These critical infrastructure operators in the Rhône department are mostly large groups in the healthcare, banking, and logistics sectors. Notable entities include Hospices Civils de Lyon, a public university hospital with over 22,000 professionals, and XPO Logistics Europe, offering end-to-end logistics solutions across Europe. Other significant firms are Caisse d'Epargne Rhone Alpes, a prominent regional bank, and Groupe APICIL, a social protection group. CNR (Compagnie Nationale du Rhône) is a major producer of renewable electricity.
A clear pattern among these companies is their long-standing presence, with many founded in the 20th century or earlier, such as Hospices Civils de Lyon (1796) and CIC Lyonnaise de Banque (1865). This indicates a mature and established economic landscape in the region, particularly within essential services.
| # | Company | Employees | |||
|---|---|---|---|---|---|
| 1 |
Hospices Civils de Lyon - HCLchu-lyon.fr
Public university hospital provides care, education, research, medical innovation, prevention, and health education with over 22,000 professionals across 14 facilities. |
8,220 | |||
| 2 |
XPO Logistics Europexpo.com
Offers end-to-end logistics solutions, including full-truckload, less-than-truckload, pallet distribution, last-mile delivery, global freight forwarding, and warehousing services across Europe. |
7,478 | |||
| 3 |
Métropole de Lyongrandlyon.com
Manages various public services including mobility, environment, urban planning, social aid, economic development, and cultural activities for 58 communes. |
3,295 | |||
| 4 |
Caisse d'Epargne Rhone Alpescaissedepargnerhonealpes.fr
A prominent banking institution in the Rhône-Alpes region serving individuals, businesses, social economy, housing, local authorities, real estate professionals, and protected individuals |
2,442 | |||
| 5 |
Banque Populaire Auvergne Rhône Alpesbanquepopulaire.fr
A regional bank in Auvergne Rhône Alpes region welcoming candidates, clients, and members They recruit hundreds of employees annually and are active on LinkedIn for recruitment |
2,313 | |||
| 6 |
Crédit Agricole Centre-estca-centrest.com
A regional banking institution with a cooperative and mutualist foundation, providing various financial services to over 1 million clients and supporting regional economic development |
2,262 | |||
| 7 |
Santé Ciesantecie.com
Provides home healthcare, dialysis treatment, and urgent care centers across France and Europe, supporting 500,000 patients annually. |
1,979 | |||
| 8 |
Groupe APICILgroupe-apicil.com
A leading French social protection group offering tailored solutions in health, insurance, savings, and retirement, with a focus on client well-being and social responsibility |
1,446 | |||
| 9 |
Centre Léon Bérardcentreleonberard.fr
Specialized cancer hospital and research center providing personalized treatment, innovative therapies, and compassionate care to support patients throughout their illness. |
1,418 | |||
| 10 |
CIC Lyonnaise de Banquecic.fr
A local bank focusing on client service and supporting the economy with over 160 years of experience, promoting innovation, entrepreneurship, and community involvement |
1,417 | |||
| 11 |
CNR (Compagnie Nationale du Rhône)tm.fr
French leading producer of 100% renewable electricity, managing the Rhône river for hydroelectricity, navigation, irrigation, and agricultural use, supporting local development and innovation |
1,256 | |||
| 12 |
Le Vinatier - Psychiatrie Universitaire Lyon Métropolech-le-vinatier.fr
Specialized psychiatric hospital providing comprehensive mental health care, treatment, and support services for individuals with mental disorders. |
1,246 | |||
| 13 | 1,161 | ||||
| 14 |
Eurofins Biomniseurofins-biomnis.com
A European leader in specialized medical pathology, providing over 2,500 tests including specialized, authorized analyses with a focus on innovation and international development |
803 | |||
| 15 |
Hôpital Saint Joseph Saint Lucsaintjosephsaintluc.fr
Innovative hospital in Lyon with 360 beds, 1200 employees, and €130M budget Offers comprehensive healthcare services without extra charges, focusing on patient care |
646 | |||
Want more companies than this list?This page shows the largest ones only. Connect to Tamtam to see every company that matches, filter by size, industry or growth, and reach their decision-makers. | |||||
| 16 |
ARHM (soins - accompagnement - recherche)fondationarhm.fr
Management of psychiatric, mental and physical disability, and addiction care facilities serving over 16,000 patients annually in Lyon region. |
643 | |||
| 17 |
Médipôle Lyon-Villeurbannemedipolelyonvilleurbanne.fr
This private hospital pole combines two entities, offering diverse medical and surgical specialties across medicine, surgery, obstetrics, and rehabilitation care. |
486 | |||
| 18 |
Eurofins Biologie Médicaleeurofins.com
Network of over 280 medical biology laboratories in France providing quality patient care, early diagnostics, and innovative medical testing services. |
412 | |||
| 19 |
Hôpitaux Nord-Ouesthno.fr
Comprehensive healthcare services across five hospitals and ten care homes, providing consultations, hospitalizations, and continuous public health coverage. |
407 | |||
| 20 | 354 | ||||
| 21 |
HOPITAL PRIVE JEAN MERMOZhopital-prive-jean-mermoz-lyon.ramsaysante.fr
Hospital and Health Care company in Lyon, France, providing medical services from its location on Av Jean Mermoz in Rhone-Alpes |
353 | |||
| 22 |
Infirmerie Protestante de Lyoninfirmerie-protestante.com
Non-profit healthcare institution in Lyon specializing in cardiovascular, cancer, orthopedic, ophthalmology surgeries, and internal medicine services. |
346 | |||
| 23 |
Clinique du Parc Lyon - ELSANelsan.care
Specialized surgical care center in Lyon offering orthopedic, plastic, ophthalmologic, neuro, bariatric surgeries with advanced imaging and rehabilitation services. |
295 | |||
| 24 |
Clinique de la Sauvegarderamsaysante.fr
A hospital and health care company based in Lyon, France, specializing in providing medical services to patients in need of care |
289 | |||
| 25 |
Crédit Mutuel du Sud-Estcreditmutuel.fr
Mutualist regional bank serving 650,000 clients with 143 branches, supporting local economy, social values, and community partnerships. |
288 | |||
| 26 |
Centre Hospitalier Saint Cyr au Mont d'Orch-st-cyr69.fr
Public mental health institution providing prevention, diagnosis, treatment, rehabilitation, and social reintegration across a large regional territory. |
271 | |||
| 27 |
IMADIS Groupeimadis-groupe.fr
Providing remote radiology solutions supporting healthcare facilities across metropolitan France and overseas, ensuring continuous, equal access to imaging diagnostics. |
260 | |||
| 28 |
SYTRALsytral-mobilites.fr
The company aims to provide the best transport network for residents through the development of public transportation services and infrastructure in Lyon |
253 | |||
| 29 |
UGECAM Rhône-Alpesgroupe-ugecam.fr
Management of healthcare and medico-social facilities providing rehabilitation, medical care, and social support with multidisciplinary professional teams. |
253 | |||
| 30 |
Soins et Santé Groupesoinsetsante.org
Specializing in home care for elderly, sick, and disabled individuals, the association provides a range of coordinated services in the Lyon region for over 50 years |
228 | |||
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How this list is built
Every company on this list has a Tamtam company profile. The industry is the one the company gives on LinkedIn; categories such as SaaS or fintech are classified by Tamtam's AI from the company's website and LinkedIn page; and the headquarters city must match the company's own address. Companies are ranked by the number of employees on LinkedIn, and the list is refreshed every night. Classifications can be wrong, so treat the list as a starting point rather than an official ranking. Last updated Nov 11, 2026.
More company lists in the Rhône department
- The largest companies in the Rhône department 4,813
- Multinational companies in the Rhône department 577
- Companies with in-house R&D in the Rhône department 509
- Professional services firms in the Rhône department 400
- Manufacturers in the Rhône department 322
- Retail chains in the Rhône department 302
- IT services companies in the Rhône department 286
- SaaS companies in the Rhône department 284
- Software Development companies in the Rhône department 264
- IT Services and IT Consulting companies in the Rhône department 253
- Hardware manufacturers in the Rhône department 243
- Consulting firms in the Rhône department 242
- Business Consulting and Services companies in the Rhône department 219
- Distributors and wholesalers in the Rhône department 185
- Higher Education companies in the Rhône department 155
- Education providers in the Rhône department 154
- Law Practice companies in the Rhône department 152
- Real Estate companies in the Rhône department 151
- Family-owned companies in the Rhône department 149
- Subscription businesses in the Rhône department 149
- Construction companies in the Rhône department 140
- Pharmaceutical companies in the Rhône department 134
- Financial services firms in the Rhône department 132
- Advertising Services companies in the Rhône department 126
The same list elsewhere in France
- Critical infrastructure operators in France 2,721
- Critical infrastructure operators in Île-de-France 780
- Critical infrastructure operators in Auvergne-Rhône-Alpes 299
- Critical infrastructure operators in Grand Est 257
- Critical infrastructure operators in Occitanie 216
- Critical infrastructure operators in Nouvelle-Aquitaine 209
- Critical infrastructure operators in Provence-Alpes-Côte d'Azur 200
- Critical infrastructure operators in Hauts-de-France 174
- Critical infrastructure operators in the Hauts-de-Seine department 169
- Critical infrastructure operators in Pays de la Loire 127
- Critical infrastructure operators in Brittany 120
- Critical infrastructure operators in Normandy 103
- Critical infrastructure operators in the Bouches-du-Rhône department 98
- Critical infrastructure operators in Centre-Val de Loire 87
- Critical infrastructure operators in the Nord department 87
- Critical infrastructure operators in Bourgogne-Franche-Comté 76
- Critical infrastructure operators in the Haute-Garonne department 64
- Critical infrastructure operators in the Gironde department 63
- Critical infrastructure operators in the Loire-Atlantique department 59
- Critical infrastructure operators in the Hérault department 57
- Critical infrastructure operators in the Seine-Saint-Denis department 53
- Critical infrastructure operators in the Seine-Maritime department 46
- Critical infrastructure operators in the Ille-et-Vilaine department 45
- Critical infrastructure operators in Paris 331