These companies are the largest in-house R&D employers in Minnesota. They include major players in healthcare technology and food production, alongside significant firms in industrial machinery and chemical manufacturing. Companies like Medtronic, a healthcare technology firm, and Cargill, providing food and ingredients, lead the sector. Other notable companies are 3M, known for its science and technology applications, and Ecolab, a global provider of water, hygiene, and infection prevention solutions.
The data shows a strong concentration of headquarters in Minneapolis and Saint Paul, indicating these cities are key hubs for research and development activities in the state. The mix of industries represented, from medical equipment to agriculture, highlights a diverse R&D landscape.
| # | Company | Employees | |||
|---|---|---|---|---|---|
| 1 |
Medtronicmedtronic.com
A healthcare technology company tackling challenging health issues worldwide with innovative solutions that significantly impact and improve lives |
100,323 | |||
| 2 |
Cargillcargill.com
A family company providing food, ingredients, solutions, and products in a sustainable way Partnering with producers and customers for a better future |
69,086 | |||
| 3 | 63,807 | ||||
| 4 |
Ecolabecolab.com
A global leader providing water, hygiene, and infection prevention solutions for various industries worldwide through comprehensive services and personalized insights |
48,879 | |||
| 5 |
Mayo Clinicmayoclinic.org
A leading not-for-profit medical practice founded on values of patient-centered care, teamwork, professionalism, and excellence in healthcare services |
48,774 | |||
| 6 |
General Millsgeneralmills.com
The company is dedicated to creating beloved food products while prioritizing positive impact, learning, innovation, and growth through collaboration and leadership |
25,309 | |||
| 7 |
Xcel Energyxcelenergy.com
providing reliable, resilient, and sustainable energy services to customers across eight states, focusing on excellent service and growth opportunities |
12,073 | |||
| 8 |
Polaris Inc.polaris.com
Global leader in Powersports, offering a diverse product lineup including off-road vehicles, motorcycles, snowmobiles, boats, and accessories, with a focus on innovation and outdoor experiences |
9,228 | |||
| 9 |
Essentia Healthessentiahealth.org
Integrated health system providing patient-centered care through hospitals, clinics, long-term care, pharmacies, ambulance services, and research in three states. |
8,194 | |||
| 10 |
Donaldsondonaldson.com
Global provider of filtration technologies and high-quality filters for various industries worldwide, with a strong focus on solving complex contamination control challenges |
8,011 | |||
| 11 |
Land O'Lakes, Inc.landolakesinc.com
A farmer and retailer-owned cooperative committed to creating new market opportunities, championing farming's potential, and creating a better world for all |
6,867 | |||
| 12 |
The Toro Companythetorocompany.com
Portfolio of global brands providing innovative equipment and solutions for landscaping, construction, irrigation, and outdoor maintenance industries worldwide. |
6,275 | |||
| 13 |
Covidien (Medtronic Minimally Invasive Therapies Group)medtronic.com
A company acquired by Medtronic in 2015, focused on healthcare products Visit Medtronic's LinkedIn page for more information |
6,168 | |||
| 14 |
St. Jude Medicalcardiovascular.abbott
Global medical device manufacturer transforming treatment for epidemic diseases with cost-effective technologies, focusing on cardiac, cardiovascular, and neuromodulation products. |
5,896 | |||
| 15 |
H.B. Fullerhbfuller.com
Global provider of adhesives, sealants, and specialty chemicals enhancing product quality and convenience across multiple industries worldwide. |
5,627 | |||
| 16 | 4,942 | ||||
| 17 |
Daikin Applied Americasdaikinapplied.com
Provides advanced HVAC systems focusing on air quality, energy efficiency, IoT integration, and next-generation compressors through global sales and service network. |
4,833 | |||
| 18 | 4,056 | ||||
| 19 |
Sleep Number Corporationsleepnumber.com
Company improves health and wellbeing through innovative sleep products, operating retail stores, distribution centers, and supporting diverse workforce nationwide. |
3,632 | |||
| 20 |
Marvinmarvin.com
A family-owned business offering a diverse portfolio of customizable window and door solutions for builders, architects, and homeowners worldwide |
3,375 | |||
| 21 |
Arctic Wolfarcticwolf.com
Provides security operations as a concierge service, offering 24x7 monitoring, detection, response, and ongoing risk management to strengthen security posture. |
3,297 | |||
| 22 |
TENNANT SAtennantco.com
A leader in the cleaning industry, developing innovative and sustainable solutions to address indoor and outdoor cleaning challenges globally |
2,671 | |||
| 23 |
Bio-Technebio-techne.com
A leading developer and manufacturer of high-quality purified proteins, reagent solutions, diagnostic products, and genomic tools for research and clinical use globally |
2,924 | |||
| 24 |
Starkey Hearingstarkey.com
Design, develop, manufacture, and distribute advanced digital hearing aids globally through multiple brands with evidence-based technology. |
2,527 | |||
| 25 |
Thermo Kingthermoking.com
Development and innovation of sustainable transport refrigeration and temperature control solutions aimed at improving customer quality of life. |
2,512 | |||
Want more companies than this list?This page shows the largest ones only. Connect to Tamtam to see every company that matches, filter by size, industry or growth, and reach their decision-makers. | |||||
| 26 | 2,382 | ||||
| 27 |
Perforce Softwareperforce.com
Leader in digital product development, providing innovative solutions for faster and higher quality output through the power of Perforce technology |
2,028 | |||
| 28 |
Cirruscirrusaircraft.com
A global leader in personal aviation, known for best-selling piston aircraft, innovative single-engine jet, and pioneering safety systems |
1,832 | |||
| 29 |
HealthEastfairview.org
A leading nonprofit healthcare provider in Minnesota offering a full range of services including hospitals, clinics, senior care, rehabilitation, and home health services with compassion |
1,830 | |||
| 30 |
Winnebago Industrieswinnebagoind.com
The company is a leading manufacturer of outdoor lifestyle products, providing innovative solutions for leisure travel and recreation activities with a focus on work-life balance |
1,695 | |||
| 31 |
MTS Systems Corporationmts.com
A global supplier of test and simulation systems that partners with customers to innovate and revolutionize products across various industries |
1,687 | |||
| 32 |
Protolabsprotolabs.com
Digital manufacturing resource providing injection molding, CNC machining, 3D printing, and sheet metal fabrication from prototyping to production. |
1,648 | |||
| 33 |
TSI Incorporatedtsi.com
Global leader in precision measurement instruments for aerosol science, air flow, indoor air quality, fluid dynamics, and biohazard detection Headquarters in US with worldwide presence |
1,559 | |||
| 34 |
Hazelden Betty Ford Foundationhazeldenbettyford.org
A nonprofit treatment provider offering recovery solutions, addiction education, prevention programs, and advocacy for diverse communities nationwide Join the team today |
1,458 | |||
| 35 |
Kindeva Drug Deliverykindevadd.com
CDMO advancing drug projects with expertise in injectable, inhalation, and dermal delivery, optimizing development and manufacturing for pharmaceutical companies. |
1,369 | |||
| 36 |
T.O. Plasticstoplastics.com
A company specializing in designing and producing custom packaging and products from thermoformed plastics for various industries, ensuring quality and customer satisfaction |
1,352 | |||
| 37 |
Inspire Medical Systemsinspiresleep.com
Develops a neurostimulation device for obstructive sleep apnea. This device stimulates airway muscles to reduce OSA severity and improve patient quality of life. |
1,341 | |||
| 38 |
Gillette Children'sgillettechildrens.org
Specializing in brain, bone, and movement conditions starting in childhood, we provide research, treatment, and technologies for children to thrive |
1,313 | |||
| 39 |
Banner Engineeringbannerengineering.com
Global leader in industrial automation with a wide range of sensors, vision sensors, LED lights, wireless, and safety products for various industries worldwide |
1,224 | |||
| 40 |
Loram Maintenance of Way, Inc.loram.com
Specializes in railway maintenance services and equipment, with a focus on safety, expertise, environmental sustainability, and a vision to be a global leader in the industry |
1,124 | |||
| 41 |
Heraeus Medeviobit.ly
Provides contract design, development, and manufacturing of medical devices globally, supporting companies from concept through product lifecycle with materials science expertise. |
1,124 | |||
| 42 |
Cretex Medicalcretexmedical.com
Specializing in medical device manufacturing and engineering, providing metal and plastic machining, injection molding, sterilization case design, custom instrument manufacturing, assembly, and packaging services |
1,062 | |||
| 43 |
Federal Reserve Bank of Minneapolisminneapolisfed.org
Support national monetary and financial system stability, uphold ethical standards, embrace diversity, and provide development opportunities for workforce excellence. |
1,047 | |||
| 44 |
CPMonecpm.com
The company innovates nutrition for both people and animals, produces renewable fuels, and contributes materials for a more sustainable world |
1,005 | |||
| 45 |
Hearth & Home Technologieshearthnhome.com
The company is a leading producer and installer of hearth products including fireplaces, inserts, stoves, and more, focused on making houses feel like homes |
1,005 | |||
| 46 |
Digi Internationaldigi.com
Provider of reliable IoT and M2M connectivity products, embedded modules, routers, gateways, cloud software, and professional services for critical communications. |
978 | |||
| 47 |
Teleflex Medical OEMteleflexmedicaloem.com
Design, prototype, and manufacture custom medical devices including catheters, tubing, sutures, and related components with in-house engineering and production. |
936 | |||
| 48 | 936 | ||||
| 49 |
R&D Systemsrndsystems.com
This company brings together various brands such as R&D Systems, Tocris, and Novus Biologicals to be a stronger scientific partner in helping customers achieve their research goals |
863 | |||
| 50 |
Hutchinson Technology Inc.hutchinson.tdk.com
Specializing in close-tolerance products that blend chemical, mechanical, and electronic technologies, this company is a leader in the electronics industry worldwide |
817 | |||
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How this list is built
Every company on this list has a Tamtam company profile. The industry is the one the company gives on LinkedIn; categories such as SaaS or fintech are classified by Tamtam's AI from the company's website and LinkedIn page; and the headquarters city must match the company's own address. Companies are ranked by the number of employees on LinkedIn, and the list is refreshed every night. Classifications can be wrong, so treat the list as a starting point rather than an official ranking. Last updated Nov 11, 2026.
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The same list elsewhere in United States
- Companies with in-house R&D in the United States 6,796
- Companies with in-house R&D in California 1,276
- Companies with in-house R&D in Texas 442
- Companies with in-house R&D in New York State 419
- Companies with in-house R&D in Massachusetts 396
- Companies with in-house R&D in Illinois 322
- Companies with in-house R&D in Michigan 287
- Companies with in-house R&D in Ohio 277
- Companies with in-house R&D in Pennsylvania 255
- Companies with in-house R&D in New Jersey 224
- Companies with in-house R&D in Florida 221
- Companies with in-house R&D in Alabama 214
- Companies with in-house R&D in Georgia 173
- Companies with in-house R&D in Virginia 166
- Companies with in-house R&D in North Carolina 158
- Companies with in-house R&D in Wisconsin 154
- Companies with in-house R&D in Washington State 140
- Companies with in-house R&D in Colorado 113
- Companies with in-house R&D in Maryland 107
- Companies with in-house R&D in Indiana 104
- Companies with in-house R&D in New York 223
- Companies with in-house R&D in San Francisco 147
- Companies with in-house R&D in Houston 129
- Companies with in-house R&D in San Jose 103