These Colorado companies with in-house R&D are mostly large, established organizations, with several founded in the late 19th or early 20th century. They span diverse sectors including technology, manufacturing, healthcare, and higher education. Notable examples include EchoStar Corporation, a provider of networking and connectivity solutions; Trimble Inc., which delivers positioning and data analytics solutions; Ball Corporation, specializing in aluminum packaging; and Children's Hospital Colorado, offering pediatric healthcare.
A significant pattern among these companies is the strong presence of higher education institutions, with the University of Colorado system appearing multiple times across its Boulder, Anschutz, and Denver campuses, alongside the Colorado School of Mines. This indicates a robust academic research environment contributing to the state's R&D landscape. Headquarters are distributed across various cities, including Denver, Westminster, Aurora, and Boulder.
| # | Company | Employees | |||
|---|---|---|---|---|---|
| 1 |
EchoStar Corporationechostar.com
provider of technology, networking services, television entertainment, and connectivity solutions for consumers, enterprises, operators, and governments worldwide |
28,509 | |||
| 2 |
University of Colorado Bouldercolorado.edu
A dynamic community of scholars and learners at a Colorado university, known for its spectacular campus and academic excellence |
15,809 | |||
| 3 |
Trimble Inc.trimble.com
A technology company delivering solutions in positioning, modeling, and data analytics to improve productivity, quality, safety, and sustainability in various industries |
11,061 | |||
| 4 |
Ball Corporationball.com
Global company specializing in aluminum packaging solutions for beverages, personal care, and household products with a focus on sustainability. |
10,972 | |||
| 5 |
Children's Hospital Coloradochildrenscolorado.org
Providing specialized, compassionate pediatric healthcare through multiple hospitals, specialty centers, and outreach clinics across Colorado and the region. |
8,954 | |||
| 6 |
Gates Corporationgates.com
Manufacture application-specific fluid power and power transmission products, invest in R&D, support diverse industries with innovative, reliable solutions. |
8,421 | |||
| 7 |
Crocs, Inc.crocs.com
designing and producing comfortable, stylish casual footwear with a focus on personalization, sustainability, and inclusive company culture. |
7,741 | |||
| 8 |
University of Colorado Anschutzcuanschutz.edu
Largest academic health center in Rocky Mountain region, providing patient care, professional training, and conducting world-renowned medical research. |
7,196 | |||
| 9 |
Woodward, Inc.woodward.com
The company specializes in providing energy conversion and control solutions for aerospace and industrial equipment markets, facilitating a cleaner, decarbonized world |
6,438 | |||
| 10 |
The North Facethenorthface.com
Design and manufacture advanced outdoor apparel and equipment, fostering exploration and protecting natural environments worldwide. |
5,513 | |||
| 11 |
Colorado School of Minesmines.edu
A public research university specializing in engineering and applied science, with a focus on responsible resource stewardship and addressing global challenges |
5,464 | |||
| 12 |
Advanced Energyadvancedenergy.com
Global leader in designing and manufacturing precision power solutions for mission-critical applications in industries like semiconductor, medical, data center, and telecommunications |
5,078 | |||
| 13 | 4,947 | ||||
| 14 |
DaVitadavita.com
A global healthcare provider specializing in kidney care, prioritizing employee and patient well-being, innovation, and community impact |
4,925 | |||
| 15 |
University of Coloradocu.edu
Public university system with campuses offering diverse programs in research, healthcare, business, engineering, arts, and community engagement across Colorado. |
3,948 | |||
| 16 |
Terumo Blood and Cell Technologiesterumobct.com
Global leader in blood component, therapeutic apheresis, and cellular technologies providing innovative solutions to improve patient care worldwide. |
3,744 | |||
| 17 |
National Laboratory of the Rockiesnlr.gov
Research and development of advanced energy systems, focusing on innovative technologies to improve energy efficiency and sustainability. |
3,732 | |||
| 18 | 3,646 | ||||
| 19 |
University of Colorado Colorado Springsuccs.edu
A leading academic institution in southern Colorado offering high-tech education and research programs, with a focus on innovation and growth |
3,295 | |||
| 20 |
United Launch Alliance (ULA)ulalaunch.com
providing reliable, accurate rocket launch services with advanced technology, high performance, and affordability for diverse payload delivery. |
3,185 | |||
| 21 |
Johns Manvillejm.com
Manufacture commercial roofing, premium insulation, and engineered products with global reach, emphasizing employee values and customer service. |
3,138 | |||
| 22 |
Liberty Energylinktr.ee
A leading North American oilfield services provider offering innovative completion services and technologies for onshore oil and gas exploration and production |
2,546 | |||
| 23 |
DigitalOceandigitalocean.com
DigitalOcean simplifies cloud computing for businesses, providing mission-critical infrastructure and fully managed offerings to help developers rapidly build, deploy, and scale innovative applications |
2,444 | |||
| 24 |
Ball Aerospacebaesystems.com
Expertise in spacecraft, instruments, ground systems, sensors, tactical systems, operations, and data analytics to support customer missions. |
2,061 | |||
| 25 |
CoorsTek, Inc.coorstek.com
International provider of high-performance engineered technical ceramics and advanced materials Offers expertise in materials engineering, research, manufacturing, and collaborative relationships since 1910 |
2,056 | |||
Want more companies than this list?This page shows the largest ones only. Connect to Tamtam to see every company that matches, filter by size, industry or growth, and reach their decision-makers. | |||||
| 26 |
National Jewish Healthnationaljewish.org
Advanced research and personalized care for pulmonary, cardiac, immune, and related conditions, focusing on predicting, preventing, and treating diseases for better health outcomes |
1,658 | |||
| 27 |
Tungsten Automationtungstenautomation.com
Global leader in intelligent workflow automation solutions with 40 years of trusted legacy, serving 25,000+ global customers to drive efficiencies and reduce costs |
1,587 | |||
| 28 |
University of Colorado Anschutz School of Medicinemedschool.cuanschutz.edu
Health care professionals receive interdisciplinary lifelong learning with cutting-edge labs, research, and faculty providing top clinical care, transforming health care |
1,568 | |||
| 29 |
Innospec Inc.innospec.com
Global specialty company providing chemicals, additives, and formulations for various industries including construction, fuel additives, oilfield, and personal care Operations in 24 countries |
1,384 | |||
| 30 |
Ardent Millsardentmills.com
Experienced teams of ingredient specialists and culinary experts develop innovative food products focused on nutrition and future food sustainability. |
1,361 | |||
| 31 |
Maxar Technologiesvantor.com
Provider of secure, precise geospatial insights using advanced satellite imagery and AI software to support global safety and disaster response. |
1,325 | |||
| 32 | 1,094 | ||||
| 33 |
Corza Medicalcorza.com
Provides medical devices and biosurgery products to surgeons, teams, distributors, and OEM partners, with a focus on surgical sutures, ophthalmic instruments, and sealant matrix. |
970 | |||
| 34 |
Tolmartolmar.com
A specialty pharmaceutical company innovating treatments in urology, oncology, and endocrinology, recognized for advanced long-acting injectable drug delivery capabilities globally. |
942 | |||
| 35 |
Craig Hospitalcraighospital.org
A renowned rehabilitation hospital specializing in spinal cord and brain injury care, offering comprehensive medical services for optimal patient outcomes |
905 | |||
| 36 |
Stolle Machinery Company LLCstollemachinery.com
A global leader in providing high-speed machinery for canmaking industry, offering complete can and end lines, OEM spare parts, and innovative technology solutions |
839 | |||
| 37 |
Exabeamexabeam.com
Leader in behavior intelligence for the agentic enterprise, applying agent-powered analytics to understand and govern human and non-human insider behavior to reduce risk. |
796 | |||
| 38 |
CCRM Fertilityccrmivf.com
A global leader in fertility treatment and research, specializing in advanced IVF, egg freezing, genetic testing, and egg donation services across 13 major metropolitan areas |
755 | |||
| 39 |
Paragon 28paragon28.com
orthopedic foot and ankle company, developing bio-mechanically and clinically relevant surgical solutions, specialty instruments, and next-generation implants, improving clinical outcomes through research. |
753 | |||
| 40 |
Quantinuumquantinuum.com
Unites software and hardware, scaling quantum computing and developing applications to solve the world's most pressing challenges today. |
688 | |||
| 41 |
Voyager Technologiesvoyagertechnologies.com
Pioneering mission-critical solutions for civil and government missions while tackling complex challenges to fortify national security and protect assets from ground to space. |
650 | |||
| 42 |
Strive Healthstrivehealth.com
A value-based kidney care solution offering high-touch care teams, advanced technology, seamless integration, and next-generation dialysis services for payors and providers |
633 | |||
| 43 |
ICR, Inc.icr-team.com
A pioneering company solving Intelligence and Defense engineering challenges through practical solutions, a culture of mentorship, and employee ownership |
611 | |||
| 44 |
Barber-Nicholsbarber-nichols.com
Specializing in engineering design and production of turbomachinery, the company offers custom products for aerospace, cryogenic, defense, and energy applications, as well as consulting and contract manufacturing |
572 | |||
| 45 |
SPARTAdomaineasy.com
A provider of technical products and services to US government sectors, specializing in critical analysis, computer science solutions, network architecture, and acquisition support |
543 | |||
| 46 |
Particle Measuring Systemspmeasuring.com
Develops specialized monitoring technology and sensors to help clean manufacturers improve process yields and comply with strict regulatory requirements globally. |
537 | |||
| 47 |
Zynex Medicalzynex.com
Engineers, manufactures, and markets stroke rehabilitation and pain management devices, providing electrotherapy products for home use to improve patient quality of life. |
519 | |||
| 48 |
Laboratory for Atmospheric and Space Physicslasp.colorado.edu
Researches space science, weather, and planets; develops instruments and small satellites; explores habitable worlds with students and partners. |
502 | |||
| 49 |
KeyPoint Government Solutionsperaton.com
Perspecta is a diverse provider of capabilities to US government customers, specializing in defense, intelligence, healthcare, and digital transformation with a focus on innovation |
489 | |||
| 50 |
OtterBoxotterbox.com
Innovates and designs premium protective cases for smartphones and tablets. Focuses on inspiring kids through entrepreneurship and philanthropy. |
474 | |||
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How this list is built
Every company on this list has a Tamtam company profile. The industry is the one the company gives on LinkedIn; categories such as SaaS or fintech are classified by Tamtam's AI from the company's website and LinkedIn page; and the headquarters city must match the company's own address. Companies are ranked by the number of employees on LinkedIn, and the list is refreshed every night. Classifications can be wrong, so treat the list as a starting point rather than an official ranking. Last updated Nov 11, 2026.
More company lists in Colorado
- The largest companies in Colorado 2,042
- Multinational companies in Colorado 228
- Retail chains in Colorado 178
- Manufacturers in Colorado 147
- SaaS companies in Colorado 145
- Critical infrastructure operators in Colorado 137
- Healthcare providers in Colorado 126
- Education providers in Colorado 122
- Hospitals and Health Care companies in Colorado 115
- Energy companies in Colorado 113
- Subscription businesses in Colorado 108
- Professional services firms in Colorado 106
- Software Development companies in Colorado 105
- Hardware manufacturers in Colorado 103
- Financial services firms in Colorado 100
- Companies with a mobile app in Colorado 100
- IT Services and IT Consulting companies in Colorado 99
- Construction companies in Colorado 93
- Hotel and hospitality groups in Colorado 86
- Real Estate companies in Colorado 83
- Public sector organisations in Colorado 80
- Financial Services companies in Colorado 78
- IT services companies in Colorado 78
- Consulting firms in Colorado 77
The same list elsewhere in United States
- Companies with in-house R&D in the United States 6,796
- Companies with in-house R&D in California 1,276
- Companies with in-house R&D in Texas 442
- Companies with in-house R&D in New York State 419
- Companies with in-house R&D in Massachusetts 396
- Companies with in-house R&D in Illinois 322
- Companies with in-house R&D in Michigan 287
- Companies with in-house R&D in Ohio 277
- Companies with in-house R&D in Pennsylvania 255
- Companies with in-house R&D in New Jersey 224
- Companies with in-house R&D in Florida 221
- Companies with in-house R&D in Alabama 214
- Companies with in-house R&D in Georgia 173
- Companies with in-house R&D in Virginia 166
- Companies with in-house R&D in North Carolina 158
- Companies with in-house R&D in Wisconsin 154
- Companies with in-house R&D in Minnesota 146
- Companies with in-house R&D in Washington State 140
- Companies with in-house R&D in Maryland 107
- Companies with in-house R&D in Indiana 104
- Companies with in-house R&D in New York 223
- Companies with in-house R&D in San Francisco 147
- Companies with in-house R&D in Houston 129
- Companies with in-house R&D in San Jose 103