The companies with in-house R&D in São Paulo are mostly large Brazilian groups. They span diverse sectors such as food production with JBS, personal care with Natura, and pulp and paper with Suzano and Klabin. The list also includes major healthcare providers like Einstein Hospital Israelita and Sírio-Libanês, as well as technology firms such as TOTVS, which provides business digitalization solutions.
A notable characteristic of these companies is their strong representation in the healthcare sector, with multiple large hospitals and healthcare networks. Another pattern is the significant presence of companies founded in the mid-20th century, indicating established industrial development in the region.
| # | Company | Employees | |||
|---|---|---|---|---|---|
| 1 |
JBSjbs.com.br
Global leader in protein-based food production with diverse product portfolio spanning multiple countries and industries, committed to feeding the world with excellence and innovation |
88,182 | |||
| 2 |
Naturanatura.com.br
A Brazilian multinational in cosmetics and personal care known for sustainable practices, direct sales, cruelty-free and vegan products, and Amazon biodiversity protection |
47,988 | |||
| 3 |
Einstein Hospital Israelitaeinstein.br
A leading healthcare institution offering cutting-edge treatments, compassionate care, social responsibility initiatives, and education and research programs for the community |
40,979 | |||
| 4 |
Dasadasa.com.br
The company is the largest integrated healthcare network in Brazil, focusing on preventive, predictive, and personalized healthcare with a wide range of services and innovative solutions |
32,801 | |||
| 5 |
Suzanosuzano.com.br
Global leader in sustainable use of natural resources, producing eucalyptus pulp and paper, with innovative solutions promoting renewable bio-based materials worldwide |
23,529 | |||
| 6 |
Sírio-Libanêshospitalsiriolibanes.org.br
A renowned healthcare institution with philanthropic roots, offering top-notch medical services, cutting-edge technology, education, research, and social responsibility initiatives for 100 years |
19,137 | |||
| 7 | 17,675 | ||||
| 8 |
Klabinklabin.com.br
A leading producer of renewable and biodegradable paper, cardboard, packaging, and wood products, focused on developing smart solutions for customer needs |
16,499 | |||
| 9 |
Braskembraskem.com
Global company dedicated to sustainable solutions in chemicals and plastics, driving the Circular Economy with innovation and a diverse product portfolio for various industries worldwide |
10,586 | |||
| 10 |
Votorantim Cimentosvotorantimcimentos.com.br
A leading international provider of construction materials, with a diverse portfolio including cement, concrete, and aggregates Also active in agricultural inputs and waste management |
9,998 | |||
| 11 |
Senai São Paulosp.senai.br
Industry-managed institution in Brazil and Latin America specializing in professional training for the industrial sector since 1942, with over 85 schools and training centers |
9,989 | |||
| 12 |
Universidade Estadual Paulista Júlio de Mesquita Filhowww2.unesp.br
A leading Brazilian university with a multicampus structure offering quality education, research opportunities, and community services to students and society |
9,365 | |||
| 13 |
CEJAM - Centro de Estudos e Pesquisas Dr. João Amorim - OFICIALcejam.org.br
Non-profit institution supporting the Brazilian public health system with over 30 years of experience in primary care, specialized services, emergency care, and hospital management |
8,271 | |||
| 14 |
Hospital das Clínicas da Faculdade de Medicina da USPhc.fm.usp.br
A public institution affiliated with a medical school in São Paulo, dedicated to health public healthcare through education, research, assistance, and management |
8,241 | |||
| 15 |
União Química Farmacêutica Nacionaluniaoquimica.com.br
A pharmaceutical company in Brazil with a strong focus on innovation, social responsibility, and environmental sustainability, offering various benefits to employees |
7,519 | |||
Want more companies than this list?This page shows the largest ones only. Connect to Tamtam to see every company that matches, filter by size, industry or growth, and reach their decision-makers. | |||||
| 16 |
BP - A Beneficência Portuguesa de São Paulobp.org.br
The organization prioritizes valuing and celebrating life through research, understanding, and technology, with a focus on continuous evolution and respect for all |
6,759 | |||
| 17 |
A.C.Camargo Cancer Centeraccamargo.org.br
A specialized center focused on cancer diagnosis, treatment, education, and research with highly specialized healthcare professionals working together in one place |
6,452 | |||
| 18 |
Uninove - Universidade Nove de Julhouninove.br
A leading educational institution in São Paulo offering a wide range of undergraduate, postgraduate, and research programs through innovative teaching methods and state-of-the-art facilities |
6,396 | |||
| 19 |
Hyperahypera.com.br
Leading Brazilian pharmaceutical company across various segments including consumer health, prescription products, dermocosmetics, and generics, offering high-quality, safe products through continuous innovation. |
6,251 | |||
| 20 |
Hospital Alemão Oswaldo Cruzhospitaloswaldocruz.org.br
A leading hospital in Latin America providing comprehensive healthcare services, high complexity treatments, and innovative care models focused on patient-centered approach |
6,204 | |||
| 21 | 6,195 | ||||
| 22 |
Saint-Gobain Brasilsaint-gobain.com.br
A global leader in sustainable construction materials and solutions, operating in 66 countries with a focus on well-being, performance, and sustainability |
5,593 | |||
| 23 |
Universidade Presbiteriana Mackenziemackenzie.br
Educates individuals for citizenship, fosters personal and societal development through teaching, research, extension, cultural, sports, social, and spiritual activities, grounded in reformed Christian faith. |
5,286 | |||
| 24 |
LIBBS FARMACÊUTICA LTDAlibbs.com.br
A national pharmaceutical company focused on producing healthcare solutions with a strong commitment to research, development, innovation, and social initiatives |
5,236 | |||
| 25 |
QuintoAndarcarreiras.quintoandar.com.br
Largest Latin America real estate ecosystem offering diverse brands and innovative technologies to enhance and support all housing journey stages. |
5,039 | |||
| 26 |
Biolab & Cobiolabfarma.com.br
Pharmaceutical innovator in Brazil, offering over 170 products for various health needs Leading in Cardiology, Dermatology, Gynecology, and more |
5,014 | |||
| 27 |
Whirlpool Latin Americawhirlpool.com.br
Leading Latin American market in home appliances with popular brands, manufacturing plants, extensive R&D labs, and recognition for innovation and sustainability efforts Visit website for more information |
4,104 | |||
| 28 |
Instituto do Câncer do Estado de São Paulo - ICESPicesp.org.br
A leading oncology center in Latin America, focused on providing high-quality care, education, and research in the public health system |
4,018 | |||
| 29 |
UTC Engenhariautc.com.br
An industry leader in various sectors including oil & gas, petrochemicals, power generation, and steel production with over 1,000 successful contracts |
3,618 | |||
| 30 |
Ajinomoto do Brasilajinomoto.com.br
Specializing in creating products for various industries using umami flavor, with a focus on food, cosmetics, pharmaceuticals, animal nutrition, and agriculture |
3,618 | |||
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Every company on this list has a Tamtam company profile. The industry is the one the company gives on LinkedIn; categories such as SaaS or fintech are classified by Tamtam's AI from the company's website and LinkedIn page; and the headquarters city must match the company's own address. Companies are ranked by the number of employees on LinkedIn, and the list is refreshed every night. Classifications can be wrong, so treat the list as a starting point rather than an official ranking. Last updated Nov 13, 2026.
More company lists in São Paulo
- The largest companies in São Paulo 3,842
- Multinational companies in São Paulo 472
- Financial Services companies in São Paulo 440
- Retail chains in São Paulo 397
- Financial services firms in São Paulo 381
- Education providers in São Paulo 293
- Manufacturers in São Paulo 279
- Companies with a mobile app in São Paulo 277
- Critical infrastructure operators in São Paulo 251
- IT Services and IT Consulting companies in São Paulo 239
- E-commerce companies in São Paulo 218
- Retail companies in São Paulo 212
- Professional services firms in São Paulo 200
- Healthcare providers in São Paulo 197
- Corporate groups and holding companies in São Paulo 182
- Fintech companies in São Paulo 171
- Consulting firms in São Paulo 138
- IT services companies in São Paulo 130
- Hospitals and Health Care companies in São Paulo 116
- Franchise networks in São Paulo 114
- Subscription businesses in São Paulo 110
- Distributors and wholesalers in São Paulo 103
- Publicly traded companies in São Paulo 102
- SaaS companies in São Paulo 102
The same list elsewhere in Brazil
- Companies with in-house R&D in Brazil 755
- Companies with in-house R&D in São Paulo State 370
- Companies with in-house R&D in Minas Gerais 62
- Companies with in-house R&D in Paraná 61
- Companies with in-house R&D in Santa Catarina 58
- Companies with in-house R&D in Rio de Janeiro State 43
- Companies with in-house R&D in Rio Grande do Sul 42
- Companies with in-house R&D in Rio de Janeiro 32