Clermont-Ferrand's in-house R&D landscape is diverse, featuring large established groups, public institutions, and younger specialized firms. Michelin, founded in 1889, manufactures tires and components for various sectors, including mobility and healthcare. The CHU de Clermont-Ferrand, a university hospital, provides extensive care, teaching, and research. Atelier industriel de l'aéronautique de Clermont-Fd maintains French military aircraft, while BeYs offers digital trust solutions like electronic signatures.
A notable pattern is the strong presence of both traditional manufacturing and advanced biotechnology. AFYREN develops biobased compounds through fermentation, and CARBIOS focuses on enzyme-based plastic and textile biorecycling. The city also hosts significant public and semi-public research and development entities, reflecting a broad range of R&D activities from heavy industry to specialized scientific fields.
| # | Company | Employees | |||
|---|---|---|---|---|---|
| 1 |
Michelinmichelin.com
Manufactures high-quality tires, components, and composites for mobility, construction, aeronautics, low-carbon energies, and healthcare. Offers exceptional experiences through connected solutions, AI, and the MICHELIN Guide. |
56,897 | |||
| 2 |
CHU de Clermont-Ferrandchu-clermontferrand.fr
A university hospital with over 8000 employees in Clermont-Ferrand, providing care, prevention, teaching, and research services across multiple sites |
2,531 | |||
| 3 |
centre jean perrincjp.fr
Specialized cancer treatment, research, education, and training center serving 28,000 patients annually with equitable access and no extra fees. |
448 | |||
| 4 |
UNIVERSITE D'AUVERGNEuca.fr
provides student information, orientation, career insertion support, monitors academic success, conducts graduate follow-up surveys, and facilitates study reorientation |
374 | |||
| 5 |
Atelier industriel de l'aéronautique de Clermont-Fddefense.gouv.fr
State military aeronautical industrial service maintains French armed forces transport, fighter, training aircraft, and helicopters. Expert in industrial maintenance, modifications, repairs, and equipment maintenance. |
256 | |||
| 6 |
MICHELIN Innovation Labmichelin.com
Innovation lab focused on exploring new territories and leveraging expertise beyond tires |
200 | |||
| 7 |
NOREVA GROUPEnoreva-laboratoires.com
Development of high-tolerance dermatological skincare products addressing skin health holistically, suitable for all ages and skin conditions. |
163 | |||
| 8 | 153 | ||||
| 9 |
AFYRENafyren.com
Develops biobased compounds via patented fermentation for diverse industries like food and cosmetics, focusing on low-carbon and zero-waste production. |
145 | |||
| 10 |
MICHELIN Aircraft Tyreaircraft.michelin.com
Manufacturing bias and radial tires for military, commercial, regional, and general aviation markets. Essential for takeoff, landing, and taxiing aircraft. |
139 | |||
| 11 |
Babymoov Groupbabymoov.com
French company creating solutions for parents through 6 ranges: feeding, comfort, safety, caring, outdoor, playing. Products found in over 70 countries, lifetime warranty. |
129 | |||
| 12 |
CARBIOScarbios.com
Develops enzyme-based processes for plastic and textile biorecycling and biodegradation, promoting a circular economy with industrial-scale solutions supported by major brands. |
102 | |||
| 13 |
AUBRILAMaubrilam.com
Designs and manufactures outdoor furniture to enhance urban spaces, offering over 300 customizable products for various environments worldwide |
86 | |||
| 14 |
SURGARsurgar-surgery.com
Specializing in augmented reality for laparoscopic surgery on mobile organs, we aim to enhance precision and save lives through better surgery |
46 | |||
| 15 | 44 | ||||
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| 16 |
Trelleborg Oil & Marinetrelleborg.com
The company specializes in providing high-performing, innovative flexible hose solutions for oil and gas transfer applications, tailored to unique requirements |
38 | |||
| 17 |
Alfa Informatiquealfainfo.fr
Since 1980, this company designs and develops management software tailored to the needs of healthcare, social, and medical sectors, becoming a leading French editor in this market |
30 | |||
| 18 |
Théa Pharma Francetheapharma.fr
Specializes in research, development, and commercialization of ophthalmology products with a strong presence across Europe and worldwide. |
27 | |||
| 19 |
BBS Slamabbs-logiciels.com
Developing innovative calculation solutions for professionals in energy efficiency to accurately study thermal aspects of buildings, ensuring compliance with regulations and improving energy performance |
24 | |||
| 20 |
SYLink Technologiesylink.fr
SYLink Technologie offers AI-driven products for securing networks, IoT devices, and business data, simplifying cybersecurity with user-friendly interfaces and unique designs |
21 | |||
| 21 |
CELIUM ENERGIEScelium.pro
Industrial project design and implementation in the Auvergne Rhône-Alpes region Specializing in heating, air conditioning, ventilation, industrial piping, dust removal, and fire protection systems |
19 | |||
| 22 | 12 | ||||
| 23 |
BIENESISbienesis.fr
Development of innovative system protecting vineyards from climate hazards like frost, hail, diseases, reducing production losses and chemical runoff. |
11 | |||
| 24 |
Punch Powertrain France - former APOJEEpunchpowertrain.com
High-technology supplier in power electronics & ignition/combustion fields for automotive, aerospace, and industrial sectors, offering innovative solutions for efficiency |
10 | |||
| 25 |
Biotech Open Platformbiotechopenplatform.com
Formed by Danone, Michelin, DMC, and Crédit Agricole. Accelerates industrialization of precision fermentation for bio-based materials and ingredients, driving biotech innovation and scalable production. |
10 | |||
| 26 |
BioUppbioupp.com
Developed a patented innovation converting excess electricity into biogas by utilizing CO2, recognized by i-Lab and Women TechEU. |
9 | |||
| 27 |
Qarboon (ex-Dense Fluid Degreasing)dense-fluid-degreasing.com
A French company specializing in innovative and ecological cleaning machines utilizing supercritical CO2 for industrial cleaning, decontamination, sterilization, and extraction |
9 | |||
| 28 |
ECHODIAechodia.fr
Specialized in hearing assessment, the company develops and sells devices for auditory measurements in otorhinolaryngology and neuroscience fields, catering to healthcare professionals' needs |
6 | |||
| 29 |
CALNESIScalnesis.com
Independent laboratory specializing in Physical Chemistry, offering R&D studies, measurements, and analyses in various fields with customized measurement benches and software solutions |
5 | |||
| 30 |
Probionovprobionov.com
Specializing in innovative probiotic formulations, we develop products for gastroenterology, gynecology, and immune system defense, with a focus on pharmaceutical-grade research and development |
4 | |||
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Every company on this list has a Tamtam company profile. The industry is the one the company gives on LinkedIn; categories such as SaaS or fintech are classified by Tamtam's AI from the company's website and LinkedIn page; and the headquarters city must match the company's own address. Companies are ranked by the number of employees on LinkedIn, and the list is refreshed every night. Classifications can be wrong, so treat the list as a starting point rather than an official ranking. Last updated Nov 11, 2026.
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