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50 leading multinational companies in Missouri

Tamtam tracks 201 multinational companies headquartered in Missouri. This list ranks the 50 largest by number of employees on LinkedIn, led by O'Reilly Auto Parts, Enterprise Mobility and Emerson. Their median headcount is 4,395. Half of them were founded in 1915 or later. The most common headquarters are St. Louis (24), Chesterfield (7) and Kansas City (7).

馃嚭馃嚫 Missouri50 companiesUpdated Nov 11, 2026

This selection of multinational companies in Missouri shows a strong presence of large, established firms across diverse sectors. Key players include O'Reilly Auto Parts, a major automotive aftermarket retailer; Enterprise Mobility, offering global transportation solutions; Emerson, a technology and engineering firm; and Edward Jones, providing financial advisory services. These companies are well-known for their extensive operations and significant employee bases.

A notable pattern is the concentration of headquarters in St. Louis, which hosts a significant number of these large multinationals, including Enterprise Mobility, Emerson, and Edward Jones. Other major cities like Kansas City and Springfield also feature prominently, indicating a broad distribution of economic activity across the state.

#CompanyIndustryHeadquarters EmployeesFounded
1
O'Reilly Auto Partsoreillyauto.com

A leading retailer in the automotive aftermarket industry with over 6,000+ locations, committed to serving customers, community, and team members

Retail 馃嚭馃嚫 Springfield 84,000 1957
2
Enterprise Mobilityenterprisemobility.com

Provides comprehensive mobility solutions worldwide, focusing on innovative, accessible, efficient, and sustainable transportation for people and goods.

Travel Arrangements 馃嚭馃嚫 St. Louis 70,005 n/a
3
Emersonemerson.com

A global technology and engineering company providing innovative solutions for industrial and commercial markets, driving innovation for a healthier, safer, and smarter world

Automation Machinery Manufacturing 馃嚭馃嚫 St. Louis 51,841 1890
4
Edward Jonesedwardjones.com

Provides personalized financial advisory and investment services through a large network of advisors to help clients achieve financial goals.

Financial Services 馃嚭馃嚫 St. Louis 45,845 1922
5
Amdocsamdocs.com

A global company empowers clients to innovate and create exceptional digital experiences, accelerate cloud migration, differentiate in 5G era, and enhance communication and media experiences

Software Development 馃嚭馃嚫 Chesterfield 34,637 n/a
6
Enterpriseenterprisemobility.com

Provides car rental services globally through multiple brands, offering employment opportunities and vehicle access in many countries.

Travel Arrangements 馃嚭馃嚫 St. Louis 32,638 n/a
7
Bungebunge.com

Connecting farmers to consumers by moving agricultural commodities globally, processing oilseeds, and delivering plant-based food, feed, and fuel products.

Food and Beverage Manufacturing 馃嚭馃嚫 Chesterfield 26,107 1818
8
Wal Mart Corporation

This company provides access to Walmart executive speeches, financial reports, press releases, photos, videos, and interactive global location map

Entertainment Providers 馃嚭馃嚫 Sikeston 19,478 n/a
9
Hallmark Cardscareers.hallmark.com

Family-owned global business creating emotionally connected world through greeting cards, gifts, media networks, real estate development, and art products for children worldwide

Retail 馃嚭馃嚫 Kansas City 17,388 1910
10
Burns & McDonnellburnsmcd.com

Engineering, construction, architecture, planning, and community engagement with a strong ownership mentality and commitment to client success and safety.

Construction 馃嚭馃嚫 Kansas City 16,200 n/a
11
Caleres, Inc.jobs.caleres.com

This company is a global footwear brand portfolio with diverse offerings, including famous labels like Sam Edelman and Naturalizer, focusing on consumer-driven innovation and quality craftsmanship

Retail Apparel and Fashion 馃嚭馃嚫 St. Louis 9,313 1878
12
Monsanto Companybayer.com

Leading in modern agriculture with a focus on seeds, plant traits, and crop protection through innovative breakthroughs for global impact

Farming 馃嚭馃嚫 St. Louis 9,303 n/a
13
Nestl茅 Purina North Americapurinajobs.com

Advances pet nutrition science, collaborates on innovation, and enriches lives of pets and owners. Builds strong teams for pet care.

Manufacturing 馃嚭馃嚫 St. Louis 8,321 1894
14
Graybargraybar.com

A Fortune 500 employee-owned corporation distributes electrical, communications, and networking products, offering supply chain management and logistics services to customers

Wholesale 馃嚭馃嚫 St. Louis 8,118 1869
15
Saint Louis Universityslu.edu

A Jesuit, Catholic university in St Louis, MO offering top research programs Oldest university in the West, with a campus in Madrid, Spain

Higher Education 馃嚭馃嚫 St. Louis 7,855 1818
16
Stifel Financial Corp.stifel.com

Providing brokerage, trading, investment banking, advisory, and trust services to individuals, businesses, and municipalities across the U.S.

Financial Services 馃嚭馃嚫 St. Louis 7,384 1890
17
Anheuser-Buschanheuser-busch.com

A leading brewer in the United States with a legacy of crafting high-quality beers, supporting communities, and valuing talented employees

Food and Beverage Services 馃嚭馃嚫 St. Louis 7,091 1852
18
Premium Retail Servicespremiumretail.com

A leading company in the US and Canada helps brands develop winning retail strategies, train associates, engage customers, and drive sales growth

Retail 馃嚭馃嚫 Chesterfield 6,209 1985
19
Energizer Holdingsenergizerholdings.com

A global organization creating innovative products to improve lives, focused on serving customers, driving revenue, and delivering long-term value

Manufacturing 馃嚭馃嚫 St. Louis 6,098 1896
20
Missouri State Universitymissouristate.edu

The company focuses on community engagement, ethical leadership, and cultural competence as part of Missouri State's public affairs mission

Higher Education 馃嚭馃嚫 Springfield 5,090 1905
21
Nidec Motor Corporationacim.nidec.com

manufacture high efficiency commercial and industrial motors, controls, and generators for applications in water treatment, mining, oil, gas, and refrigeration

Appliances, Electrical, and Electronics Manufacturing 馃嚭馃嚫 Creve Coeur 5,082 n/a
22
Copelandcopeland.com

Develop sustainable HVACR technologies for residential, commercial, and industrial spaces, ensuring cold chain integrity and global comfort.

Climate Technology Product Manufacturing 馃嚭馃嚫 St. Louis 4,804 n/a
23
Leggett & Plattleggett.com

Designing and manufacturing innovative products and components for bedding, furniture, seating, homes, offices, airplanes, and automobiles worldwide.

Furniture and Home Furnishings Manufacturing 馃嚭馃嚫 Carthage 4,601 1883
24
Reinsurance Group of America, Incorporatedrgare.com

Global leader in life and health reinsurance providing financial solutions to manage risk, optimize capital, and ensure financial protection accessibility.

Insurance 馃嚭馃嚫 Chesterfield 4,444 1973
25
Barry-Wehmillerbarrywehmiller.com

The company is dedicated to improving the lives of its global team through meaningful work, care, compassion, and personal growth initiatives

Machinery Manufacturing 馃嚭馃嚫 St. Louis 4,395 n/a

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26
Perficientperficient.com

Global consultancy specializing in digital transformation for large enterprises, offering strategy, creative, and technology solutions to drive business growth and success

IT Services and IT Consulting 馃嚭馃嚫 St Louis 4,362 n/a
27
Emerson Commercial & Residential Solutions

A company formerly known as Emerson Commercial and Residential Solutions now operates as Copeland, specializing in commercial and residential solutions

Appliances, Electrical, and Electronics Manufacturing 馃嚭馃嚫 St. Louis 4,189 n/a
28
Belden Inc.belden.com

Connecting information and intelligence to simplify, secure, and enhance the digital journey for customers transforming the way the world works

Manufacturing 馃嚭馃嚫 St. Louis 4,091 1902
29
Pi Beta Phi Fraternity for Womenpibetaphi.org

An organization established in 1867, empowering women through a fraternity, foundation, and housing corporation, with over 300,000 members

Non-profit Organizations 馃嚭馃嚫 Town and Country 3,846 1867
30
Olinolin.com

Manufacturing and supplying chemical products with a focus on innovation, customer needs, ethical standards, and environmental stewardship worldwide.

Chemical Manufacturing 馃嚭馃嚫 Clayton 3,682 1892
31
Build-A-Bear Workshopbuildabear.com

A beloved brand offering unique retail and entertainment experiences through customizable furry friend creations in over 400 worldwide locations

Retail 馃嚭馃嚫 St. Louis 3,522 1997
32
Sigma-Aldrichbit.ly

Providing scientists with lab materials, technologies, and services to simplify, accelerate, and improve life science research and biotech production worldwide.

Biotechnology Research 馃嚭馃嚫 St. Louis 3,467 1951
33
Enterprise Fleet Managementefleets.com

A family-owned enterprise managing nearly a million vehicles in the US and Canada, offering fleet management services for businesses and organizations

Motor Vehicle Manufacturing 馃嚭馃嚫 St. Louis 3,409 1957
34
Webster Universitywebster.edu

A global network of faculty, staff, students, and alumni focused on high-quality learning experiences for global citizenship and individual excellence

Higher Education 馃嚭馃嚫 St. Louis 3,249 1915
35
Whelan Securitygarda.com

Industry-leading contract security company in the US, providing quality services to diverse clients and seeking talented individuals for security officer positions

Security and Investigations 馃嚭馃嚫 St. Louis 3,133 1949
36
Peabody Energypeabodyenergy.com

Leading coal producer supplying essential materials for affordable energy generation and steel manufacturing with a strong focus on sustainability.

Mining 馃嚭馃嚫 St. Louis 3,106 1883
37
JCI (Junior Chamber International)jci.cc

Empowering young people worldwide through projects, events, training, and programs to develop leadership and community impact skills.

Non-profit Organizations 馃嚭馃嚫 Chesterfield 2,970 1915
38
Watlowwatlow.com

Global industrial technology company, expertise in thermal systems, providing temperature control, power control, heater technologies, and temperature sensing platforms to various industries.

Industrial Machinery Manufacturing 馃嚭馃嚫 St. Louis 2,840 1922
39
Rose Internationalroseint.com

Provides staffing and total talent solutions across various industries, offering challenging assignments to skilled professionals for corporations and government agencies.

Staffing and Recruiting 馃嚭馃嚫 Chesterfield 2,270 1993
40
Veterans of Foreign Wars (VFW)vfw.org

A nonprofit veterans service organization dedicated to providing support, advocacy, and community service programs for eligible veterans and military service members worldwide

Civic and Social Organizations 馃嚭馃嚫 Kansas City 2,236 1899
41
Par Healthparhealth.com

Manufactures generic medicines, active pharmaceutical ingredients, and sterile injectables across multiple therapeutic areas, providing essential healthcare solutions for patients and providers.

Pharmaceutical Manufacturing 馃嚭馃嚫 St Louis 2,196 1978
42
MiTekmii.com

Providing software, services, engineered products, and automated solutions to optimize integrated offsite construction for residential and commercial buildings.

Construction 馃嚭馃嚫 Chesterfield 2,171 n/a
43
CRBcrbgroup.com

A leading provider of sustainable engineering, architecture, construction, and consulting solutions to global life sciences and food & beverage industries

Construction 馃嚭馃嚫 Kansas City 2,008 1984
44
American Century Investmentsamcen.co

Leading asset manager delivering investment results while funding medical research to improve health and support long-term client prosperity.

Financial Services 馃嚭馃嚫 Kansas City 1,900 1958
45
CTIcti.com

CTI provides complete audio visual and information technology integration solutions, including design, installation, support, video conferencing, event services, and production

IT Services and IT Consulting 馃嚭馃嚫 St. Louis 1,887 1988
46
National Beef Packing Company LLCnationalbeef.com

Processing and marketing fresh beef, consumer-ready products, beef by-products, leather, and providing transportation and logistical services across multiple U.S. locations.

Food and Beverage Manufacturing 馃嚭馃嚫 Kansas City 1,757 1992
47
CFIcfidrive.com

This company provides truckload, temperature-controlled, and Mexico services including LTL and TL trucking, transloading, consolidation, brokerage, and cross-border expertise #peopledrivepossibility

Truck Transportation 馃嚭馃嚫 Joplin 1,628 1951
48
International Brotherhood of Boilermakersboilermakers.org

This company specializes in labor organization, focusing on advocating for and representing workers in various industries

Non-profit Organizations 馃嚭馃嚫 Kansas City 1,555 1880
49
Dent Wizard Internationaldentwizard.com

Leader in automotive reconditioning services, providing paintless dent removal, paint repair, interior repair, and other services to automotive industry clients

Motor Vehicle Manufacturing 馃嚭馃嚫 Bridgeton 1,554 1983
50
Hunter Engineering Companyhunter.com

Global leader in automotive service equipment with innovative wheel alignment systems, balancers, tire changers, inspection equipment, brake lathes, and patented features for efficient undercar service

Motor Vehicle Manufacturing 馃嚭馃嚫 Bridgeton 1,535 1946

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How this list is built

Every company on this list has a Tamtam company profile. The industry is the one the company gives on LinkedIn; categories such as SaaS or fintech are classified by Tamtam's AI from the company's website and LinkedIn page; and the headquarters city must match the company's own address. Companies are ranked by the number of employees on LinkedIn, and the list is refreshed every night. Classifications can be wrong, so treat the list as a starting point rather than an official ranking. Last updated Nov 11, 2026.

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