This selection of multinational companies in Missouri shows a strong presence of large, established firms across diverse sectors. Key players include O'Reilly Auto Parts, a major automotive aftermarket retailer; Enterprise Mobility, offering global transportation solutions; Emerson, a technology and engineering firm; and Edward Jones, providing financial advisory services. These companies are well-known for their extensive operations and significant employee bases.
A notable pattern is the concentration of headquarters in St. Louis, which hosts a significant number of these large multinationals, including Enterprise Mobility, Emerson, and Edward Jones. Other major cities like Kansas City and Springfield also feature prominently, indicating a broad distribution of economic activity across the state.
| # | Company | Employees | |||
|---|---|---|---|---|---|
| 1 |
O'Reilly Auto Partsoreillyauto.com
A leading retailer in the automotive aftermarket industry with over 6,000+ locations, committed to serving customers, community, and team members |
84,000 | |||
| 2 |
Enterprise Mobilityenterprisemobility.com
Provides comprehensive mobility solutions worldwide, focusing on innovative, accessible, efficient, and sustainable transportation for people and goods. |
70,005 | |||
| 3 |
Emersonemerson.com
A global technology and engineering company providing innovative solutions for industrial and commercial markets, driving innovation for a healthier, safer, and smarter world |
51,841 | |||
| 4 |
Edward Jonesedwardjones.com
Provides personalized financial advisory and investment services through a large network of advisors to help clients achieve financial goals. |
45,845 | |||
| 5 |
Amdocsamdocs.com
A global company empowers clients to innovate and create exceptional digital experiences, accelerate cloud migration, differentiate in 5G era, and enhance communication and media experiences |
34,637 | |||
| 6 |
Enterpriseenterprisemobility.com
Provides car rental services globally through multiple brands, offering employment opportunities and vehicle access in many countries. |
32,638 | |||
| 7 | 26,107 | ||||
| 8 |
Wal Mart Corporation
This company provides access to Walmart executive speeches, financial reports, press releases, photos, videos, and interactive global location map |
19,478 | |||
| 9 |
Hallmark Cardscareers.hallmark.com
Family-owned global business creating emotionally connected world through greeting cards, gifts, media networks, real estate development, and art products for children worldwide |
17,388 | |||
| 10 |
Burns & McDonnellburnsmcd.com
Engineering, construction, architecture, planning, and community engagement with a strong ownership mentality and commitment to client success and safety. |
16,200 | |||
| 11 |
Caleres, Inc.jobs.caleres.com
This company is a global footwear brand portfolio with diverse offerings, including famous labels like Sam Edelman and Naturalizer, focusing on consumer-driven innovation and quality craftsmanship |
9,313 | |||
| 12 |
Monsanto Companybayer.com
Leading in modern agriculture with a focus on seeds, plant traits, and crop protection through innovative breakthroughs for global impact |
9,303 | |||
| 13 |
Nestl茅 Purina North Americapurinajobs.com
Advances pet nutrition science, collaborates on innovation, and enriches lives of pets and owners. Builds strong teams for pet care. |
8,321 | |||
| 14 |
Graybargraybar.com
A Fortune 500 employee-owned corporation distributes electrical, communications, and networking products, offering supply chain management and logistics services to customers |
8,118 | |||
| 15 |
Saint Louis Universityslu.edu
A Jesuit, Catholic university in St Louis, MO offering top research programs Oldest university in the West, with a campus in Madrid, Spain |
7,855 | |||
| 16 |
Stifel Financial Corp.stifel.com
Providing brokerage, trading, investment banking, advisory, and trust services to individuals, businesses, and municipalities across the U.S. |
7,384 | |||
| 17 |
Anheuser-Buschanheuser-busch.com
A leading brewer in the United States with a legacy of crafting high-quality beers, supporting communities, and valuing talented employees |
7,091 | |||
| 18 |
Premium Retail Servicespremiumretail.com
A leading company in the US and Canada helps brands develop winning retail strategies, train associates, engage customers, and drive sales growth |
6,209 | |||
| 19 |
Energizer Holdingsenergizerholdings.com
A global organization creating innovative products to improve lives, focused on serving customers, driving revenue, and delivering long-term value |
6,098 | |||
| 20 |
Missouri State Universitymissouristate.edu
The company focuses on community engagement, ethical leadership, and cultural competence as part of Missouri State's public affairs mission |
5,090 | |||
| 21 |
Nidec Motor Corporationacim.nidec.com
manufacture high efficiency commercial and industrial motors, controls, and generators for applications in water treatment, mining, oil, gas, and refrigeration |
5,082 | |||
| 22 |
Copelandcopeland.com
Develop sustainable HVACR technologies for residential, commercial, and industrial spaces, ensuring cold chain integrity and global comfort. |
4,804 | |||
| 23 |
Leggett & Plattleggett.com
Designing and manufacturing innovative products and components for bedding, furniture, seating, homes, offices, airplanes, and automobiles worldwide. |
4,601 | |||
| 24 |
Reinsurance Group of America, Incorporatedrgare.com
Global leader in life and health reinsurance providing financial solutions to manage risk, optimize capital, and ensure financial protection accessibility. |
4,444 | |||
| 25 |
Barry-Wehmillerbarrywehmiller.com
The company is dedicated to improving the lives of its global team through meaningful work, care, compassion, and personal growth initiatives |
4,395 | |||
Want more companies than this list?This page shows the largest ones only. Connect to Tamtam to see every company that matches, filter by size, industry or growth, and reach their decision-makers. | |||||
| 26 |
Perficientperficient.com
Global consultancy specializing in digital transformation for large enterprises, offering strategy, creative, and technology solutions to drive business growth and success |
4,362 | |||
| 27 |
Emerson Commercial & Residential Solutions
A company formerly known as Emerson Commercial and Residential Solutions now operates as Copeland, specializing in commercial and residential solutions |
4,189 | |||
| 28 |
Belden Inc.belden.com
Connecting information and intelligence to simplify, secure, and enhance the digital journey for customers transforming the way the world works |
4,091 | |||
| 29 |
Pi Beta Phi Fraternity for Womenpibetaphi.org
An organization established in 1867, empowering women through a fraternity, foundation, and housing corporation, with over 300,000 members |
3,846 | |||
| 30 | 3,682 | ||||
| 31 |
Build-A-Bear Workshopbuildabear.com
A beloved brand offering unique retail and entertainment experiences through customizable furry friend creations in over 400 worldwide locations |
3,522 | |||
| 32 |
Sigma-Aldrichbit.ly
Providing scientists with lab materials, technologies, and services to simplify, accelerate, and improve life science research and biotech production worldwide. |
3,467 | |||
| 33 |
Enterprise Fleet Managementefleets.com
A family-owned enterprise managing nearly a million vehicles in the US and Canada, offering fleet management services for businesses and organizations |
3,409 | |||
| 34 |
Webster Universitywebster.edu
A global network of faculty, staff, students, and alumni focused on high-quality learning experiences for global citizenship and individual excellence |
3,249 | |||
| 35 |
Whelan Securitygarda.com
Industry-leading contract security company in the US, providing quality services to diverse clients and seeking talented individuals for security officer positions |
3,133 | |||
| 36 |
Peabody Energypeabodyenergy.com
Leading coal producer supplying essential materials for affordable energy generation and steel manufacturing with a strong focus on sustainability. |
3,106 | |||
| 37 |
JCI (Junior Chamber International)jci.cc
Empowering young people worldwide through projects, events, training, and programs to develop leadership and community impact skills. |
2,970 | |||
| 38 |
Watlowwatlow.com
Global industrial technology company, expertise in thermal systems, providing temperature control, power control, heater technologies, and temperature sensing platforms to various industries. |
2,840 | |||
| 39 |
Rose Internationalroseint.com
Provides staffing and total talent solutions across various industries, offering challenging assignments to skilled professionals for corporations and government agencies. |
2,270 | |||
| 40 |
Veterans of Foreign Wars (VFW)vfw.org
A nonprofit veterans service organization dedicated to providing support, advocacy, and community service programs for eligible veterans and military service members worldwide |
2,236 | |||
| 41 |
Par Healthparhealth.com
Manufactures generic medicines, active pharmaceutical ingredients, and sterile injectables across multiple therapeutic areas, providing essential healthcare solutions for patients and providers. |
2,196 | |||
| 42 | 2,171 | ||||
| 43 |
CRBcrbgroup.com
A leading provider of sustainable engineering, architecture, construction, and consulting solutions to global life sciences and food & beverage industries |
2,008 | |||
| 44 |
American Century Investmentsamcen.co
Leading asset manager delivering investment results while funding medical research to improve health and support long-term client prosperity. |
1,900 | |||
| 45 | 1,887 | ||||
| 46 |
National Beef Packing Company LLCnationalbeef.com
Processing and marketing fresh beef, consumer-ready products, beef by-products, leather, and providing transportation and logistical services across multiple U.S. locations. |
1,757 | |||
| 47 |
CFIcfidrive.com
This company provides truckload, temperature-controlled, and Mexico services including LTL and TL trucking, transloading, consolidation, brokerage, and cross-border expertise #peopledrivepossibility |
1,628 | |||
| 48 |
International Brotherhood of Boilermakersboilermakers.org
This company specializes in labor organization, focusing on advocating for and representing workers in various industries |
1,555 | |||
| 49 |
Dent Wizard Internationaldentwizard.com
Leader in automotive reconditioning services, providing paintless dent removal, paint repair, interior repair, and other services to automotive industry clients |
1,554 | |||
| 50 |
Hunter Engineering Companyhunter.com
Global leader in automotive service equipment with innovative wheel alignment systems, balancers, tire changers, inspection equipment, brake lathes, and patented features for efficient undercar service |
1,535 | |||
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How this list is built
Every company on this list has a Tamtam company profile. The industry is the one the company gives on LinkedIn; categories such as SaaS or fintech are classified by Tamtam's AI from the company's website and LinkedIn page; and the headquarters city must match the company's own address. Companies are ranked by the number of employees on LinkedIn, and the list is refreshed every night. Classifications can be wrong, so treat the list as a starting point rather than an official ranking. Last updated Nov 11, 2026.
More company lists in Missouri
- The largest companies in Missouri 1,495
- Manufacturers in Missouri 162
- Retail chains in Missouri 143
- Education providers in Missouri 130
- Critical infrastructure operators in Missouri 120
- Healthcare providers in Missouri 118
- Hospitals and Health Care companies in Missouri 118
- Financial services firms in Missouri 116
- Companies with in-house R&D in Missouri 96
- Family-owned companies in Missouri 84
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- Higher Education companies in Missouri 70
- IT Services and IT Consulting companies in Missouri 69
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- Corporate groups and holding companies in Missouri 59
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- Logistics companies in Missouri 46
- Consulting firms in Missouri 43
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The same list elsewhere in United States
- Multinational companies in the United States 16,197
- Multinational companies in California 2,592
- Multinational companies in New York State 2,216
- Multinational companies in Texas 1,418
- Multinational companies in Florida 897
- Multinational companies in Illinois 831
- Multinational companies in Massachusetts 637
- Multinational companies in New Jersey 624
- Multinational companies in Georgia 521
- Multinational companies in Pennsylvania 472
- Multinational companies in Michigan 468
- Multinational companies in Alabama 416
- Multinational companies in Virginia 396
- Multinational companies in Ohio 390
- Multinational companies in North Carolina 358
- Multinational companies in Washington State 288
- Multinational companies in Colorado 228
- Multinational companies in New York 1,836
- Multinational companies in San Francisco 446
- Multinational companies in Houston 402
- Multinational companies in Chicago 366
- Multinational companies in Miami 289
- Multinational companies in Atlanta 252
- Multinational companies in Boston 241