and data loss, while coaching on security awareness

Computer and Network Security 馃嚭馃嚫 Boston 41 2013
48
Beaconcurebeaconcure.com

The company provides technology to validate clinical trial data, detect inconsistencies, and accelerate the regulatory approval process for pharmaceutical companies and CROs

Software Development 馃嚭馃嚫 Boston 34 2016
49
ARInsightsarinsights.com

A market-leading SaaS platform for managing analyst relations, providing comprehensive databases, interaction management solutions, and complementary products for improving AR efficiency

Software Development 馃嚭馃嚫 Needham 29 2004
50
99Degrees99degreescustom.com

A leading US activewear manufacturer specializing in tech-integrated apparel, providing fast production to reduce inventory issues and promote sustainability

Retail Apparel and Fashion 馃嚭馃嚫 Lawrence 16 2013
51
Kraaftkraaft.co

Mobile-first communication platform for construction industry enabling messaging, photo sharing, document management, scheduling, and AI-powered reporting on job sites.

Mobile Computing Software Products 馃嚭馃嚫 15 2020
52
Accion Systemsaccion-systems.com

The company specializes in reinventing propulsion for New Space by creating a more efficient ion thruster called the Tiled Ionic Liquid Electrospray engine

Defense and Space Manufacturing 馃嚭馃嚫 Charlestown 14 2014
53
Diadem Capitalapp.diademcapital.com

This company revolutionizes fundraising by providing founders with a platform to connect with institutional investors and secure venture backing for real growth potential

Venture Capital and Private Equity Principals 馃嚭馃嚫 Burlington 7 2022
54
Perceptive Automataperceptiveautomata.com

A team of experts founded in 2016 to develop AI technology enabling autonomous vehicles to understand human behavior for safer driving experiences

Software Development 馃嚭馃嚫 Boston 1 2016

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How this list is built

Every company on this list has a Tamtam company profile. The industry is the one the company gives on LinkedIn; categories such as SaaS or fintech are classified by Tamtam's AI from the company's website and LinkedIn page; and the headquarters city must match the company's own address. Companies are ranked by the number of employees on LinkedIn, and the list is refreshed every night. Classifications can be wrong, so treat the list as a starting point rather than an official ranking. Last updated Nov 2, 2026.

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