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List of critical infrastructure operators in Missouri

Tamtam tracks 76 critical infrastructure operators headquartered in Missouri. This list ranks all of them by number of employees on LinkedIn, led by Ascension, Edward Jones and Centene Corporation. Their median headcount is 1,279. Half of them were founded in 1956 or later. The most common headquarters are St. Louis (22), Kansas City (11) and Jefferson City (6).

馃嚭馃嚫 Missouri76 companiesUpdated Oct 24, 2026
#CompanyIndustryHeadquarters EmployeesFounded
1
Ascensionhealthcare.ascension.org

A faith-based healthcare organization focused on providing compassionate care to those in need across the US through various services and programs

Hospitals and Health Care 馃嚭馃嚫 St. Louis 66,381 1999
2
Edward Jonesedwardjones.com

Provides personalized financial advisory and investment services through a large network of advisors to help clients achieve financial goals.

Financial Services 馃嚭馃嚫 St. Louis 45,845 1922
3
Centene Corporationcentene.com

Providing affordable, high-quality healthcare plans for Medicaid, Medicare, and marketplace members, focusing on under-insured and uninsured individuals nationwide.

Hospitals and Health Care 馃嚭馃嚫 St. Louis 36,022 1984
4
Mercymercy.net

A nationally recognized health system providing excellent patient care, with over 50 hospitals, 900+ physician locations, and outreach ministries across multiple states

Hospitals and Health Care 馃嚭馃嚫 Chesterfield 30,240 1886
5
BJC Healthbjc.org

One of the largest nonprofit health care organizations in the US, focused on providing a wide range of healthcare services in St Louis and southern Illinois regions

Hospitals and Health Care 馃嚭馃嚫 St. Louis 29,641 n/a
6
SSM Healthssmhealth.com

Provides innovative, sustainable, and compassionate Catholic healthcare services including hospitals, physician offices, home care, hospice, pharmacy, and insurance.

Hospitals and Health Care 馃嚭馃嚫 St. Louis 20,202 1872
7
Children's Mercychildrensmercy.org

Specialized pediatric healthcare provider focusing on exceptional care, innovative research, and education to improve children's health and well-being.

Hospitals and Health Care 馃嚭馃嚫 Kansas City 8,393 1897
8
Stifel Financial Corp.stifel.com

Providing brokerage, trading, investment banking, advisory, and trust services to individuals, businesses, and municipalities across the U.S.

Financial Services 馃嚭馃嚫 St. Louis 7,384 1890
9
Saint Luke'ssaintlukeskc.org

A faith-based health system providing excellence in healthcare services, including specialized programs and hospitals across the Kansas City region

Hospitals and Health Care 馃嚭馃嚫 Kansas City 6,749 1882
10
Barnes-Jewish Hospitalbarnesjewish.org

Flagship hospital of BJC HealthCare offering advanced cancer treatment through the only National Cancer Institute-designated Comprehensive Cancer Center in Missouri.

Hospitals and Health Care 馃嚭馃嚫 St. Louis 6,733 n/a
11
Commerce Bankcommercebank.com

A regional bank offering a full range of financial services, including banking, loans, credit cards, and wealth management, focused on customer relationships and community support

Banking 馃嚭馃嚫 Kansas City 5,058 1865
12
St. Luke's Hospitalstlukes-stl.com

An independent, nonprofit healthcare provider offering personalized healthcare services at multiple locations in the St Louis area, focused on improving quality of life

Hospitals and Health Care 馃嚭馃嚫 Chesterfield 4,878 1866
13
CoxHealthcoxhealth.com

A leading healthcare provider in southwest Missouri with six hospitals, 80+ clinics, 5 ERs, and 13,000+ employees dedicated to improving community health

Hospitals and Health Care 馃嚭馃嚫 Springfield 4,842 1906
14
Accredo Specialty Pharmacyaccredo.com

specialty pharmacy providing personalized care and medication management for patients with chronic, complex, and rare conditions through expert clinical teams

Hospitals and Health Care 馃嚭馃嚫 St. Louis 3,599 n/a
15
University of Missouri Health Caremuhealth.org

A premier academic medical center in Missouri offering a full spectrum of care, from primary to specialized treatment for severe illnesses and injuries

Hospitals and Health Care 馃嚭馃嚫 Columbia 2,962 1839
16
University Health KCuniversityhealthkc.org

Academic health system offering acute care, behavioral health, primary care, specialty clinics, trauma services, and teaching medical professionals.

Hospitals and Health Care 馃嚭馃嚫 Kansas City 2,929 1962
17
Central Bankcentralbank.net

Privately held bank serving multiple states with community-focused banking, advanced technology, local lending decisions, and extensive ATM network.

Financial Services 馃嚭馃嚫 Jefferson City 2,885 1902
18
St. Louis Children's Hospitalstlouischildrens.org

A leading pediatric teaching hospital offering comprehensive medical care, education, and injury-prevention programs with a team dedicated to children's well-being

Hospitals and Health Care 馃嚭馃嚫 St. Louis 2,635 1879
19
North Kansas City Hospitalnkch.org

A leading healthcare provider in the Northland with a focus on providing quality care, a wide range of medical services, and community wellness programs

Hospitals and Health Care 馃嚭馃嚫 North Kansas City 2,287 1958
20
Suddenlink Communicationsoptimum.com

The company is a leading cable operator in the US, providing information, communication, and entertainment services to residential and commercial customers in multiple states

Telecommunications 馃嚭馃嚫 St. Louis 2,260 2003
21
Freeman Health Systemfreemanhealth.com

A locally owned, nationally recognized health system providing a wide range of medical services, including behavioral health, with career opportunities and generous benefits

Hospitals and Health Care 馃嚭馃嚫 Joplin 2,221 1925
22
Missouri Department of Transportationmodot.org

Manage Missouri's transportation infrastructure including roads, bridges, railroads, airports, and ports ensuring safety, reliability, and economic development.

Truck Transportation 馃嚭馃嚫 Jefferson City 2,147 1913
23
Air Evac Lifeteamlifeteam.net

A leading provider of helicopter air ambulance services that offers rapid access to definitive healthcare during life-threatening emergencies within the Global Medical Response family

Hospitals and Health Care 馃嚭馃嚫 O'fallon 1,923 1985
24
Evergylinkedin.com

The company delivers energy to communities in Kansas and Missouri, prioritizing sustainability, safety, and a people-first mindset to empower a better future

Utilities 馃嚭馃嚫 Kansas City 1,895 2018
25
Mosaic Life Caremymlc.com

Health care provider focusing on holistic wellness through innovative life-care model, safe and high-quality care, and collaboration with Mayo Clinic

Hospitals and Health Care 馃嚭馃嚫 St Joseph 1,888 2012
26
Federal Reserve Bank of Kansas Citykansascityfed.org

A regional Reserve Bank in the Federal Reserve System with 1,500 employees across multiple offices, focused on promoting a stable economy and protecting the banking system

Banking 馃嚭馃嚫 Kansas City 1,797 1921
27
Enterprise Bank & Trustenterprisebank.com

An organization committed to guiding individuals toward financial success by empowering businesses, securing families' futures, and investing in communities through personal service

Banking 馃嚭馃嚫 Clayton 1,725 1988
28
Compass Health Networkcompasshealthnetwork.org

Providing compassionate and quality care to improve physical and emotional health, offering innovative services to meet community needs with integrity

Hospitals and Health Care 馃嚭馃嚫 Clinton 1,637 1972
29
CFIcfidrive.com

This company provides truckload, temperature-controlled, and Mexico services including LTL and TL trucking, transloading, consolidation, brokerage, and cross-border expertise #peopledrivepossibility

Truck Transportation 馃嚭馃嚫 Joplin 1,628 1951
30
SSM Health Saint Louis University Hospitalssmhealth.com

An academic medical center affiliated with Saint Louis University School of Medicine, offering cutting-edge treatments, research, and compassionate care to patients

Hospitals and Health Care 馃嚭馃嚫 St. Louis 1,563 n/a
31
St. Anthony's Medical Centermercy.net

A leading medical center providing advanced medical treatment in various specialties and services to communities in Missouri and Illinois Staffed by skilled professionals

Hospitals and Health Care 馃嚭馃嚫 St. Louis 1,542 n/a
32
Missouri Baptist Medical Centermissouribaptist.org

A member of BJC HealthCare, providing world-class medical treatments, innovative technology, and career development opportunities in a compassionate environment

Hospitals and Health Care 馃嚭馃嚫 St. Louis 1,486 n/a
33
Federal Reserve Bank of St. Louisstlouisfed.org

The company serves as a central bank of the United States, conducting monetary policy, regulating banks, providing payment services, and promoting community development and financial education

Banking 馃嚭馃嚫 St. Louis 1,431 1914
34
Missouri Department of Health and Senior Serviceshealth.mo.gov

Promoting health and safety for all Missourians through prevention, collaboration, education, innovation, and responsive services with integrity, excellence, and accountability

Wellness and Fitness Services 馃嚭馃嚫 Jefferson City 1,326 1883
35
SSM Health St. Louisssmhealth.com

A Catholic, not-for-profit health system known for using quality measures to improve care, with hospitals and facilities in the St Louis region

Hospitals and Health Care 馃嚭馃嚫 St. Louis 1,314 n/a
36
Boone Healthboone.health

A leading regional hospital center providing quality healthcare in cardiovascular medicine, obstetrics, neurology, oncology, orthopedics, and surgical services with excellent patient service

Hospitals and Health Care 馃嚭馃嚫 Columbia 1,300 n/a
37
Blue Cross and Blue Shield of Kansas Citybluekc.com

Independent not-for-profit health insurance provider serving over one million members in Kansas City and surrounding counties, focusing on affordable healthcare access.

Insurance 馃嚭馃嚫 Kansas City 1,288 n/a
38
BJC HealthCarebjc.org

Nonprofit healthcare organization providing integrated hospital services, focusing on community health, innovation, education, and exceptional patient care across Missouri and Illinois.

Hospitals and Health Care 馃嚭馃嚫 St. Louis 1,279 n/a
39
Research Medical Centerhcamidwest.com

Specialized healthcare provider with a 590-bed hospital in Kansas City offering advanced technology, emergency services, specialized programs, and medical specialties

Hospitals and Health Care 馃嚭馃嚫 Kansas City 1,222 n/a
40
Liberty Hospitallibertyhospital.org

The company is focused on providing health solutions and creating a space where individuals can improve and maintain their well-being

Hospitals and Health Care 馃嚭馃嚫 Liberty 1,178 1974
41
Kansas City Southernkcsouthern.com

Transportation holding company with railroad investments in the U.S., Mexico, and Panama, linking major commercial and industrial centers.

Rail Transportation 馃嚭馃嚫 Kansas City 1,147 n/a
42
Insituform Technologiesazuria.com

A global leader in pipeline rehabilitation, specializing in CIPP technology to repair aging and defective pipelines, offering cost-effective and non-disruptive solutions

Construction 馃嚭馃嚫 Chesterfield 1,067 1971
43
Saint Francis Healthcare Systemsfmc.net

A healthcare system founded in 1875, providing compassionate care and innovative medical treatments to serve over 713,000 people across multiple states

Hospitals and Health Care 馃嚭馃嚫 Cape Girardeau 1,046 n/a
44
GoJet Airlinesgojetairlines.com

A premier regional airline operating as United Express, flying Bombardier CRJ-550 with first-class, economy plus, and coach cabins, based in St Louis

Airlines and Aviation 馃嚭馃嚫 Bridgeton 993 2005
45
Burrell Behavioral Healthburrellcenter.com

A leading behavioral health center in Missouri, providing care for over 40,000 clients through a network of 400+ licensed providers

Mental Health Care 馃嚭馃嚫 Springfield 988 1977
46
City of Springfield, Missourispringfieldmo.gov

The city of Springfield offers diverse attractions, dining options, and cultural activities, with various career opportunities, competitive pay, benefits, and community involvement

Government Administration 馃嚭馃嚫 Springfield 972 n/a
47
Great Southern Bankgreatsouthernbank.com

A multi-state bank offering comprehensive banking products and services, committed to building relationships with customers, communities, and shareholders

Banking 馃嚭馃嚫 Springfield 890 1923
48
PROENERGYproenergyservices.com

Integrated service provider delivering cost-effective, safe, and reliable solutions to the global energy industry with offices in multiple countries

Fossil Fuel Electric Power Generation 馃嚭馃嚫 Sedalia 866 2002
49
Bi-State Developmentbistatedev.org

A dynamic organization focused on economic development, public transit, regional freight logistics, and infrastructure improvements in the St Louis region since 1949

Civic and Social Organizations 馃嚭馃嚫 St. Louis 852 1949
50
BJC Medical Groupbjc.org

A healthcare group with over 600 doctors providing personalized care in St Louis, mid-Missouri, and southern Illinois, backed by top resources and recognized as a top workplace

Hospitals and Health Care 馃嚭馃嚫 St. Louis 836 n/a
51
SSM Health Cardinal Glennon Children's Hospitalssmhealth.com

A non-profit Catholic pediatric hospital providing high-quality care to children with complex conditions, located in St Louis, MO

Hospitals and Health Care 馃嚭馃嚫 St. Louis 824 1956
52
Citizens Memorialcitizensmemorial.com

Healthcare provider in Bolivar, Missouri offering a full range of medical and surgical services, including specialist clinics and long-term care facilities

Hospitals and Health Care 馃嚭馃嚫 Bolivar 821 1982
53
Phelps Healthphelpshealth.org

Healthcare organization offering a variety of job opportunities, including clinical and non-clinical roles, focused on integrity, compassion, innovation, and philanthropy

Hospitals and Health Care 馃嚭馃嚫 Rolla 782 1951
54
Lake Regional Health Systemlakeregional.com

Comprehensive healthcare services provider in the Lake of the Ozarks region, offering state-of-the-art hospital facilities, specialized physicians, and various clinics and pharmacies

Hospitals and Health Care 馃嚭馃嚫 Osage Beach 761 1978
55
Scottradescottrade.com

Financial services firm that partners with retail clients to provide trading services and investment solutions, offering advanced online products and a nationwide branch network

Financial Services 馃嚭馃嚫 St. Louis 723 1980
56
St. Mary's Medical Centerstmaryskc.com

Provides compassionate acute care, 24-hour emergency services, surgical procedures, and specialized treatment for stroke, chest pain, joint health, and wound care.

Hospitals and Health Care 馃嚭馃嚫 Blue Springs 717 1981
57
HNB Bankhnbbanks.com

This company is a national bank that was originally established in 1888 as the Bank of Hannibal in Missouri

Banking 馃嚭馃嚫 Hannibal 696 1888
58
Hannibal Regionalhannibalregional.org

A healthcare system with deep community roots, providing modern medical services through a dedicated team of nearly 1,000 professionals

Hospitals and Health Care 馃嚭馃嚫 Hannibal 670 n/a
59
Ozarks Healthcareozarkshealthcare.com

A not-for-profit healthcare system in south-central Missouri and north-central Arkansas, offering hospital services, clinics, rehabilitation, and home care

Hospitals and Health Care 馃嚭馃嚫 West Plains 628 1959
60
City Utilities of Springfieldcityutilities.net

A community-owned utility company in southwest Missouri providing electricity, natural gas, water, broadband, and transit services with competitive prices and hometown service

Utilities 馃嚭馃嚫 Springfield 624 1945
61
Missouri Farm Bureaumofbinsurance.com

A multi-line insurance company in Missouri providing auto, home, life, and business insurance products with top ratings for security

Insurance 馃嚭馃嚫 Jefferson City 606 n/a
62
Capital Region Medical Centercrmc.org

A 100-bed hospital in Jefferson City providing a wide range of medical services, including obstetrics, orthopaedics, cardiac care, oncology, and rehabilitation

Hospitals and Health Care 馃嚭馃嚫 Jefferson City 582 1951
63
Fulton State Hospitallinktr.ee

Fulton State Hospital provides treatment and rehabilitation services for individuals with mental health disorders, developmental disabilities, and forensic patients, specializing in diverse diagnoses

Hospitals and Health Care 馃嚭馃嚫 Fulton 582 1851
64
Academy Bankacademybank.com

A family-owned bank offering affordable, accessible credit and retail banking services through branches, ATMs, online banking, and mobile banking

Banking 馃嚭馃嚫 Kansas City 572 n/a
65
Metropolitan St. Louis Sewer Districtmsdprojectclear.org

A public agency in St Louis responsible for wastewater and stormwater management, serving a population of 13 million with 7 treatment facilities

Utilities 馃嚭馃嚫 St. Louis 559 1956
66
Socket Fibersocket.net

A Missouri-based telecommunications provider offering high-speed internet, telephone services, and fiber-optic network expansion to homes and businesses with local support

Telecommunications 馃嚭馃嚫 Columbia 383 1994
67
First Bank of the Lakefblake.bank

A customer-focused bank offering a full range of banking products and services to help individuals and businesses achieve their financial goals

Banking 馃嚭馃嚫 Osage Beach 206 1985
68
ITF GROUPitfgroup.com

A diverse and growing company specializing in FL & LTL load management across the USA and Canada, focused on delivering high-quality transport services

Transportation, Logistics, Supply Chain and Storage 馃嚭馃嚫 Hazelwood 166 2012
69
Neighbors Credit Unionneighborscu.org

A top credit union in Missouri offering financial services, education, and products to individuals, families, and businesses with a focus on member satisfaction and empowerment

Financial Services 馃嚭馃嚫 St. Louis 125 n/a
70
Legacy Bank and Trustlegacybankandtrust.com

A community-focused bank providing innovative banking solutions, fostering local growth, building strong relationships, and helping customers and businesses thrive

Banking 馃嚭馃嚫 Springfield 115 1907
71
Jaguar Transport Holdings, LLCjag-transport.com

A logistics company offering trucking, warehousing, rail, and transloading services with a focus on innovating sustainable solutions and personalized service

Truck Transportation 馃嚭馃嚫 Joplin 83 2018
72
UMB Financial Corpumbfinancial.com

A diversified financial holding company providing banking services, investment management, asset servicing, and payment solutions to customers in the US and globally

Banking 馃嚭馃嚫 Kansas City 61 1967
73
Central Electric Power Cooperativecepc.net

Electric generation and transmission cooperative serving central Missouri, owned by eight distribution cooperatives and covering a 22,000 square mile area

Utilities 馃嚭馃嚫 Jefferson City 46 n/a
74
Farmers' Electric Cooperative, Inc.fec-co.com

Member-owned utility providing electric service to over 12,800 connections in nine northwest Missouri counties, with a focus on safety, member satisfaction, and reliable power delivery

Utilities 馃嚭馃嚫 Chillicothe 45 1938
75
Rogers Trucking Inc.rogerstruckingky.com

Family-owned truckload carrier based in Columbia, Kentucky since 1965, offering exceptional service in transportation across 48 states and Canada with a focus on customer satisfaction and employee well-being

Truck Transportation 馃嚭馃嚫 Columbia 41 1965
76
Citizens Bank of the Midwestcbmw.bank

A financial institution offering a wide range of banking services to individuals and businesses, focusing on trust and personalized customer relationships

Banking 馃嚭馃嚫 Rolla 8 1944

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How this list is built

Every company on this list has a Tamtam company profile. The industry is the one the company gives on LinkedIn; categories such as SaaS or fintech are classified by Tamtam's AI from the company's website and LinkedIn page; and the headquarters city must match the company's own address. Companies are ranked by the number of employees on LinkedIn, and the list is refreshed every night. Classifications can be wrong, so treat the list as a starting point rather than an official ranking. Last updated Oct 24, 2026.

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