100 leading critical infrastructure operators in North Carolina (2026 list)

#	Company	Industry	Headquarters	Employees	Founded
1	Bank of America bankofamerica.com Global financial institution providing comprehensive banking, investing, and asset management services to individuals, small businesses, and large corporations through diverse risk management products.	Banking	🇺🇸 Charlotte	304,000	n/a
2	Labcorp labcorp.com Provides innovative, comprehensive laboratory services, insights, and advanced science to improve health outcomes and develop new drugs for global clients and patients.	Hospitals and Health Care	🇺🇸 Burlington	42,780	1905
3	Advocate Health advocatehealth.org Advocate Health redefines care delivery to help people live well by providing equitable services across six states for better outcomes at lower costs	Hospitals and Health Care	🇺🇸 Charlotte	34,037	n/a
4	Atrium Health atriumhealth.org Nationally recognized health leader providing innovative research, education, and compassionate patient care through top-ranked specialties, medical education, and community benefits	Hospitals and Health Care	🇺🇸 Charlotte	30,465	1940
5	Truist truist.com A financial institution formed to inspire and improve lives and communities, offering a wide range of services to individuals and businesses nationwide	Financial Services	🇺🇸 Charlotte	29,080	n/a
6	Duke Energy Corporation duke-energy.com Electric and natural gas utilities serving millions, focusing on clean energy transition, grid upgrades, and net-zero emissions goals.	Utilities	🇺🇸 Charlotte	25,788	n/a
7	Novant Health novanthealth.org Integrated network of healthcare facilities in North and South Carolina with over 1,900 physicians and 36,000 team members providing care at 800+ locations	Hospitals and Health Care	🇺🇸 Winston-Salem	23,780	1997
8	UNC Health unchealthcare.org Providing patient care, medical education, and research leadership to improve health and well-being across North Carolina and beyond.	Hospitals and Health Care	🇺🇸 Chapel Hill	20,114	1952
9	First Citizens Bank firstcitizens.com A family-controlled bank providing general banking, commercial banking, and wealth services with a nationwide presence and a legacy of strength and stability since 1898	Banking	🇺🇸 Raleigh	18,899	n/a
10	Bank of America Merrill Lynch business.bofa.com Global banking and markets business providing strategic advisory, securities, investment banking, retirement services, and commercial banking activities across local and global financial markets.	Financial Services	🇺🇸 Charlotte	16,335	n/a
11	BB&T bbt.com Financial services provider offering retail, small business, and commercial banking, insurance, mortgage, asset management, and wealth management for millions of households and businesses.	Financial Services	🇺🇸 Charlotte	13,189	1872
12	Duke University Health System dukehealth.org Academic health system focused on innovative research, education, evidence-based medicine, community health improvement, and eliminating health disparities globally and locally.	Hospitals and Health Care	🇺🇸 Durham	12,096	n/a
13	Atrium Health Wake Forest Baptist wakehealth.edu Academic medical center with hospitals, clinics, medical school, research, and community health services providing extensive patient care and education.	Hospitals and Health Care	🇺🇸 Winston-Salem	11,679	n/a
14	SunTrust truist.com Financial institution providing retail, small business, and commercial banking services, including asset management, capital markets, insurance, mortgage, specialized lending, and wealth management solutions.	Financial Services	🇺🇸 Charlotte	11,613	1891
15	Vidant Health ecuhealth.org A healthcare organization in eastern North Carolina offering opportunities for both service and care, focused on improving the health of the community Visit our LinkedIn page!	Hospitals and Health Care	🇺🇸 Greenville	8,762	n/a
16	Carolinas HealthCare System atriumhealth.org A leading healthcare system providing quality healthcare services and medical treatment options for patients in the Carolinas region	Hospitals and Health Care	🇺🇸 Charlotte	8,087	n/a
17	Cone Health conehealth.com Healthcare provider with 5 hospitals, 3 ambulatory care centers, physician practices, retirement communities, and more, dedicated to serving central North Carolina communities	Hospitals and Health Care	🇺🇸 Greensboro	8,055	1953
18	WakeMed wakemed.org A private, not-for-profit healthcare organization in Raleigh, NC with a network of hospitals, outpatient centers, emergency departments, and physician practices	Hospitals and Health Care	🇺🇸 Raleigh	7,552	1961
19	Old Dominion Freight Line odfl.com Less-than-truckload motor carrier offering regional, national LTL services, expedited transport, drayage, brokerage, consulting, and warehousing across the U.S.	Truck Transportation	🇺🇸 Thomasville	7,404	1934
20	Blue Cross NC bluecrossnc.com Leading provider of health insurance in North Carolina with a focus on improving health and well-being through innovative approaches and passionate employees	Insurance	🇺🇸 Durham	6,148	1933
21	SECU ncsecu.org Largest credit union in North Carolina, serving over 26 million members with 270+ branches, 24/7 account access, and award-winning financial services since 1937	Financial Services	🇺🇸 Raleigh	6,148	1937
22	First National Bank firstcitizens.com A leading family-controlled bank in the US offering a variety of financial products and services to individuals and businesses	Banking	🇺🇸 Raleigh	5,812	1898
23	RXO, Inc.rxo.com An asset-light transportation provider leveraging scale, technology, and third-party capacity to efficiently move freight for customers	Truck Transportation	🇺🇸 Charlotte	4,781	2022
24	UNC Health Rex rexhealth.com A private, not-for-profit health care system providing expert care and services to the Wake County community for over 120 years	Hospitals and Health Care	🇺🇸 Raleigh	4,478	1894
25	ECU Health ecuhealth.org Mission-driven healthcare system serving 14 million people in eastern North Carolina, focusing on excellence in care amidst evolving challenges and technologies	Hospitals and Health Care	🇺🇸 Greenville	4,217	n/a
26	Cape Fear Valley Health capefearvalley.com A regional health system with 8 hospitals and over 1 million patients annually, offering a wide range of medical services and nationally recognized for quality care	Hospitals and Health Care	🇺🇸 Fayetteville	4,018	n/a
27	NCDOT ncdot.gov A government agency in North Carolina with over 9,000 employees focused on providing high-quality transportation options including highways, rail, aviation, and public transit	Truck Transportation	🇺🇸 Raleigh	3,840	1915
28	Duke University Hospital A leading academic medical center known for exceptional care, groundbreaking research, and commitment to improving the health of individuals and communities	Hospitals and Health Care	🇺🇸 Durham	3,704	1925
29	Vidant Medical Center vidanthealth.com A flagship hospital within a larger health system, providing trauma care, nursing excellence, and serving as a teaching hospital in eastern North Carolina	Hospitals and Health Care	🇺🇸 Greenville	3,477	n/a
30	City of Charlotte charlottenc.gov Local government providing economic development, neighborhood improvement, transportation planning, and efficient management for over 870,000 residents.	Government Administration	🇺🇸 Charlotte	3,454	n/a
31	City of Raleigh raleighnc.gov A leading city in North Carolina known for innovation, education, and quality of life with diverse career opportunities for various professionals	Government Administration	🇺🇸 Raleigh	3,352	1792
32	New Hanover Regional Medical Center novanthealth.org A not-for-profit health care system serving the southeastern North Carolina and northeastern South Carolina regions, offering a wide range of health care services	Hospitals and Health Care	🇺🇸 Wilmington	3,206	1967
33	PSA Airlines, Inc.bit.ly Fleet of Bombardier regional jets, operating over 800 daily flights to nearly 100 destinations for American Airlines with crew bases across the US	Airlines and Aviation	🇺🇸 Charlotte	3,135	1983
34	Mission Health missionhealth.org Mission Health is a leading healthcare provider in western North Carolina with acute care hospitals, outpatient/surgery centers, trauma center, and long-term care services	Hospitals and Health Care	🇺🇸 North Carolina	3,118	n/a
35	CaroMont Health caromonthealth.org Regional health system providing medical and wellness services through a network of physician practices, urgent care, hospice, and emergency facilities, with advanced medical technology and skilled doctors	Hospitals and Health Care	🇺🇸 Gastonia	2,616	1946
36	Pike Corporation pike.com A leading provider of utilities solutions, offering planning, design, installation, and maintenance for electric, gas, and communication infrastructure for over 70 years	Construction	🇺🇸 Mount Airy	2,520	1945
37	Brightspeed brightspeed.com A new internet provider expanding connectivity across America with fast, reliable internet for streaming, gaming, and work in millions of homes	Telecommunications	🇺🇸 Charlotte	2,311	2022
38	FirstHealth of the Carolinas firsthealth.org Private, not-for-profit health care network with 6,100 employees serving 15 counties in central North Carolina, offering quality healthcare for the community's whole patient	Hospitals and Health Care	🇺🇸 Pinehurst	2,220	1995
39	Progress Energy progress-energy.com The merged company is the nation's largest utility, delivering affordable, reliable, and clean energy to 7 million customers with efficient operations and a consolidated online presence	Utilities	🇺🇸 Raleigh	2,015	1908
40	Davita Dialysis Provider of dialysis treatments and support services for patients with chronic kidney failure, also known as end-stage renal disease (ESRD)	Hospitals and Health Care	🇺🇸 Madison	2,011	n/a
41	Lumos Fiber lumosfiber.com Provider of 100% Fiber Optic Internet for families, small businesses, and communities, offering high-speed connectivity for multiple devices and a bright future	Technology, Information and Internet	🇺🇸 High Point	1,762	n/a
42	RBC Bank rbcbank.com The company provides banking solutions for Canadians in the US, including accounts, credit cards, loans, mortgages, and cross-border financing options	Banking	🇺🇸 Raleigh	1,752	n/a
43	Truist Wealth truist.com Providing guidance in building wealth, protecting assets, and generating income in retirement through personalized financial planning and innovative solutions	Financial Services	🇺🇸 Charlotte	1,736	2021
44	Alliance Health alliancehealthplan.org This company manages public mental health, intellectual/developmental disability, and substance abuse services for Medicaid-eligible citizens in multiple counties, focusing on whole-person care and community-based support	Hospitals and Health Care	🇺🇸 Durham	1,607	2012
45	Brighthouse Financial brighthousefinancial.com provider of annuities and life insurance products helping customers protect their earnings and ensure long-term financial security	Insurance	🇺🇸 Charlotte	1,367	2017
46	Durham County Government dconc.gov Provides local government services, elects commissioners, manages county operations through a professional manager, supports community living and business environment.	Government Administration	🇺🇸 Durham	1,296	1881
47	First Bank (FBNC)localfirstbank.com Established in 1935, we are the largest independent community bank in North Carolina Offering financial solutions with a personal touch	Banking	🇺🇸 Southern Pines	1,273	1935
48	Duke Raleigh Hospital dukehealth.org A community-focused hospital providing compassionate care with access to advanced technology and leading-edge medicine Dedicated to building a experienced and compassionate health care team	Hospitals and Health Care	🇺🇸 Raleigh	1,198	1978
49	TTX Company ttx.com Provides nearly 175,000 railcars and freight car management tools supporting diverse North American industries with efficient transportation solutions.	Rail Transportation	🇺🇸 Charlotte	1,138	1955
50	Segra segra.com Provider of advanced fiber infrastructure network with services including Ethernet, MPLS, dark fiber, data center, IP, managed services, voice, and cloud solutions Serving various industries nationwide	Telecommunications	🇺🇸 Charlotte	1,107	1897
51	Live Oak Bank liveoak.bank America's small business bank, offering digital banking products including loans, checking, savings, and CDs to help business owners buy, build, and expand.	Banking	🇺🇸 Wilmington	1,067	2008
52	UNC Health Wayne linktr.ee UNC Health Wayne provides comprehensive medical services and a supportive work environment to improve the health and wellness of the community	Hospitals and Health Care	🇺🇸 Goldsboro	1,059	n/a
53	CarolinaEast Health System carolinaeasthealth.com A leading medical center offering a full range of inpatient and outpatient services, specialized care units, and a dedicated team of medical professionals focused on patient-centric care	Hospitals and Health Care	🇺🇸 New Bern	1,032	1963
54	Bank of America Business business.bofa.com Global banking and markets services including commercial lending, financial instrument trading, strategic advisory, and investment banking activities for diverse clients across international jurisdictions.	Financial Services	🇺🇸 Charlotte	983	n/a
55	Piedmont Natural Gas piedmontng.com A subsidiary of a major electric power holding company supplying electricity and natural gas to millions of customers in the Southeast and Midwest	Utilities	🇺🇸 Charlotte	980	n/a
56	NorthState lumosfiber.com Provider of high-speed fiber internet, Wi-Fi, voice, and TV services to residential and business customers in North Carolina and Virginia	Telecommunications	🇺🇸 High Point	965	1895
57	Live Oak Bancshares A financial holding company and its subsidiary are focused on revolutionizing the banking industry through technology and innovation for customer efficiency	Financial Services	🇺🇸 Wilmington	939	2008
58	Womack Army Medical Center womack.tricare.mil Military complex in Fort Bragg, NC housing key Army commands and the largest Army installation globally, including Womack Army Medical Center	Wellness and Fitness Services	🇺🇸 Fort Liberty	929	1918
59	Duke Regional Hospital dukehealth.org A leading healthcare facility providing comprehensive inpatient, outpatient, surgical, emergency care, and specialized services to the community with high-quality, safe care	Hospitals and Health Care	🇺🇸 Durham	900	1976
60	UNC Health Pardee pardeehospital.org A leading hospital in North Carolina offering quality healthcare services, with a comprehensive physician network, cancer center, urgent care locations, and orthopedic clinics	Hospitals and Health Care	🇺🇸 Hendersonville	895	1953
61	FastMed Urgent Care fastmed.com A leading urgent care provider offering acute/episodic, preventive, and occupational healthcare, as well as family medicine at selected clinics and telemedicine services	Medical Practices	🇺🇸 Durham	870	2001
62	PowerSecure, Inc.powersecure.com Innovative provider of energy solutions, specializing in distributed energy resources, microgrid solutions, and energy efficient lighting technology for utilities and customers	Electrical Equipment Manufacturing	🇺🇸 Durham	861	2000
63	UNC Health Johnston johnstonhealth.org A healthcare system in Johnston County, offering top-notch care with modern facilities, experienced staff, and a strong partnership with UNC Health	Hospitals and Health Care	🇺🇸 Smithfield	839	1951
64	Truliant Federal Credit Union truliantfcu.org A credit union serving over 300,000 members in the Carolinas and Virginia, providing financial solutions and guidance with a focus on member satisfaction	Banking	🇺🇸 Winston-Salem	839	1952
65	Carteret Health Care carterethealth.org An independent 135-bed hospital on the Crystal Coast providing acute care, diagnostic services, outpatient care, and wellness programs to the community, with Mayo Clinic Care Network membership	Hospitals and Health Care	🇺🇸 Morehead City	811	1967
66	Appalachian Regional Healthcare System apprhs.org Healthcare leader in the High Country with hospitals, medical practices, cancer center, heart & vascular center, pain management, rehabilitation, and wellness services Committed to improving community health	Hospitals and Health Care	🇺🇸 Boone	807	n/a
67	City of Asheville ashevillenc.gov Regional local government managing public policy, strategic planning, and municipal services through dedicated professionals focused on safety, diversity, and community welfare improvements.	Government Administration	🇺🇸 Asheville	788	n/a
68	Frye Regional Medical Center fryemedctr.com A leading medical center providing quality healthcare services with over 300 physicians and a dedicated staff, supported by Duke LifePoint Healthcare resources	Hospitals and Health Care	🇺🇸 Hickory	781	1911
69	Daymark Recovery Services daymarkrecovery.org A community-focused organization providing culturally sensitive mental health and substance abuse services to individuals of all ages and their families	Mental Health Care	🇺🇸 Concord	767	n/a
70	Randolph Health randolphhealth.org Nationally recognized healthcare provider dedicated to quality care, promoting health and wellness, and ensuring the best-quality care for patients and families	Hospitals and Health Care	🇺🇸 Asheboro	763	1928
71	Coastal Credit Union coastal24.com A not-for-profit financial institution providing exceptional customer service, competitive rates, and top-notch mobile banking services in central North Carolina with 23 branches	Banking	🇺🇸 Raleigh	761	1967
72	UNC Health Nash nashunchealthcare.org A non-profit hospital authority providing superior quality healthcare services, improving community health, and leveraging resources of a leading national healthcare system	Hospitals and Health Care	🇺🇸 Rocky Mount	758	1971
73	Onslow Memorial Hospital onslow.org A 162-bed hospital in North Carolina offering state-of-the-art healthcare services, including diagnostic, maternity, intensive care, emergency, and rehabilitation services	Hospitals and Health Care	🇺🇸 Jacksonville	753	1944
74	Wilmington Health wilmingtonhealth.com Committed to community health in Southeastern North Carolina, a multi-specialty clinic providing comprehensive care through a coordinated approach and focus on innovation	Hospitals and Health Care	🇺🇸 Wilmington	750	1971
75	Liberty Health liberty-healthcare.com Family-owned healthcare company providing high-quality services, retirement communities, and programs across multiple states, emphasizing personal independence and community involvement	Hospitals and Health Care	🇺🇸 Wilmington	737	1875
76	Iredell Health System iredellhealth.org This healthcare system includes hospitals, specialty centers, urgent care, physician practices, and wellness programs to inspire wellbeing in the community	Hospitals and Health Care	🇺🇸 Statesville	726	1954
77	High Point Regional Health wakehealth.edu A 351-bed hospital in High Point, North Carolina, offering a wide range of patient-centered care with specialty services including heart, cancer, neurology, women's health, emergency, and joint replacement	Hospitals and Health Care	🇺🇸 High Point	717	1904
78	City of Fayetteville, North Carolina fayettevillenc.gov Local government fostering community growth, supporting military presence, promoting economic development, cultural activities, and educational institutions in a thriving city environment.	Government Administration	🇺🇸 Fayetteville	711	1762
79	OneWest Bank firstcitizens.com A banking institution that was formerly known as OneWest Bank, now operating under the name First Citizens Bank Member FDIC	Banking	🇺🇸 Raleigh	695	n/a
80	Piedmont HealthCare piedmonthealthcare.com A leading multi-specialty healthcare group in North Carolina providing comprehensive medical care with over 60 locations and 200 providers across 32 specialties	Medical Practices	🇺🇸 Statesville	685	1996
81	Vaya Health vayahealth.com A whole-person health organization providing support for behavioral health, intellectual/developmental disabilities, connecting individuals with providers for healing and recovery	Hospitals and Health Care	🇺🇸 Asheville	681	1972
82	Wilson Medical Center wilsonmedical.com A 294-bed healthcare organization providing comprehensive cardiac care, imaging services, women's and children's services, and primary/specialty care through physician practices	Hospitals and Health Care	🇺🇸 Wilson	670	1964
83	Allergy Partners PLLC allergypartners.com Nation's largest single-specialty practice in allergy, asthma and immunology with over 130 providers in 23 states, offering diagnosis and treatment for various allergic diseases	Hospitals and Health Care	🇺🇸 Asheville	669	n/a
84	Charlotte Eye Ear Nose & Throat Associates, P.A. (CEENTA)ceenta.com Specialty medical practice providing comprehensive eye, ear, nose, and throat care as well as additional services across the Carolinas	Hospitals and Health Care	🇺🇸 Charlotte	669	1923
85	Naval Medical Center Camp Lejeune camp-lejeune.tricare.mil Naval Hospital Camp Lejeune provides healthcare services and employment opportunities while maintaining a family-friendly and informative online presence	Hospitals and Health Care	🇺🇸 Camp Lejeune	654	n/a
86	Trillium Health Resources trilliumhealthresources.org Specialty behavioral health management in North Carolina, providing services for mental health, disabilities, brain injuries, and substance use disorders to improve well-being	Insurance	🇺🇸 Ahoskie	652	n/a
87	The City of Rocky Mount rockymountnc.gov A city in North Carolina providing public utilities and services to residents, focusing on community well-being, safety, and collaboration for a vibrant future	Government Administration	🇺🇸 Rocky Mount	638	1816
88	MOSES CONE HEALTH SYSTEM A hospital and health care company based in Greensboro, North Carolina providing healthcare services to the community in the United States	Hospitals and Health Care	🇺🇸 Greensboro	625	n/a
89	Southeastern Regional Medical Center unchealthsoutheastern.org Comprehensive healthcare system offering acute care, intensive care, and psychiatric services to thousands of inpatients and emergency patients annually Nonprofit organization	Hospitals and Health Care	🇺🇸 Lumberton	623	1953
90	HomeTrust Bank htb.com A regional bank providing full-service commercial banking tailored to businesses' needs through relationship-focused, personalized solutions by experienced local bankers	Financial Services	🇺🇸 Asheville	614	1926
91	Atrium Health Levine Children's atriumhealth.org Integrated network for children's healthcare in Charlotte, NC, offering pediatric offices, urgent care, hospital programs, specialty care, and a focus on children's well-being	Hospitals and Health Care	🇺🇸 Charlotte	606	2007
92	Well Care Health wellcarehealth.com Trusted provider of high quality, specialized in-home health care services in the Carolina's for over 34 years, prioritizing patients' needs and comfort	Home Health Care Services	🇺🇸 Wilmington	605	1987
93	Epes Transport System, LLC epestransport.com Provides dedicated truckload capacity, drayage, shuttle, general truckload, and yard switching services with extensive regional terminal coverage and shipment tracking.	Transportation, Logistics, Supply Chain and Storage	🇺🇸 Greensboro	578	1931
94	Lumexa Imaging lumexaimaging.com A leading radiology group with 180+ imaging centers across 14 states, providing top-notch clinical excellence, advanced technology, and best-in-class patient care	Hospitals and Health Care	🇺🇸 Raleigh	566	2018
95	The Fidelity Bank fidelitybanknc.com A full-service financial institution offering personal service, independence, security, and profitability to customers through various banking products and services	Banking	🇺🇸 Fuquay-Varina	553	1909
96	Wachovia Corp wachovia.com A leading provider of investment and advisory services, catering to individuals, corporations, and institutions in the financial sector	Financial Services	🇺🇸 Charlotte	507	1879
97	UNC Hospitals uncmedicalcenter.org Providing medical services to patients from North Carolina and the southeast region since 1952 through UNC Hospitals and the faculty practice	Hospitals and Health Care	🇺🇸 Chapel Hill	503	n/a
98	Charlotte Douglas International Airport cltairport.com Airport department managing one of the busiest global hubs, facilitating domestic and international flights, supporting economic growth and connectivity.	Airlines and Aviation	🇺🇸 Charlotte	484	1935
99	Deriva Energy derivaenergy.com An established leader in clean energy, with significant wind, solar, and storage assets across the US, backed by Brookfield's expertise	Services for Renewable Energy	🇺🇸 Charlotte	364	n/a
100	HonorBridge honorbridge.org Organ donation and tissue recovery organization serving 78 counties, 100 hospitals, and 200+ transplant centers, making a lifesaving impact	Hospitals and Health Care	🇺🇸 Chapel Hill	246	n/a

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100 leading critical infrastructure operators in North Carolina

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