Critical infrastructure operators headquartered in Pennsylvania (2026 list)

#	Company	Industry	Headquarters	Employees	Founded
1	Comcast comcast.com Delivering broadband, mobile, and video products, along with entertainment, sports, news, and theme park experiences; driven by passionate creators and innovators	Telecommunications	🇺🇸 Philadelphia	189,000	1963
2	PNC pnc.com Provides financial services focused on managing money effectively to simplify clients' financial lives and support their life goals.	Financial Services	🇺🇸 Pittsburgh	64,159	n/a
3	UPMC upmc.com A leading health care provider and insurer in Pittsburgh, offering patient-centered care, innovative models, and community benefits through hospitals and insurance services	Hospitals and Health Care	🇺🇸 Pittsburgh	41,860	n/a
4	Select Medical careers.selectmedical.com Specialized hospital and rehabilitative care provider operating recovery hospitals, outpatient centers, and occupational health facilities across the United States.	Hospitals and Health Care	🇺🇸 Mechanicsburg	25,292	n/a
5	Penn Medicine, University of Pennsylvania Health System pennmedicine.org Leading academic medical center combining cutting-edge research, comprehensive patient care, and education to improve health and transform lives regionally.	Hospitals and Health Care	🇺🇸 Philadelphia	21,979	n/a
6	Jefferson Health jeffersonhealth.org This company is dedicated to providing excellent clinical care, educating future health professionals, and advancing research in health sciences	Hospitals and Health Care	🇺🇸 Philadelphia	18,520	n/a
7	Children's Hospital of Philadelphia chop.edu Specialized pediatric hospital providing exceptional patient care, pioneering medical research, and training future pediatric healthcare professionals.	Hospitals and Health Care	🇺🇸 Philadelphia	18,042	1855
8	Geisinger geisinger.org Healthcare organization with 13 hospital campuses, research centers, medical college, and health plan serving millions in Pennsylvania Committed to quality healthcare	Hospitals and Health Care	🇺🇸 Danville	15,962	1915
9	Highmark Health highmarkhealth.org Provides health insurance, care delivery, population health management, dental solutions, reinsurance, and innovative technology to millions of customers across the nation.	Hospitals and Health Care	🇺🇸 Pittsburgh	15,876	n/a
10	Genesis genesishcc.com Provider of high-quality healthcare services, including skilled nursing, senior living, rehabilitation therapy, and staffing, emphasizing diversity, equity, and inclusion in all aspects	Hospitals and Health Care	🇺🇸 Kennett Square	14,566	1985
11	Lehigh Valley Health Network lvhn.org Comprehensive healthcare network delivering high-quality, award-winning medical services focused on patient safety, nursing excellence, and community well-being.	Hospitals and Health Care	🇺🇸 Allentown	12,163	n/a
12	Penske Logistics penskelogistics.com provider of dedicated transportation, distribution management, 4PL, freight brokerage, and technology solutions for diverse industries worldwide	Transportation, Logistics, Supply Chain and Storage	🇺🇸 Reading	11,808	1969
13	Allegheny Health Network ahn.org Integrated healthcare delivery system with hospitals, medical centers, wellness pavilions, and numerous physician practices serving Western Pennsylvania.	Hospitals and Health Care	🇺🇸 Pittsburgh	11,676	n/a
14	WellSpan Health wellspan.org Integrated delivery system in South Central Pennsylvania and northern Maryland, providing comprehensive healthcare solutions through a network of providers, hospitals, home care, and behavioral health services	Hospitals and Health Care	🇺🇸 York	11,400	1880
15	UHS uhs.com A leading healthcare provider with a focus on compassionate care, operating hospitals, behavioral health facilities, outpatient facilities, and ambulatory care access points	Hospitals and Health Care	🇺🇸 King of Prussia	11,329	1979
16	St. Luke's University Health Network slhn.org Integrated non-profit healthcare network in PA and NJ with 14 campuses, 300+ outpatient sites, medical school, nursing school, and top quality rankings	Hospitals and Health Care	🇺🇸 Bethlehem	11,156	1872
17	Lincoln Financial lincolnfinancial.com Provides annuities, investments, life insurance, group protection, and retirement plan services to help customers achieve long-term financial security and reach personal goals.	Financial Services	🇺🇸 Radnor	10,801	1905
18	Comcast Business business.comcast.com A technology solutions provider offering connectivity, networking, cybersecurity, and communications solutions to businesses of all sizes, with a focus on driving innovation and growth	Telecommunications	🇺🇸 Philadelphia	9,292	n/a
19	Main Line Health mainlinehealth.org A not-for-profit health system with hospitals, rehab facilities, outpatient centers, and physician networks, offering advancement opportunities and a supportive work environment	Hospitals and Health Care	🇺🇸 Radnor Township	9,033	1985
20	Penn State Health pennstatehealth.org Multi-hospital health system in central Pennsylvania with medical centers, outpatient practices, and a partnership with Highmark Health for community care	Hospitals and Health Care	🇺🇸 Hershey	8,037	1963
21	F.N.B. Corporation fnb-online.com Diversified financial services company offering commercial banking, consumer banking, wealth management, and insurance solutions across multiple U.S. states.	Financial Services	🇺🇸 Pittsburgh	7,832	1864
22	Highmark highmark.com A leading health insurance organization delivering high-quality, accessible, and affordable solutions to 68 million members in multiple states	Insurance	🇺🇸 Pittsburgh	7,672	n/a
23	PPL Corporation pplweb.com Providing electricity to millions, building smarter, resilient power grids, advancing sustainable energy solutions, and fostering inclusive work environments.	Utilities	🇺🇸 Allentown	7,118	1920
24	Erie Insurance Group erieinsurance.com Multi-line insurance company offering auto, home, business, and life insurance through independent agents across 12 states and D.C.	Insurance	🇺🇸 Erie	6,685	1925
25	Temple Health – Temple University Health System templehealth.org Temple Health provides advanced research and clinical care, offering innovative treatments through renowned physicians, nurses, and researchers in various medical facilities and practices	Hospitals and Health Care	🇺🇸 Philadelphia	5,770	1892
26	Newrez newrez.com Providing personalized mortgage loans, refinancing options, and home equity solutions with dedicated support, especially for military families.	Financial Services	🇺🇸 Fort Washington	5,327	2018
27	UGI Corporation ugicorp.com An international energy distribution and services company focusing on delivering energy products, providing great service, serving communities, and delivering value to investors	Utilities	🇺🇸 King of Prussia	5,226	1882
28	Penn Medicine Lancaster General Health pennmedicine.org Comprehensive healthcare system offering hospital services, outpatient care, physician network, behavioral health, rehabilitation, and health sciences education across multiple facilities.	Hospitals and Health Care	🇺🇸 Lancaster	4,900	1893
29	UPMC Health Plan upmchealthplan.com A leading health insurer offering quality health insurance plans for individuals, families, and businesses, with a focus on providing top-ranked care and innovative wellness programs	Insurance	🇺🇸 Pittsburgh	4,550	1996
30	Southeastern Pennsylvania Transportation Authority (SEPTA)septa.org A major public transit system in Southeastern Pennsylvania offering bus, subway, trolley, Regional Rail, paratransit, and shared ride services across multiple counties	Ground Passenger Transportation	🇺🇸 Philadelphia	3,982	1964
31	Xfinity xfinity.com Revolutionizing connectivity with the Xfinity 10G Network, leading the way into the future of high-speed internet services	Telecommunications	🇺🇸 Philadelphia	3,979	n/a
32	Select Specialty Hospital selectspecialtyhospitals.com Specializing in critical and complex medical conditions, our hospitals provide tailored programs and services to improve patient wellness and outcomes	Hospitals and Health Care	🇺🇸 Mechanicsburg	3,892	n/a
33	Einstein Healthcare Network jeffersonhealth.org Healthcare network serving Philadelphia and Montgomery County, offering comprehensive medical services and patient care across multiple facilities.	Hospitals and Health Care	🇺🇸 Philadelphia	3,812	n/a
34	Pennsylvania Department of Transportation (PennDOT)pa.gov This company oversees highway programs, transportation policies, bridges, vehicle registrations, driver's licenses, safety programs, and emission inspections in Pennsylvania	Truck Transportation	🇺🇸 Harrisburg	3,764	1970
35	UPMC Children's Hospital of Pittsburgh chp.edu A leader in treating childhood conditions, developing therapies, educating pediatricians, and advancing research with strong community support since 1890	Hospitals and Health Care	🇺🇸 Pittsburgh	3,489	1890
36	PAM Health pamhealth.com The company is dedicated to providing high-quality patient care and customer service in post-acute services, supporting recovery through education and research	Hospitals and Health Care	🇺🇸 Enola	3,455	n/a
37	Aqua aquawater.com Providing water and wastewater services to over 3 million people across multiple U.S. states with a focus on safety and integrity.	Utilities	🇺🇸 Bryn Mawr	3,174	n/a
38	Fulton Bank fultonbank.com A community-oriented bank focused on personalized service, financial solutions, and fostering lasting relationships while promoting equality and career growth	Banking	🇺🇸 Lancaster	2,886	1882
39	Tower Health towerhealth.org Regional integrated healthcare system offering leading-edge, compassionate healthcare and wellness services across multiple counties, with various hospitals, urgent care facilities, and medical services	Hospitals and Health Care	🇺🇸 West Reading	2,823	n/a
40	Bryn Mawr Trust bmt.com Provider of wealth management solutions, planning, investment management, trust, estate planning, brokerage, and investment services for individual, corporate, and institutional clients	Financial Services	🇺🇸 Bryn Mawr	2,507	1889
41	PECO peco.com A historic company in the energy sector, dedicated to providing safe, reliable, affordable, and clean energy services while promoting environmental awareness and innovation	Utilities	🇺🇸 Philadelphia	2,481	1881
42	Independence Health System independence.health Provides quality cardiology, orthopedics, maternity, surgical, emergency, behavioral health services with a large network of primary care physicians.	Hospitals and Health Care	🇺🇸 Greensburg	2,261	2004
43	Trinity Health Mid-Atlantic trinityhealthma.org A regional health system in the Greater Philadelphia Area with multiple hospitals, part of Trinity Health of Livonia, Michigan	Hospitals and Health Care	🇺🇸 Newtown Square	2,158	n/a
44	Fox Chase Cancer Center foxchase.org Dedicated cancer hospital with expert multidisciplinary teams advancing prevention, diagnosis, treatment, and survivorship through pioneering research and clinical care.	Hospitals and Health Care	🇺🇸 Philadelphia	2,146	1904
45	Northwest Bank northwest.bank A financial institution focused on improving lives through award-winning customer service in Pennsylvania, New York, Indiana, and Ohio	Banking	🇺🇸 Warren	2,003	1896
46	EQT Corporation eqt.com A leading independent natural gas producer focused on responsible development in the Appalachian Basin, striving to create long-term value for stakeholders	Oil and Gas	🇺🇸 Canonsburg	1,809	1888
47	Heritage Valley Health System heritagevalley.org An integrated delivery network offering comprehensive healthcare services in Pennsylvania, Ohio, and West Virginia through hospitals, physician offices, and community facilities	Hospitals and Health Care	🇺🇸 Beaver	1,705	n/a
48	Penn Medicine Chester County Hospital chestercountyhospital.org Delivering compassionate and innovative healthcare as part of a leading health system for over 125 years, offering new treatment options	Hospitals and Health Care	🇺🇸 West Chester	1,701	1892
49	Penn Highlands Healthcare phhealthcare.org Penn Highlands Healthcare in Pennsylvania provides a full range of healthcare services through multiple hospitals, home care agencies, senior living facilities, and affiliates	Hospitals and Health Care	🇺🇸 Dubois	1,694	2011
50	Crozer-Keystone Health System crozerhealth.org A leading health care provider offering a full spectrum of wellness, acute care, and rehabilitation services in Delaware County, PA	Hospitals and Health Care	🇺🇸 Springfield	1,684	1990
51	Penn Medicine Doylestown Health doylestownhealth.org Healthcare organization offering a wide range of services including hospital care, surgery center, home health care, hospice, physicians, retirement community, and childcare services	Hospitals and Health Care	🇺🇸 Doylestown	1,635	1923
52	Redeemer Health redeemerhealth.org A Catholic healthcare provider in PA and NJ offering a wide range of services, including acute care, home health, hospice, and housing programs	Hospitals and Health Care	🇺🇸 Meadowbrook	1,588	1924
53	Inframark inframark.com Specializing in water infrastructure management, operations, and support services, we tailor solutions for clients to achieve performance, safety, compliance, and reliability	Utilities	🇺🇸 Horsham	1,527	n/a
54	Conemaugh Health System, Duke LifePoint Healthcare conemaugh.org A leading healthcare provider in west central Pennsylvania, offering a wide range of medical services with a focus on excellence and exceptional clinical outcomes	Hospitals and Health Care	🇺🇸 Johnstown	1,515	1889
55	UPMC Susquehanna susquehannahealth.org This healthcare network in northcentral Pennsylvania provides clinically excellent services through six hospitals and various medical offices, serving a 16-county region	Hospitals and Health Care	🇺🇸 Williamsport	1,491	1994
56	Vibra Healthcare vibrahealthcare.com Providing patient-centered care with a supportive culture, career growth, flexible hours, and a commitment to clinical excellence.	Hospitals and Health Care	🇺🇸 Mechanicsburg	1,480	2004
57	UPMC Pinnacle upmcpinnacle.com Health system with seven hospitals, outpatient clinics, and over 2,900 healthcare professionals serving multiple counties in Pennsylvania	Hospitals and Health Care	🇺🇸 Harrisburg	1,449	n/a
58	Dollar Bank dollar.bank An inclusive community bank investing in customers, empowering employees, and strengthening communities while prioritizing customer privacy and data protection	Banking	🇺🇸 Pittsburgh	1,442	1855
59	Duquesne Light Company duquesnelight.com Providing safe, reliable electric service to over 600,000 customers in southwestern Pennsylvania with a focus on clean energy transition.	Utilities	🇺🇸 Pittsburgh	1,428	1880
60	Aria - Jefferson Health jeffersonhealth.org A leading healthcare provider in Northeast Philadelphia and Lower Bucks County, offering community hospitals, outpatient centers, and primary care physicians to improve lives	Hospitals and Health Care	🇺🇸 Philadelphia	1,421	n/a
61	CNX cnx.com Premier natural gas developer in Appalachia, prioritizing local resources to make a tangible impact on regional communities and beyond Producing low cost, low emission natural gas	Oil and Gas	🇺🇸 Canonsburg	1,413	1864
62	First Commonwealth Bank fcbanking.com A community-focused financial institution dedicated to improving the financial well-being of individuals and businesses through authentic banking experiences and thoughtful leadership	Banking	🇺🇸 Indiana	1,409	1982
63	St. Clair Health stclair.org An independent acute-care medical center in southwestern Pennsylvania, offering a wide range of high-quality health care services to the community	Hospitals and Health Care	🇺🇸 Pittsburgh	1,408	1954
64	St. Christopher's Hospital for Children towerhealth.org A renowned pediatric care provider in Philadelphia offering exceptional services and nationally recognized programs for children worldwide since 1875	Hospitals and Health Care	🇺🇸 Philadelphia	1,364	1875
65	Mount Nittany Health mountnittany.org A healthcare system in Central Pennsylvania with a 120-year legacy, providing best-in-class care and compassion for the community	Hospitals and Health Care	🇺🇸 State College	1,339	1902
66	Metro Bank fnb-online.com regional financial services provider with multiple banking offices across Pennsylvania, offering full-service banking to local communities and businesses.	Banking	🇺🇸 Harrisburg	1,316	n/a
67	Sacred Heart Hospital affiliated with Sacred Heart HealthCare System slhn.org A Catholic medical center offering a wide range of advanced medical services, including obstetrics, surgery, cardiology, rehabilitation, and behavioral health services	Hospitals and Health Care	🇺🇸 Allentown	1,284	1912
68	KidsPeace kidspeace.org Dedicated private charity serving behavioral and mental health needs of children, families, and communities through psychiatric hospital, residential treatment, educational, foster care, and community-based programs	Mental Health Care	🇺🇸 Schnecksville	1,273	1882
69	Pyramid Healthcare, Inc.pyramid-healthcare.com Provider of behavioral health services since 1999, with over 80 facilities offering mental health, substance use, and recovery services for adults and teens	Hospitals and Health Care	🇺🇸 Duncansville	1,267	1999
70	UGI Utilities, Inc.ugi.com Natural gas and electric utility providing safe, reliable, and affordable energy services to customers across Pennsylvania and Maryland counties.	Utilities	🇺🇸 Denver	1,232	1882
71	Penn Mutual pennmutual.com With over 175 years of experience, this company partners with Financial Professionals to provide life insurance, annuities, wealth management, and institutional asset management solutions	Insurance	🇺🇸 Philadelphia	1,183	1847
72	Regency Hospital Company regencyhospital.com Regency Hospitals, part of Select Medical, specializes in providing comprehensive care to acutely ill patients with catastrophic illnesses or injuries	Hospitals and Health Care	🇺🇸 Mechanicsburg	1,154	n/a
73	Customers Bank customersbank.com A community-based, full-service bank offering loans to businesses and consumers nationwide, with a focus on human connections, innovation, and technology	Banking	🇺🇸 Reading	1,149	2009
74	PJM Interconnection pjm.com Manage high-voltage electric system serving 67 million people across 13 states and DC, administer wholesale electricity market, ensure grid reliability.	Utilities	🇺🇸 Audubon	1,148	1927
75	Members 1st Federal Credit Union members1st.org A company offering financial tools and services since 1950, helping members plan for the future and afford the things they love	Banking	🇺🇸 Enola	1,095	1950
76	Philadelphia Gas Works pgworks.com provides natural gas energy services and solutions to over 500,000 residential and commercial customers in Philadelphia city	Utilities	🇺🇸 Philadelphia	1,047	1836
77	UPMC Hillman Cancer Center hillmanresearch.upmc.edu An NCI-designated cancer center affiliated with a university, providing high-level clinical care, research, and education to cancer patients and professionals	Hospitals and Health Care	🇺🇸 Pittsburgh	1,028	n/a
78	Allied Services allied-services.org Leading provider of healthcare and human services in northeastern Pennsylvania, offering a wide range of programs for individuals with disabilities and chronic illnesses since 1958	Hospitals and Health Care	🇺🇸 Clarks Summit	1,018	1958
79	Good Shepherd Rehabilitation goodshepherdrehab.org A not-for-profit rehabilitation network offering inpatient, outpatient, and community-based services for patients of all ages and abilities in eastern PA and NJ	Hospitals and Health Care	🇺🇸 Allentown	1,004	1908
80	Univest univest.net A growing financial corporation offering banking, insurance, investments, trust, wealth management, leasing, and mortgage banking services to local communities	Financial Services	🇺🇸 Souderton	1,004	1876
81	S&T Bank stbank.com A financial services company founded in 1902, offering a range of services to families and businesses in Pennsylvania and Ohio	Financial Services	🇺🇸 Indiana	947	1902
82	PSECU psecu.com A member-owned credit union founded in 1934, providing financial services to over 500,000 members with $7 billion in assets Non-profit organization	Banking	🇺🇸 Harrisburg	938	1934
83	St. Mary Medical Center, Langhorne, PA trinityhealthma.org A comprehensive medical center offering advanced care and state-of-the-art technology, with a focus on patient safety, quality care, and community outreach initiatives	Hospitals and Health Care	🇺🇸 Langhorne	919	1973
84	Meadville Medical Center mmchs.org A community hospital in Pennsylvania offering state-of-the-art facilities, leading healthcare services, and innovative technology to meet the community's needs	Hospitals and Health Care	🇺🇸 Meadville	903	n/a
85	PinnacleHealth System upmcpinnacle.com A healthcare provider offering high-quality, patient-centered services in central Pennsylvania with over 2,900 physicians, 11,000 employees, and eight acute care hospitals	Hospitals and Health Care	🇺🇸 Harrisburg	903	1873
86	Pittsburgh Regional Transit rideprt.org Operate and maintain bus, rail, and incline transit services in the Pittsburgh metropolitan area with a workforce of 2,600 employees.	Truck Transportation	🇺🇸 Pittsburgh	892	1964
87	Independence Health System - Butler/Clarion Area independence.health Provides quality care in cardiology, orthopedics, maternity, surgery, emergency, behavioral health, and primary care across multiple hospitals.	Hospitals and Health Care	🇺🇸 Butler	883	1898
88	Fulton Financial Corporation fultonbank.com A regional financial holding company offering a wide range of products and services, focused on building lasting relationships and providing excellent customer service	Banking	🇺🇸 Lancaster	871	1882
89	Berkshire Hathaway GUARD Insurance Companies guard.com A highly rated property & casualty insurer offering customizable insurance products through independent agents, with a focus on customer needs and privacy	Insurance	🇺🇸 Wilkes-Barre	867	1983
90	Philadelphia Water Department water.phila.gov This company provides integrated water, wastewater, and stormwater services to the City of Philadelphia's 15 million residents, focusing on high-quality water supply and watershed management	Government Administration	🇺🇸 Philadelphia	863	1951
91	Federal Reserve Bank of Philadelphia philadelphiafed.org Implement monetary policy, supervise banks, provide financial services to institutions and government One of 12 regional Reserve Banks in Federal Reserve System	Financial Services	🇺🇸 Philadelphia	852	1914
92	Evangelical Community Hospital wellspan.org Providing personalized, affordable healthcare with diverse specialty services including orthopaedics, surgical care, diabetes management, and urgent care for communities.	Hospitals and Health Care	🇺🇸 Lewisburg	834	1926
93	Nazareth Hospital trinityhealthma.org Providing compassionate healthcare services to Northeast Philadelphia and surrounding areas for over 75 years with a focus on personal care	Hospitals and Health Care	🇺🇸 Philadelphia	825	1940
94	Pennsylvania Turnpike Commission paturnpike.com Operates and maintains 564 miles of toll roads in Pennsylvania, including America's first superhighway Visit wwwpaturnpikecom for more information	Truck Transportation	🇺🇸 Middletown	816	1940
95	QNB Bank qnbbank.com A community-focused bank providing a range of financial services, including banking, loans, investments, and digital banking options in Pennsylvania since 1877	Banking	🇺🇸 Quakertown	799	1877
96	Grand View Health gvh.org A community health system providing a range of inpatient and outpatient services including cancer care, cardiology, orthopaedics, surgery, and women's and children's health	Hospitals and Health Care	🇺🇸 Sellersville	784	1873
97	Sun Healthcare Group genesishcc.com Sun Healthcare Group was acquired by Genesis HealthCare Employees should update profiles to Genesis HealthCare Followers should start following Genesis HealthCare for updates	Hospitals and Health Care	🇺🇸 Kennett Square	738	n/a
98	CNB Bank cnbbank.bank Leader in integrated financial solutions offering checking, savings, loans, credit cards, wealth management, and more in multiple states, with a focus on community involvement	Banking	🇺🇸 Clearfield	734	1865
99	The Pennsylvania Department of Human Services dhs.pa.gov The company's mission is to help Pennsylvanians lead safe and healthy lives while responsibly managing commonwealth resources for vulnerable individuals and families	Government Administration	🇺🇸 Harrisburg	732	n/a
100	Philadelphia Fire Department phila.gov The company provides fire protection, emergency medical services, and specialized divisions to investigate fires and protect Philadelphia International Airport	Public Safety	🇺🇸 Philadelphia	722	1871

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Critical infrastructure operators headquartered in Pennsylvania

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