These Lyon-based organizations with in-house R&D are primarily large groups and mid-sized firms, spanning diverse sectors from healthcare to industrial manufacturing and higher education. They include major institutions like Hospices Civils de Lyon, a public university hospital, and Cegid, a European leader in cloud management solutions. Université Lumière Lyon 2 and Université Jean Moulin are large public universities. Cerema is a public referent for territory development, and Gerflor produces innovative flooring and wallcovering.
A notable pattern among these companies is their strong presence in both public service and industrial sectors. Several organizations, such as Hospices Civils de Lyon, Université Lumière Lyon 2, and Cerema, are public or quasi-public entities. Concurrently, there is a significant cluster of manufacturing and industrial firms like Gerflor, Sicame Group, and KEM ONE, indicating a mixed economic landscape in Lyon.
| # | Company | Employees | |||
|---|---|---|---|---|---|
| 1 |
Hospices Civils de Lyon - HCLchu-lyon.fr
Public university hospital provides care, education, research, medical innovation, prevention, and health education with over 22,000 professionals across 14 facilities. |
8,220 | |||
| 2 | 4,896 | ||||
| 3 |
Université Lumière Lyon 2univ-lyon2.fr
Large French public university offering diverse programs from bachelor to doctorate, focusing on research, international partnerships, and societal engagement. |
3,390 | |||
| 4 |
Université Jean Moulin (Lyon III)univ-lyon3.fr
Public university offering multidisciplinary higher education and research in law, management, humanities, and social sciences with strong societal engagement. |
2,461 | |||
| 5 | 2,160 | ||||
| 6 |
emlyon business schoolem-lyon.com
World-renowned business school offering higher education and continued education programs with a focus on skill hybridization, social responsibility, and impactful alumni worldwide |
2,101 | |||
| 7 |
Gerflorgerflor.com
Production and distribution of design-driven, innovative, environmentally-friendly flooring, wallcovering, and finishes across international healthcare, housing, education, sport, transport, retail, and industrial markets. |
2,037 | |||
| 8 |
Sicame Groupsicame-group.com
World leader in production, sales of accessories and services for electrical energy transmission and distribution, safety equipment, and industrial applications. |
1,999 | |||
| 9 |
CTCctcgroupe.com
CTC offers cross-disciplinary solutions for the leather, footwear, and textile industries, focusing on ethical practices, cost savings, waste reduction, and performance improvement worldwide |
1,622 | |||
| 10 |
NEMERAnemera.net
Designs, develops, and manufactures drug delivery devices for ophthalmic, nasal, inhalation, dermal, and parenteral routes, prioritizing patient needs and treatment efficacy. |
1,616 | |||
| 11 |
Centre Léon Bérardcentreleonberard.fr
Specialized cancer hospital and research center providing personalized treatment, innovative therapies, and compassionate care to support patients throughout their illness. |
1,418 | |||
| 12 |
CNR (Compagnie Nationale du Rhône)tm.fr
French leading producer of 100% renewable electricity, managing the Rhône river for hydroelectricity, navigation, irrigation, and agricultural use, supporting local development and innovation |
1,256 | |||
| 13 |
Eurofins Biomniseurofins-biomnis.com
A European leader in specialized medical pathology, providing over 2,500 tests including specialized, authorized analyses with a focus on innovation and international development |
803 | |||
| 14 |
Agicapagicap.com
Elevating cash flow management strategies for businesses to optimize financial operations and achieve greater success |
685 | |||
| 15 |
KEM ONEkemone.com
Industrial chemical company specializing in PVC production with activities from salt extraction to manufacturing, focusing on export markets and promoting diversity and career growth |
667 | |||
Want more companies than this list?This page shows the largest ones only. Connect to Tamtam to see every company that matches, filter by size, industry or growth, and reach their decision-makers. | |||||
| 16 |
Laboratoire Aguettantaguettant-corporate.com
Develops, produces, distributes innovative injectable pharmaceutical specialties for healthcare professionals and patients. European actor in hospital-initiated injectable drugs. |
611 | |||
| 17 |
Babolatbabolat.com
Family-owned company, racquet sports equipment supplier, expertise in strings, serving tennis, padel, badminton players worldwide since 1875. |
589 | |||
| 18 |
Distech Controlsdistech-controls.com
provides innovative building automation technologies and services enhancing health, efficiency, and sustainability across multiple global market segments |
507 | |||
| 19 |
Novasepnovasep.com
Leading provider of molecule production & purification services for life science industries Specializing in small molecule APIs, natural products, purification equipment, and global R&D capabilities |
496 | |||
| 20 |
Flexitechflexitech.com
Experienced engineers develop custom hose routing solutions with extensive global production ensuring quality, competitive pricing, and supplier consolidation support. |
484 | |||
| 21 |
ECAM LaSalleecam.fr
Offers five CTI-recognized engineering programs, including generalist and specialized options, a cybersecurity bachelor's, and a continuous improvement master's, located in Lyon. |
364 | |||
| 22 | 354 | ||||
| 23 |
Percall Grouppercallgroup.com
French IT engineering services company, specializing in CAD, PLM, and IoT software integration for major high-tech industries, a PTC partner. |
347 | |||
| 24 |
Gerflor Francegerflor.fr
Designs, manufactures, and markets eco-responsible residential and professional floor coverings through global distribution, utilizing six production sites and three dedicated research and development centers. |
331 | |||
| 25 |
LA ROSÉElarosee-cosmetiques.com
Formulates and manufactures natural, effective, eco-designed cosmetic products in France, sold in pharmacies across 12 countries. Focuses on sustainability and customer trust. |
326 | |||
| 26 |
ISISPHARMAisispharma.com
Development of scientifically rigorous, targeted dermatological products focused on emotional well-being and educational support for skin health balance. |
317 | |||
| 27 |
FIDUCIAL Informatiquefiducial.fr
design comprehensive software solutions and provide personalized services for various professional sectors including accounting, billing, payroll, and specialized industries |
281 | |||
| 28 |
Cegid for SMBcegid.com
This company enables people to achieve more together by making more opportunities possible |
273 | |||
| 29 | 268 | ||||
| 30 | 266 | ||||
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Every company on this list has a Tamtam company profile. The industry is the one the company gives on LinkedIn; categories such as SaaS or fintech are classified by Tamtam's AI from the company's website and LinkedIn page; and the headquarters city must match the company's own address. Companies are ranked by the number of employees on LinkedIn, and the list is refreshed every night. Classifications can be wrong, so treat the list as a starting point rather than an official ranking. Last updated Nov 11, 2026.
More company lists in Lyon
- The largest companies in Lyon 2,679
- Multinational companies in Lyon 283
- Professional services firms in Lyon 265
- SaaS companies in Lyon 211
- Software Development companies in Lyon 178
- IT services companies in Lyon 171
- Consulting firms in Lyon 163
- IT Services and IT Consulting companies in Lyon 160
- Retail chains in Lyon 154
- Business Consulting and Services companies in Lyon 141
- Law Practice companies in Lyon 140
- Higher Education companies in Lyon 115
- Subscription businesses in Lyon 112
- Education providers in Lyon 107
- Financial services firms in Lyon 105
- Real Estate companies in Lyon 104
- Advertising Services companies in Lyon 99
- Recruitment and staffing agencies in Lyon 88
- Marketing and communications agencies in Lyon 78
- Companies with a mobile app in Lyon 78
- Events Services companies in Lyon 72
- Professional Training and Coaching companies in Lyon 72
- Legal Services companies in Lyon 70
- Manufacturers in Lyon 69
The same list elsewhere in France
- Companies with in-house R&D in France 8,750
- Companies with in-house R&D in Île-de-France 2,695
- Companies with in-house R&D in Auvergne-Rhône-Alpes 1,460
- Companies with in-house R&D in Occitanie 680
- Companies with in-house R&D in Grand Est 640
- Companies with in-house R&D in Provence-Alpes-Côte d'Azur 613
- Companies with in-house R&D in Nouvelle-Aquitaine 566
- Companies with in-house R&D in the Hauts-de-Seine department 510
- Companies with in-house R&D in the Rhône department 509
- Companies with in-house R&D in Pays de la Loire 480
- Companies with in-house R&D in Hauts-de-France 410
- Companies with in-house R&D in Brittany 366
- Companies with in-house R&D in the Haute-Garonne department 323
- Companies with in-house R&D in the Bouches-du-Rhône department 321
- Companies with in-house R&D in the Isère department 304
- Companies with in-house R&D in Bourgogne-Franche-Comté 261
- Companies with in-house R&D in the Nord department 237
- Companies with in-house R&D in Normandy 227
- Companies with in-house R&D in the Gironde department 225
- Companies with in-house R&D in the Loire-Atlantique department 207
- Companies with in-house R&D in the Essonne department 198
- Companies with in-house R&D in Centre-Val de Loire 195
- Companies with in-house R&D in Paris 1,249
- Companies with in-house R&D in Toulouse 172