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Top 50 companies with in-house R&D in North Carolina

Tamtam tracks 158 companies with in-house R&D headquartered in North Carolina. This list ranks the 50 largest by number of employees on LinkedIn, led by IQVIA, Collins Aerospace and Lenovo. Their median headcount is 5,907. Half of them were founded in 1970 or later. The most common headquarters are Charlotte (13), Durham (11) and Raleigh (7).

馃嚭馃嚫 North Carolina50 companiesUpdated Nov 11, 2026

This selection of companies with in-house R&D in North Carolina reveals a strong presence of large organizations, particularly in the healthcare and technology sectors. Companies like IQVIA and Labcorp, both in Hospitals and Health Care, employ tens of thousands, providing clinical research, laboratory services, and healthcare intelligence. Other significant players include Lenovo, a global technology powerhouse, and Collins Aerospace, delivering connected solutions for aviation.

A notable pattern among these companies is the concentration of headquarters in a few key cities. Charlotte emerges as a prominent hub, hosting Advocate Health, Atrium Health, and Duke Energy Corporation, which focuses on utilities and clean energy transition. Raleigh also features prominently with Red Hat, an enterprise open source solutions leader, and North Carolina State University, specializing in STEM education.

#CompanyIndustryHeadquarters EmployeesFounded
1
IQVIAiqvia.com

Provides clinical research, commercial insights, and healthcare intelligence to life sciences and healthcare industries, accelerating medical treatments for better patient outcomes.

Hospitals and Health Care 馃嚭馃嚫 Durham 80,633 1954
2
Collins Aerospacertx.com

Global aerospace company designing and delivering connected solutions for passenger safety, mission success, space exploration, and operational efficiency.

Aviation and Aerospace Component Manufacturing 馃嚭馃嚫 Charlotte 51,969 n/a
3
Lenovolenovo.com

A global technology powerhouse with a focus on delivering smarter technology through innovation, serving millions of customers worldwide in various markets

IT Services and IT Consulting 馃嚭馃嚫 Morrisville 47,094 1984
4
Labcorplabcorp.com

Provides innovative, comprehensive laboratory services, insights, and advanced science to improve health outcomes and develop new drugs for global clients and patients.

Hospitals and Health Care 馃嚭馃嚫 Burlington 42,780 1905
5
Advocate Healthadvocatehealth.org

Advocate Health redefines care delivery to help people live well by providing equitable services across six states for better outcomes at lower costs

Hospitals and Health Care 馃嚭馃嚫 Charlotte 34,037 n/a
6
Atrium Healthatriumhealth.org

Nationally recognized health leader providing innovative research, education, and compassionate patient care through top-ranked specialties, medical education, and community benefits

Hospitals and Health Care 馃嚭馃嚫 Charlotte 30,465 1940
7
Duke Energy Corporationduke-energy.com

Electric and natural gas utilities serving millions, focusing on clean energy transition, grid upgrades, and net-zero emissions goals.

Utilities 馃嚭馃嚫 Charlotte 25,788 n/a
8
Red Hatredhat.com

A global leader in enterprise open source solutions, delivering high-performing Linux, hybrid cloud, edge, and Kubernetes technologies through community collaboration Join us and make an impact

Software Development 馃嚭馃嚫 Raleigh 21,000 1993
9
North Carolina State Universityncsu.edu

Comprehensive university specializing in STEM education and research, committed to improving quality of life locally and globally through innovation.

Higher Education 馃嚭馃嚫 Raleigh 20,729 1887
10
SASsas.com

A trusted analytics partner providing fast and productive AI solutions, empowering customers worldwide with the power to generate insights quickly

Software Development 馃嚭馃嚫 Cary 18,697 1976
11
Sealed Air Corporationsealedair.com

Development and supply of automated, sustainable packaging solutions protecting food, liquids, and goods, enhancing e-commerce and reducing environmental impact.

Packaging and Containers Manufacturing 馃嚭馃嚫 Charlotte 17,000 n/a
12
Duke Universityduke.edu

Private research university offering undergraduate, graduate, and professional education with strong emphasis on research and academic excellence.

Higher Education 馃嚭馃嚫 Durham 16,307 1924
13
Ingersoll Randirco.com

Provider of durable, high-performance industrial flow creation and solutions, supporting complex environments with expertise and productivity.

Industrial Machinery Manufacturing 馃嚭馃嚫 Davidson 15,367 n/a
14
Trane Technologiestranetechnologies.com

This company challenges industry norms, commits to ambitious sustainability goals, and aims to influence global change through innovative solutions for heating, cooling, and refrigeration

Industrial Machinery Manufacturing 馃嚭馃嚫 Davidson 15,027 n/a
15
Duke University Health Systemdukehealth.org

Academic health system focused on innovative research, education, evidence-based medicine, community health improvement, and eliminating health disparities globally and locally.

Hospitals and Health Care 馃嚭馃嚫 Durham 12,096 n/a
16
Epic Gamesepicgames.com

Provider of 3D engine technology powering games and industries, operator of Fortnite, and digital ecosystem for developers and creators.

Computer Games 馃嚭馃嚫 Cary 11,831 n/a
17
Atrium Health Wake Forest Baptistwakehealth.edu

Academic medical center with hospitals, clinics, medical school, research, and community health services providing extensive patient care and education.

Hospitals and Health Care 馃嚭馃嚫 Winston-Salem 11,679 n/a
18
Dentsply Sironadentsplysirona.com

World's largest maker of professional dental products and technologies, enabling dental professionals to offer improved, safer, and quicker dental care. Comprehensive solutions across consumables, equipment, technology, specialty products.

Medical Equipment Manufacturing 馃嚭馃嚫 Charlotte 11,331 1899
19
Labcorp Drug Developmentlabcorp.com

A global leader in diagnostics and drug development, providing insights to improve health and lives through innovative solutions and unparalleled capabilities

Hospitals and Health Care 馃嚭馃嚫 Burlington 9,425 n/a
20
FHI 360fhi360.org

Nonprofit organization advancing equity, health, and well-being worldwide through research, resources, and locally led, data-driven solutions.

International Trade and Development 馃嚭馃嚫 Durham 8,644 1971
21
East Carolina Universityecu.edu

Educates North Carolina residents, conducts research, and provides community service, preparing future workforce leaders through academic programs and partnerships, especially in eastern North Carolina.

Higher Education 馃嚭馃嚫 Greenville 8,642 1907
22
RTI Internationalrti.org

Independent scientific research institute providing technical, social, statistical, and engineering expertise to solve critical global challenges and improve human conditions.

Research Services 馃嚭馃嚫 Research Triangle Park 6,607 1958
23
Vontiervontier.com

A global industrial technology company specializing in smarter transportation, mobility technologies, fueling, fleet management, telematics, vehicle diagnostics, and smart cities solutions

Transportation Equipment Manufacturing 馃嚭馃嚫 Raleigh 6,201 2020
24
Ralliantralliant.com

Design, develop, and deliver high-performance instruments and solutions enabling engineers to innovate and accelerate advanced product development worldwide.

Electrical Equipment Manufacturing 馃嚭馃嚫 Raleigh 6,173 n/a
25
FUJIFILM Biotechnologiesfujifilm.com

Accelerates biopharma progress, expands capabilities, streamlines processes, and strengthens innovation for cures, vaccines, and biologics, improving patient outcomes worldwide.

Biotechnology Research 馃嚭馃嚫 Billingham 5,907 2011

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26
Curtiss-Wright Corporationcurtisswright.com

Global manufacturer providing highly engineered products and advanced technology solutions for critical functions within international commercial, industrial, defense, and energy market sectors.

Defense and Space Manufacturing 馃嚭馃嚫 Davidson 5,835 n/a
27
Avalaraavalara.com

Provides an agentic AI platform for global tax and compliance, automating calculations, return filings, and exemption certificate management for businesses worldwide.

Software Development 馃嚭馃嚫 Durham 5,649 2004
28
University of North Carolina Wilmingtonuncw.edu

A coastal university emphasizing teaching, research, and service, offering a range of baccalaureate, master's, and doctoral programs with a focus on student engagement and diversity

Higher Education 馃嚭馃嚫 Wilmington 5,547 1947
29
JELD-WEN, Inc.corporate.jeld-wen.com

designs manufactures distributes high-performance interior exterior doors windows related building products for new construction repair remodeling sectors

Wholesale Building Materials 馃嚭馃嚫 Charlotte 5,204 1960
30
Albemarle Corporationalbemarle.com

A global leader in transforming essential resources into mobility, energy, connectivity, and health solutions with a focus on sustainability and innovation

Chemical Manufacturing 馃嚭馃嚫 Charlotte 4,300 n/a
31
SPX FLOW, Inc.spxflow.com

manufacturing and delivering technology, service, and support to nutrition, health, and industrial sectors for efficient manufacturing processes

Industrial Machinery Manufacturing 馃嚭馃嚫 Charlotte 4,154 2015
32
Extreme Networksextremenetworks.com

Leader in AI-powered cloud networking, delivering a unified platform simplifying and securing IT operations, connecting devices, applications, and users for thousands of customers.

Software Development 馃嚭馃嚫 Morrisville 4,064 1996
33
UTC Aerospace Systemscollinsaerospace.com

The company designs and manufactures aerospace systems that power, control, and monitor aircraft, enabling modern flight and technological innovation worldwide

Aviation and Aerospace Component Manufacturing 馃嚭馃嚫 Charlotte 4,046 2012
34
Novolexnovolex.com

Leader in packaging innovation and sustainability, offering products in paper, plastic, and sustainable materials for food, retail, health, and industrial markets

Packaging and Containers Manufacturing 馃嚭馃嚫 Charlotte 3,879 2004
35
Duke University Hospital

A leading academic medical center known for exceptional care, groundbreaking research, and commitment to improving the health of individuals and communities

Hospitals and Health Care 馃嚭馃嚫 Durham 3,704 1925
36
Kontoor Brands, Inc.kontoorbrands.com

Portfolio management of iconic lifestyle, outdoor, and workwear brands including Wrangler, Lee, and Helly Hansen.

Retail Apparel and Fashion 馃嚭馃嚫 Greensboro 3,283 2019
37
Merz Aestheticsmerzaesthetics.com

A global medical aesthetics business offering injectables, devices, and skincare treatments to help individuals look, feel, and live confidently worldwide

Pharmaceutical Manufacturing 馃嚭馃嚫 Raleigh 3,164 n/a
38
Center for Creative Leadershipccl.org

A global leader in executive education, using research to develop individuals and organizations into better leaders across the world

Professional Training and Coaching 馃嚭馃嚫 Greensboro 2,969 1970
39
University of North Carolina Systemnorthcarolina.edu

A multi-campus university system in North Carolina dedicated to teaching, research, outreach, and service with over 225,000 students enrolled

Higher Education 馃嚭馃嚫 Raleigh 2,948 1776
40
Goodrichgoodrich.com

A global supplier to aerospace, defense, and homeland security markets with a diversified product portfolio, serving customers worldwide with innovative systems and services

Aviation and Aerospace Component Manufacturing 馃嚭馃嚫 Charlotte 2,616 1870
41
Duke University School of Medicinemedschool.duke.edu

Leading medical school with a focus on interdisciplinary collaboration, research, and innovation to improve human health locally and globally

Higher Education 馃嚭馃嚫 Durham 2,542 1930
42
Toshiba Global Commerce Solutionscommerce.toshiba.com

Global leader in retail store technology, providing integrated in-store solutions that enhance customer engagement, transform the in-store experience, and accelerate digital transformation

Technology, Information and Internet 馃嚭馃嚫 Durham 2,537 2012
43
Wolfspeedwolfspeed.com

Global leader in Silicon Carbide technology for over 30 years, enabling breakthroughs in electric vehicles, 5G, renewable energy, aerospace, and defense industries

Semiconductor Manufacturing 馃嚭馃嚫 Durham 2,460 2015
44
Parker Lordparker.com

Global leader in motion and control technologies serving industrial and aerospace markets with diverse products for manufacturing, transportation, and infrastructure

Industrial Machinery Manufacturing 馃嚭馃嚫 Cary 2,455 1924
45
N-ablen-able.com

Protects businesses from cyberthreats with a unified cyber resiliency platform. Manages, secures, and recovers data using AI-powered technology and partner support.

Computer and Network Security 馃嚭馃嚫 Morrisville 2,289 n/a
46
insightsoftwareinsightsoftware.com

Global provider of reporting, analytics, and performance management solutions empowering finance teams with insights to make informed decisions and drive financial intelligence

Software Development 馃嚭馃嚫 Raleigh 2,267 n/a
47
Mack Truckslinktr.ee

Designs, builds, and delivers tools and services for business success since 1900 Dedicated to personal relationships, industry expertise, and long-lasting value Born Ready

Truck Transportation 馃嚭馃嚫 Greensboro 2,108 1900
48
Columbus McKinnoncolumbusmckinnon.com

A global leader in intelligent motion solutions, offering high-quality brands for increasing safety, improving productivity, and moving the world forward

Machinery Manufacturing 馃嚭馃嚫 Charlotte 1,807 1875
49
KBI Biopharmakbibiopharma.com

Provides fully-integrated, accelerated drug development and biomanufacturing services to pharmaceutical and biotechnology companies globally with world-class analytical capabilities.

Biotechnology Research 馃嚭馃嚫 Durham 1,694 1996
50
Creewolfspeed.com

Specializing in Silicon Carbide technology, we provide cutting-edge solutions and innovations Follow us at Wolfspeed, Inc for the latest updates

Semiconductor Manufacturing 馃嚭馃嚫 Durham 1,658 1987

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How this list is built

Every company on this list has a Tamtam company profile. The industry is the one the company gives on LinkedIn; categories such as SaaS or fintech are classified by Tamtam's AI from the company's website and LinkedIn page; and the headquarters city must match the company's own address. Companies are ranked by the number of employees on LinkedIn, and the list is refreshed every night. Classifications can be wrong, so treat the list as a starting point rather than an official ranking. Last updated Nov 11, 2026.

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