The Overijssel region shows a strong presence of higher education and machinery manufacturing companies with in-house R&D. Key players include the University of Twente, conducting cutting-edge research, and Saxion University of Applied Sciences, offering Bachelor and Master programs. Medisch Spectrum Twente is a top clinical hospital, while Tembo Group provides manufacturing solutions for sustainable alternatives. ITM specializes in solutions for the tobacco industry, and Topicus develops IT solutions for healthcare, education, and finance.
A notable pattern is the concentration of headquarters in Enschede, which hosts several significant institutions like the University of Twente, Saxion University of Applied Sciences, Medisch Spectrum Twente, and Demcon, a firm that develops innovative and complex systems. This indicates a hub for research, education, and advanced engineering within the region.
| # | Company | Employees | |||
|---|---|---|---|---|---|
| 1 |
University of Twenteutwente.nl
A forward-thinking university with 3,300 professionals conducting cutting-edge research, driving innovation, and providing inspiring education for over 12,000 students |
5,632 | |||
| 2 |
Saxion University of Applied Sciencessaxion.nl
A university of applied sciences in the Netherlands offering Bachelor and Master programs, short courses, and preparatory courses in English to local and international students |
4,348 | |||
| 3 |
Windesheimwindesheim.nl
Provides practice-oriented higher education with 87 study programs, emphasizing international elements and welcoming foreign students and lecturers. |
3,800 | |||
| 4 |
Medisch Spectrum Twentemst.nl
A top clinical hospital in Twente offering a wide range of healthcare services, medical education, research, trauma care, and collaboration within a network of hospitals |
2,709 | |||
| 5 |
Tembo Grouptembo.eu
A global family business with a focus on sustainability, providing manufacturing solutions for sustainable alternatives and innovative cross-over products |
1,083 | |||
| 6 | 916 | ||||
| 7 |
Topicustopicus.nl
The company develops user-friendly IT solutions that benefit healthcare, education, finance, and social sectors, aiming to empower citizens and reduce vulnerability |
812 | |||
| 8 |
TenCateus.tencatefabrics.com
Design, develop, and produce advanced protective fabrics for professionals in firefighting, military, industry, and energy sectors ensuring safety and comfort. |
755 | |||
| 9 | 663 | ||||
| 10 |
Voortman Steel Groupcareers.voortman.net
A global steel group focused on modern steel processing machines, innovative software, and services, driven by technology and entrepreneurship |
597 | |||
| 11 | 530 | ||||
| 12 |
Demcondemcon.com
Develops, prototypes, industrializes, and manufactures high-quality, innovative, and complex systems and products, integrating various engineering fields to solve societal and technological challenges. |
487 | |||
| 13 |
Voortman Steel Machineryvoortman.net
Design and manufacture CNC steel processing machinery with integrated software solutions, providing automation, optimization, and comprehensive customer support worldwide. |
487 | |||
| 14 |
VDL Enabling Technologies Group (ETG) Almelovdletg.com
Develop and produce complex, innovative modules and systems. Focused on further development of computer chips, combating diseases, and researching the universe for international clients. |
468 | |||
| 15 |
Bizzdesignbizzdesign.com
This company offers enterprise architecture software to improve success rates of enterprise transformation, investment allocation, and risk management for organizations |
440 | |||
| 16 |
Royal GDgddiergezondheid.nl
The company focuses on improving animal health and safety of animal products through veterinary specialists' guidance on disease prevention, animal husbandry, and welfare |
436 | |||
| 17 |
Roessingh, Centrum voor Revalidatieroessingh.nl
Specializing in rehabilitation treatment and care for adults and children with various diagnoses, including stroke, pain, and high spinal cord injuries |
407 | |||
| 18 |
Faculty of Geo-Information Science and Earth Observation (ITC) of the University of Twenteutwente.nl
A leading international knowledge hub in geospatial sciences, specializing in collaborative education and research for solving global challenges with spatial information |
387 | |||
| 19 |
HITEC Power Protectionhitec-ups.com
Manufacturing turnkey power solutions with dynamic UPS systems using flywheel energy storage, ensuring continuous, conditioned power supply to mission critical processes worldwide |
386 | |||
| 20 |
Koninklijke Euroma BVeuroma.com
A leading European provider of spice-based solutions for the food industry, specializing in developing tasty, healthy, sustainable, and safe ingredients |
357 | |||
Want more companies than this list?This page shows the largest ones only. Connect to Tamtam to see every company that matches, filter by size, industry or growth, and reach their decision-makers. | |||||
| 21 | 317 | ||||
| 22 |
AHV Internationalahvint.com
Innovative provider of animal health solutions, supporting livestock farmers and veterinarians with natural, scientific animal feeds and expert services for better care results |
299 | |||
| 23 |
Brink Groupbrink.eu
Designs and manufactures high-quality towbars for various vehicles, enabling safe and easy towing worldwide with extensive experience. |
252 | |||
| 24 |
HoSt Grouphost.nl
A fast-growing family company leading the way in renewable energy generation, specializing in clean conversion technology for sustainable energy solutions globally |
240 | |||
| 25 |
Bosch Thermotechniek Deventernefit-bosch.nl
In Deventer, part of an international group, Bosch Thermotechniek is a leading provider of heating technology, with expertise in research, production, and sales |
219 | |||
| 26 |
Aeronamicaeronamic.com
Aeronamic is a leading aerospace company specializing in design, manufacturing, testing, and maintenance of advanced turbomachinery, engine systems, and critical components for aviation |
214 | |||
| 27 |
Agrifac Machinery B.V.agrifac.com
Design and manufacture of self-propelled sprayers focusing on economics, ecology, efficiency, and ergonomics for sustainable farming. |
213 | |||
| 28 |
Rollecaterollecate.nl
A leading provider of custom aluminum and steel windows, doors, and complex facade systems for residential and commercial buildings since 1954 |
212 | |||
| 29 |
Beaphar B.V.beaphar.com
Develops manufactures pharmaceuticals, healthcare products, and super premium complete foods for all types of pets, improving their lives for over 80 years. |
177 | |||
| 30 | 148 | ||||
| 31 |
DGS Processing Solutionsdgs-ps.com
Designs, manufactures, installs, and maintains highly automated systems and lines for primary meat processing and product handling, including robotics. |
108 | |||
| 32 |
TKH Grouptkhgroup.com
A leading technology company focusing on innovative systems in Smart Vision, Manufacturing, and Connectivity, aiming to improve efficiency, sustainability, safety, and security globally |
103 | |||
| 33 |
Alltech Coppensalltechcoppens.com
Provides aquaculture feed solutions for all farmed fish stages, focusing on nutrition, health, and sustainable feed production technology, maximizing farm performance. |
92 | |||
| 34 |
QuiX Quantumquixquantum.com
Building photonic quantum computers designed for scalability, data-center readiness, and the path toward fault-tolerant quantum computing through integrated photonics and quantum optics. |
72 | |||
| 35 |
De Dessert Meesterslinktr.ee
A Dutch company creates unique ice cream desserts with high-quality ingredients and innovative flavors, available in 26 European countries |
42 | |||
| 36 |
OneThirdonethird.io
The company utilizes optical sensors and AI to predict produce spoilage, helping retailers reduce food waste and improve inventory management |
33 | |||
| 37 |
Datacadabra BVdatacadabra.nl
Develops data science and artificial intelligence for practical applications, saving time and costs through smart, scalable solutions for various organizations. |
17 | |||
| 38 |
Davines Group - Netherlands | Certified B Corpdavinesgroup.com
A family-owned group producing high-end hair and skin care products, promoting a holistic, sustainable lifestyle with a focus on beauty, ethics, and sustainability globally |
13 | |||
| 39 |
Hitec Food Systems B.V.hitecbv.nl
A company with 35 years of experience specializing in developing and producing stainless steel process solutions for the food industry |
12 | |||
| 40 |
Spectro-AIspectroai.ai
Designs and develops AI solutions, software and hardware, for detecting and analyzing objects and areas from sky (drone) and space (satellite). |
8 | |||
| 41 |
Intelligent Data & Internet Of Thingstheidiotcompany.eu
The company provides intelligent data and secure sensor solutions to businesses, aiming to bring control and insight while reducing environmental impact |
2 | |||
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Every company on this list has a Tamtam company profile. The industry is the one the company gives on LinkedIn; categories such as SaaS or fintech are classified by Tamtam's AI from the company's website and LinkedIn page; and the headquarters city must match the company's own address. Companies are ranked by the number of employees on LinkedIn, and the list is refreshed every night. Classifications can be wrong, so treat the list as a starting point rather than an official ranking. Last updated Nov 11, 2026.
More company lists in Overijssel
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- Manufacturers in Overijssel 77
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- IT Services and IT Consulting companies in Overijssel 27
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The same list elsewhere in Netherlands
- Companies with in-house R&D in the Netherlands 738
- Companies with in-house R&D in North Holland 188
- Companies with in-house R&D in South Holland 140
- Companies with in-house R&D in Gelderland 101
- Companies with in-house R&D in North Brabant 97
- Companies with in-house R&D in Limburg 29
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- Companies with in-house R&D in Utrecht 26