These large companies in Lazio, primarily headquartered in Rome, represent a diverse range of sectors with a strong emphasis on research and development. Key players include Leonardo, a defense and security multinational, and Eni, an integrated energy business. Enel Group focuses on electricity operations, while Ferrovie dello Stato Italiane manages national rail infrastructure. Sapienza Università di Roma and Consiglio Nazionale delle Ricerche are prominent research institutions, and Engineering Group is a digital transformation company.
A notable pattern among these companies is their significant employee count, with many having tens of thousands of employees, indicating established, large-scale operations. The concentration of headquarters in Rome also highlights the city as a central hub for these major Italian enterprises.
| # | Company | Employees | |||
|---|---|---|---|---|---|
| 1 |
Leonardoleonardo.com
Defense and security multinational company specializing in aerospace, cybersecurity, military systems, and advanced technology solutions |
38,521 | |||
| 2 | 32,259 | ||||
| 3 |
Enel Groupenel.com
Multinational company reshaping the future of energy, a leading integrated electricity operator. Distributes and supplies electricity to millions of end users. |
31,218 | |||
| 4 |
Ferrovie dello Stato Italiane S.p.A.fsitaliane.it
National rail infrastructure management, passenger transport services, logistics solutions, and urban regeneration projects across Italy. |
28,071 | |||
| 5 |
Sapienza Università di Romauniroma1.it
A prestigious, historic university in Rome with a diverse range of academic programs, research opportunities, and international exchange programs for students and academics |
16,981 | |||
| 6 |
Engineering Groupeng.it
Leading digital transformation company with global presence, specializing in innovation, proprietary solutions, R&D, and diverse market expertise. |
11,815 | |||
| 7 |
Consiglio Nazionale delle Ricerchecnr.it
A public organization in Italy that conducts and promotes interdisciplinary research in various sectors for scientific, technological, and social development |
6,744 | |||
| 8 | 5,058 | ||||
| 9 |
INAIL, Istituto Nazionale Assicurazione contro gli Infortuni sul Lavoroinail.it
A public non-profit entity founded in 1883, provides insurance for all workers against work-related accidents, disabilities, health damage, and occupational diseases Additionally, supports injured workers with rehabilitation and reintegration assistance |
4,031 | |||
| 10 |
Fondazione Policlinico Universitario Agostino Gemelli IRCCSpoliclinicogemelli.it
A leading Italian hospital specializing in personalized medicine, innovative biotechnologies, and clinical care for a wide range of specialties, including oncology and rare diseases |
3,810 | |||
| 11 |
Telespaziotelespazio.com
Provides comprehensive space services, from system design to satellite control, Earth observation, communication, and navigation, utilizing AI for advanced applications improving life and addressing climate change. |
2,864 | |||
| 12 | 2,659 | ||||
| 13 | 2,332 | ||||
| 14 |
Translatedtranslated.com
A leading provider of human translation services in 150+ languages, combining human creativity and machine intelligence for speedy, high-quality translations |
2,070 | |||
| 15 |
Angelini Pharmaangelinipharma.com
A pharmaceutical company dedicated to developing new medicines and solutions for patients, with a focus on CNS, mental health, and consumer health |
2,043 | |||
| 16 |
ELT Groupeltgroup.net
A global leader in electronic defense systems, specializing in managing the electromagnetic spectrum and offering technology solutions for defense, cyber, space, and biodefense |
1,728 | |||
| 17 |
Yokohama TWSyokohama-tws.com
A global leader in sustainable tire and wheel solutions for various industries, focusing on innovation, technology, and environmental responsibility |
1,680 | |||
| 18 |
Angelini Industriesangeliniindustries.com
Operates globally in health, industrial technology, and consumer goods sectors, focusing on growth, R&D, environmental impact reduction, and worker safety. |
2,855 | |||
| 19 |
BSP Pharmaceuticals S.p.A.bsppharmaceuticals.com
A contract development and manufacturing organization specializing in producing cytotoxic, high potent oncology drugs, innovative compounds, peptides, proteins, oligonucleotides, and nano medicines |
1,413 | |||
| 20 |
Italtelitaltel.com
The company provides communication technology solutions, integrates traditional and new technologies, offers managed services, and focuses on sustainability and inclusivity |
1,398 | |||
| 21 | 1,254 | ||||
| 22 |
CREA Ricercacrea.gov.it
Leading Italian research organization focused on agri-food supply chains Innovative and sustainable solutions in agriculture, livestock, food science, and socio-economics Promoting circular economy and consumer protection |
1,128 | |||
| 23 |
KT - Kinetics Technologykt-met.com
Specialized EPC Contractor for refining industry, offering integrated engineering solutions with focus on process design, licensing, sulphur recovery, and hydrogen/syngas production |
1,088 | |||
| 24 |
Daikin Applied Europedaikinapplied.eu
Multinational company manufacturing components for hydronic HVAC systems with premium quality, reliability, and efficiency, leading development, manufacturing, and sale in Europe, Middle East, and Africa |
1,056 | |||
| 25 |
Istituto Poligrafico e Zecca dello Stato (IPZS)ipzs.it
The company protects citizens' physical and digital identities, secures sensitive data, ensures production reliability, and enhances cultural heritage through tailored solutions and products |
1,038 | |||
Want more companies than this list?This page shows the largest ones only. Connect to Tamtam to see every company that matches, filter by size, industry or growth, and reach their decision-makers. | |||||
| 26 |
Università degli Studi di Cassino e del Lazio Meridionaleunicas.it
The University offers a wide range of undergraduate and graduate programs, including courses in English, joint degrees with foreign universities, postgraduate opportunities, and various campus facilities |
1,002 | |||
| 27 |
San Raffaelesanraffaele.it
A leading healthcare organization providing excellence in research, rehabilitation, and patient care with a network of facilities and specialists across Italy |
944 | |||
| 28 |
Università degli Studi Niccolò Cusanounicusano.it
An online university established in 2006, with a campus in Rome including dorms, sports facilities, a theater, and a Medical-Scientific Research Center |
922 | |||
| 29 |
Istituto Nazionale di Geofisica e Vulcanologiaingv.it
The company specializes in monitoring geophysical phenomena, such as seismic activity and volcanic eruptions, in Italy through advanced instrumentation and collaboration with universities and research institutions |
916 | |||
| 30 |
Amplia Infrastructuresampliaspa.it
A construction company specializing in roads, motorways, bridges, airports, and road surface materials International presence in Eastern Europe, Middle East, and South America |
891 | |||
| 31 |
Topnetwork S.p.A.topnetwork.it
A service agency supporting digital transformation with innovative solutions, integrating AI, blockchain, Cloud, Data Science, IoT, robotics, and more |
836 | |||
| 32 |
Fondazione Santa Luciafondazionesantalucia.it
Specializing in neurorehabilitation, the organization provides autonomy and quality of life for adults and children through research and high levels of care |
823 | |||
| 33 |
INAF Istituto Nazionale di Astrofisicainaf.it
The company promotes, coordinates, and conducts research in Astronomy, Radioastronomy, Space Astrophysics, and Cosmic Physics It also promotes astronomy education in schools and society |
777 | |||
| 34 | 702 | ||||
| 35 | 696 | ||||
| 36 |
MSD Italiamsd-italia.it
A multinational pharmaceutical leader dedicated to discovering innovative products and services to save and improve patients' lives worldwide |
598 | |||
| 37 |
Università degli Studi Guglielmo Marconiunimarconi.it
A world-class university offering innovative learning methodologies, interdisciplinary research, and programs to prepare students for global challenges with virtual labs and simulations |
562 | |||
| 38 |
Fondazione Policlinico Universitario Campus Bio-Medicopoliclinicocampusbiomedico.it
A non-profit foundation focused on protecting and promoting human health through healthcare, education, scientific research, and innovation in biomedicine |
536 | |||
| 39 |
Gruppo Servizi Associati S.p.A.grupposerviziassociati.it
A leading company in safety services with over 25 years of experience, offering fire prevention, rescue, and training services nationally and in Europe |
523 | |||
| 40 |
University of Viterbo "La Tuscia"unitus.it
Leader in research and teaching in various fields including agriculture, bio-science, economics, law, engineering, languages, and social studies in Italy |
491 | |||
| 41 |
Eustema S.p.A.eustema.it
A consulting and software engineering company in Italy, providing ICT solutions to public administrations and businesses in telecom, transportation, utilities, and services sectors |
466 | |||
| 42 |
MOVYONmovyon.com
Design and implement smart, sustainable mobility solutions including infrastructure, traffic management, tolling, and smart city technologies for public and private sectors. |
457 | |||
| 43 |
Takeda Italiatakeda.com
Innovative healthcare company focused on gastroenterology and oncology, committed to advancing healthcare through new medicines and building a patient-centered model |
449 | |||
| 44 |
Tinexta Infocertinfocert.it
It empowers customers' digital transformation with innovative solutions, ensuring trustworthiness, compliance, and sustainability across various sectors in Europe. |
443 | |||
| 45 | 413 | ||||
| 46 |
IDI IRCCS - Istituto Dermopatico dell'Immacolataidi.it
An Italian scientific research institute specializing in dermatology, providing high-quality inpatient and outpatient care with a multidisciplinary approach and expertise in rare skin diseases |
392 | |||
| 47 |
Almawavealmawave.com
Italian company specializing in Data and Artificial Intelligence. Offers proprietary technologies, solutions, services for digital evolution of companies and public administrations. |
369 | |||
| 48 | 360 | ||||
| 49 |
GCF GENERALE COSTRUZIONI FERROVIARIE SPAgeneralecostruzioniferroviarie.com
A leader in railway infrastructure, electrification, and signaling with over 60 years of experience, strong presence in Europe and international markets, high productivity, safety, and quality standards |
355 | |||
| 50 |
Fondazione Telethonfondazionetelethon.it
Leading Italian biomedical charity advancing research for muscular dystrophies and genetic diseases through funding research projects from basic to clinical trials since 1990 |
343 | |||
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How this list is built
Every company on this list has a Tamtam company profile. The industry is the one the company gives on LinkedIn; categories such as SaaS or fintech are classified by Tamtam's AI from the company's website and LinkedIn page; and the headquarters city must match the company's own address. Companies are ranked by the number of employees on LinkedIn, and the list is refreshed every night. Classifications can be wrong, so treat the list as a starting point rather than an official ranking. Last updated Nov 11, 2026.
More company lists in Lazio
- The largest companies in Lazio 1,243
- Multinational companies in Lazio 226
- Retail chains in Lazio 128
- Critical infrastructure operators in Lazio 105
- Public sector organisations in Lazio 102
- Financial services firms in Lazio 98
- IT services companies in Lazio 84
- IT Services and IT Consulting companies in Lazio 78
- Manufacturers in Lazio 77
- Companies with a mobile app in Lazio 75
- Financial Services companies in Lazio 61
- Education providers in Lazio 60
- Consulting firms in Lazio 59
- Professional services firms in Lazio 58
- Corporate groups and holding companies in Lazio 51
- Software Development companies in Lazio 48
- Hospitality companies in Lazio 46
- Family-owned companies in Lazio 46
- Aerospace and defence companies in Lazio 45
- E-commerce companies in Lazio 45
- Hotel and hospitality groups in Lazio 43
- Consumer goods companies in Lazio 42
- Healthcare providers in Lazio 42
- Luxury brands in Lazio 39
The same list elsewhere in Italy
- Companies with in-house R&D in Italy 1,418
- Companies with in-house R&D in Lombardy 432
- Companies with in-house R&D in Emilia-Romagna 195
- Companies with in-house R&D in Veneto 182
- Companies with in-house R&D in Piedmont 102
- Companies with in-house R&D in Tuscany 80
- Companies with in-house R&D in Campania 44
- Companies with in-house R&D in Friuli-Venezia Giulia 43
- Companies with in-house R&D in the Marche 34
- Companies with in-house R&D in Apulia 26
- Companies with in-house R&D in Trentino-South Tyrol 25
- Companies with in-house R&D in Milan 124
- Companies with in-house R&D in Rome 82
- Companies with in-house R&D in Turin 31