The companies with in-house R&D in Lille are predominantly large educational and healthcare institutions. The University of Lille 1 Sciences and Technology, CHU de Lille, and Université catholique de Lille are major employers, focusing on education, research, and healthcare. Other notable entities include the Centre Oscar Lambret, which specializes in cancer treatment and research, and the Institut Pasteur de Lille, dedicated to fundamental research in infectious diseases and other health conditions.
A clear pattern is the strong presence of public and private higher education and healthcare organizations, many of which were founded in the late 19th or early 20th century. Beyond these, there are also manufacturing companies like VPK Packaging France, which produces paper and cardboard packaging, and technology firms such as NeoLedge, providing ECM solutions, and Sencrop, which offers ag-weather stations for farmers.
| # | Company | Employees | |||
|---|---|---|---|---|---|
| 1 |
University of Lille 1 Sciences and Technologyuniv-lille.fr
Public university specializing in science and technology education, research, and innovation, offering diverse programs and fostering academic excellence. |
8,043 | |||
| 2 |
CHU de Lillechu-lille.fr
A leading hospital-university campus in northern Europe, specializing in healthcare, research, innovation, and sustainability with over 15,000 professionals and 14 million patients yearly |
5,567 | |||
| 3 |
Université catholique de Lilleuniv-catholille.fr
An innovative university offering a wide range of programs focusing on teaching, research, and societal service, with a strong emphasis on sustainability and internationalization |
1,720 | |||
| 4 |
Centre Oscar Lambretcentreoscarlambret.fr
Specialized cancer treatment, research, and education center with multidisciplinary professionals dedicated to improving patient outcomes and advancing oncology knowledge. |
561 | |||
| 5 |
Junia_ingénieursjunia.com
Engineering school providing rigorous, human-centered education and applied research to prepare students for industrial, digital, and environmental challenges. |
540 | |||
| 6 |
Sciences Po Lillesciencespo-lille.eu
Teaches students social sciences and politics through a five-year curriculum, granting a Master's degree. One of nine French Political Studies Institutes. |
416 | |||
| 7 |
VPK Packaging Francevpkgroup.com
Integrated European group producing paper, corrugated, and compact cardboard packaging. Controls entire manufacturing chain, enabling reactivity, meeting deadlines, and competitive technical solutions. |
411 | |||
| 8 |
Institut Pasteur de Lillepasteur-lille.fr
A foundation focusing on fundamental research and prevention in infectious diseases, cancer, cardiovascular, and neurodegenerative diseases to improve health and longevity |
383 | |||
| 9 |
HEI - Hautes Etudes d'Ingénieurjunia.com
This company specializes in professional training across 13 domains including architecture, mechanical design, healthcare engineering, IT, and sustainable chemistry |
362 | |||
| 10 |
Institut Catholique de Lilleuniv-catholille.fr
Higher education institution with 13 establishments, research activities, and healthcare services including hospitals and medico-social centers across multiple campuses. |
343 | |||
| 11 |
ACALY Conseil en Ingénierieacaly.eu
The company provides technical and organizational consulting services, offers work packages for project outsourcing, and focuses on research and innovation for clients' success |
183 | |||
| 12 |
NeoLedgeneoledge.com
NeoLedge provides ECM solutions for document digitization, information acquisition, EDM/EMM, BPM, and case management, helping businesses improve efficiency and decision-making |
173 | |||
| 13 |
Ondulysvpkgroup.com
A European integrated group producing paper, corrugated, and solid board packaging, offering competitive solutions with expertise in design and timely delivery |
165 | |||
| 14 |
Sencropsencrop.com
Provides ag-weather stations and a collaborative platform, enabling farmers to access real-time field conditions and ultra-local weather for informed agricultural decisions. |
81 | |||
| 15 |
Les-Tilleuls.cooples-tilleuls.coop
Design and development of innovative web and mobile projects using open-source software, with democratic cooperative governance and profit sharing. |
74 | |||
Want more companies than this list?This page shows the largest ones only. Connect to Tamtam to see every company that matches, filter by size, industry or growth, and reach their decision-makers. | |||||
| 16 |
WayKonectwaykonect.com
WayKonect specializes in professional mobility management, collecting and analyzing data to help companies reduce costs and transition to sustainable transportation solutions globally |
66 | |||
| 17 |
VAN RYSELvanryselcycling.com
The company provides reliable and innovative technologies for cyclists and triathletes to achieve marginal gains and maximum pleasure in their performances, without compromising quality |
63 | |||
| 18 | 57 | ||||
| 19 | 52 | ||||
| 20 |
Qualineoqualineo.io
Quality management software for medical and social organizations, offering innovative solutions to engage teams, manage risks, ensure compliance, and drive continuous improvement |
47 | |||
| 21 |
Speechispeechi.com
A leading provider of interactive screens, videoconferencing solutions, and collaborative software with showrooms in Lille, Paris, and Brussels |
44 | |||
| 22 |
GenoScreengenoscreen.fr
Innovative genomics company providing tailored solutions in healthcare, agronomy, skincare, etc through DNA analysis, sequencing, consultation, and training services |
39 | |||
| 23 |
ACT BEAUTYactbeautyfrance.com
Design and manufacture high-end beauty accessories, custom packaging, and lifestyle products for luxury retail and promotional sectors. |
39 | |||
| 24 |
WEBREATHEwebreathe.com
The company is developing a people flow intelligence system to make cities and public transport smarter by providing real-time information and forecasting services |
36 | |||
| 25 |
GRASP Earthgrasp-earth.com
Research and develops technologies for monitoring Earth's atmosphere and surface, specializing in aerosols using polarimetric observations and advanced algorithms with satellite data. |
31 | |||
| 26 |
Axomoveaxomove.com
A French digital health startup providing tele-rehabilitation solutions to improve access to rehabilitation care and innovative healthcare programs with major partners |
30 | |||
| 27 |
4P-Pharma4p-pharma.com
clinical-stage biotech company developing first-in-class therapies for serious diseases using innovative R&D and expedited regulatory strategies |
30 | |||
| 28 | 28 | ||||
| 29 |
Arterailarterail.com
Arterail specializes in optimizing the lifecycle of rolling stock for railway owners and operators by providing services for fleet evolution, renovation, modernization, and maintenance support |
28 | |||
| 30 | 24 | ||||
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How this list is built
Every company on this list has a Tamtam company profile. The industry is the one the company gives on LinkedIn; categories such as SaaS or fintech are classified by Tamtam's AI from the company's website and LinkedIn page; and the headquarters city must match the company's own address. Companies are ranked by the number of employees on LinkedIn, and the list is refreshed every night. Classifications can be wrong, so treat the list as a starting point rather than an official ranking. Last updated Nov 11, 2026.
More company lists in Lille
- The largest companies in Lille 891
- SaaS companies in Lille 104
- Retail chains in Lille 77
- Software Development companies in Lille 77
- Multinational companies in Lille 76
- IT Services and IT Consulting companies in Lille 66
- IT services companies in Lille 56
- Professional services firms in Lille 54
- Education providers in Lille 51
- Public sector organisations in Lille 50
- Real Estate companies in Lille 43
- Consulting firms in Lille 38
- Companies with a mobile app in Lille 37
- Higher Education companies in Lille 36
- Professional Training and Coaching companies in Lille 32
- Law Practice companies in Lille 31
- Subscription businesses in Lille 31
- Advertising Services companies in Lille 30
- Technology, Information and Internet companies in Lille 30
- Critical infrastructure operators in Lille 28
- Business Consulting and Services companies in Lille 28
- Civic and Social Organizations companies in Lille 28
- Recruitment and staffing agencies in Lille 26
- Government Administration companies in Lille 25
The same list elsewhere in France
- Companies with in-house R&D in France 8,750
- Companies with in-house R&D in Île-de-France 2,695
- Companies with in-house R&D in Auvergne-Rhône-Alpes 1,460
- Companies with in-house R&D in Occitanie 680
- Companies with in-house R&D in Grand Est 640
- Companies with in-house R&D in Provence-Alpes-Côte d'Azur 613
- Companies with in-house R&D in Nouvelle-Aquitaine 566
- Companies with in-house R&D in the Hauts-de-Seine department 510
- Companies with in-house R&D in the Rhône department 509
- Companies with in-house R&D in Pays de la Loire 480
- Companies with in-house R&D in Hauts-de-France 410
- Companies with in-house R&D in Brittany 366
- Companies with in-house R&D in the Haute-Garonne department 323
- Companies with in-house R&D in the Bouches-du-Rhône department 321
- Companies with in-house R&D in the Isère department 304
- Companies with in-house R&D in Bourgogne-Franche-Comté 261
- Companies with in-house R&D in the Nord department 237
- Companies with in-house R&D in Normandy 227
- Companies with in-house R&D in the Gironde department 225
- Companies with in-house R&D in the Loire-Atlantique department 207
- Companies with in-house R&D in the Essonne department 198
- Companies with in-house R&D in Centre-Val de Loire 195
- Companies with in-house R&D in Paris 1,249
- Companies with in-house R&D in Lyon 192