These large organizations in Pennsylvania engage in in-house research and development across diverse sectors. Comcast delivers broadband and entertainment, UPMC provides healthcare and insurance, PPG develops paints and coatings, and Penn State University offers interdisciplinary education. Other notable companies include Wabtec Corporation, which supplies rail equipment, and Air Products, a global supplier of industrial gases.
The data reveals a strong concentration of R&D activities in the state's major cities. A significant number of these large companies are either headquartered in Philadelphia or Pittsburgh, with several prominent universities and healthcare systems also located in these urban centers. The presence of both long-established companies, like PPG (founded 1883), and more recent ventures, highlights a varied historical footprint.
| # | Company | Employees | |||
|---|---|---|---|---|---|
| 1 |
Comcastcomcast.com
Delivering broadband, mobile, and video products, along with entertainment, sports, news, and theme park experiences; driven by passionate creators and innovators |
189,000 | |||
| 2 | 41,860 | ||||
| 3 | 33,277 | ||||
| 4 |
Penn State Universitypsu.edu
Providing interdisciplinary education and resources across multiple campuses, fostering student success and positive global community impact through knowledge and experience. |
31,986 | |||
| 5 |
Wabtec Corporationwabteccorp.com
Provider of equipment, systems, digital solutions, and services for freight rail, transit, mining, industrial, and marine transportation sectors. |
27,000 | |||
| 6 |
University of Pennsylvaniaupenn.edu
Renowned Ivy League university with 12 schools offering a wide range of programs including arts, sciences, engineering, business, and medicine |
22,558 | |||
| 7 |
Penn Medicine, University of Pennsylvania Health Systempennmedicine.org
Leading academic medical center combining cutting-edge research, comprehensive patient care, and education to improve health and transform lives regionally. |
21,979 | |||
| 8 |
Air Productsairproducts.com
Supplier of industrial gases serving over 250,000 customers in more than 50 countries worldwide with diverse applications. |
20,000 | |||
| 9 |
University of Pittsburghpitt.edu
Top-ranked public institution in Pennsylvania, member of leading research universities Known for innovative discoveries and shaping future paths |
19,349 | |||
| 10 |
Children's Hospital of Philadelphiachop.edu
Specialized pediatric hospital providing exceptional patient care, pioneering medical research, and training future pediatric healthcare professionals. |
18,042 | |||
| 11 |
Viatrisviatris.com
Global healthcare company providing extensive medicine portfolio and supply chain to deliver high-quality medicines addressing diverse health needs worldwide. |
17,886 | |||
| 12 |
Geisingergeisinger.org
Healthcare organization with 13 hospital campuses, research centers, medical college, and health plan serving millions in Pennsylvania Committed to quality healthcare |
15,962 | |||
| 13 |
Mylanviatris.com
Empowering people worldwide to live healthier at every stage of life through a merger with Upjohn, now known as Viatris |
15,198 | |||
| 14 |
Temple Universitytemple.edu
A top-tier research institution in a vibrant city, offering diverse degree programs to prepare future leaders for impactful careers |
13,124 | |||
| 15 |
FMC Corporationfmc.com
The company is dedicated to innovating sustainable technologies to protect crops, support farmers, and tackle agriculture's challenges using science |
11,986 | |||
| 16 |
Allegheny Health Networkahn.org
Integrated healthcare delivery system with hospitals, medical centers, wellness pavilions, and numerous physician practices serving Western Pennsylvania. |
11,676 | |||
| 17 |
The Hershey Companythehersheycompany.com
Leading global snacks company producing iconic confectionery brands, committed to quality products, community support, and educational initiatives. |
11,057 | |||
| 18 |
Teleflexteleflex.com
Provides diverse medical technologies and solutions across various therapy areas, improving health and quality of life for people worldwide through purpose-driven innovation. |
9,909 | |||
| 19 |
Penn State Healthpennstatehealth.org
Multi-hospital health system in central Pennsylvania with medical centers, outpatient practices, and a partnership with Highmark Health for community care |
8,037 | |||
| 20 |
Axaltaaxalta.com
A global provider of performance coatings for industrial, automotive, and refinish applications, focused on innovation for a sustainable future |
7,744 | |||
| 21 |
B. Braun Medical Inc. (US)bbraunusa.com
A global healthcare leader specializing in infusion therapy, pain management, nutrition, pharmacy admixture, and dialysis products and services Committed to safety and innovation |
7,619 | |||
| 22 |
Drexel Universitydrexel.edu
Academically comprehensive urban research university with a globally engaged community and a premier cooperative education program nationwide. |
7,580 | |||
| 23 |
Howmet Aerospacehowmet.com
A global provider of advanced engineered solutions for aerospace and transportation industries, specializing in jet engine components, aerospace fastening systems, and titanium structural parts |
7,402 | |||
| 24 |
Coherent Corp.coherent.com
Development and delivery of breakthrough technologies and innovations for industrial, communications, electronics, and instrumentation market applications worldwide. |
7,389 | |||
| 25 |
Clarioclario.com
A leading healthcare research and technology company providing expertise and technology for advancing clinical trials in various therapeutic areas worldwide |
7,151 | |||
| 26 |
PPL Corporationpplweb.com
Providing electricity to millions, building smarter, resilient power grids, advancing sustainable energy solutions, and fostering inclusive work environments. |
7,118 | |||
| 27 |
United States Steel Corporationussteel.com
Developing and delivering profitable, next-generation steel solutions focused on safety and meeting current and future customer needs. |
6,794 | |||
| 28 |
Kennametalkennametal.com
A global industrial technology leader specializing in advanced materials innovation, tooling, and wear-resistant solutions to enhance productivity for various industries |
6,659 | |||
| 29 | 6,283 | ||||
| 30 |
West Pharmaceutical Serviceswestpharma.com
provider of high-quality injectable components and devices ensuring safe, effective delivery and containment of medicines worldwide |
6,268 | |||
| 31 |
EnerSysenersys.com
Global leader in stored energy solutions for industrial applications, offering motive power, reserve power, aerospace/defense, specialty batteries, and integrated services worldwide |
6,257 | |||
| 32 |
AMETEKametek.com
Global provider of industrial technology solutions with over $60 billion in annual sales, serving niche markets with differentiated technology solutions and focused on shareholder value generation |
5,963 | |||
| 33 |
Crown Holdings, Inc.crowncork.com
Design manufacture and sale of steel and aluminum cans, glass bottles, closures, and industrial packaging products and equipment worldwide. |
5,891 | |||
| 34 |
Temple Health โ Temple University Health Systemtemplehealth.org
Temple Health provides advanced research and clinical care, offering innovative treatments through renowned physicians, nurses, and researchers in various medical facilities and practices |
5,770 | |||
| 35 |
Thomas Jefferson Universityjefferson.edu
University focused on innovative health education, interdisciplinary learning, expert faculty collaboration, and redefining possibilities in health, education, and discovery. |
5,700 | |||
| 36 |
Bentley Systemsbentley.com
Innovative software for infrastructure engineering, design, construction, and operations, advancing global economy and environment with industry-leading solutions in multiple sectors worldwide |
5,633 | |||
| 37 |
Vishay Intertechnology, Inc.vishay.com
Manufactures extensive range of discrete semiconductors and passive electronic components for automotive, industrial, computing, consumer, telecom, military, aerospace, and medical markets worldwide. |
5,426 | |||
| 38 |
PCI Pharma Servicespci.com
Provides world-class solutions for drug development, manufacturing, advanced drug delivery, clinical trials, and commercial packaging, delivering life-changing therapies globally. |
4,795 | |||
| 39 |
Olympus Corporation of the Americasolympusamerica.com
A global medical technology company partnering with healthcare professionals to provide solutions for early detection, diagnosis, and minimally invasive treatment |
4,752 | |||
| 40 |
Arconicarconic.com
A leading provider of aluminum products for automotive, aerospace, transportation, industrial, packaging, and construction markets, committed to innovation and advancement |
4,672 | |||
| 41 | 4,561 | ||||
| 42 |
MSA - The Safety Companymsasafety.com
Designs and manufactures advanced safety products and technologies protecting workers and infrastructure worldwide across diverse industries. |
4,260 | |||
| 43 |
Naval Nuclear Laboratory (FMP)navalnuclearlab.energy.gov
The company operates the Naval Nuclear Laboratory, supporting the US Naval Nuclear Propulsion Program through research, development, training, and technical support |
3,940 | |||
| 44 |
TRIUMPHtriumphgroup.com
Design, engineering, manufacturing, repair, and overhaul of aviation and industrial components, partnering with OEMs and operators globally. |
3,933 | |||
| 45 |
Susquehanna International Groupsig.com
global proprietary trading firm providing liquidity, competitive pricing, quantitative strategies, private equity, structured capital, and institutional brokerage services |
3,913 | |||
| 46 |
Graham Packaginggrahampackaging.com
A leader in sustainable packaging design, manufacturing, and sales for food, beverage, household, and automotive industries with global reach |
3,562 | |||
| 47 |
Quaker Houghtonhome.quakerhoughton.com
Global leader in industrial process fluids, serving advanced manufacturing industries with expertise in chemistry and engineering for efficient operations and future growth |
3,523 | |||
| 48 |
CertainTeedcertainteed.com
A leading provider of sustainable exterior and interior building products in North America, with a focus on innovation and environmental responsibility |
3,511 | |||
| 49 |
Crane Payment Innovationscranepi.com
Provides world-class, automated payment solutions and experiences, developing products in currency validation, cash management, digital payment, mobile apps, and security for global consumers. |
3,504 | |||
| 50 |
UPMC Children's Hospital of Pittsburghchp.edu
A leader in treating childhood conditions, developing therapies, educating pediatricians, and advancing research with strong community support since 1890 |
3,489 | |||
Want more companies than this list?This page shows the largest ones only. Connect to Tamtam to see every company that matches, filter by size, industry or growth, and reach their decision-makers. | |||||
| 51 |
Globus Medicalglobusmedical.com
Development and manufacturing of innovative orthopedic surgical products focused on improving patient outcomes and enabling pain-free, active lives. |
3,451 | |||
| 52 |
Eurofins Lancaster Laboratorieseurofinsus.com
A global contract laboratory providing comprehensive services in pharmaceutical, biopharmaceutical, and environmental sciences to a diverse range of clients worldwide |
3,426 | |||
| 53 |
Victaulicvictaulic.com
A global leader in pipe joining and flow control solutions for construction projects, offering innovative products and technologies for increased system durability |
3,373 | |||
| 54 |
SunGard - now part of FISfisglobal.com
Financial technology company offering updates and news through LinkedIn and FISGlobalcom after acquiring SunGard |
3,348 | |||
| 55 |
Lutron Electronicslutron.com
Design and manufacture innovative lighting, shading, and control systems to enhance everyday experiences through transformative light technology. |
3,347 | |||
| 56 |
Boeing Defense, Space & Securityboeing.com
A division of a leading company focusing on defense and aerospace products and services, based in Arlington, Virginia Formerly known as Boeing Integrated Defense Systems |
3,334 | |||
| 57 |
Carpenter Technology Corporationcarpentertechnology.com
Producer and distributor of premium specialty alloys and advanced materials for aerospace, transportation, medical, energy, and additive manufacturing applications. |
3,271 | |||
| 58 |
Armstrong World Industriesarmstrongceilings.com
Design and manufacture innovative ceiling and wall systems enhancing aesthetics, acoustics, well-being, and sustainability in various interior spaces. |
3,186 | |||
| 59 |
Excelitas Technologies Corp.excelitas.com
Provider of advanced photonic technologies specializing in sensing, detection, imaging, optics, and specialty illumination for diverse global industries. |
3,129 | |||
| 60 |
JLG Industriesjlg.com
Manufacturing mobile elevating work platforms, telehandlers, utility vehicles, and accessories for construction and industrial safety worldwide. |
3,052 | |||
| 61 | 3,030 | ||||
| 62 |
Auroraaurora.tech
Aurora provides self-driving technology for transportation, making it safer, more accessible, and efficient for various vehicle types and industries |
2,568 | |||
| 63 |
Matthews Internationalmatw.com
Global provider of precision industrial technologies and memorialization products, serving industries and funeral homes with innovative, efficient solutions. |
2,226 | |||
| 64 |
Dorman Productsdormanproducts.com
Manufacture and supply aftermarket automotive, heavy-duty, and specialty vehicle replacement parts designed to save time, money, and increase reliability. |
2,210 | |||
| 65 |
University of Pittsburgh School of Medicinemedschool.pitt.edu
Training physician leaders and scientists to improve health, advance research, promote equity, and collaborate internationally in medicine and education. |
2,199 | |||
| 66 |
Fox Chase Cancer Centerfoxchase.org
Dedicated cancer hospital with expert multidisciplinary teams advancing prevention, diagnosis, treatment, and survivorship through pioneering research and clinical care. |
2,146 | |||
| 67 |
DDI | Development Dimensions Internationalddiworld.com
Global leadership consulting firm assisting organizations with hiring, promotion, and development of exceptional leaders from first-time managers to senior C-suite executive levels. |
2,120 | |||
| 68 |
Trinseotrinseo.com
A specialty material solutions provider partnering with companies to innovate and create sustainable products across various industries worldwide |
2,009 | |||
| 69 |
Drexel University College of Medicinedrexel.edu
A prestigious medical school offering MD and graduate programs, committed to diversity and excellence in medical education and research |
1,935 | |||
| 70 |
Industrial Coatingsppg.com
Global provider of advanced coatings, paints, and specialty materials focused on protecting and enhancing industrial products and landmarks. |
1,830 | |||
| 71 |
Southco, Inc.southco.com
Global leader in engineered access solutions for transportation, industrial, medical, and data center applications, with innovative products and a dedicated global team serving customers worldwide |
1,720 | |||
| 72 |
Crayolacrayola.com
A leading art product company inspiring creativity in children globally, promoting diversity, inclusion, and sustainability in its operations and products |
1,687 | |||
| 73 |
Ebara Elliott Energyelliott-turbo.com
Designs and manufactures centrifugal compressors, steam turbines, pumps, and cryogenic products for petrochemical, refining, oil and gas industries. |
1,644 | |||
| 74 |
Certaracertara.com
This company accelerates medicine development by using biosimulation software, technology, and services to revolutionize drug discovery and development globally |
1,514 | |||
| 75 |
Sharp Servicessharpservices.com
Provides commercial packaging, clinical services, and sterile manufacturing for pharmaceutical and biotech clients, covering R&D to market launch globally. |
1,506 | |||
| 76 |
TestingXpertstestingxperts.com
A global leader in Quality Engineering and Digital Assurance services, offering a comprehensive range of testing solutions for Next Gen technologies |
1,480 | |||
| 77 |
SK pharmtecoskpharmteco.com
Global contract development and manufacturing organization for active pharmaceutical ingredients, advanced intermediates, and cell and gene therapy for the pharmaceutical industry. |
1,433 | |||
| 78 | 1,408 | ||||
| 79 |
Vishay Precision Group, Inc. (VPG)vpgsensors.com
A global leader in precision measurement sensing technologies, focusing on accuracy, reliability, and repeatability for various applications worldwide |
1,334 | |||
| 80 |
Aquatechaquatech.com
Global leader in water technology, specializing in desalination, water reuse, and zero liquid discharge solutions to reduce water and carbon footprint worldwide |
1,270 | |||
| 81 |
Greene Tweedgtweed.com
Global manufacturer of high-performance thermoplastics, composites, seals, and engineered components for industries like semiconductor, oil & gas, aerospace, defense, and pharmaceutical processing |
1,238 | |||
| 82 |
Colorconcolorcon.com
Develops, supplies, and supports formulated film coating systems, modified release technologies, core excipients, and functional packaging for the pharmaceutical industry. |
1,228 | |||
| 83 |
Concurrent Technologies Corporationctc.com
Independent nonprofit organization providing applied scientific research, development, testing, prototyping, and innovative solutions supporting national security and American manufacturing. |
1,134 | |||
| 84 |
Madrigal Pharmaceuticalsmadrigalpharma.com
Clinical-stage biopharmaceutical company developing novel therapeutics for NASH, focusing on thyroid hormone receptor agonist to target underlying causes in the liver |
1,133 | |||
| 85 |
Koppers Inc.koppers.com
A global wood preservation technology company creating environmentally responsible solutions for various industries, with a focus on safety and sustainability |
1,080 | |||
| 86 |
Software Engineering Institute | Carnegie Mellon Universitysei.cmu.edu
The company conducts research on software engineering, cybersecurity, and AI, creating and testing innovative technologies for government and private industry since 1984 |
1,061 | |||
| 87 |
Tobyhanna Army Depottobyhanna.army.mil
Leader in logistics support for military C5ISR systems, offering sustainment, overhaul, manufacturing, engineering, integration, and field support for the Department of Defense |
1,046 | |||
| 88 |
Talogytalogy.com
Experts in talent management crafting solutions for screening, selecting, developing, and engaging talent worldwide using psychology and technology for data-driven decisions |
1,036 | |||
| 89 |
Spark Therapeutics, Inc.sparktx.com
Leading gene therapy company focused on treating inherited diseases through innovative science, integrated expertise, and commitment to accelerating healthcare transformation globally |
1,035 | |||
| 90 | 1,028 | ||||
| 91 |
Temple University - Lewis Katz School of Medicinetemple.edu
Leading medical school offering humanistic education, top clinical training, and groundbreaking research, recognized internationally, honored nationally, and essential locally |
1,015 | |||
| 92 |
Good Shepherd Rehabilitationgoodshepherdrehab.org
A not-for-profit rehabilitation network offering inpatient, outpatient, and community-based services for patients of all ages and abilities in eastern PA and NJ |
1,004 | |||
| 93 |
EXALTA Groupexalta.com
Global provider of manufacturing and integrated OEM solutions supporting leading MedTech companies in delivering innovative medical devices worldwide. |
995 | |||
| 94 |
Lake Erie College of Osteopathic Medicine (LECOM)lecom.edu
Training future healthcare professionals in osteopathy, pharmacy, dentistry, and podiatry with a focus on innovation, excellence, and affordability |
956 | |||
| 95 |
Clair Globalclairglobal.com
A tech company specializing in live production services and integrated permanent solutions for events |
943 | |||
| 96 |
Federal Reserve Bank of Philadelphiaphiladelphiafed.org
Implement monetary policy, supervise banks, provide financial services to institutions and government One of 12 regional Reserve Banks in Federal Reserve System |
852 | |||
| 97 |
PennEngineeringยฎpemnet.com
A global leader in engineered fastening, installation, and wire protection solutions with in-house technical engineering experts worldwide since 1942 |
840 | |||
| 98 |
HarbisonWalker Internationalthinkhwi.com
A global leader in refractory products delivering solutions to industries worldwide with over 150 years of excellence in performance and value |
809 | |||
| 99 |
Minaris Advanced Therapiesminaris.com
Global cell and gene therapy CDMO and biosafety testing provider with deep experience supporting therapeutic programs from IND through commercial supply. |
808 | |||
| 100 |
Fullerfuller-technologies.com
Providing pioneering cement technologies, reliable services, and expertise to help producers operate sustainably and improve performance worldwide. |
786 | |||
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Every company on this list has a Tamtam company profile. The industry is the one the company gives on LinkedIn; categories such as SaaS or fintech are classified by Tamtam's AI from the company's website and LinkedIn page; and the headquarters city must match the company's own address. Companies are ranked by the number of employees on LinkedIn, and the list is refreshed every night. Classifications can be wrong, so treat the list as a starting point rather than an official ranking. Last updated Nov 11, 2026.
More company lists in Pennsylvania
- The largest companies in Pennsylvania 3,427
- Multinational companies in Pennsylvania 472
- Education providers in Pennsylvania 373
- Manufacturers in Pennsylvania 364
- Financial services firms in Pennsylvania 264
- Healthcare providers in Pennsylvania 264
- Retail chains in Pennsylvania 246
- Professional services firms in Pennsylvania 245
- Hospitals and Health Care companies in Pennsylvania 243
- Critical infrastructure operators in Pennsylvania 225
- Hardware manufacturers in Pennsylvania 173
- Higher Education companies in Pennsylvania 173
- IT Services and IT Consulting companies in Pennsylvania 172
- Financial Services companies in Pennsylvania 160
- IT services companies in Pennsylvania 157
- Consulting firms in Pennsylvania 144
- Companies with a mobile app in Pennsylvania 130
- Family-owned companies in Pennsylvania 130
- Public sector organisations in Pennsylvania 123
- Corporate groups and holding companies in Pennsylvania 120
- Publicly traded companies in Pennsylvania 116
- SaaS companies in Pennsylvania 114
- Construction companies in Pennsylvania 106
- Insurance companies in Pennsylvania 101
The same list elsewhere in United States
- Companies with in-house R&D in the United States 6,796
- Companies with in-house R&D in California 1,276
- Companies with in-house R&D in Texas 442
- Companies with in-house R&D in New York State 419
- Companies with in-house R&D in Massachusetts 396
- Companies with in-house R&D in Illinois 322
- Companies with in-house R&D in Michigan 287
- Companies with in-house R&D in Ohio 277
- Companies with in-house R&D in New Jersey 224
- Companies with in-house R&D in Florida 221
- Companies with in-house R&D in Alabama 214
- Companies with in-house R&D in Georgia 173
- Companies with in-house R&D in Virginia 166
- Companies with in-house R&D in North Carolina 158
- Companies with in-house R&D in Wisconsin 154
- Companies with in-house R&D in Minnesota 146
- Companies with in-house R&D in Washington State 140
- Companies with in-house R&D in Colorado 113
- Companies with in-house R&D in Maryland 107
- Companies with in-house R&D in Indiana 104
- Companies with in-house R&D in New York 223
- Companies with in-house R&D in San Francisco 147
- Companies with in-house R&D in Houston 129
- Companies with in-house R&D in San Jose 103