This selection of companies with in-house R&D in North Carolina reveals a strong presence of large organizations, particularly in the healthcare and technology sectors. Companies like IQVIA and Labcorp, both in Hospitals and Health Care, employ tens of thousands, providing clinical research, laboratory services, and healthcare intelligence. Other significant players include Lenovo, a global technology powerhouse, and Collins Aerospace, delivering connected solutions for aviation.
A notable pattern among these companies is the concentration of headquarters in a few key cities. Charlotte emerges as a prominent hub, hosting Advocate Health, Atrium Health, and Duke Energy Corporation, which focuses on utilities and clean energy transition. Raleigh also features prominently with Red Hat, an enterprise open source solutions leader, and North Carolina State University, specializing in STEM education.
| # | Company | Employees | |||
|---|---|---|---|---|---|
| 1 | 80,633 | ||||
| 2 |
Collins Aerospacertx.com
Global aerospace company designing and delivering connected solutions for passenger safety, mission success, space exploration, and operational efficiency. |
51,969 | |||
| 3 |
Lenovolenovo.com
A global technology powerhouse with a focus on delivering smarter technology through innovation, serving millions of customers worldwide in various markets |
47,094 | |||
| 4 |
Labcorplabcorp.com
Provides innovative, comprehensive laboratory services, insights, and advanced science to improve health outcomes and develop new drugs for global clients and patients. |
42,780 | |||
| 5 |
Advocate Healthadvocatehealth.org
Advocate Health redefines care delivery to help people live well by providing equitable services across six states for better outcomes at lower costs |
34,037 | |||
| 6 |
Atrium Healthatriumhealth.org
Nationally recognized health leader providing innovative research, education, and compassionate patient care through top-ranked specialties, medical education, and community benefits |
30,465 | |||
| 7 |
Duke Energy Corporationduke-energy.com
Electric and natural gas utilities serving millions, focusing on clean energy transition, grid upgrades, and net-zero emissions goals. |
25,788 | |||
| 8 |
Red Hatredhat.com
A global leader in enterprise open source solutions, delivering high-performing Linux, hybrid cloud, edge, and Kubernetes technologies through community collaboration Join us and make an impact |
21,000 | |||
| 9 |
North Carolina State Universityncsu.edu
Comprehensive university specializing in STEM education and research, committed to improving quality of life locally and globally through innovation. |
20,729 | |||
| 10 | 18,697 | ||||
| 11 |
Sealed Air Corporationsealedair.com
Development and supply of automated, sustainable packaging solutions protecting food, liquids, and goods, enhancing e-commerce and reducing environmental impact. |
17,000 | |||
| 12 |
Duke Universityduke.edu
Private research university offering undergraduate, graduate, and professional education with strong emphasis on research and academic excellence. |
16,307 | |||
| 13 |
Ingersoll Randirco.com
Provider of durable, high-performance industrial flow creation and solutions, supporting complex environments with expertise and productivity. |
15,367 | |||
| 14 |
Trane Technologiestranetechnologies.com
This company challenges industry norms, commits to ambitious sustainability goals, and aims to influence global change through innovative solutions for heating, cooling, and refrigeration |
15,027 | |||
| 15 |
Duke University Health Systemdukehealth.org
Academic health system focused on innovative research, education, evidence-based medicine, community health improvement, and eliminating health disparities globally and locally. |
12,096 | |||
| 16 |
Epic Gamesepicgames.com
Provider of 3D engine technology powering games and industries, operator of Fortnite, and digital ecosystem for developers and creators. |
11,831 | |||
| 17 |
Atrium Health Wake Forest Baptistwakehealth.edu
Academic medical center with hospitals, clinics, medical school, research, and community health services providing extensive patient care and education. |
11,679 | |||
| 18 |
Dentsply Sironadentsplysirona.com
World's largest maker of professional dental products and technologies, enabling dental professionals to offer improved, safer, and quicker dental care. Comprehensive solutions across consumables, equipment, technology, specialty products. |
11,331 | |||
| 19 |
Labcorp Drug Developmentlabcorp.com
A global leader in diagnostics and drug development, providing insights to improve health and lives through innovative solutions and unparalleled capabilities |
9,425 | |||
| 20 |
FHI 360fhi360.org
Nonprofit organization advancing equity, health, and well-being worldwide through research, resources, and locally led, data-driven solutions. |
8,644 | |||
| 21 |
East Carolina Universityecu.edu
Educates North Carolina residents, conducts research, and provides community service, preparing future workforce leaders through academic programs and partnerships, especially in eastern North Carolina. |
8,642 | |||
| 22 |
RTI Internationalrti.org
Independent scientific research institute providing technical, social, statistical, and engineering expertise to solve critical global challenges and improve human conditions. |
6,607 | |||
| 23 |
Vontiervontier.com
A global industrial technology company specializing in smarter transportation, mobility technologies, fueling, fleet management, telematics, vehicle diagnostics, and smart cities solutions |
6,201 | |||
| 24 |
Ralliantralliant.com
Design, develop, and deliver high-performance instruments and solutions enabling engineers to innovate and accelerate advanced product development worldwide. |
6,173 | |||
| 25 |
FUJIFILM Biotechnologiesfujifilm.com
Accelerates biopharma progress, expands capabilities, streamlines processes, and strengthens innovation for cures, vaccines, and biologics, improving patient outcomes worldwide. |
5,907 | |||
Want more companies than this list?This page shows the largest ones only. Connect to Tamtam to see every company that matches, filter by size, industry or growth, and reach their decision-makers. | |||||
| 26 |
Curtiss-Wright Corporationcurtisswright.com
Global manufacturer providing highly engineered products and advanced technology solutions for critical functions within international commercial, industrial, defense, and energy market sectors. |
5,835 | |||
| 27 |
Avalaraavalara.com
Provides an agentic AI platform for global tax and compliance, automating calculations, return filings, and exemption certificate management for businesses worldwide. |
5,649 | |||
| 28 |
University of North Carolina Wilmingtonuncw.edu
A coastal university emphasizing teaching, research, and service, offering a range of baccalaureate, master's, and doctoral programs with a focus on student engagement and diversity |
5,547 | |||
| 29 |
JELD-WEN, Inc.corporate.jeld-wen.com
designs manufactures distributes high-performance interior exterior doors windows related building products for new construction repair remodeling sectors |
5,204 | |||
| 30 |
Albemarle Corporationalbemarle.com
A global leader in transforming essential resources into mobility, energy, connectivity, and health solutions with a focus on sustainability and innovation |
4,300 | |||
| 31 |
SPX FLOW, Inc.spxflow.com
manufacturing and delivering technology, service, and support to nutrition, health, and industrial sectors for efficient manufacturing processes |
4,154 | |||
| 32 |
Extreme Networksextremenetworks.com
Leader in AI-powered cloud networking, delivering a unified platform simplifying and securing IT operations, connecting devices, applications, and users for thousands of customers. |
4,064 | |||
| 33 |
UTC Aerospace Systemscollinsaerospace.com
The company designs and manufactures aerospace systems that power, control, and monitor aircraft, enabling modern flight and technological innovation worldwide |
4,046 | |||
| 34 |
Novolexnovolex.com
Leader in packaging innovation and sustainability, offering products in paper, plastic, and sustainable materials for food, retail, health, and industrial markets |
3,879 | |||
| 35 |
Duke University Hospital
A leading academic medical center known for exceptional care, groundbreaking research, and commitment to improving the health of individuals and communities |
3,704 | |||
| 36 |
Kontoor Brands, Inc.kontoorbrands.com
Portfolio management of iconic lifestyle, outdoor, and workwear brands including Wrangler, Lee, and Helly Hansen. |
3,283 | |||
| 37 |
Merz Aestheticsmerzaesthetics.com
A global medical aesthetics business offering injectables, devices, and skincare treatments to help individuals look, feel, and live confidently worldwide |
3,164 | |||
| 38 |
Center for Creative Leadershipccl.org
A global leader in executive education, using research to develop individuals and organizations into better leaders across the world |
2,969 | |||
| 39 |
University of North Carolina Systemnorthcarolina.edu
A multi-campus university system in North Carolina dedicated to teaching, research, outreach, and service with over 225,000 students enrolled |
2,948 | |||
| 40 |
Goodrichgoodrich.com
A global supplier to aerospace, defense, and homeland security markets with a diversified product portfolio, serving customers worldwide with innovative systems and services |
2,616 | |||
| 41 |
Duke University School of Medicinemedschool.duke.edu
Leading medical school with a focus on interdisciplinary collaboration, research, and innovation to improve human health locally and globally |
2,542 | |||
| 42 |
Toshiba Global Commerce Solutionscommerce.toshiba.com
Global leader in retail store technology, providing integrated in-store solutions that enhance customer engagement, transform the in-store experience, and accelerate digital transformation |
2,537 | |||
| 43 |
Wolfspeedwolfspeed.com
Global leader in Silicon Carbide technology for over 30 years, enabling breakthroughs in electric vehicles, 5G, renewable energy, aerospace, and defense industries |
2,460 | |||
| 44 |
Parker Lordparker.com
Global leader in motion and control technologies serving industrial and aerospace markets with diverse products for manufacturing, transportation, and infrastructure |
2,455 | |||
| 45 |
N-ablen-able.com
Protects businesses from cyberthreats with a unified cyber resiliency platform. Manages, secures, and recovers data using AI-powered technology and partner support. |
2,289 | |||
| 46 |
insightsoftwareinsightsoftware.com
Global provider of reporting, analytics, and performance management solutions empowering finance teams with insights to make informed decisions and drive financial intelligence |
2,267 | |||
| 47 |
Mack Truckslinktr.ee
Designs, builds, and delivers tools and services for business success since 1900 Dedicated to personal relationships, industry expertise, and long-lasting value Born Ready |
2,108 | |||
| 48 |
Columbus McKinnoncolumbusmckinnon.com
A global leader in intelligent motion solutions, offering high-quality brands for increasing safety, improving productivity, and moving the world forward |
1,807 | |||
| 49 |
KBI Biopharmakbibiopharma.com
Provides fully-integrated, accelerated drug development and biomanufacturing services to pharmaceutical and biotechnology companies globally with world-class analytical capabilities. |
1,694 | |||
| 50 |
Creewolfspeed.com
Specializing in Silicon Carbide technology, we provide cutting-edge solutions and innovations Follow us at Wolfspeed, Inc for the latest updates |
1,658 | |||
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How this list is built
Every company on this list has a Tamtam company profile. The industry is the one the company gives on LinkedIn; categories such as SaaS or fintech are classified by Tamtam's AI from the company's website and LinkedIn page; and the headquarters city must match the company's own address. Companies are ranked by the number of employees on LinkedIn, and the list is refreshed every night. Classifications can be wrong, so treat the list as a starting point rather than an official ranking. Last updated Nov 11, 2026.
More company lists in North Carolina
- The largest companies in North Carolina 2,409
- Multinational companies in North Carolina 358
- Manufacturers in North Carolina 271
- Retail chains in North Carolina 221
- Education providers in North Carolina 207
- Critical infrastructure operators in North Carolina 171
- Hospitals and Health Care companies in North Carolina 157
- Healthcare providers in North Carolina 153
- Financial services firms in North Carolina 143
- Professional services firms in North Carolina 142
- Public sector organisations in North Carolina 139
- Hardware manufacturers in North Carolina 129
- IT Services and IT Consulting companies in North Carolina 120
- Higher Education companies in North Carolina 118
- SaaS companies in North Carolina 108
- Software Development companies in North Carolina 105
- Companies with a mobile app in North Carolina 96
- IT services companies in North Carolina 96
- Publicly traded companies in North Carolina 91
- Construction companies in North Carolina 87
- Consulting firms in North Carolina 85
- Financial Services companies in North Carolina 82
- Family-owned companies in North Carolina 80
- Real Estate companies in North Carolina 79
The same list elsewhere in United States
- Companies with in-house R&D in the United States 6,796
- Companies with in-house R&D in California 1,276
- Companies with in-house R&D in Texas 442
- Companies with in-house R&D in New York State 419
- Companies with in-house R&D in Massachusetts 396
- Companies with in-house R&D in Illinois 322
- Companies with in-house R&D in Michigan 287
- Companies with in-house R&D in Ohio 277
- Companies with in-house R&D in Pennsylvania 255
- Companies with in-house R&D in New Jersey 224
- Companies with in-house R&D in Florida 221
- Companies with in-house R&D in Alabama 214
- Companies with in-house R&D in Georgia 173
- Companies with in-house R&D in Virginia 166
- Companies with in-house R&D in Wisconsin 154
- Companies with in-house R&D in Minnesota 146
- Companies with in-house R&D in Washington State 140
- Companies with in-house R&D in Colorado 113
- Companies with in-house R&D in Maryland 107
- Companies with in-house R&D in Indiana 104
- Companies with in-house R&D in New York 223
- Companies with in-house R&D in San Francisco 147
- Companies with in-house R&D in Houston 129
- Companies with in-house R&D in San Jose 103