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Top 30 companies with in-house R&D in Lyon

Tamtam tracks 192 companies with in-house R&D headquartered in Lyon. This list ranks the 30 largest by number of employees on LinkedIn, led by Hospices Civils de Lyon - HCL, Cegid and Université Lumière Lyon 2. Their median headcount is 667. Half of them were founded in 1973 or later.

🇫🇷 Lyon30 companiesUpdated Nov 11, 2026

These Lyon-based organizations with in-house R&D are primarily large groups and mid-sized firms, spanning diverse sectors from healthcare to industrial manufacturing and higher education. They include major institutions like Hospices Civils de Lyon, a public university hospital, and Cegid, a European leader in cloud management solutions. Université Lumière Lyon 2 and Université Jean Moulin are large public universities. Cerema is a public referent for territory development, and Gerflor produces innovative flooring and wallcovering.

A notable pattern among these companies is their strong presence in both public service and industrial sectors. Several organizations, such as Hospices Civils de Lyon, Université Lumière Lyon 2, and Cerema, are public or quasi-public entities. Concurrently, there is a significant cluster of manufacturing and industrial firms like Gerflor, Sicame Group, and KEM ONE, indicating a mixed economic landscape in Lyon.

#CompanyIndustryHeadquarters EmployeesFounded
1
Hospices Civils de Lyon - HCLchu-lyon.fr

Public university hospital provides care, education, research, medical innovation, prevention, and health education with over 22,000 professionals across 14 facilities.

Hospitals and Health Care 🇫🇷 Lyon 8,220 1796
2
Cegidcegid.com

European leader cloud management solutions finance, HR, accounting, retail, and entrepreneurs. Offers tailored solutions for digital business transformation worldwide.

Software Development 🇫🇷 Lyon 4,896 n/a
3
Université Lumière Lyon 2univ-lyon2.fr

Large French public university offering diverse programs from bachelor to doctorate, focusing on research, international partnerships, and societal engagement.

Higher Education 🇫🇷 Lyon 3,390 1973
4
Université Jean Moulin (Lyon III)univ-lyon3.fr

Public university offering multidisciplinary higher education and research in law, management, humanities, and social sciences with strong societal engagement.

Higher Education 🇫🇷 Lyon 2,461 1973
5
Ceremacerema.fr

Public referent for territory development, assisting government, communities, and businesses in adapting areas to climate change across six activity domains.

Government Administration 🇫🇷 Lyon 2,160 2014
6
emlyon business schoolem-lyon.com

World-renowned business school offering higher education and continued education programs with a focus on skill hybridization, social responsibility, and impactful alumni worldwide

Education Administration Programs 🇫🇷 Lyon 2,101 n/a
7
Gerflorgerflor.com

Production and distribution of design-driven, innovative, environmentally-friendly flooring, wallcovering, and finishes across international healthcare, housing, education, sport, transport, retail, and industrial markets.

Wholesale Building Materials 🇫🇷 Lyon 2,037 1937
8
Sicame Groupsicame-group.com

World leader in production, sales of accessories and services for electrical energy transmission and distribution, safety equipment, and industrial applications.

Manufacturing 🇫🇷 Lyon 1,999 1955
9
CTCctcgroupe.com

CTC offers cross-disciplinary solutions for the leather, footwear, and textile industries, focusing on ethical practices, cost savings, waste reduction, and performance improvement worldwide

International Trade and Development 🇫🇷 Lyon 1,622 1899
10
NEMERAnemera.net

Designs, develops, and manufactures drug delivery devices for ophthalmic, nasal, inhalation, dermal, and parenteral routes, prioritizing patient needs and treatment efficacy.

Medical Equipment Manufacturing 🇫🇷 Lyon 1,616 2015
11
Centre Léon Bérardcentreleonberard.fr

Specialized cancer hospital and research center providing personalized treatment, innovative therapies, and compassionate care to support patients throughout their illness.

Hospitals and Health Care 🇫🇷 Lyon 1,418 1923
12
CNR (Compagnie Nationale du Rhône)tm.fr

French leading producer of 100% renewable electricity, managing the Rhône river for hydroelectricity, navigation, irrigation, and agricultural use, supporting local development and innovation

Electric Power Generation 🇫🇷 Lyon 1,256 1934
13
Eurofins Biomniseurofins-biomnis.com

A European leader in specialized medical pathology, providing over 2,500 tests including specialized, authorized analyses with a focus on innovation and international development

Medical and Diagnostic Laboratories 🇫🇷 Lyon 803 1897
14
Agicapagicap.com

Elevating cash flow management strategies for businesses to optimize financial operations and achieve greater success

Software Development 🇫🇷 Lyon 685 2016
15
KEM ONEkemone.com

Industrial chemical company specializing in PVC production with activities from salt extraction to manufacturing, focusing on export markets and promoting diversity and career growth

Chemical Manufacturing 🇫🇷 Lyon 667 2012

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16
Laboratoire Aguettantaguettant-corporate.com

Develops, produces, distributes innovative injectable pharmaceutical specialties for healthcare professionals and patients. European actor in hospital-initiated injectable drugs.

Pharmaceutical Manufacturing 🇫🇷 Lyon 611 1903
17
Babolatbabolat.com

Family-owned company, racquet sports equipment supplier, expertise in strings, serving tennis, padel, badminton players worldwide since 1875.

Sporting Goods Manufacturing 🇫🇷 Lyon 589 1875
18
Distech Controlsdistech-controls.com

provides innovative building automation technologies and services enhancing health, efficiency, and sustainability across multiple global market segments

Software Development 🇫🇷 Lyon 507 1995
19
Novasepnovasep.com

Leading provider of molecule production & purification services for life science industries Specializing in small molecule APIs, natural products, purification equipment, and global R&D capabilities

Chemical Manufacturing 🇫🇷 Lyon 496 1993
20
Flexitechflexitech.com

Experienced engineers develop custom hose routing solutions with extensive global production ensuring quality, competitive pricing, and supplier consolidation support.

Motor Vehicle Manufacturing 🇫🇷 Lyon 484 1956
21
ECAM LaSalleecam.fr

Offers five CTI-recognized engineering programs, including generalist and specialized options, a cybersecurity bachelor's, and a continuous improvement master's, located in Lyon.

Higher Education 🇫🇷 Lyon 364 1900
22
Indyindy.fr

Provides advanced AI-powered tools for businesses to manage their own bookkeeping and accounting efficiently without needing extensive financial knowledge.

Technology, Information and Internet 🇫🇷 Lyon 354 2016
23
Percall Grouppercallgroup.com

French IT engineering services company, specializing in CAD, PLM, and IoT software integration for major high-tech industries, a PTC partner.

IT Services and IT Consulting 🇫🇷 Lyon 347 2000
24
Gerflor Francegerflor.fr

Designs, manufactures, and markets eco-responsible residential and professional floor coverings through global distribution, utilizing six production sites and three dedicated research and development centers.

Wholesale Building Materials 🇫🇷 Lyon 331 n/a
25
LA ROSÉElarosee-cosmetiques.com

Formulates and manufactures natural, effective, eco-designed cosmetic products in France, sold in pharmacies across 12 countries. Focuses on sustainability and customer trust.

Retail Health and Personal Care Products 🇫🇷 Lyon 326 2014
26
ISISPHARMAisispharma.com

Development of scientifically rigorous, targeted dermatological products focused on emotional well-being and educational support for skin health balance.

Pharmaceutical Manufacturing 🇫🇷 Lyon 317 1987
27
FIDUCIAL Informatiquefiducial.fr

design comprehensive software solutions and provide personalized services for various professional sectors including accounting, billing, payroll, and specialized industries

Software Development 🇫🇷 Lyon 281 2000
28
Cegid for SMBcegid.com

This company enables people to achieve more together by making more opportunities possible

Software Development 🇫🇷 Lyon 273 n/a
29
Cissciss.fr

Designs, develops, and sells SaaS solutions for payment, customer relations, security, and data to enhance digital performance and trust for clients.

IT Services and IT Consulting 🇫🇷 Lyon 268 2001
30
LABlab.fr

Engineering and construction of turnkey flue gas cleaning and condensation systems to reduce emissions and improve thermal plant efficiency.

Environmental Services 🇫🇷 Lyon 266 1953

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How this list is built

Every company on this list has a Tamtam company profile. The industry is the one the company gives on LinkedIn; categories such as SaaS or fintech are classified by Tamtam's AI from the company's website and LinkedIn page; and the headquarters city must match the company's own address. Companies are ranked by the number of employees on LinkedIn, and the list is refreshed every night. Classifications can be wrong, so treat the list as a starting point rather than an official ranking. Last updated Nov 11, 2026.

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