These companies in the Yonne department are predominantly involved in specialized manufacturing and biotechnology research, alongside significant civic and social organizations. Notable companies include EPNAK, which supports individuals with disabilities, and AFM-Téléthon, a patient-led association fighting rare genetic diseases. Genethon is a nonprofit laboratory developing gene therapy treatments, while FRUEHAUF specializes in manufacturing trailers. PNEU LAURENT is a European leader in heavy truck tire retreading, and Guernet designs and distributes compressed air equipment.
A significant cluster of biotechnology research firms is present, with several companies based in Évry focusing on gene therapy, genomics, and industrial biotechnology. This concentration suggests a specialized scientific and industrial base within the region.
| # | Company | Employees | |||
|---|---|---|---|---|---|
| 1 | 1,189 | ||||
| 2 |
AFM-Téléthonafm-telethon.fr
A parent and patient-led association fighting against rare and debilitating genetic diseases through research, patient support, and public awareness initiatives |
702 | |||
| 3 |
Genethongenethon.fr
Nonprofit laboratory developing gene therapy treatments for rare genetic diseases including neuromuscular, immune, blood, liver, and vision disorders. |
321 | |||
| 4 |
TopSolid Francetopsolid.com
Creating ideas efficiently and effectively through fast-paced production processes |
260 | |||
| 5 |
FRUEHAUFfruehauf.com
A French company specializing in manufacturing and marketing a wide range of trailers for transportation solutions, known for durability, innovation, and quality service |
256 | |||
| 6 |
Yposkesi, an SK pharmteco companyskpharmteco.com
Yposkesi is a leading CDMO in Europe specializing in gene therapy viral vector manufacturing for ATMPs, with a focus on innovation and quality |
137 | |||
| 7 |
Texcelltexcell.com
Texcell provides comprehensive support for biotech and pharma companies, offering services in virology, immunology, analytical labs, viral safety testing, and GMP cell banking |
107 | |||
| 8 |
PNEU LAURENTlaurentretread.com
European leader in heavy truck tire retreading, manufacturing premolded tread bands and offering products for civil engineering vehicles. |
80 | |||
| 9 |
Guernetguernet.com
Design and distribution of compressed air equipment, garage tools, mobile installations, and intervention vehicles with customer-focused technical support. |
69 | |||
| 10 |
Abolis Biotechnologiesabolis.fr
Develops tailor-made industrial solutions using microorganisms for various sectors, addressing challenges like renewable resources, supply chain security, and emissions reduction. |
66 | |||
| 11 |
CHARLATTE RESERVOIRS - Fayat groupfayat.com
Design and supply bladder type surge vessels and compressor regulated vessels for water, wastewater, and sewage applications worldwide with in-house hydraulic analysis. |
61 | |||
| 12 |
Conimast Internationalconimast.fr
Conimast, based in Saint-florentin, Yonne, operates a 110,000m² industrial site producing made in France lighting masts in-house, supporting local employment |
55 | |||
| 13 |
CHAROTcharot.com
This company specializes in HVAC engineering, offering a wide range of products, innovative solutions in thermal energy, and a commitment to sustainability and community involvement |
51 | |||
| 14 |
IntegraGenintegragen.com
Specializes in genomics of cancer and rare genetic diseases, providing DNA sequencing services and genomic data interpretation software for research institutes. |
44 | |||
| 15 |
ISOSTAisosta.com
Design and manufacture of sandwich panels, facades, and joinery fillings providing aesthetic, technical, innovative, and durable solutions for construction professionals. |
39 | |||
Want more companies than this list?This page shows the largest ones only. Connect to Tamtam to see every company that matches, filter by size, industry or growth, and reach their decision-makers. | |||||
| 16 |
MATREX | Conveyors for industry and airportmatrex.fr
A small business specializing in designing and manufacturing industrial handling solutions for baggage and various industries, located south of Paris |
35 | |||
| 17 |
Global Bioenergiesglobal-bioenergies.com
Development of unique processes producing sustainable aviation fuels and cosmetic ingredients from renewable resources, certified and supported by major industry players. |
34 | |||
| 18 |
EFIRACKefirack.fr
Specializing in designing solutions for datacenters, EFIRACK offers expertise in thermal corridors, server racks, cooling, security, and services, providing personalized installations for IT challenges |
30 | |||
| 19 |
Mistral Coolersmistralcoolers.com
Manufacture and innovation of durable, ergonomic water coolers focused on hygiene, performance, and user-friendly design for European markets. |
28 | |||
| 20 | 26 | ||||
| 21 |
TOPSOLID Corporatetopsolid.com
Leading publisher of CAD/CAM software, offering fully integrated solutions for mechanical, sheet metal, and wood industries worldwide. |
25 | |||
| 22 |
Eurofeedbackeurofeedback.com
Designing and manufacturing of electrical/electronic equipment for industrial, medical, and aesthetic sectors since 1989 in France |
20 | |||
| 23 | 13 | ||||
| 24 |
Abcell-bioabcell-bio.com
A company with 10 years in stem cell research, offering expertise in cell culture, hematopoiesis, and vascular biology using various cell types and custom media |
7 | |||
| 25 | 6 | ||||
| 26 |
Infodevinfodev.fr
A software company specializing in ERP solutions for industrial businesses, offering software for sales, purchasing, production, and tailored software development services |
6 | |||
| 27 |
NEED-Roboticsneedrobotics.net
Specializing in robotics, mechatronics, and industrial automation, we provide innovative solutions tailored to market needs, based in France |
6 | |||
| 28 |
SE-Therapeuticssetherapeutics.com
Innovative technology for intracellular delivery of antibodies and gene editing RNPs to provide life-changing cures for cancer and neurodegenerative disorders |
6 | |||
| 29 |
EDE Innovede-innov.com
Specializing in designing and implementing custom machines, prototypes, and innovative products across various industries, with expertise in mechanics, electronics, sensors, and industrial computing |
4 | |||
| 30 |
IDC MEDICALidc-medical.com
A French company developing custom solutions based on identified medical issues, with a focus on high disinfection of medical devices |
2 | |||
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Every company on this list has a Tamtam company profile. The industry is the one the company gives on LinkedIn; categories such as SaaS or fintech are classified by Tamtam's AI from the company's website and LinkedIn page; and the headquarters city must match the company's own address. Companies are ranked by the number of employees on LinkedIn, and the list is refreshed every night. Classifications can be wrong, so treat the list as a starting point rather than an official ranking. Last updated Nov 11, 2026.
More company lists in the Yonne department
The same list elsewhere in France
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- Companies with in-house R&D in the Rhône department 509
- Companies with in-house R&D in Pays de la Loire 480
- Companies with in-house R&D in Hauts-de-France 410
- Companies with in-house R&D in Brittany 366
- Companies with in-house R&D in the Haute-Garonne department 323
- Companies with in-house R&D in the Bouches-du-Rhône department 321
- Companies with in-house R&D in the Isère department 304
- Companies with in-house R&D in Bourgogne-Franche-Comté 261
- Companies with in-house R&D in the Nord department 237
- Companies with in-house R&D in Normandy 227
- Companies with in-house R&D in the Gironde department 225
- Companies with in-house R&D in the Loire-Atlantique department 207
- Companies with in-house R&D in the Essonne department 198
- Companies with in-house R&D in Centre-Val de Loire 195
- Companies with in-house R&D in Paris 1,249
- Companies with in-house R&D in Lyon 192