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AI-native companies headquartered in Massachusetts

Tamtam tracks 88 AI-native companies headquartered in Massachusetts. This list ranks all of them by number of employees on LinkedIn, led by Nuance Communications, ArisGlobal and Cerence AI. Their median headcount is 176. Half of them were founded in 2016 or later. The most common headquarters are Boston (47), Cambridge (17) and Burlington (6).

馃嚭馃嚫 Massachusetts88 companiesUpdated Oct 24, 2026
#CompanyIndustryHeadquarters EmployeesFounded
1
Nuance Communicationsdragon.nuance.com

Development of conversational, ambient, and generative AI solutions serving hospitals and Fortune 100 companies to enhance communication and assistance.

Software Development 馃嚭馃嚫 Burlington 3,369 n/a
2
ArisGlobalarisglobal.com

Transforms life sciences companies by automating drug development with an integrated technology platform, boosting efficiency, ensuring compliance, and reducing costs.

Software Development 馃嚭馃嚫 Waltham 2,028 1987
3
Cerence AIcerence.com

A global leader in creating AI-powered interactive experiences for connected mobility, partnering with automakers to advance the future of transportation

Software Development 馃嚭馃嚫 Burlington 1,195 2019
4
Motionalmotional.com

Innovating driverless technology to create safe, reliable, and accessible vehicles through a joint venture between Aptiv and Hyundai Motor Group

Software Development 馃嚭馃嚫 Boston 970 2020
5
TraceLinktracelink.com

The company specializes in building integrated business ecosystems and supply chain solutions for digitization, leveraging industry intelligence for customer-centric agility

Software Development 馃嚭馃嚫 Wilmington 922 2009
6
DataRobotdatarobot.com

Value-driven AI company accelerating AI impact with innovative AI lifecycle platform for organizations to build, operate, and govern AI landscapes confidently

Software Development 馃嚭馃嚫 Boston 881 2012
7
ConcertAIconcertai.com

Innovative AI-powered SaaS data company specializing in healthcare, experiencing rapid growth as a leader in the industry

Biotechnology Research 馃嚭馃嚫 Cambridge 840 2018
8
Motusmotus.com

Specializes in vehicle reimbursement solutions and driver risk mitigation, leveraging extensive data to reduce corporate risk exposure.

Software Development 馃嚭馃嚫 Boston 840 2004
9
Advisor360掳advisor360.com

Utilize a SaaS WealthTech platform to enhance productivity, generate more revenue, streamline operations, and mitigate costs and regulatory risk

Financial Services 馃嚭馃嚫 Needham 626 n/a
10
smartShiftsmartshift.com

AI-powered solutions for SAP customers focusing on rapid, secure, and optimized custom code migration and modernization, trusted globally.

Software Development 馃嚭馃嚫 Boston 586 2002
11
All jobsalljobs.ai

An AI-driven recruitment marketing platform that efficiently publishes job postings to Google for Jobs and attracts high-quality candidates quickly

Human Resources Services 馃嚭馃嚫 Westford 549 n/a
12
FORMform.com

It provides mobile technology solutions for frontline workers, enhancing task management, communication, and decision-making for enterprises and Fortune 500 companies.

Software Development 馃嚭馃嚫 Quincy 507 2002
13
Mentor Collectivementorcollective.org

Provider of impact-driven mentoring programs for higher education institutions, with proven results in reducing melt rates and increasing retention Industry-leading and mission-driven Hiring opportunities available

Business Intelligence Platforms 馃嚭馃嚫 Boston 496 2015
14
Cambridge Mobile Telematicscmtelematics.com

AI-driven platform identifying and reducing driving risks, partnering with insurers and automakers to prevent crashes and enhance road safety worldwide.

Software Development 馃嚭馃嚫 Cambridge 477 2010
15
Penterapentera.io

AI-powered Automated Security Validation for enterprise teams. Emulates real-world attacks across on-prem, cloud, and external environments to reveal exploitable vulnerabilities.

Computer and Network Security 馃嚭馃嚫 Burlington 469 2015
16
NetBrain Technologies Inc.netbraintech.com

Network automation and observability platform founded in 2004, enabling quick transformation of hybrid network operations into automation, used by global enterprises

Software Development 馃嚭馃嚫 Burlington 438 2004
17
Sunosuno.com

Platform enabling music creation for all skill levels, removing barriers and allowing users to create songs using imagination alone.

Technology, Information and Internet 馃嚭馃嚫 Cambridge 424 2022
18
codemantracodemantra.com

Global leader providing AI-driven Intelligent Document Processing platform for automating digital document accessibility, extraction, classification, and transformation services across various industries

IT Services and IT Consulting 馃嚭馃嚫 Boston 420 2002
19
Lendbuzzlendbuzz.com

An AI auto finance platform using alternative data and machine-learning to provide fair credit access for car purchases to underserved consumers and support dealership growth

Financial Services 馃嚭馃嚫 Boston 389 2015
20
Texttext.com

The company provides tools for better customer service, including live chat, chatbots, helpdesk, knowledge base, and website widgets, enabling automation and scalability

Artificial Intelligence 馃嚭馃嚫 Boston 386 2002
21
Berkshire Greyberkshiregrey.com

Revolutionizing business through AI and Robotics, Berkshire Grey automates omni-channel fulfillment for retailers, eCommerce, and logistics, advancing pick, pack, and sort operations

Robot Manufacturing 馃嚭馃嚫 Bedford 373 2013
22
BostonGenebostongene.com

BostonGene specializes in providing transformative AI-integrated molecular analytics for precision matching of therapies for cancer and immune-related diseases, improving patient lives

Biotechnology Research 馃嚭馃嚫 Waltham 370 2015
23
XtalPi Inc.en.xtalpi.com

A quantum physics-based, AI-powered drug R&D company revolutionizing drug discovery with integrated technology platform and support from renowned investors

Biotechnology Research 馃嚭馃嚫 Cambridge 349 2015
24
Validity Inc.validity.com

It provides solutions for marketing, sales, and customer success teams to effectively target, engage, and retain customers using data.

Software Development 馃嚭馃嚫 Boston 348 2018
25
OVERJEToverjet.com

A dental AI company founded by MIT and Harvard experts, Overjet provides FDA-cleared technology for precise pathology detection and patient education

Software Development 馃嚭馃嚫 Boston 341 2018
26
CallMinercallminer.com

It provides AI-powered conversation intelligence to analyze customer interactions, enabling organizations to improve customer experience and drive business growth.

Software Development 馃嚭馃嚫 Waltham 336 2002
27
Generate:Biomedicinesgeneratebiomedicines.com

Innovating in generative biology to develop innovative therapeutics that drive breakthroughs in the field

Biotechnology Research 馃嚭馃嚫 Somerville 335 n/a
28
Cynet Securitycynet.com

All-in-one cybersecurity platform providing unified protection, detection, and expert support tailored for small-to-medium enterprises and MSPs.

Computer and Network Security 馃嚭馃嚫 Boston 334 2014
29
DeepHealthdeephealth.com

An AI-powered subsidiary focused on healthcare informatics, DeepHealth aims to enhance care delivery by leveraging advanced AI technologies and personalized workflows

Hospitals and Health Care 馃嚭馃嚫 Cambridge 307 n/a
30
PathAIpathai.com

AI-powered pathology company improving patient outcomes through accurate diagnosis and effective treatment, leveraging machine learning with a diverse and passionate team

Software Development 馃嚭馃嚫 Boston 281 2016
31
Drift, a Salesloft companydrift.com

Inspires businesses engaging customer experiences. Translates conversational data, buyer behavior into deeper relationships, more pipeline and revenue. Human-centric, AI-powered platform delivers personalized experiences.

Software Development 馃嚭馃嚫 Boston 271 2015
32
Mend.iomend.io

A company offering an enterprise suite of application security tools to help build and manage proactive AppSec programs, fostering collaboration between dev and security teams

Software Development 馃嚭馃嚫 Boston 257 2011
33
Saras Analyticssarasanalytics.com

Builds AI workforce and enterprise tools for D2C brands, simplifying complex data challenges and enabling informed decisions through better data infrastructure and expert services.

Data Infrastructure and Analytics 馃嚭馃嚫 Westborough 215 2016
34
TetraSciencetetrascience.com

A Scientific Data and AI Cloud platform connecting lab instruments and software to accelerate scientific discovery in the biopharma industry

Software Development 馃嚭馃嚫 Boston 213 2019
35
Simerasimera.me

AI-powered platform for global remote hiring, vetting, onboarding, training, and managing professionals for businesses without upfront costs.

Software Development 馃嚭馃嚫 Cambridge 199 2021
36
Lakeside Softwarelakesidesoftware.com

AI-driven platform providing proactive IT management, reducing costs, preventing failures, and enhancing decision-making through comprehensive digital employee experience insights.

Software Development 馃嚭馃嚫 Boston 198 1997
37
Kensho Technologieskensho.com

An engineering-driven company in Cambridge, MA, using AI to extract insights from messy data for critical business decisions

Software Development 馃嚭馃嚫 Cambridge 189 2013
38
Anumanaanumana.ai

Utilizing AI and translational science, Anumana decodes electrical signals from the heart to enable earlier diagnoses and life-saving treatments in cardiac care

Technology, Information and Internet 馃嚭馃嚫 Cambridge 183 2021
39
Teikametricsteikametrics.com

Teikametrics helps Amazon and Walmartcom sellers grow with AI technology, data analysis, and marketplace expertise Optimizing advertising, inventory, and market intelligence

Technology, Information and Internet 馃嚭馃嚫 Boston 180 2015
40
Videavidea.ai

Transforms dentistry with AI-powered solutions, reducing complexity, elevating care standards, improving productivity, and driving business value across diagnostics, workflows, analytics, and revenue optimization.

Software Development 馃嚭馃嚫 Boston 180 2018
41
Poshposh.ai

Revolutionizing banking with AI technology developed at MIT, Posh automates contact centers and customer interactions for financial institutions Join our innovative team!

Software Development 馃嚭馃嚫 Boston 178 2018
42
The AI Institutetheaiinstitute.com

A research-driven organization in Cambridge focusing on AI and robotics to develop intelligent machines for productivity, safety, and human well-being

Research Services 馃嚭馃嚫 Cambridge 177 2022
43
Wysawysa.com

An AI-enabled mental wellness platform offering early intervention through AI chatbot, self-help tools, and therapist support, serving millions globally

Mental Health Care 馃嚭馃嚫 Boston 177 2015
44
Iterative Healthiterative.health

Leading computational gastroenterology company utilizing AI tools for physician decision support, drug development acceleration, and clinical trial facilitation in Cambridge, MA

Pharmaceutical Manufacturing 馃嚭馃嚫 Cambridge 176 2017
45
Jobiakjobiak.ai

AI-based recruitment marketing platform helping recruiters publish job postings on Google for Jobs quickly, maximizing visibility and attracting qualified candidates with ease

Software Development 馃嚭馃嚫 Burlington 176 2018
46
Nextuplenextuple.com

Nextuple Inc specializes in leveling the playing field for Omnichannel retailers by utilizing microservices to enhance fulfillment experiences and accelerate time-to-value

IT Services and IT Consulting 馃嚭馃嚫 Andover 171 2017
47
Originuseorigin.com

Integrated money management platform for modern workforce, offering solutions for compensation, benefits, and personal finances with support from financial professionals

Financial Services 馃嚭馃嚫 Boston 167 2018
48
Beacon Biosignalsbeacon.bio

This company uses an AI platform, FDA-cleared EEG wearables, and machine learning algorithms to develop new treatments for neurological and psychiatric diseases

Software Development 馃嚭馃嚫 Boston 167 2019
49
Persivia Inc.persivia.com

Persivia provides an AI-driven platform for managing value-based care models, integrating data sources for real-time insights and clinical decision support

Hospitals and Health Care 馃嚭馃嚫 Marlborough 165 2005
50
Progress Data Platformprogress.com

The company offers a data platform to unlock data value, accelerate decisions, and achieve data agility by combining data with metadata for smarter decisions

Software Development 馃嚭馃嚫 Burlington 160 2001
51
Minemineos.ai

Leading data privacy platform offering simplified compliance through unique automation and ML-assisted features, making managing data requests, consent, and compliance effortless

Technology, Information and Media 馃嚭馃嚫 Boston 153 2019
52
Findability Sciencesfindability.ai

Findability Sciences specializes in AI solutions for traditional enterprises, offering advanced forecasting and business process co-pilots through their proprietary platform

IT Services and IT Consulting 馃嚭馃嚫 Boston 151 2018
53
Point Wildpointwild.com

Provides AI-driven data breach resilience, response, and remediation for consumer and enterprise endpoints using extensive threat data and network effects.

Data Security Software Products 馃嚭馃嚫 Boston 149 n/a
54
PaxeraHealthpaxerahealth.com

Develops enterprise imaging AI platform and no-code algorithm authoring platform for democratizing AI in medical imaging, improving diagnosis, and reducing physician burnout.

Hospitals and Health Care 馃嚭馃嚫 Boston 149 2009
55
Fairmarkitfairmarkit.com

An autonomous sourcing platform utilizing AI to help organizations source competitively at scale, resulting in significant cost savings for procurement teams

Software Development 馃嚭馃嚫 Boston 146 2017
56
Atomicworkatomicwork.com

Provides an agentic service management platform, unifying AI Coworkers, a Universal Agent, and an AI Automation Engine to simplify enterprise IT support and service operations.

Technology, Information and Internet 馃嚭馃嚫 Palo Alto 146 2022
57
Zoovuzoovu.com

It provides AI-driven product discovery solutions for enterprises, enhancing customer engagement and satisfaction across various channels and product categories.

Technology, Information and Internet 馃嚭馃嚫 Boston 140 2006
58
Gryphon AIgryphon.ai

It offers AI-powered conversation intelligence and compliance solutions, ensuring real-time guidance for sales and customer service teams during calls.

Software Development 馃嚭馃嚫 Boston 134 1999
59
Gradient AIgradientai.com

A leading provider of AI solutions for the insurance industry, improving loss ratios, profitability, and operational efficiencies through predictive analytics and intelligent automation

Software Development 馃嚭馃嚫 Boston 130 2018
60
Implicityimplicity.com

Provides a universal cardiac remote monitoring and research platform to hospitals and clinics, enhancing remote care for cardiac patients.

Hospitals and Health Care 馃嚭馃嚫 Cambridge 125 2016
61
Mirai RiskTechmirairisktech.com

Global technology leader in Balance Sheet Management, Financial Risks, and Regulation, offering enterprise SaaS solutions and consulting services for banks worldwide

Software Development 馃嚭馃嚫 Boston 120 2013
62
Tamrtamr.com

It provides an AI-native Master Data Management solution for real-time data accessibility, enhancing decision-making, revenue growth, and customer experiences.

Software Development 馃嚭馃嚫 Cambridge 119 2013
63
Proton.aiproton.ai

AI-powered CRM centralizing customer, product, and sales data to guide distributor sales reps on where to focus for success.

Software Development 馃嚭馃嚫 Cambridge 118 2018
64
BriefCam (Now Milestone)milestonesys.com

The company provides leading video analytics software for unlocking insights from video surveillance content, benefiting organizations across various industries for operational intelligence

Software Development 馃嚭馃嚫 Newton 117 2007
65
Databoxlinktr.ee

It provides tools for tracking and improving business performance through custom dashboards, reports, and goal-setting, fostering a supportive work environment.

Technology, Information and Internet 馃嚭馃嚫 Boston 116 2012
66
Soniosonio.ai

Innovative women's health practice management software powered by AI for prenatal examinations, ultrasound readings, and clinical excellence throughout pregnancy

Software Development 馃嚭馃嚫 Boston 111 2020
67
Mainstaymainstay.com

The company specializes in an Engagement Platform that facilitates conversations, drives action at scale, and helps individuals progress towards their goals

Higher Education 馃嚭馃嚫 Boston 90 2014
68
hOS Inchosinc.co

An early-stage AI technology company founded by DataRobot alumni, operating in stealth-mode to develop scalable technologies for positive change

IT Services and IT Consulting 馃嚭馃嚫 Boston 79 n/a
69
United Imaging Intelligenceuii-ai.com

A leading international medical AI company founded in 2017, providing innovative solutions for healthcare through AI technology in various medical fields

Research Services 馃嚭馃嚫 Boston 70 2017
70
lowtouch.ailowtouch.ai

Cloud Control Solutions specializes in Cloud Migration, Modernization, and Management with a Kubernetes-first approach to deliver reliable, cost-optimized solutions

Technology, Information and Internet 馃嚭馃嚫 Boston 65 2018
71
Bluesensesmartbeauty.bluesense.ai

A leading AI company specializing in computer vision, machine learning, and AI technology to create innovative solutions and offer top-notch consultancy services

IT Services and IT Consulting 馃嚭馃嚫 Boston 62 2023
72
Akkioakkio.com

It offers an AI data platform that allows users to interact with data, create visualizations, and forecast business outcomes efficiently.

Software Development 馃嚭馃嚫 Cambridge 57 2019
73
Reprisereprise.com

It provides a comprehensive platform for creating customized sales demos, interactive leave-behinds, and product tours for enterprise teams.

Software Development 馃嚭馃嚫 Boston 54 2020
74
EAIGLEeaigle.com

An AI platform for supply chain and retail industries, offering solutions for automated vehicle access control, yard monitoring, and warehouse pallet tracking

Software Development 馃嚭馃嚫 Boston 42 2018
75
Tessianproofpoint.com

A leading cloud email security platform using machine learning to protect organizations against advanced threats and data loss, while coaching on security awareness

Computer and Network Security 馃嚭馃嚫 Boston 41 2013
76
Outcomes4Meoutcomes4me.com

AI-driven platform empowering cancer patients with personalized treatment options, real-time clinical information, and promoting health equity and innovation in healthcare

Wellness and Fitness Services 馃嚭馃嚫 Boston 32 2017
77
APERIOaperio.ai

This company specializes in industrial data quality solutions, utilizing AI machine learning to validate operational data for improved accuracy and decision-making

Software Development 馃嚭馃嚫 Boston 30 2017
78
Yobe Inc.yobeinc.com

Yobe specializes in intelligent voice control software for brands, enabling accurate voice interactions in noisy environments and offering expertise in voice data analysis

Software Development 馃嚭馃嚫 Boston 25 2016
79
Provarityprovarity.ai

It provides an AI-powered platform for sales engineers to enhance efficiency, shorten sales cycles, and improve overall sales performance.

Software Development 馃嚭馃嚫 Boston 23 2018
80
Spiro.AIspiro.ai

It provides AI-driven CRM solutions for manufacturers and distributors, enhancing customer engagement and driving significant business growth through automation.

Software Development 馃嚭馃嚫 Boston 20 2014
81
Fundzfundz.net

It provides a real-time database of companies with new funding, executives, or acquisitions, integrated with key contact information.

Technology, Information and Internet 馃嚭馃嚫 Braintree 14 2015
82
Emerald Innovationsemeraldinno.com

A healthcare startup using machine learning and wireless sensing to develop digital biomarkers for disease management and drug development

Software Development 馃嚭馃嚫 Cambridge 14 2016
83
Waffle Labswaffle-labs.com

An insurtech startup disrupting traditional insurance by providing personalized, transparent, and affordable insurance solutions such as renters, pet, cyber, and term life insurance

Technology, Information and Internet 馃嚭馃嚫 Boston 13 2018
84
NuMind (YC S22)numind.ai

Provider of large language models specialized in extracting structured information from documents using NuExtract and NuMarkdown models.

Software Development 馃嚭馃嚫 Cambridge 12 2022
85
Phoenix AIphoenixpitchdeck.webflow.io

The company develops AI-powered software to combat non-consensual sexual abuse material online by automating the takedown process and preserving evidence

Computer and Network Security 馃嚭馃嚫 Baltimore 9 n/a
86
Teranalyticsteranalytics.com

Tech company specializing in data analytics, AI, and Big Data Develops predictive machine learning solutions for various industries such as market forecasting, customer segmentation, and supply chain management

Software Development 馃嚭馃嚫 Newton 4 2016
87
Terawatt Energyterawattenergies.com

A renewable energy company providing customized solar solutions to increase access to clean energy for individuals, families, and communities worldwide

Services for Renewable Energy 馃嚭馃嚫 Cambridge 4 2019
88
Daotong Venturesdaotong.ai

Venture capital firm specializing in investing in companies that leverage artificial intelligence technology to drive growth and innovation

Financial Services 馃嚭馃嚫 Brookline 3 n/a

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How this list is built

Every company on this list has a Tamtam company profile. The industry is the one the company gives on LinkedIn; categories such as SaaS or fintech are classified by Tamtam's AI from the company's website and LinkedIn page; and the headquarters city must match the company's own address. Companies are ranked by the number of employees on LinkedIn, and the list is refreshed every night. Classifications can be wrong, so treat the list as a starting point rather than an official ranking. Last updated Oct 24, 2026.

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