The Puy-de-Dôme department hosts a diverse array of companies with significant in-house R&D capabilities, ranging from large industrial groups to specialized firms. Key players include Michelin, a major manufacturer of tires and mobility solutions, CHU de Clermont-Ferrand, a large university hospital, and DÔMES PHARMA, which develops pet health solutions. Other notable companies are JOUBERT Group, specializing in technical textiles, and OMERIN Group, a global leader in wires and cables for extreme conditions.The companies in Puy-de-Dôme demonstrate a strong concentration in manufacturing, particularly in automotive, textiles, and specialized electronics. There is also a notable presence in healthcare and biotechnology, with institutions like Centre Jean Perrin focusing on cancer treatment and AFYREN developing biobased compounds. A significant cluster of these companies, including Michelin and CHU de Clermont-Ferrand, are headquartered in Clermont-Ferrand, highlighting its role as a regional economic hub.
| # | Company | Employees | |||
|---|---|---|---|---|---|
| 1 |
Michelinmichelin.com
Manufactures high-quality tires, components, and composites for mobility, construction, aeronautics, low-carbon energies, and healthcare. Offers exceptional experiences through connected solutions, AI, and the MICHELIN Guide. |
56,897 | |||
| 2 |
CHU de Clermont-Ferrandchu-clermontferrand.fr
A university hospital with over 8000 employees in Clermont-Ferrand, providing care, prevention, teaching, and research services across multiple sites |
2,531 | |||
| 3 |
centre jean perrincjp.fr
Specialized cancer treatment, research, education, and training center serving 28,000 patients annually with equitable access and no extra fees. |
448 | |||
| 4 |
UNIVERSITE D'AUVERGNEuca.fr
provides student information, orientation, career insertion support, monitors academic success, conducts graduate follow-up surveys, and facilitates study reorientation |
374 | |||
| 5 |
JOUBERT Groupjoubert.fr
Designing and manufacturing technical textile products like nets, straps, and automotive accessories for industrial, consumer, and original equipment applications across diverse sectors globally. |
330 | |||
| 6 |
Atelier industriel de l'aéronautique de Clermont-Fddefense.gouv.fr
State military aeronautical industrial service maintains French armed forces transport, fighter, training aircraft, and helicopters. Expert in industrial maintenance, modifications, repairs, and equipment maintenance. |
256 | |||
| 7 |
DÔMES PHARMAdomespharma.com
Develops, manufactures, and markets solutions for pet health and well-being, leveraging expertise across the entire medicine value chain and all distribution channels. |
239 | |||
| 8 |
LIMAGRAIN INGREDIENTSlimagrain-ingredients.com
The company specializes in creating trustworthy nutritional products by innovating with grain to enhance well-balanced nutrition for healthy and enjoyable experiences |
236 | |||
| 9 |
OMERIN Groupomerin.com
A global leader in manufacturing wires and cables for extreme temperatures and severe environments with a focus on medical devices and safety sectors |
207 | |||
| 10 |
MICHELIN Innovation Labmichelin.com
Innovation lab focused on exploring new territories and leveraging expertise beyond tires |
200 | |||
| 11 |
SIGMA Clermontsigma-clermont.fr
A school on the Clermont-Ferrand science campus offering specialized education in mechanical engineering and chemistry, with strong industry collaborations and cutting-edge research facilities |
179 | |||
| 12 |
NOREVA GROUPEnoreva-laboratoires.com
Development of high-tolerance dermatological skincare products addressing skin health holistically, suitable for all ages and skin conditions. |
163 | |||
| 13 |
AddUpaddupsolutions.com
Designs and sells metal additive manufacturing machines, including powder bed fusion and directed energy deposition systems, offering comprehensive support for industrial production transitions. |
162 | |||
| 14 | 153 | ||||
| 15 |
AFYRENafyren.com
Develops biobased compounds via patented fermentation for diverse industries like food and cosmetics, focusing on low-carbon and zero-waste production. |
145 | |||
Want more companies than this list?This page shows the largest ones only. Connect to Tamtam to see every company that matches, filter by size, industry or growth, and reach their decision-makers. | |||||
| 16 |
BIOCORPbiocorpsys.com
A French company specializing in connected medical devices, focusing on innovating solutions for patients with diabetes and other diseases |
144 | |||
| 17 |
MICHELIN Aircraft Tyreaircraft.michelin.com
Manufacturing bias and radial tires for military, commercial, regional, and general aviation markets. Essential for takeoff, landing, and taxiing aircraft. |
139 | |||
| 18 |
Babymoov Groupbabymoov.com
French company creating solutions for parents through 6 ranges: feeding, comfort, safety, caring, outdoor, playing. Products found in over 70 countries, lifetime warranty. |
129 | |||
| 19 |
CARBIOScarbios.com
Develops enzyme-based processes for plastic and textile biorecycling and biodegradation, promoting a circular economy with industrial-scale solutions supported by major brands. |
102 | |||
| 20 |
Sol Solution SASsol-solution.com
Design, develop, and distribute geotechnical investigation and compaction equipment with strong focus on innovation and research. |
102 | |||
| 21 |
COMPTE.Rcompte-r.com
Designs and manufactures wood and biomass thermal generators, leading renewable energy solutions with international presence across Europe and North America. |
89 | |||
| 22 |
AUBRILAMaubrilam.com
Designs and manufactures outdoor furniture to enhance urban spaces, offering over 300 customizable products for various environments worldwide |
86 | |||
| 23 |
GCK EMIgck-emi.com
Design and production of advanced embedded electronics and electromechanical components for mobility, including control units, power electronics, and industrial assemblies. |
83 | |||
| 24 | 77 | ||||
| 25 |
Top Clean Packaging Grouptopcleanpackaging.com
Manufacturing and supplying innovative packaging solutions using thermoforming, injection molding, assembly, and clean room packaging with ISO certifications. |
76 | |||
| 26 |
VERDOTverdot-biotechnologies.com
Design and supply of single-use and stainless steel purification systems for biopharmaceuticals, including chromatography and filtration solutions. |
71 | |||
| 27 |
CELTA - Groupe Rossmannrossmann.com
Family-owned independent supplier of custom corrugated packaging solutions Offering a wide range of eco-friendly products, including unique packaging solutions for fragile items and long objects |
69 | |||
| 28 |
CIDECOcideco.tech
The company specializes in diagnosing and rehabilitating buildings and structures, implementing IoT sensors for monitoring, creating 3D models, and promoting sustainable materials |
61 | |||
| 29 |
Issoire Aviationissoire-aviation.fr
Design, manufacture, and certification of high-performance composite aerospace components and complete aircraft, including proprietary all-carbon planes and subcontracting services. |
57 | |||
| 30 |
Brüggen Francebrueggen.com
European leader producing breakfast cereals for all ages, operating a major production site and R&D center in France. |
55 | |||
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How this list is built
Every company on this list has a Tamtam company profile. The industry is the one the company gives on LinkedIn; categories such as SaaS or fintech are classified by Tamtam's AI from the company's website and LinkedIn page; and the headquarters city must match the company's own address. Companies are ranked by the number of employees on LinkedIn, and the list is refreshed every night. Classifications can be wrong, so treat the list as a starting point rather than an official ranking. Last updated Nov 12, 2026.
More company lists in the Puy-de-Dôme department
- The largest companies in the Puy-de-Dôme department 585
- Manufacturers in the Puy-de-Dôme department 62
- Retail chains in the Puy-de-Dôme department 59
- Multinational companies in the Puy-de-Dôme department 51
- Public sector organisations in the Puy-de-Dôme department 42
- IT services companies in the Puy-de-Dôme department 34
- Hardware manufacturers in the Puy-de-Dôme department 33
- Family-owned companies in the Puy-de-Dôme department 33
- Professional services firms in the Puy-de-Dôme department 30
- Contract manufacturers in the Puy-de-Dôme department 29
- IT Services and IT Consulting companies in the Puy-de-Dôme department 29
The same list elsewhere in France
- Companies with in-house R&D in France 8,749
- Companies with in-house R&D in Île-de-France 2,695
- Companies with in-house R&D in Auvergne-Rhône-Alpes 1,460
- Companies with in-house R&D in Occitanie 680
- Companies with in-house R&D in Grand Est 640
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- Companies with in-house R&D in Nouvelle-Aquitaine 566
- Companies with in-house R&D in the Hauts-de-Seine department 510
- Companies with in-house R&D in the Rhône department 509
- Companies with in-house R&D in Pays de la Loire 480
- Companies with in-house R&D in Hauts-de-France 410
- Companies with in-house R&D in Brittany 366
- Companies with in-house R&D in the Haute-Garonne department 323
- Companies with in-house R&D in the Bouches-du-Rhône department 320
- Companies with in-house R&D in the Isère department 304
- Companies with in-house R&D in Bourgogne-Franche-Comté 261
- Companies with in-house R&D in the Nord department 237
- Companies with in-house R&D in Normandy 227
- Companies with in-house R&D in the Gironde department 225
- Companies with in-house R&D in the Loire-Atlantique department 207
- Companies with in-house R&D in the Essonne department 198
- Companies with in-house R&D in Centre-Val de Loire 195
- Companies with in-house R&D in Paris 1,249
- Companies with in-house R&D in Lyon 192