The largest companies in the Rhône department are primarily established firms, with a notable presence of large groups. Many are headquartered in Lyon, showing the city's role as a business hub. For example, bioMérieux specializes in in vitro diagnostic solutions, Groupe SEB manufactures small domestic equipment, and Hospices Civils de Lyon is a public university hospital.
Other significant entities include XPO Logistics Europe, providing end-to-end logistics solutions, GL events, which designs and hosts various events globally, and Grand Frais, a specialized fresh food retailer. The data indicates a mix of sectors, with a strong representation in healthcare, manufacturing, and logistics, alongside retail and professional services.
| # | Company | Employees | |||
|---|---|---|---|---|---|
| 1 |
Team for the Planetteam-planet.com
Create and fund open-source companies targeting greenhouse gas reduction, recruit experienced entrepreneurs, and enable global climate action through investments. |
19,051 | |||
| 2 |
bioMérieuxbiomerieux.com
A leading provider of in vitro diagnostic solutions worldwide, focusing on improving patient health and ensuring consumer safety through disease detection and contamination analysis |
13,106 | |||
| 3 |
Groupe SEBgroupeseb.com
Leading company small domestic equipment and professional coffee machines, offering innovative products improving daily lives consumers globally, operating nearly 150 countries. |
9,900 | |||
| 4 |
Hospices Civils de Lyon - HCLchu-lyon.fr
Public university hospital provides care, education, research, medical innovation, prevention, and health education with over 22,000 professionals across 14 facilities. |
8,220 | |||
| 5 |
XPO Logistics Europexpo.com
Offers end-to-end logistics solutions, including full-truckload, less-than-truckload, pallet distribution, last-mile delivery, global freight forwarding, and warehousing services across Europe. |
7,478 | |||
| 6 |
GL eventsgl-events.com
Designs, produces, and hosts corporate, cultural, sporting, political, and inter-governmental events globally, operating through three complementary divisions worldwide. |
6,716 | |||
| 7 |
Grand Fraisgrandfrais.com
Specialized fresh food retailer with 338 stores, bringing together five food professionals under one roof: greengrocer, cheesemonger, butcher, fishmonger, and global grocer. |
5,191 | |||
| 8 | 4,896 | ||||
| 9 |
Université Claude Bernard Lyon 1univ-lyon1.fr
Public university specializing in sciences, medicine, and pharmacy with significant research facilities and a strong regional academic presence. |
4,476 | |||
| 10 |
Handicap International - Humanity & Inclusionhi.org
An international organization specialized in disability assistance, supporting individuals to become self-reliant in various contexts and emergencies worldwide |
4,345 | |||
| 11 |
In Extensoinextenso.fr
French accounting leader with broad services for businesses. Offers accounting, administrative, legal, tax, social, M&A, tourism, wealth, innovation, and legal advice. |
3,533 | |||
| 12 |
Université Lumière Lyon 2univ-lyon2.fr
Large French public university offering diverse programs from bachelor to doctorate, focusing on research, international partnerships, and societal engagement. |
3,390 | |||
| 13 |
Métropole de Lyongrandlyon.com
Manages various public services including mobility, environment, urban planning, social aid, economic development, and cultural activities for 58 communes. |
3,295 | |||
| 14 |
Carrefour Express
Operates supermarkets, providing groceries and daily essentials to customers in various neighborhoods, focusing on convenience and accessibility for local communities. |
3,201 | |||
| 15 |
Adéquat Interim & Recrutementlejobadequat.com
Provides comprehensive temporary work and recruitment solutions, including permanent contracts and associated services, to various organizations across all sectors in France. |
3,167 | |||
| 16 |
RAS Intérimras-interim.fr
Founded in 1969, this French company provides 24/7 staffing solutions nationwide with a highly responsive, flexible, and reliable team for specialized and urgent recruitment needs |
3,048 | |||
| 17 |
EFORefor-group.com
supports pharmaceutical, biotech, and medtech companies in ensuring production compliance and expediting the market launch of safe and effective medical products |
2,913 | |||
| 18 |
Ville de Lyonemploi-territorial.fr
The City of Lyon, located in the Rhône-Alpes region, offers a high quality of life and exceptional economic dynamism, providing public services to its residents |
2,820 | |||
| 19 |
entreprise individuellegrandclement.fr
This company specializes in web development, SEO, online advertising campaigns, VBNet development, e-commerce, Access development, training, and consulting for SMEs |
2,587 | |||
| 20 | 2,571 | ||||
| 21 |
Université Jean Moulin (Lyon III)univ-lyon3.fr
Public university offering multidisciplinary higher education and research in law, management, humanities, and social sciences with strong societal engagement. |
2,461 | |||
| 22 |
Caisse d'Epargne Rhone Alpescaissedepargnerhonealpes.fr
A prominent banking institution in the Rhône-Alpes region serving individuals, businesses, social economy, housing, local authorities, real estate professionals, and protected individuals |
2,442 | |||
| 23 |
Boccardboccard.com
Designs and builds industrial plants, offering integrated digital expertise in engineering, manufacturing, construction, and maintenance across various global industries. |
2,390 | |||
| 24 |
Banque Populaire Auvergne Rhône Alpesbanquepopulaire.fr
A regional bank in Auvergne Rhône Alpes region welcoming candidates, clients, and members They recruit hundreds of employees annually and are active on LinkedIn for recruitment |
2,313 | |||
| 25 |
Région Auvergne-Rhône-Alpesauvergnerhonealpes.fr
A regional government in Auvergne with 4 departments, 1310 communes, and a budget of over €600 million, focusing on education, transportation, and vocational training |
2,304 | |||
| 26 |
INTERPOLinterpol.int
Provides technical and operational support to law enforcement worldwide, facilitating cross-border investigations and communication among member countries. |
2,289 | |||
| 27 |
Crédit Agricole Centre-estca-centrest.com
A regional banking institution with a cooperative and mutualist foundation, providing various financial services to over 1 million clients and supporting regional economic development |
2,262 | |||
| 28 |
Feu Vert Francefeuvert-group.com
Passionate about automobiles, Feu Vert is a French leader in automotive equipment and maintenance, valuing its dedicated team and fostering personal growth |
2,249 | |||
| 29 | 2,160 | ||||
| 30 |
YESSS ELECTRIQUEyesss-fr.com
Significant distributor of electrical supplies for professionals, with a focus on service, teamwork, and adaptability to an ever-evolving market |
2,132 | |||
| 31 |
emlyon business schoolem-lyon.com
World-renowned business school offering higher education and continued education programs with a focus on skill hybridization, social responsibility, and impactful alumni worldwide |
2,101 | |||
| 32 |
Adecco Medicaladecco.com
Leader in healthcare employment solutions, providing staffing for medical professionals across various sectors, offering temporary, permanent, and vacation contracts, and supporting career development. |
2,038 | |||
| 33 |
Gerflorgerflor.com
Production and distribution of design-driven, innovative, environmentally-friendly flooring, wallcovering, and finishes across international healthcare, housing, education, sport, transport, retail, and industrial markets. |
2,037 | |||
| 34 |
Sicame Groupsicame-group.com
World leader in production, sales of accessories and services for electrical energy transmission and distribution, safety equipment, and industrial applications. |
1,999 | |||
| 35 |
Santé Ciesantecie.com
Provides home healthcare, dialysis treatment, and urgent care centers across France and Europe, supporting 500,000 patients annually. |
1,979 | |||
| 36 |
STSsts-certified.com
Technical advisory and conformity assessment services for solar and storage components, including manufacturing audits and inspections for global renewable energy project developers. |
1,900 | |||
| 37 |
Reelreelinternational.com
Designs, produces, and maintains complex lifting and handling systems and solutions for highly technical installations in diverse markets like aerospace, nuclear, and energy. |
1,882 | |||
| 38 | 1,877 | ||||
| 39 |
DESCOURS & CABAUDdescours-cabaud.com
Leading distributor supporting building, public works, industry, and public or private tertiary sectors with professional supplies across France and Europe. |
1,861 | |||
| 40 |
Groupama Rhone-Alpes Auvergnegroupama.fr
Provides insurance services through a mutualist model emphasizing proximity, solidarity, and responsibility with extensive regional presence and community involvement. |
1,852 | |||
| 41 |
INSA Lyon - Institut National des Sciences Appliquées de Lyoninsa-lyon.fr
International multidisciplinary engineering school focusing on high-quality education, research, and fostering global openness and social aspects in curriculum. |
1,831 | |||
| 42 |
Prosolprosol-recrute.fr
French company specialized in grande distribution management and operations, providing retail services and logistical support from its headquarters in the Chaponnay region. |
1,761 | |||
| 43 |
CLASQUINclasquin.com
Multinational freight forwarding and overseas logistics provider managing tailor-made transport solutions through an integrated network of offices for end-to-end supply chain coordination. |
1,700 | |||
| 44 |
SOLUTECsolutec.fr
Provides IT engineering, consulting, and services. Supports clients through project phases like management, infrastructure, operations, and coordination across various sectors. |
1,659 | |||
| 45 | 1,652 | ||||
| 46 |
CTCctcgroupe.com
CTC offers cross-disciplinary solutions for the leather, footwear, and textile industries, focusing on ethical practices, cost savings, waste reduction, and performance improvement worldwide |
1,622 | |||
| 47 |
NEMERAnemera.net
Designs, develops, and manufactures drug delivery devices for ophthalmic, nasal, inhalation, dermal, and parenteral routes, prioritizing patient needs and treatment efficacy. |
1,616 | |||
| 48 |
GESERICK BVla-boate.com
It offers artistic mediation, theater training, cultural education, writing support, and correction services to enhance creative expression and learning. |
1,553 | |||
| 49 |
ECOLE PRIMAIRE PRIVEE
A primary/secondary education company located in Lyon, France, providing private schooling services for students in Auvergne-Rhône-Alpes |
1,537 | |||
| 50 |
Restalliancerestalliance.fr
For nearly 30 years, this company provides tailored food, hospitality services, cleaning, and professional training solutions exclusively for healthcare facilities, improving patient care and well-being |
1,476 | |||
Want more companies than this list?This page shows the largest ones only. Connect to Tamtam to see every company that matches, filter by size, industry or growth, and reach their decision-makers. | |||||
| 51 |
Habitat et Humanismehabitat-humanisme.org
The organization works to address exclusion and isolation by providing housing, social integration, and support for individuals in need through various innovative initiatives and programs |
1,457 | |||
| 52 |
Groupe LIP Interim et Recrutementgroupelip.com
Independent group specializing in temporary staffing and recruitment across various sectors, matching skilled professionals with appropriate positions and supporting career paths. |
1,454 | |||
| 53 |
Groupe APICILgroupe-apicil.com
A leading French social protection group offering tailored solutions in health, insurance, savings, and retirement, with a focus on client well-being and social responsibility |
1,446 | |||
| 54 |
Centre Léon Bérardcentreleonberard.fr
Specialized cancer hospital and research center providing personalized treatment, innovative therapies, and compassionate care to support patients throughout their illness. |
1,418 | |||
| 55 |
CIC Lyonnaise de Banquecic.fr
A local bank focusing on client service and supporting the economy with over 160 years of experience, promoting innovation, entrepreneurship, and community involvement |
1,417 | |||
| 56 |
Lycée du Parcfondationlyceeduparc.fr
Established in 1914, this high school prepares students for the baccalaureate and entrance exams to top literary, economic, and scientific Grandes Écoles, fostering a supportive and excellence-driven environment |
1,374 | |||
| 57 |
Académie de Lyonac-lyon.fr
Regional educational authority managing and coordinating all public schools across Ain, Loire, and Rhône departments in France. |
1,323 | |||
| 58 |
SEQENSseqens.com
Worldwide leader pharmaceutical solutions, specialty ingredients. Operates manufacturing sites, R&D centers. Offers broad portfolio active ingredients, intermediates, specialty ingredients. |
1,285 | |||
| 59 |
École normale supérieure de Lyonens-lyon.fr
Higher education institution specializing in interdisciplinary research and training, fostering scientific excellence and social engagement in education and research. |
1,268 | |||
| 60 |
CNR (Compagnie Nationale du Rhône)tm.fr
French leading producer of 100% renewable electricity, managing the Rhône river for hydroelectricity, navigation, irrigation, and agricultural use, supporting local development and innovation |
1,256 | |||
| 61 |
Le Vinatier - Psychiatrie Universitaire Lyon Métropolech-le-vinatier.fr
Specialized psychiatric hospital providing comprehensive mental health care, treatment, and support services for individuals with mental disorders. |
1,246 | |||
| 62 | 1,213 | ||||
| 63 |
OPTEVENfr.opteven.com
A European group providing tailored warranties and services for mobility, including mechanical breakdown coverage, maintenance contracts, and assistance to 3 million beneficiaries |
1,200 | |||
| 64 |
Relyens en Francerelyens.eu
Manages and prevents risks for healthcare and territorial actors in Europe, combining steering, prevention solutions, and insurance to secure their activities. |
1,167 | |||
| 65 | 1,161 | ||||
| 66 |
Domino RHdomino-rh.com
Established in 1999, this group offers temporary assignments, recruitment, training, HR consulting, and management services with a national network across France and expanding internationally |
1,144 | |||
| 67 |
EDF solutions solairesedf-solutions-solaires.com
Offers turnkey solar solutions for individuals, professionals, and communities, supporting energy transition and enabling self-production of sustainable, local, and decarbonized energy. |
1,132 | |||
| 68 |
Commerçant+proxity-edf.com
Accelerates collective, commercial, and digital revitalization of city centers by offering a shared turnkey solution, adapting to new retail challenges with digital, proximity, authenticity, and unique shopping experiences. |
1,114 | |||
| 69 |
PM
Enterprise architecture firm specializing in project management, systems design, and business strategy to optimize organizational structure and processes for efficiency |
1,087 | |||
| 70 | 1,063 | ||||
| 71 |
Adapei 69adapei69.fr
An association providing tailored support and integration for individuals with intellectual disabilities, autism, and mental health disorders through a variety of services and facilities |
1,045 | |||
| 72 |
JTEKT European Operationsjtekt.eu
Designs and manufactures automotive components, bearings for various industries, and a range of machine tools for manufacturing jobs. |
1,006 | |||
| 73 |
Rubix Francerubix.com
Industrial solutions provider with expertise in products, services, and logistics, dedicated to improving European industry through innovation, value-creation, and customer-focused solutions |
998 | |||
| 74 |
Clayens NPclayens.com
Transforms high-performance polymers, composites, and precision metal parts, offering tailored solutions from project to production across diverse industrial sectors. |
978 | |||
| 75 |
Département du Rhônerhone.fr
Regional government providing public services, promoting equality, supporting innovation, and enhancing quality of life for 440,000 residents. |
956 | |||
| 76 |
Université catholique de Lyonucly.fr
Higher education institution offering multiple faculties, advanced schools, and research centers focused on various academic disciplines and studies. |
936 | |||
| 77 | 920 | ||||
| 78 |
Aldes Groupealdesgroup.com
Designs, manufactures, and sells integrated solutions for air quality and thermal comfort in residential and commercial buildings, including ventilation, heating, and cooling. |
914 | |||
| 79 |
IDRAC Business schoolecoles-idrac.com
A multi-campus business school offering commercial, management, and marketing training in both continuous education and initial academic programs Services include short courses, diplomas, and student placements |
897 | |||
| 80 |
Tribunal judiciaire de Lyoncours-appel.justice.fr
The Lyon Judicial Court is the primary court for legal matters in the Lyon judicial district, under the Lyon Court of Appeals |
847 | |||
| 81 | 844 | ||||
| 82 |
Euronewseuronews.com
An international news media providing European perspective news in 17 languages on TV and digital platforms to over 400 million homes worldwide |
840 | |||
| 83 | 835 | ||||
| 84 |
Groupe Panzanigroupe-panzani.fr
A leading French agri-food company with brands like Panzani and Lustucru Sélection, focused on innovation and international growth |
831 | |||
| 85 |
Digital Virgodigitalvirgo.com
Connecting telecom operators, content creators, and brands, allowing people worldwide to access and pay for products/services via alternative payments and optimizing digital marketing. |
830 | |||
| 86 |
Soleryssolerys.fr
Solerys is a leading expert in career transition, professional reclassification, and skills assessments with a network of 450 consultants nationwide |
826 | |||
| 87 |
Carsat Rhône Alpescarsat-ra.fr
Management of retirement benefits, promotion of healthy aging, support for vulnerable insured individuals, and workplace health and safety risk prevention. |
826 | |||
| 88 |
Fondation OVEfondation-ove.fr
A recognized public utility foundation providing social and medical-social services for individuals with disabilities and those in need, serving thousands annually |
812 | |||
| 89 |
Agicapagicap.com
Platform integrating banking and ERP connectivity for cash management, liquidity planning, accounts receivable and payable, serving businesses globally. |
806 | |||
| 90 |
Eurofins Biomniseurofins-biomnis.com
A European leader in specialized medical pathology, providing over 2,500 tests including specialized, authorized analyses with a focus on innovation and international development |
803 | |||
| 91 |
Protection judiciaire de la jeunesse – Auvergne-Rhône Alpesjustice.gouv.fr
Educates and protects minors under judicial decisions, ensuring social, academic, and professional integration, and fighting recidivism within the justice ministry. |
800 | |||
| 92 |
Le Progrèsleprogres.fr
Company providing news and timely updates on their official website for their audience |
767 | |||
| 93 | 740 | ||||
| 94 |
MANILA
A hospitality company located in Lyon, France, specializing in providing services and experiences for guests in the industry |
738 | |||
| 95 |
NGE FONDATIONSnge-fondations.fr
Specializes in geotechnical works and site security, focusing on ground stabilization and safety measures for construction projects. |
737 | |||
| 96 |
Valorityvalority.com
Specialized in real estate, credit, property management, and financial investments, providing comprehensive support throughout the investment process. |
721 | |||
| 97 |
Ville de Villeurbannevilleurbanne.fr
Second largest city in Rhône with 162,000 residents, notable for its diverse population contributing to the city's unique character. |
719 | |||
| 98 |
Nutrisensnutrisens.com
The company specializes in creating nutritious and delicious food products to satisfy customers' needs and bring enjoyment to their meals |
700 | |||
| 99 |
Lyonmedia7.net
Specializing in job recruitment and opportunities in Lyon, offering a range of positions for job seekers in the area |
697 | |||
| 100 |
Groupe Thermcrossthermcross.fr
International leader distance selling technical spare parts maintenance operation heating, ventilation, air conditioning equipment. Offers high-value digital solutions logistics to installation diagnosis. |
685 | |||
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Every company on this list has a Tamtam company profile. The industry is the one the company gives on LinkedIn; categories such as SaaS or fintech are classified by Tamtam's AI from the company's website and LinkedIn page; and the headquarters city must match the company's own address. Companies are ranked by the number of employees on LinkedIn, and the list is refreshed every night. Classifications can be wrong, so treat the list as a starting point rather than an official ranking. Last updated Nov 11, 2026.
More company lists in the Rhône department
- Multinational companies in the Rhône department 577
- Companies with in-house R&D in the Rhône department 509
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- Retail chains in the Rhône department 302
- IT services companies in the Rhône department 286
- SaaS companies in the Rhône department 284
- Software Development companies in the Rhône department 264
- IT Services and IT Consulting companies in the Rhône department 253
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- Law Practice companies in the Rhône department 152
- Real Estate companies in the Rhône department 151
- Family-owned companies in the Rhône department 149
- Subscription businesses in the Rhône department 149
- Construction companies in the Rhône department 140
- Pharmaceutical companies in the Rhône department 134
- Financial services firms in the Rhône department 132
- Advertising Services companies in the Rhône department 126
- Events Services companies in the Rhône department 126
The same list elsewhere in France
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