These large Rome-based companies conduct in-house research and development. The list comprises established organizations, many of which are publicly owned or have a strong public service component. They operate in sectors such as defense, energy, utilities, and research.
Key players include Leonardo, a multinational specializing in aerospace and cybersecurity; Eni, an integrated energy business; Enel Group, a leading electricity operator; and Ferrovie dello Stato Italiane S.p.A., managing national rail infrastructure. Sapienza Università di Roma and Consiglio Nazionale delle Ricerche are prominent research institutions. A notable pattern is the dominance of large, often state-backed, entities across critical infrastructure and public services.
| # | Company | Employees | |||
|---|---|---|---|---|---|
| 1 |
Leonardoleonardo.com
Defense and security multinational company specializing in aerospace, cybersecurity, military systems, and advanced technology solutions |
38,521 | |||
| 2 | 32,259 | ||||
| 3 |
Enel Groupenel.com
Multinational company reshaping the future of energy, a leading integrated electricity operator. Distributes and supplies electricity to millions of end users. |
31,218 | |||
| 4 |
Ferrovie dello Stato Italiane S.p.A.fsitaliane.it
National rail infrastructure management, passenger transport services, logistics solutions, and urban regeneration projects across Italy. |
28,071 | |||
| 5 |
Sapienza Università di Romauniroma1.it
A prestigious, historic university in Rome with a diverse range of academic programs, research opportunities, and international exchange programs for students and academics |
16,981 | |||
| 6 |
Engineering Groupeng.it
Leading digital transformation company with global presence, specializing in innovation, proprietary solutions, R&D, and diverse market expertise. |
11,815 | |||
| 7 |
Consiglio Nazionale delle Ricerchecnr.it
A public organization in Italy that conducts and promotes interdisciplinary research in various sectors for scientific, technological, and social development |
6,744 | |||
| 8 | 5,058 | ||||
| 9 |
INAIL, Istituto Nazionale Assicurazione contro gli Infortuni sul Lavoroinail.it
A public non-profit entity founded in 1883, provides insurance for all workers against work-related accidents, disabilities, health damage, and occupational diseases Additionally, supports injured workers with rehabilitation and reintegration assistance |
4,031 | |||
| 10 |
Fondazione Policlinico Universitario Agostino Gemelli IRCCSpoliclinicogemelli.it
A leading Italian hospital specializing in personalized medicine, innovative biotechnologies, and clinical care for a wide range of specialties, including oncology and rare diseases |
3,810 | |||
| 11 |
Telespaziotelespazio.com
Provides comprehensive space services, from system design to satellite control, Earth observation, communication, and navigation, utilizing AI for advanced applications improving life and addressing climate change. |
2,864 | |||
| 12 | 2,659 | ||||
| 13 | 2,332 | ||||
| 14 |
Translatedtranslated.com
A leading provider of human translation services in 150+ languages, combining human creativity and machine intelligence for speedy, high-quality translations |
2,070 | |||
| 15 |
Angelini Pharmaangelinipharma.com
A pharmaceutical company dedicated to developing new medicines and solutions for patients, with a focus on CNS, mental health, and consumer health |
2,043 | |||
Want more companies than this list?This page shows the largest ones only. Connect to Tamtam to see every company that matches, filter by size, industry or growth, and reach their decision-makers. | |||||
| 16 |
ELT Groupeltgroup.net
A global leader in electronic defense systems, specializing in managing the electromagnetic spectrum and offering technology solutions for defense, cyber, space, and biodefense |
1,728 | |||
| 17 |
Angelini Industriesangeliniindustries.com
Operates globally in health, industrial technology, and consumer goods sectors, focusing on growth, R&D, environmental impact reduction, and worker safety. |
2,855 | |||
| 18 |
Italtelitaltel.com
The company provides communication technology solutions, integrates traditional and new technologies, offers managed services, and focuses on sustainability and inclusivity |
1,398 | |||
| 19 |
CREA Ricercacrea.gov.it
Leading Italian research organization focused on agri-food supply chains Innovative and sustainable solutions in agriculture, livestock, food science, and socio-economics Promoting circular economy and consumer protection |
1,128 | |||
| 20 |
KT - Kinetics Technologykt-met.com
Specialized EPC Contractor for refining industry, offering integrated engineering solutions with focus on process design, licensing, sulphur recovery, and hydrogen/syngas production |
1,088 | |||
| 21 |
Istituto Poligrafico e Zecca dello Stato (IPZS)ipzs.it
The company protects citizens' physical and digital identities, secures sensitive data, ensures production reliability, and enhances cultural heritage through tailored solutions and products |
1,038 | |||
| 22 |
San Raffaelesanraffaele.it
A leading healthcare organization providing excellence in research, rehabilitation, and patient care with a network of facilities and specialists across Italy |
944 | |||
| 23 |
Università degli Studi Niccolò Cusanounicusano.it
An online university established in 2006, with a campus in Rome including dorms, sports facilities, a theater, and a Medical-Scientific Research Center |
922 | |||
| 24 |
Istituto Nazionale di Geofisica e Vulcanologiaingv.it
The company specializes in monitoring geophysical phenomena, such as seismic activity and volcanic eruptions, in Italy through advanced instrumentation and collaboration with universities and research institutions |
916 | |||
| 25 |
Amplia Infrastructuresampliaspa.it
A construction company specializing in roads, motorways, bridges, airports, and road surface materials International presence in Eastern Europe, Middle East, and South America |
891 | |||
| 26 |
Topnetwork S.p.A.topnetwork.it
A service agency supporting digital transformation with innovative solutions, integrating AI, blockchain, Cloud, Data Science, IoT, robotics, and more |
836 | |||
| 27 |
Fondazione Santa Luciafondazionesantalucia.it
Specializing in neurorehabilitation, the organization provides autonomy and quality of life for adults and children through research and high levels of care |
823 | |||
| 28 |
INAF Istituto Nazionale di Astrofisicainaf.it
The company promotes, coordinates, and conducts research in Astronomy, Radioastronomy, Space Astrophysics, and Cosmic Physics It also promotes astronomy education in schools and society |
777 | |||
| 29 | 696 | ||||
| 30 |
MSD Italiamsd-italia.it
A multinational pharmaceutical leader dedicated to discovering innovative products and services to save and improve patients' lives worldwide |
598 | |||
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How this list is built
Every company on this list has a Tamtam company profile. The industry is the one the company gives on LinkedIn; categories such as SaaS or fintech are classified by Tamtam's AI from the company's website and LinkedIn page; and the headquarters city must match the company's own address. Companies are ranked by the number of employees on LinkedIn, and the list is refreshed every night. Classifications can be wrong, so treat the list as a starting point rather than an official ranking. Last updated Nov 11, 2026.
More company lists in Rome
- The largest companies in Rome 1,036
- Multinational companies in Rome 196
- Retail chains in Rome 99
- Critical infrastructure operators in Rome 92
- Financial services firms in Rome 92
- Public sector organisations in Rome 92
- IT services companies in Rome 73
- IT Services and IT Consulting companies in Rome 72
- Companies with a mobile app in Rome 62
- Financial Services companies in Rome 58
- Consulting firms in Rome 56
- Education providers in Rome 56
- Professional services firms in Rome 52
- Software Development companies in Rome 46
- Corporate groups and holding companies in Rome 46
- Hospitality companies in Rome 42
- Government Administration companies in Rome 38
- Hotel and hospitality groups in Rome 36
- Luxury brands in Rome 36
- Manufacturers in Rome 36
- Healthcare providers in Rome 35
- E-commerce companies in Rome 34
- Family-owned companies in Rome 34
- Entertainment Providers companies in Rome 31
The same list elsewhere in Italy
- Companies with in-house R&D in Italy 1,418
- Companies with in-house R&D in Lombardy 432
- Companies with in-house R&D in Emilia-Romagna 195
- Companies with in-house R&D in Veneto 182
- Companies with in-house R&D in Lazio 120
- Companies with in-house R&D in Piedmont 102
- Companies with in-house R&D in Tuscany 80
- Companies with in-house R&D in Campania 44
- Companies with in-house R&D in Friuli-Venezia Giulia 43
- Companies with in-house R&D in the Marche 34
- Companies with in-house R&D in Apulia 26
- Companies with in-house R&D in Trentino-South Tyrol 25
- Companies with in-house R&D in Milan 124
- Companies with in-house R&D in Turin 31