This list features large companies with in-house R&D operations in São Paulo State. The industries represented include food and beverage manufacturing with JBS, personal care with Natura, and aviation with Embraer, which designs and manufactures aircraft. Healthcare is prominent, with major institutions like Einstein Hospital Israelita and Dasa, Brazil's largest integrated healthcare network. Suzano and Klabin represent the paper and forest product manufacturing sector.
A notable pattern is the concentration of headquarters in the city of São Paulo for many of these large organizations, such as TOTVS, a leading technology company, and Braskem, focused on sustainable chemicals and plastics. Another key sector is manufacturing, with Volkswagen do Brasil producing vehicles and EMS operating in pharmaceutical manufacturing in Hortolandia. The presence of Senai São Paulo and Universidade Estadual Paulista Júlio de Mesquita Filho indicates significant investment in professional training and higher education.
| # | Company | Employees | |||
|---|---|---|---|---|---|
| 1 |
JBSjbs.com.br
Global leader in protein-based food production with diverse product portfolio spanning multiple countries and industries, committed to feeding the world with excellence and innovation |
88,182 | |||
| 2 |
Naturanatura.com.br
A Brazilian multinational in cosmetics and personal care known for sustainable practices, direct sales, cruelty-free and vegan products, and Amazon biodiversity protection |
47,988 | |||
| 3 |
Einstein Hospital Israelitaeinstein.br
A leading healthcare institution offering cutting-edge treatments, compassionate care, social responsibility initiatives, and education and research programs for the community |
40,979 | |||
| 4 |
Dasadasa.com.br
The company is the largest integrated healthcare network in Brazil, focusing on preventive, predictive, and personalized healthcare with a wide range of services and innovative solutions |
32,801 | |||
| 5 |
Embraerembraer.com
A global aerospace company that designs, manufactures, and services aircraft for commercial, executive, defense, security, and agricultural aviation markets worldwide |
25,284 | |||
| 6 |
Suzanosuzano.com.br
Global leader in sustainable use of natural resources, producing eucalyptus pulp and paper, with innovative solutions promoting renewable bio-based materials worldwide |
23,529 | |||
| 7 |
Sírio-Libanêshospitalsiriolibanes.org.br
A renowned healthcare institution with philanthropic roots, offering top-notch medical services, cutting-edge technology, education, research, and social responsibility initiatives for 100 years |
19,137 | |||
| 8 | 17,675 | ||||
| 9 |
Klabinklabin.com.br
A leading producer of renewable and biodegradable paper, cardboard, packaging, and wood products, focused on developing smart solutions for customer needs |
16,499 | |||
| 10 |
EMSems.com.br
A leading pharmaceutical organization in Brazil with 45 years of experience, focused on innovation, research, and expanding product lines |
14,399 | |||
| 11 |
Volkswagen do Brasilvw.com.br
Manufactures innovative cars and mobility solutions, focusing on advanced technologies and people-centric design for the Brazilian market, leading industry future. |
12,076 | |||
| 12 |
Braskembraskem.com
Global company dedicated to sustainable solutions in chemicals and plastics, driving the Circular Economy with innovation and a diverse product portfolio for various industries worldwide |
10,586 | |||
| 13 |
Votorantim Cimentosvotorantimcimentos.com.br
A leading international provider of construction materials, with a diverse portfolio including cement, concrete, and aggregates Also active in agricultural inputs and waste management |
9,998 | |||
| 14 |
Senai São Paulosp.senai.br
Industry-managed institution in Brazil and Latin America specializing in professional training for the industrial sector since 1942, with over 85 schools and training centers |
9,989 | |||
| 15 |
Universidade Estadual Paulista Júlio de Mesquita Filhowww2.unesp.br
A leading Brazilian university with a multicampus structure offering quality education, research opportunities, and community services to students and society |
9,365 | |||
| 16 |
CPFL Energiagrupocpfl.com.br
The company has been shaping the history of the Brazilian energy sector for 110 years, with a focus on distribution, generation, transmission, and services |
9,255 | |||
| 17 |
Mercedes-Benz Caminhões e Ônibusmercedes-benz-trucks.com.br
A leading manufacturer of trucks, buses, and automobiles in Brazil, known for quality, technology, and commitment to employee development |
8,533 | |||
| 18 |
CEJAM - Centro de Estudos e Pesquisas Dr. João Amorim - OFICIALcejam.org.br
Non-profit institution supporting the Brazilian public health system with over 30 years of experience in primary care, specialized services, emergency care, and hospital management |
8,271 | |||
| 19 |
Hospital das Clínicas da Faculdade de Medicina da USPhc.fm.usp.br
A public institution affiliated with a medical school in São Paulo, dedicated to health public healthcare through education, research, assistance, and management |
8,241 | |||
| 20 |
União Química Farmacêutica Nacionaluniaoquimica.com.br
A pharmaceutical company in Brazil with a strong focus on innovation, social responsibility, and environmental sustainability, offering various benefits to employees |
7,519 | |||
| 21 |
Vulcabrasvulcabras.com
Sport-focused organization with multiple brands offering innovative technology and products for athletes, promoting sports participation and sponsoring events and athletes nationally and internationally |
7,048 | |||
| 22 |
Aché Laboratóriosache.com.br
Develops similar drugs, manages a strong portfolio, and continuously develops products and services, promoting health and well-being for the population. |
6,815 | |||
| 23 |
BP - A Beneficência Portuguesa de São Paulobp.org.br
The organization prioritizes valuing and celebrating life through research, understanding, and technology, with a focus on continuous evolution and respect for all |
6,759 | |||
| 24 |
A.C.Camargo Cancer Centeraccamargo.org.br
A specialized center focused on cancer diagnosis, treatment, education, and research with highly specialized healthcare professionals working together in one place |
6,452 | |||
| 25 |
Uninove - Universidade Nove de Julhouninove.br
A leading educational institution in São Paulo offering a wide range of undergraduate, postgraduate, and research programs through innovative teaching methods and state-of-the-art facilities |
6,396 | |||
| 26 |
Hyperahypera.com.br
Leading Brazilian pharmaceutical company across various segments including consumer health, prescription products, dermocosmetics, and generics, offering high-quality, safe products through continuous innovation. |
6,251 | |||
| 27 |
Bosch Brasilbosch.com.br
A global technology supplier offering innovative solutions for smart homes, Industry 40, and connected mobility with a focus on sustainability and safety |
6,246 | |||
| 28 |
Hospital Alemão Oswaldo Cruzhospitaloswaldocruz.org.br
A leading hospital in Latin America providing comprehensive healthcare services, high complexity treatments, and innovative care models focused on patient-centered approach |
6,204 | |||
| 29 | 6,195 | ||||
| 30 |
Saint-Gobain Brasilsaint-gobain.com.br
A global leader in sustainable construction materials and solutions, operating in 66 countries with a focus on well-being, performance, and sustainability |
5,593 | |||
| 31 |
Universidade Presbiteriana Mackenziemackenzie.br
Educates individuals for citizenship, fosters personal and societal development through teaching, research, extension, cultural, sports, social, and spiritual activities, grounded in reformed Christian faith. |
5,286 | |||
| 32 |
LIBBS FARMACÊUTICA LTDAlibbs.com.br
A national pharmaceutical company focused on producing healthcare solutions with a strong commitment to research, development, innovation, and social initiatives |
5,236 | |||
| 33 |
QuintoAndarcarreiras.quintoandar.com.br
Largest Latin America real estate ecosystem offering diverse brands and innovative technologies to enhance and support all housing journey stages. |
5,039 | |||
| 34 |
Biolab & Cobiolabfarma.com.br
Pharmaceutical innovator in Brazil, offering over 170 products for various health needs Leading in Cardiology, Dermatology, Gynecology, and more |
5,014 | |||
| 35 |
Laboratório Cristáliacristalia.com.br
Chemical-pharmaceutical laboratory, leading anesthetic and anesthesia adjuvant production in Latin America. Prioritizes innovation and quality in medicine production, affordable prices. |
4,225 | |||
| 36 |
Whirlpool Latin Americawhirlpool.com.br
Leading Latin American market in home appliances with popular brands, manufacturing plants, extensive R&D labs, and recognition for innovation and sustainability efforts Visit website for more information |
4,104 | |||
| 37 |
Instituto do Câncer do Estado de São Paulo - ICESPicesp.org.br
A leading oncology center in Latin America, focused on providing high-quality care, education, and research in the public health system |
4,018 | |||
| 38 |
Hospital de Amorhospitaldeamor.com.br
Provides specialized cancer treatment for low-income patients, continuously expanding its facilities and services to meet growing demand and strengthen public healthcare. |
3,791 | |||
| 39 |
UTC Engenhariautc.com.br
An industry leader in various sectors including oil & gas, petrochemicals, power generation, and steel production with over 1,000 successful contracts |
3,618 | |||
| 40 |
Ajinomoto do Brasilajinomoto.com.br
Specializing in creating products for various industries using umami flavor, with a focus on food, cosmetics, pharmaceuticals, animal nutrition, and agriculture |
3,618 | |||
| 41 |
Hcorhcor.com.br
A leading Brazilian healthcare organization providing specialized medical services, research, training, and social initiatives to make a difference in people's lives |
3,472 | |||
| 42 |
Oncoclínicas&Cogrupooncoclinicas.com
A leading provider of oncology services in Latin America, offering advanced treatments, multidisciplinary care, and a patient-centered approach across 14 states |
3,466 | |||
| 43 |
Arco Educaçãoarcoeducacao.com.br
A Brazilian company that provides educational solutions for elementary education, developing content, technology, and services for millions of students and schools nationwide |
3,465 | |||
| 44 |
Scania Latin Americascania.com
Leading sustainable transport solutions provider, offering engines for various applications, service products, and financial services Operates globally with focus on R&D in Sweden |
3,341 | |||
| 45 |
ZARAPLAST S.A.zaraplast.com.br
A leading manufacturer of flexible packaging solutions, specializing in plastic rolls for food, cleaning, and hygiene industries ISO 9002 certified for quality |
3,199 | |||
| 46 |
Ambipar | Brasilambipar.com
This organization promotes ecological transformation through waste management, water solutions, energy projects, and decarbonization initiatives, focusing on circular economy and environmental regeneration |
3,063 | |||
| 47 |
Pontifícia Universidade Católica de Campinaspuc-campinas.edu.br
A university in Campinas, focusing on ethical and Christian values, aims to produce, enrich, and disseminate knowledge for professional excellence and holistic human development |
2,891 | |||
| 48 |
CASTcast4it.com
A technology solutions provider with 25 years of experience, offering IT services in finance, industry, services, and the public sector nationally and globally |
2,866 | |||
| 49 |
Apsen Farmacêuticaapsen.com.br
A pharmaceutical company in Brazil for over 54 years, focused on researching, developing, and providing high-quality medications, prioritizing investment in R&D, HR, and technology |
2,556 | |||
| 50 |
Hospital IGESPhospitaligesp.com.br
Specialized hospital founded in the 1950s in São Paulo, offering gastroenterology services and expanding through acquisitions for continued growth |
2,416 | |||
Want more companies than this list?This page shows the largest ones only. Connect to Tamtam to see every company that matches, filter by size, industry or growth, and reach their decision-makers. | |||||
| 51 |
Blau Farmacêuticablau.com
Established in 1987, a leading Brazilian pharmaceutical company specializes in complex medications and biotechnology They operate in various medical sectors nationally and internationally |
2,399 | |||
| 52 |
Arcor do Brasilarcor.com
Manufacturing and selling a variety of high-quality sweets and chocolates, continually expanding its product portfolio and investing in innovation |
2,372 | |||
| 53 |
Plascarplascar.com.br
Traditional Brazilian company in the automotive sector manufacturing and selling internal and external finishing parts for vehicles for decades |
2,335 | |||
| 54 |
Instituto de Pesquisas ELDORADOorg.br
A world-class provider of customized software and hardware solutions for various industries, connecting people, universities, and startups to drive technological innovation globally |
2,281 | |||
| 55 |
ISA ENERGIA BRASILisaenergiabrasil.com.br
Leading in energy transmission, this organization transports a significant portion of Brazil's electricity annually, ensuring quality and reliability through innovation and improvements |
2,245 | |||
| 56 |
LongPing High-Techlpht.com.br
A leading provider of high-quality hybrid corn and sorghum seeds, focusing on research, development, and innovation in agriculture technologies |
2,222 | |||
| 57 |
CBC - Companhia Brasileira de Cartuchoscbc.com.br
Manufacturer of a wide range of products for defense, security, sport, and leisure, including innovative ammunition Committed to supporting national and international security forces |
2,159 | |||
| 58 |
AACDaacd.org.br
Established in 1950, this organization provides assistance to children with disabilities through rehabilitation services, professional training, social integration, and resource mobilization efforts |
2,124 | |||
| 59 | 2,001 | ||||
| 60 |
Santistasantistasa.com.br
A prestigious holding company with a focus on innovation, quality products, respect for professionals, and ethical business practices in the textile industry |
1,970 | |||
| 61 |
Maxion Structural Componentsmaxionsc.com
Manufacturer of structural components for various vehicles, specializing in stamping and assembling products with a wide range of welding and surface treatment capabilities |
1,960 | |||
| 62 |
Toledo do Brasiltoledobrasil.com
A technology-driven organization that develops software, cloud platforms, and electronic labels, while also promoting employee engagement through music festivals, gaming tournaments, and cultural events |
1,915 | |||
| 63 |
LG Electronics Brasillg.com
Leading consumer electronics manufacturer in Brazil with a wide range of products including TVs, audio and video equipment, smartphones, air conditioners, home appliances, and corporate solutions |
1,833 | |||
| 64 |
Decathlon Brasildecathlon.com.br
Specialists in technical sports products Offering a wide range of personalized services and articles in 65 different sports, aiming for sustainable impact and excellence |
1,727 | |||
| 65 |
Brazilian Center for Research in Energy and Materials (CNPEM)cnpem.br
A research organization managing four national laboratories focused on synchrotron light, biotechnology, bioenergy, and nanotechnology, offering facilities to academia and industry worldwide |
1,686 | |||
| 66 |
Villares Metalsvillaresmetals.com.br
With over 75 years of history, the company is a global leader in developing high-quality special steels and alloys for various industries worldwide |
1,664 | |||
| 67 |
Luizalabsluizalabs.com
Using technology to provide a unique customer experience, this organization focuses on innovating and digitalizing the Brazilian retail sector through agile methodologies |
1,630 | |||
| 68 |
CPQDcpqd.com.br
A leading innovator in information and communication technologies, specializing in solutions for various industries, digital transformation, IoT, AI, and more |
1,577 | |||
| 69 |
Myralismyralis.com.br
A forward-looking pharmaceutical company focused on pioneering, excellence, and technology to deliver innovative medications nationwide through a strong production and distribution network |
1,506 | |||
| 70 |
Mottumottu.com.br
Top startup in Brazil offering motorbike rentals for delivering goods, providing full support and maintenance, powered by proprietary technology for a seamless customer experience |
1,470 | |||
| 71 |
ICL América do Sulicl-growingsolutions.com
Leading global provider of innovative and sustainable solutions in plant and animal nutrition, as well as raw materials for the fertilizer industry, impacting food production and environmental protection |
1,450 | |||
| 72 |
Denso Brasildenso.com
A global leader in technological innovation providing systems and components for major automotive manufacturers worldwide Committed to continuous improvement, excellence, and innovation |
1,449 | |||
| 73 |
Faculdade São Leopoldo Mandicslmandic.edu.br
Leader in dental and medical education with top ranking by MEC Offer innovative education to enhance social development in Brazil across multiple locations |
1,423 | |||
| 74 | 1,400 | ||||
| 75 |
USCS - Universidade Municipal de São Caetano do Suluscs.edu.br
A municipal higher education institution in São Caetano do Sul, with diverse academic programs and full autonomy in academics and administration |
1,399 | |||
| 76 |
GWM Brasilgwmmotors.com.br
Investing in Brazilian automotive manufacturing, producing hybrid and electric vehicles for export across Latin America, and leading in SUVs and pickup trucks. |
1,382 | |||
| 77 |
Dedinidedini.com.br
Manufacturer of capital goods, including a wide range of equipment for various industrial sectors, specializing in the global sugar and ethanol market |
1,347 | |||
| 78 |
Packing Grouppackinggroup.com.br
Leader in flexible plastic packaging in Latin America, focusing on innovation and sustainability with Nanolayer technology, circular economy model, and sustainable resin products |
1,333 | |||
| 79 | 1,321 | ||||
| 80 |
AUNDE Brasil S.A.aunde.com.br
For over 40 years, the company focuses on innovation and customer satisfaction, providing high-quality materials for vehicle interiors while prioritizing environmental conservation and occupational health |
1,314 | |||
| 81 |
&co. Cosméticosandco.ind.br
Specialized cosmetic industry with over 10 years of experience, offering personalized solutions for developing and manufacturing cosmetic products under private label, customization, or cobranding formats |
1,308 | |||
| 82 |
Unipacunipac.com.br
A leading polymer transformation industry with innovative processes, high-performance products, digital services for various markets, and sustainable strategies Part of a global conglomerate |
1,248 | |||
| 83 |
Universidade Metodista de São Paulometodista.br
A traditional higher education institution offering undergraduate, postgraduate, and short-term courses focusing on communication and information, with recognition for excellence in distance education |
1,230 | |||
| 84 |
IDEXXidexx.com.br
Leader in innovation for pet healthcare, providing veterinary diagnostics, information, and services worldwide to improve animal health and well-being Also serving livestock and water safety industries |
1,191 | |||
| 85 |
CHRIS CINTOS DE SEGURANÇAchriscintos.com.br
Established in 1952, this Latin American leader in safety belt manufacturing is committed to producing high-quality, competitively-priced products for customer satisfaction |
1,144 | |||
| 86 |
Kromberg & Schubert do Brasilkromberg-schubert.com
Global supplier of electrical systems, cables, and plastic components with a focus on innovation, customer needs, and employee development. |
1,144 | |||
| 87 |
Nitronitro.com.br
Global producer of chemical specialties for diverse industrial sectors and agricultural inputs, focusing on technological competence and safety standards for client solutions. |
1,135 | |||
| 88 |
Faculdade Israelita Albert Einsteinensino.einstein.br
A non-profit organization providing healthcare, education, research, and social projects, including a variety of educational programs in healthcare |
1,132 | |||
| 89 |
Amway do Brasil Ltdaamway.com.br
Manufacturing world-renowned brands, we empower individuals worldwide to improve their lifestyle through entrepreneurship, offering opportunities for extra income |
1,125 | |||
| 90 |
Gertecgertec.com.br
With 24 years of experience, the company specializes in manufacturing a wide range of automated products for various industries worldwide |
1,108 | |||
| 91 |
CTG Brasilctgbr.com.br
Develops world with large-scale clean energy. Investments in hydroelectric, wind, and solar power plants in Brazil. Part of a global clean energy leader. |
1,081 | |||
| 92 |
Hospital de Cancer de Barretos Fundação PIO XIIhospitaldeamor.com.br
The organization provides specialized cancer treatment services for low-income patients, founded in 1967 and continually expanding with community and governmental support |
1,062 | |||
| 93 |
Caldic LATAM
Global provider of innovative and sustainable solutions for the food, pharmaceutical, personal care, and industrial markets, focused on customer needs with expertise in research and development |
1,055 | |||
| 94 |
OBER S/Aober.com.br
A Brazilian company with over 50 years of experience in the production of nonwovens, fabrics, and converted products, focusing on quality, service, and innovation |
1,041 | |||
| 95 |
MSD Saúde Animalmsd-saude-animal.com.br
Global animal health unit providing veterinarians, farmers, pet owners, and governments with a wide range of veterinary pharmaceuticals, vaccines, and health management solutions |
1,034 | |||
| 96 |
Beontagbeontag.com
Global leader providing IoT solutions and graphic materials to drive seamless communication in multiple industries, with a focus on sustainability and diversity |
1,030 | |||
| 97 |
ARTEBarteb.com.br
A leading automotive lighting manufacturer with over 85 years of experience, specializing in headlights, tail lights, and Full LED development for major Brazilian automakers |
1,011 | |||
| 98 |
Karina Plásticoskarina.com.br
A leading specialist in producing compounds, focusing on PVC, Polyolefin Specialties, and Masterbatch for national and international clients for nearly 40 years |
1,004 | |||
| 99 |
Unigelunigel.com.br
A conglomerate with over four decades of experience in the petrochemical and plastic sector, operating nationally and internationally in four business areas |
1,004 | |||
| 100 |
SiDisidi.org.br
An R&D institute in Brazil creating transformative projects and solving problems, impacting millions through innovation and making the future happen. |
996 | |||
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How this list is built
Every company on this list has a Tamtam company profile. The industry is the one the company gives on LinkedIn; categories such as SaaS or fintech are classified by Tamtam's AI from the company's website and LinkedIn page; and the headquarters city must match the company's own address. Companies are ranked by the number of employees on LinkedIn, and the list is refreshed every night. Classifications can be wrong, so treat the list as a starting point rather than an official ranking. Last updated Nov 13, 2026.
More company lists in São Paulo State
- The largest companies in São Paulo State 6,967
- Manufacturers in São Paulo State 972
- Multinational companies in São Paulo State 757
- Retail chains in São Paulo State 741
- Financial Services companies in São Paulo State 557
- Financial services firms in São Paulo State 468
- Education providers in São Paulo State 466
- Critical infrastructure operators in São Paulo State 437
- Companies with a mobile app in São Paulo State 415
- Healthcare providers in São Paulo State 390
- Retail companies in São Paulo State 390
- E-commerce companies in São Paulo State 369
- IT Services and IT Consulting companies in São Paulo State 350
- Corporate groups and holding companies in São Paulo State 318
- Food and beverage companies in São Paulo State 267
- Professional services firms in São Paulo State 265
- Hardware manufacturers in São Paulo State 260
- Logistics companies in São Paulo State 247
- Hospitals and Health Care companies in São Paulo State 242
- Distributors and wholesalers in São Paulo State 219
- Fintech companies in São Paulo State 207
- Consumer goods companies in São Paulo State 199
- Franchise networks in São Paulo State 199
- Food and Beverage Services companies in São Paulo State 198
The same list elsewhere in Brazil
- Companies with in-house R&D in Brazil 755
- Companies with in-house R&D in Minas Gerais 62
- Companies with in-house R&D in Paraná 61
- Companies with in-house R&D in Santa Catarina 58
- Companies with in-house R&D in Rio de Janeiro State 43
- Companies with in-house R&D in Rio Grande do Sul 42
- Companies with in-house R&D in São Paulo 145
- Companies with in-house R&D in Rio de Janeiro 32