This selection of companies with in-house R&D in Massachusetts comprises mostly large corporations. They operate across diverse sectors, including biotechnology, medical equipment, higher education, and industrial machinery. Key players include Thermo Fisher Scientific, a global leader in science services; GE, focusing on aviation and energy industries; Boston Scientific, which develops medical technologies; and Harvard University, dedicated to teaching and research.
A notable pattern among these companies is their strong presence in Boston and Cambridge, indicating a concentration of research and development activities in these urban centers. The list also highlights a mix of well-established institutions like Harvard University, founded in 1636, and more recent technology companies such as Amazon Fulfillment Technologies & Robotics, established in 2003.
| # | Company | Employees | |||
|---|---|---|---|---|---|
| 1 |
Thermo Fisher Scientificthermofisher.com
A global leader in science services, providing innovative technologies and pharmaceutical support to make the world healthier, cleaner, and safer |
100,256 | |||
| 2 | 99,488 | ||||
| 3 |
GE Vernovalinktr.ee
A purpose-built company focused on electrifying the planet and decarbonizing it through a diverse portfolio of energy businesses, ensuring reliable and sustainable energy |
70,646 | |||
| 4 |
Boston Scientificbostonscientific.com
Develops and provides innovative medical technologies including devices and therapies for various diseases, improving patient health and reducing healthcare costs worldwide. |
54,633 | |||
| 5 |
Harvard Universityharvard.edu
An institution dedicated to teaching, learning, and research, producing global leaders across disciplines since 1636 Maintains flagship social media channels |
34,940 | |||
| 6 |
Analog Devicesanalog.com
Global semiconductor company combining analog, digital, and software technologies to advance digitized factories, mobility, healthcare, and climate solutions. |
27,234 | |||
| 7 |
Publicis Sapientpublicissapient.com
A digital business transformation partner, specializing in strategy, product, experience, engineering, data, and delivering impactful solutions to global organizations |
24,251 | |||
| 8 |
Massachusetts Institute of Technologyweb.mit.edu
A private research university in Cambridge, Massachusetts, advancing knowledge and educating students in science and technology-focused areas |
23,586 | |||
| 9 |
Charles River Laboratoriescriver.com
Guided by strong purpose, creating healthier lives, focusing on therapeutics for patients, animal care, planet well-being, and its passionate, skilled people. |
22,000 | |||
| 10 | 20,440 | ||||
| 11 |
Massachusetts General Hospitalmassgeneral.org
Dedicated to providing top-notch healthcare in a compassionate environment through innovative research and education, improving health in diverse communities served |
20,001 | |||
| 12 |
Amazon Fulfillment Technologies & Roboticsamazon.jobs
The company partners people with intelligent robots to enhance order fulfillment accuracy, create new jobs worldwide, and improve customer experience |
17,911 | |||
| 13 |
Mass General Brighammassgeneralbrigham.org
Integrated academic health system providing patient care, research, teaching, and community services through hospitals, insurance, and specialized medical centers. |
17,890 | |||
| 14 |
Boston Children's Hospitalchildrenshospital.org
A leading pediatric medical center providing comprehensive healthcare services for children from birth to 21 years, with specialized clinical programs and renowned physicians |
17,496 | |||
| 15 |
Keurig Dr Pepper Inc.keurigdrpepper.com
Leading North American beverage company with extensive portfolio including coffee, soft drinks, water, juice, and mixers, strong distribution network. |
13,948 | |||
| 16 |
Wayfairaboutwayfair.com
Destination for all things home, offering expert customer service, tools for easy shopping, and wide selection to help create personalized spaces |
12,524 | |||
| 17 |
Harvard Business Schoolhbs.edu
Offers MBA, PhD, executive education, and online programs focused on leadership development, business practice, and entrepreneurship worldwide. |
12,457 | |||
| 18 |
HubSpothubspot.com
It provides a comprehensive CRM platform with marketing, sales, and service tools, fostering employee growth and a flexible workplace culture. |
12,229 | |||
| 19 |
Harvard Medical Schoolhms.harvard.edu
A prestigious medical school fostering a diverse community of leaders dedicated to advancing knowledge, education, and research to alleviate human suffering |
12,076 | |||
| 20 |
University at Buffalobuffalo.edu
Extraordinary community, creative activity and research changing the world. New York State's flagship university, AAU member. |
11,906 | |||
| 21 |
Waters Corporationwaters.com
A global leader in analytical instruments and software, pioneering innovations in chromatography, mass spectrometry, and thermal analysis for various sciences |
11,842 | |||
| 22 |
New Balancenewbalance.com
Designing and manufacturing high-quality athletic footwear and apparel with a focus on comfort, fit, innovation, and community support worldwide. |
11,624 | |||
| 23 |
University of Massachusetts Amherstumass.edu
A top-ranked teaching and research institution in western Massachusetts with about 28,500 students, part of the University of Massachusetts system |
11,525 | |||
| 24 |
UMass Memorial Healthummhealth.org
Largest healthcare system in Central Massachusetts offering hospital care, outpatient services, medical training, research, and community health support. |
10,819 | |||
| 25 |
Akamai Technologiesakamai.com
A global leader in internet infrastructure, Akamai powers and protects online experiences for billions of users daily through innovative solutions |
10,647 | |||
| 26 |
Dana-Farber Cancer Institutedana-farber.org
Providing expert, compassionate care to children and adults with cancer while advancing understanding, treatment, cure, and prevention. |
8,981 | |||
| 27 |
athenahealthathenahealth.com
The company strives to simplify healthcare with innovative technology for electronic health records, revenue cycle management, and patient engagement solutions |
8,956 | |||
| 28 |
Netcracker Technologynetcracker.com
It is a software company providing critical solutions for service providers, focusing on digital transformation and cloud opportunities worldwide. |
8,935 | |||
| 29 | 8,184 | ||||
| 30 |
Toastpos.toasttab.com
Toast empowers restaurants with cloud-based software and hardware to streamline operations, drive revenue, and enhance guest experience through POS, marketing, and HR solutions |
7,762 | |||
| 31 |
Biogenbiogen.com
Company pioneers innovative science, delivering new medicines to transform patients' lives, with a global presence and focus on superior treatment outcomes. |
7,724 | |||
| 32 |
Sensata Technologiessensata.com
Supplier of sensing, electrical protection, control, and power management solutions enhancing safety, efficiency, and comfort across multiple industries worldwide. |
7,634 | |||
| 33 |
Hologic, Inc.hologic.com
Develops innovative medical products, especially for women's health, focusing on early detection and better outcomes across breast, skeletal, diagnostic, and GYN surgical solutions. |
6,921 | |||
| 34 |
Modernamodernatx.com
Pioneering mRNA technology for new medicines to improve patient lives by providing real-time instructions for protein production in cells |
6,906 | |||
| 35 |
Partners HealthCarepartners.org
Integrated healthcare system offering coordinated care, high-quality services, research, teaching, and community outreach through academic medical centers and various healthcare entities |
6,751 | |||
| 36 |
Bose Corporationbose.com
Develops advanced audio technologies and products for home, automotive, portable, and public spaces, enhancing music listening experiences worldwide. |
6,699 | |||
| 37 |
Entegrisentegris.com
A global leader in advanced science-based solutions for technology challenges, driving innovation with artificial intelligence, augmented reality, and IoT technologies |
6,612 | |||
| 38 |
Vertex Pharmaceuticalsvrtx.com
Global biotechnology company focusing on creating medicines for serious and life-threatening diseases, with a pioneering history in treating cystic fibrosis |
6,382 | |||
| 39 |
Baystate Healthbaystatehealth.org
Largest healthcare organization in western Massachusetts providing quality, compassionate care across hospitals, improving community health and economic impact. |
6,269 | |||
| 40 |
Teradyneteradyne.com
This company provides advanced test solutions for semiconductors, electronic systems, wireless devices, and robotics to improve productivity and lower costs for manufacturers worldwide |
6,210 | |||
| 41 |
Dynatracedynatrace.com
This company specializes in providing a platform that unifies observability, business, and security data with AI-driven analytics and automation to optimize cloud operations and ensure flawless digital experiences |
6,090 | |||
| 42 |
Veolia | North Americaveolianorthamerica.com
Provides resource management solutions including water decontamination, toxic waste handling, fossil fuel alternatives, wastewater reuse, and battery recycling for cities and industries. |
5,812 | |||
| 43 |
DraftKings Inc.careers.draftkings.com
The company is committed to creating popular games and betting experiences, leading the way in sports entertainment, innovation, and global collaboration |
5,760 | |||
| 44 |
Pegasystemspega.com
It provides a low-code platform for organizations to enhance agility, automate workflows, and address business challenges using AI technology. |
5,569 | |||
| 45 |
eClinicalWorkseclinicalworks.com
It provides Electronic Health Record and Practice Management solutions to medical professionals, enhancing care quality and reducing costs through technology. |
5,426 | |||
| 46 |
Insulet Corporationinsulet.com
Simplifying diabetes management for individuals with the Omnipod platform, offering tubeless, wearable insulin delivery and automated blood sugar control without injections or fingersticks globally. |
5,407 | |||
| 47 |
Alexion Pharmaceuticals, Inc.alexion.com
Development of innovative medicines targeting rare diseases, focusing on complement system biology, expanding global reach to serve patients worldwide. |
5,112 | |||
| 48 |
Brukerbruker.com
Development and provision of advanced analytical instrumentation and solutions for research, industrial production, quality assurance, and process reliability worldwide. |
4,824 | |||
| 49 | 4,581 | ||||
| 50 |
Rocket Softwarerocketsoftware.com
Partner for organizations transforming IT infrastructure, applications, and data from core systems to cloud with global support and innovation. |
4,385 | |||
Want more companies than this list?This page shows the largest ones only. Connect to Tamtam to see every company that matches, filter by size, industry or growth, and reach their decision-makers. | |||||
| 51 |
Progress Softwareprogress.com
Helping businesses drive innovation and success with high-impact application products, deployment flexibility, and secure management solutions, trusted by enterprises and developers worldwide |
4,212 | |||
| 52 |
SharkNinjasharkninja.com
A global product design and technology company known for innovative 5-star rated lifestyle solutions in household product categories like Cleaning, Cooking, and Food Preparation |
4,199 | |||
| 53 |
Quantiphiquantiphi.com
An AI-first digital engineering company that solves complex business problems with industry experience, cloud, data engineering, and cutting-edge AI research |
4,105 | |||
| 54 |
Aspen Technologyaspentech.com
Global software leader enabling industries to meet demand sustainably by optimizing asset design, operation, and maintenance lifecycle for improved operational excellence |
4,065 | |||
| 55 |
Roswell Park Comprehensive Cancer Centerroswellpark.org
A comprehensive cancer center offering cutting-edge care, research, and education to reduce the cancer burden and set national standards |
3,751 | |||
| 56 |
Cabot Corporationcabotcorp.com
Global specialty chemical and performance materials company providing solutions to address current challenges and future customer needs worldwide. |
3,719 | |||
| 57 |
MEDITECHehr.meditech.com
Healthcare organization empowering digital transformation with an intuitive and interoperable EHR system, cloud-based solutions, and personalized mobile tools to enhance efficiency and outcomes |
3,702 | |||
| 58 |
Revvityrevvity.com
Revvity specializes in innovative health science solutions, technologies, and services for healthcare advancements worldwide, covering discovery, development, and diagnosis to cure |
3,569 | |||
| 59 |
University of Massachusettsyoutube.com
Public university system offering high-quality education, conducting extensive research, and providing impactful public service to communities locally and globally. |
3,476 | |||
| 60 |
BeOne Medicinesbeonemedicines.com
Developing innovative, affordable cancer treatments for hematology and solid tumors with a global team and collaborative approach. |
3,350 | |||
| 61 |
Rapid7rapid7.com
Global leader in AI-powered managed cybersecurity operations, advancing organizations' cyber resilience through integrating security data, AI, and threat intelligence to reduce risk and disrupt attackers. |
3,268 | |||
| 62 |
Broad Institute of MIT and Harvardbroadinstitute.org
Multidisciplinary teams collaborate across labs and programs to address complex biomedical challenges in human biology and disease worldwide. |
3,204 | |||
| 63 |
Saint-Gobain Abrasivessaint-gobain-surfacesolutions.com
The company offers powerful and precise abrasives solutions for various markets, focusing on customization, performance, and safety with global presence |
3,196 | |||
| 64 |
Preciselyprecisely.com
Provides data integrity solutions that enhance data quality, integrate datasets, and support analytics for organizations worldwide, ensuring reliable business insights. |
3,014 | |||
| 65 |
CCL Labelccllabel.com
Global leader in innovative label solutions for various industries, offering pressure sensitive and extruded film materials, metal components, and complementary products worldwide |
2,988 | |||
| 66 |
Draperdraper.com
A nonprofit engineering innovation company advancing technologies for national security through collaboration with government, academia, and industry to solve complex challenges |
2,932 | |||
| 67 |
Suffolk Constructionsuffolk.com
National construction management firm providing real estate investment, design, self-perform construction, technology investment, and innovation research services across multiple industries. |
2,923 | |||
| 68 |
Viant Medicalviantmedical.com
Global provider of design and manufacturing services for medical devices across various specialties, offering end-to-end capabilities from development to packaging. |
2,921 | |||
| 69 |
Klaviyoklaviyo.com
Unified customer platform empowering brands with ownership of consumer data to automate personalized email/SMS communications, foster customer relationships, and drive growth |
2,902 | |||
| 70 |
Alnylam Pharmaceuticalsalnylam.com
A global biotech company pioneering RNAi therapeutics to treat rare genetic diseases, with a breakthrough product and a robust pipeline |
2,883 | |||
| 71 |
CyberArkcyberark.com
Global leader in identity security. Offers comprehensive security for human and machine identities across applications, workforces, cloud, and DevOps lifecycle. |
2,712 | |||
| 72 |
NETSCOUTnetscout.com
This company provides a Visibility Without Borders platform to help essential organizations manage complex networks, unlock insights, anticipate problems, and stay unstoppable |
2,708 | |||
| 73 |
Acushnet Companyemployment.acushnetgolf.com
Leading golf company offering high-quality golf equipment, apparel, and accessories for serious and recreational golfers worldwide. |
2,611 | |||
| 74 |
Cognex Corporationcognex.com
Advanced machine vision technology enabling manufacturing and distribution companies to improve quality, efficiency, and automation with AI-powered vision sensors and systems. |
2,580 | |||
| 75 | 2,532 | ||||
| 76 |
Spaulding Rehabilitation Hospitalspauldingrehab.org
A leading rehabilitation facility providing comprehensive treatment, part of a network with specialty hospitals, skilled nursing facilities, and outpatient centers in Eastern Massachusetts |
2,441 | |||
| 77 |
Abiomedabiomed.com
A leading provider of medical technology based in Danvers, MA, offering products for circulatory support and oxygenation to help patients recover |
2,388 | |||
| 78 |
Semrushsemrush.com
A leading online visibility management platform offering a suite of marketing tools to help companies improve their online presence and results |
2,357 | |||
| 79 |
argenxargenx.com
Global immunology company focused on developing novel antibody-based medicines for severe autoimmune diseases through collaborations with leading researchers |
2,315 | |||
| 80 |
Mercury Systemsmrcy.com
A technology company pushing processing power to the tactical edge for aerospace and defense missions, enabling innovation and decision superiority worldwide |
2,300 | |||
| 81 |
McLean Hospitalmcleanhospital.org
A leading psychiatric hospital dedicated to treating mental health conditions, conducting innovative research, and providing education to improve patient outcomes |
2,296 | |||
| 82 |
Curium Pharmacuriumpharma.com
Global leader in nuclear medicine, providing life-changing diagnostics and treatment for cancer patients worldwide through innovative radiopharmaceutical products and AI-driven solutions |
2,236 | |||
| 83 |
OutSystemsoutsystems.com
Provides an AI development platform for enterprises to rapidly build custom applications and AI agents while modernizing legacy core business systems. |
2,228 | |||
| 84 | 2,228 | ||||
| 85 |
Novanta Inc.novanta.com
Supplier of advanced technology solutions in precision medicine, manufacturing, robotics, and surgery, enabling high-performance, tailored equipment for OEMs. |
2,189 | |||
| 86 | 2,182 | ||||
| 87 |
InterSystemsintersystems.com
InterSystems provides data platforms and connected care solutions for healthcare, business, and government to drive better decisions and outcomes worldwide |
2,127 | |||
| 88 |
Symboticsymbotic.com
This company develops innovative robotics and software for advanced automation solutions in the supply chain industry to increase efficiency and profitability |
2,074 | |||
| 89 | 2,033 | ||||
| 90 |
ArisGlobalarisglobal.com
Transforms life sciences companies by automating drug development with an integrated technology platform, boosting efficiency, ensuring compliance, and reducing costs. |
2,028 | |||
| 91 |
HP Hood LLChood.com
Established in 1846, this company is a leading dairy processor in the US, known for high-quality dairy products under various brands |
2,006 | |||
| 92 |
Brooks Automationbrooks.com
Provider of automation solutions for the semiconductor industry, specializing in robotics, automation systems, and contamination control to empower chip manufacturers worldwide |
1,982 | |||
| 93 |
BeiGenebeonemedicines.com
Global oncology company developing accessible and affordable cancer treatments through innovative research, collaborations, and commitment to improving medicine access for patients worldwide |
1,967 | |||
| 94 |
Harvard Medical School and Massachusetts General Hospitalmassgeneral.org
A prestigious hospital affiliated with Harvard Medical School, offering clinical experience and clerkships while supporting a large research enterprise |
1,967 | |||
| 95 |
Werfen North Americawerfen.com
Worldwide leader specialized diagnostics: hemostasis, acute care, transfusion, autoimmunity, transplant. Operates in over 100 territories, with headquarters in Barcelona, Spain, and technology centers in the US and Europe. |
1,933 | |||
| 96 |
Duck Creek Technologiesduckcreek.com
Provides cloud-based software solutions for property, casualty, and general insurance industries enabling agile, intelligent, and transparent insurance operations. |
1,904 | |||
| 97 |
IPG Photonicsipgphotonics.com
Global leader in fiber laser technology, providing reliable and efficient laser solutions across various industries with a strong focus on innovation and customer needs |
1,901 | |||
| 98 |
Creation Technologiescreationtech.com
Global Electronics Manufacturing Services provider with 14 locations worldwide offering Full Product Development, Manufacturing, Test & Design Services for OEMs in various industries |
1,882 | |||
| 99 | 1,861 | ||||
| 100 |
Mass General Hospitalmassgeneral.org
A higher education company located in Cambridge, Massachusetts, United States, specializing in providing healthcare services and medical research at Mass General Hospital |
1,839 | |||
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How this list is built
Every company on this list has a Tamtam company profile. The industry is the one the company gives on LinkedIn; categories such as SaaS or fintech are classified by Tamtam's AI from the company's website and LinkedIn page; and the headquarters city must match the company's own address. Companies are ranked by the number of employees on LinkedIn, and the list is refreshed every night. Classifications can be wrong, so treat the list as a starting point rather than an official ranking. Last updated Nov 11, 2026.
More company lists in Massachusetts
- The largest companies in Massachusetts 3,419
- Multinational companies in Massachusetts 637
- SaaS companies in Massachusetts 339
- Education providers in Massachusetts 313
- Software Development companies in Massachusetts 273
- Manufacturers in Massachusetts 269
- Professional services firms in Massachusetts 249
- AI companies in Massachusetts 243
- Financial services firms in Massachusetts 235
- Healthcare providers in Massachusetts 213
- Hospitals and Health Care companies in Massachusetts 197
- Hardware manufacturers in Massachusetts 196
- Subscription businesses in Massachusetts 183
- IT Services and IT Consulting companies in Massachusetts 176
- Retail chains in Massachusetts 168
- Critical infrastructure operators in Massachusetts 165
- Companies with a mobile app in Massachusetts 159
- Higher Education companies in Massachusetts 158
- Venture capital and private equity firms in Massachusetts 157
- IT services companies in Massachusetts 155
- Consulting firms in Massachusetts 153
- Financial Services companies in Massachusetts 153
- Pharmaceutical companies in Massachusetts 143
- Publicly traded companies in Massachusetts 125
The same list elsewhere in United States
- Companies with in-house R&D in the United States 6,796
- Companies with in-house R&D in California 1,276
- Companies with in-house R&D in Texas 442
- Companies with in-house R&D in New York State 419
- Companies with in-house R&D in Illinois 322
- Companies with in-house R&D in Michigan 287
- Companies with in-house R&D in Ohio 277
- Companies with in-house R&D in Pennsylvania 255
- Companies with in-house R&D in New Jersey 224
- Companies with in-house R&D in Florida 221
- Companies with in-house R&D in Alabama 214
- Companies with in-house R&D in Georgia 173
- Companies with in-house R&D in Virginia 166
- Companies with in-house R&D in North Carolina 158
- Companies with in-house R&D in Wisconsin 154
- Companies with in-house R&D in Minnesota 146
- Companies with in-house R&D in Washington State 140
- Companies with in-house R&D in Colorado 113
- Companies with in-house R&D in Maryland 107
- Companies with in-house R&D in Indiana 104
- Companies with in-house R&D in New York 223
- Companies with in-house R&D in San Francisco 147
- Companies with in-house R&D in Houston 129
- Companies with in-house R&D in San Jose 103