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Companies with in-house R&D headquartered in Missouri

Tamtam tracks 96 companies with in-house R&D headquartered in Missouri. This list ranks the 50 largest by number of employees on LinkedIn, led by Emerson, Amdocs and University of Missouri-Columbia. Their median headcount is 1,059. Half of them were founded in 1956 or later. The most common headquarters are St. Louis (25), Kansas City (4) and Chesterfield (3).

🇺🇸 Missouri50 companiesUpdated Nov 11, 2026

These Missouri-based companies are largely established enterprises with significant employee numbers, predominantly focused on manufacturing, technology, and healthcare. Many of the featured companies, such as Emerson, Monsanto Company, Nestlé Purina North America, and Anheuser-Busch, are deeply rooted in the state's industrial landscape.

A notable pattern among these companies is their long-standing presence; several were founded in the late 19th or early 20th centuries, indicating a history of sustained operations and development within Missouri. For example, Anheuser-Busch was founded in 1852, Emerson in 1890, and Nestlé Purina North America in 1894.

#CompanyIndustryHeadquarters EmployeesFounded
1
Emersonemerson.com

A global technology and engineering company providing innovative solutions for industrial and commercial markets, driving innovation for a healthier, safer, and smarter world

Automation Machinery Manufacturing 🇺🇸 St. Louis 51,841 1890
2
Amdocsamdocs.com

A global company empowers clients to innovate and create exceptional digital experiences, accelerate cloud migration, differentiate in 5G era, and enhance communication and media experiences

Software Development 🇺🇸 Chesterfield 34,637 n/a
3
University of Missouri-Columbiamissouri.edu

State-supported research university providing education, advancing arts, sciences, and professions, focusing on public service and economic development.

Higher Education 🇺🇸 Columbia 14,879 n/a
4
Monsanto Companybayer.com

Leading in modern agriculture with a focus on seeds, plant traits, and crop protection through innovative breakthroughs for global impact

Farming 🇺🇸 St. Louis 9,303 n/a
5
Children's Mercychildrensmercy.org

Specialized pediatric healthcare provider focusing on exceptional care, innovative research, and education to improve children's health and well-being.

Hospitals and Health Care 🇺🇸 Kansas City 8,393 1897
6
Nestlé Purina North Americapurinajobs.com

Advances pet nutrition science, collaborates on innovation, and enriches lives of pets and owners. Builds strong teams for pet care.

Manufacturing 🇺🇸 St. Louis 8,321 1894
7
Anheuser-Buschanheuser-busch.com

A leading brewer in the United States with a legacy of crafting high-quality beers, supporting communities, and valuing talented employees

Food and Beverage Services 🇺🇸 St. Louis 7,091 1852
8
Nidec Motor Corporationacim.nidec.com

manufacture high efficiency commercial and industrial motors, controls, and generators for applications in water treatment, mining, oil, gas, and refrigeration

Appliances, Electrical, and Electronics Manufacturing 🇺🇸 Creve Coeur 5,082 n/a
9
Copelandcopeland.com

Develop sustainable HVACR technologies for residential, commercial, and industrial spaces, ensuring cold chain integrity and global comfort.

Climate Technology Product Manufacturing 🇺🇸 St. Louis 4,804 n/a
10
EquipmentShareequipmentshare.com

A nationwide equipment and digital solutions company empowering construction industry with technology platform, equipment rental, retail, and service solutions

Construction 🇺🇸 Columbia 4,193 2014
11
Sigma-Aldrichbit.ly

Providing scientists with lab materials, technologies, and services to simplify, accelerate, and improve life science research and biotech production worldwide.

Biotechnology Research 🇺🇸 St. Louis 3,467 1951
12
Missouri University of Science and Technologymst.edu

A prestigious technological research university offering degrees in engineering, science, business, IT, humanities, and education with a focus on technological literacy

Higher Education 🇺🇸 Rolla 3,410 n/a
13
Hussmannhussmann.com

A global leader in providing innovative display cases and refrigeration systems, Hussmann focuses on improving food retailing with value-added solutions and services since 1906

Retail Groceries 🇺🇸 Bridgeton 3,148 n/a
14
Watlowwatlow.com

Global industrial technology company, expertise in thermal systems, providing temperature control, power control, heater technologies, and temperature sensing platforms to various industries.

Industrial Machinery Manufacturing 🇺🇸 St. Louis 2,840 1922
15
Par Healthparhealth.com

Manufactures generic medicines, active pharmaceutical ingredients, and sterile injectables across multiple therapeutic areas, providing essential healthcare solutions for patients and providers.

Pharmaceutical Manufacturing 🇺🇸 St Louis 2,196 1978
16
SSM Health Saint Louis University Hospitalssmhealth.com

An academic medical center affiliated with Saint Louis University School of Medicine, offering cutting-edge treatments, research, and compassionate care to patients

Hospitals and Health Care 🇺🇸 St. Louis 1,563 n/a
17
Hunter Engineering Companyhunter.com

Global leader in automotive service equipment with innovative wheel alignment systems, balancers, tire changers, inspection equipment, brake lathes, and patented features for efficient undercar service

Motor Vehicle Manufacturing 🇺🇸 Bridgeton 1,535 1946
18
EyeCare Partnerseyecare-partners.com

EyeCare Partners is dedicated to reinventing eye care by uniting optometry and ophthalmology practices to provide high-quality, accessible, and personalized vision health solutions nationwide

Hospitals and Health Care 🇺🇸 St. Louis 1,457 2015
19
Silgan Plasticssilganplastics.com

Silgan Plastics offers innovative and customized packaging solutions, from design to production, to help clients achieve packaging success

Plastics Manufacturing 🇺🇸 Chesterfield 1,397 1987
20
Herzogherzog.com

A leading industry expert in railroad construction, maintenance, and operations with in-house equipment design for data-driven operational decisions

Construction 🇺🇸 St Joseph 1,356 1969
21
Vegetables by Bayervegetables.bayer.com

A St Louis-based food production company specializing in vegetable seeds, part of Bayer CropScience

Farming 🇺🇸 St. Louis 1,354 n/a
22
Lumerislumeris.com

Value-based care managed services operator aligning providers and payers to achieve high-quality, cost-effective care with satisfied consumers and engaged physicians

Hospitals and Health Care 🇺🇸 Maryland Heights 1,149 2012
23
Arch Resources, Inccorenaturalresources.com

Producer and exporter of metallurgical and thermal coals, operating multiple mines and marine export terminals focused on seaborne markets.

Mining 🇺🇸 St. Louis 1,136 n/a
24
Kansas City Universitykansascity.edu

A private university offering programs in osteopathic medicine, dental medicine, biosciences, and clinical psychology, known for academic excellence and hands-on learning opportunities

Higher Education 🇺🇸 Kansas City 1,122 1916
25
Carbolinecarboline.com

This company offers a comprehensive range of high-performance coatings, linings, and fireproofing products, providing proven and reliable protective solutions globally for industrial and commercial markets.

Chemical Manufacturing 🇺🇸 St. Louis 1,059 1947

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26
Kansas City National Security Campuskcnsc.doe.gov

An advanced engineering and manufacturing facility dedicated to ensuring the safety and security of our country's nuclear deterrence

Defense and Space Manufacturing 🇺🇸 Kansas City 1,018 1949
27
MLCmlc.com

A leading supplier of high-quality lime products, calcium carbonate, and technical solutions with a strong focus on customer satisfaction and reliable distribution network

Chemical Manufacturing 🇺🇸 St. Louis 1,010 1907
28
Nestlé Purina Latin America & Caribbeannestle.com

This company focuses on enhancing the lives of pets and their owners through nutritious food sourced responsibly, with a portfolio of recognized brands

Manufacturing 🇺🇸 St. Louis 999 n/a
29
LMI Aerospace - A Member of the Sonaca Groupsonaca.com

Designing, building, and manufacturing aerospace structures, systems, and components for commercial, business, regional, and military aerospace industries.

Aviation and Aerospace Component Manufacturing 🇺🇸 St. Charles 905 1948
30
PROENERGYproenergyservices.com

Integrated service provider delivering cost-effective, safe, and reliable solutions to the global energy industry with offices in multiple countries

Fossil Fuel Electric Power Generation 🇺🇸 Sedalia 866 2002
31
SSM Health Cardinal Glennon Children's Hospitalssmhealth.com

A non-profit Catholic pediatric hospital providing high-quality care to children with complex conditions, located in St Louis, MO

Hospitals and Health Care 🇺🇸 St. Louis 824 1956
32
Saint Louis Zoostlzoo.org

A world-renowned zoo with over 16,000 animals and 500 species, focusing on animal care, wildlife conservation, research, and education

Museums, Historical Sites, and Zoos 🇺🇸 St. Louis 793 1910
33
Pretium Packagingpretiumpkg.com

Plastic container manufacturer specializing in sustainable packaging for food, beverage, healthcare, personal care, and more with custom design capabilities

Packaging and Containers Manufacturing 🇺🇸 St. Louis 760 n/a
34
Anchor Packaginganchorpackaging.com

A leading thermoform packaging producer in North America, specializing in custom designs for foodservice industry with a focus on sustainability and innovation

Packaging and Containers Manufacturing 🇺🇸 St. Louis 698 1963
35
Fike Corporationfike.com

Designs and manufactures rupture discs, explosion protection, fire alarm, and suppression systems for global businesses seeking disaster prevention and safety assurance.

Engineering Services 🇺🇸 Blue Springs 692 1945
36
SunEdison Semiconductorgw-semi.com

Global leader in semiconductor technology, providing silicon wafers for electronic devices and industrial applications, serving top chip manufacturers worldwide since 1959

Semiconductor Manufacturing 🇺🇸 St. Peters 674 1959
37
The Doe Run Companydoerun.com

A privately held natural resources company in St Louis, USA, providing lead, copper, and zinc concentrates, with a focus on environmentally responsible mineral production and recycling

Mining 🇺🇸 St. Louis 546 1994
38
CST Industries, Inc.cstindustries.com

Global leader in manufacturing factory coated metal storage tanks, aluminum domes, and specialty covers with a worldwide presence in various industries

Machinery Manufacturing 🇺🇸 Kansas City 540 1893
39
Vi-Jonvijon.com

A provider of private brand dry goods bath and personal care products, including Epsom salts and other personal care items

Manufacturing 🇺🇸 St. Louis 523 2020
40
EaglePicher Technologieseaglepicher.com

Leading producer of batteries and energetic devices. Serving mission-critical aerospace, defense, and aviation battery markets for over 80 years. Provides power solutions.

Defense and Space Manufacturing 🇺🇸 Joplin 518 1843
41
The Gund Companythegundcompany.com

Custom engineered material solutions provider, manufacturing and fabricating parts worldwide. Material specialists offer consultative services, optimizing production for efficiency and cost reduction.

Appliances, Electrical, and Electronics Manufacturing 🇺🇸 St. Louis 505 1951
42
White River Marine Groupwhiterivermg.com

The company is a leading manufacturer of fishing and recreational boats, ATVs, side-by-sides, kayaks, and provides financing solutions for outdoor recreational products

Maritime Transportation 🇺🇸 Springfield 473 1978
43
Brewer Sciencebrewerscience.com

A global leader in developing innovative materials, processes, and equipment for cutting-edge microdevices used in electronics, specializing in advanced lithography and nanotechnology

Semiconductor Manufacturing 🇺🇸 Rolla 447 1981
44
University of Missouri-Columbia, School of Medicinemedicine.missouri.edu

An academic health system dedicated to patient care, research, and education, serving patients from all Missouri counties and training future healthcare providers

Higher Education 🇺🇸 Columbia 431 n/a
45
Schaeffer Mfg. Companyschaefferoil.com

Family-owned company delivering specialized lubricant solutions for equipment challenges, enhancing engine durability, fuel economy, and overall equipment efficiency for customers.

Oil and Gas 🇺🇸 St. Louis 431 1839
46
Exegyexegy.com

Global leader in market data and trading technology, offering fully managed solutions powered by cutting-edge hardware, AI, and service automation technologies worldwide

Financial Services 🇺🇸 St. Louis 423 2003
47
Alpha Packagingalphap.com

Manufacturer of plastic bottles and jars for various industries worldwide, offering stock and custom PET and HDPE containers in sizes up to 1 gallon

Plastics Manufacturing 🇺🇸 St. Louis 411 1969
48
Spartech LLCspartech.com

Develops custom engineered plastic sheet and rollstock solutions for diverse industries, offering various materials, specializing in thermoforming, medical, military, and packaging applications.

Plastics Manufacturing 🇺🇸 St. Louis 407 1960
49
ALTORaltorsolutions.com

Innovative company revolutionizing Life Sciences and Engineered Transport Solutions industries with extensive manufacturing and distribution network in US and Mexico

Packaging and Containers Manufacturing 🇺🇸 Chesterfield 403 1957
50
AFB Internationalafbinternational.com

A global leader creating high-quality palatability enhancers for pet food Enhancing taste and providing essential nutrients for companion animals worldwide

Food and Beverage Manufacturing 🇺🇸 St. Charles 394 1986

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How this list is built

Every company on this list has a Tamtam company profile. The industry is the one the company gives on LinkedIn; categories such as SaaS or fintech are classified by Tamtam's AI from the company's website and LinkedIn page; and the headquarters city must match the company's own address. Companies are ranked by the number of employees on LinkedIn, and the list is refreshed every night. Classifications can be wrong, so treat the list as a starting point rather than an official ranking. Last updated Nov 11, 2026.

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