These Missouri-based companies are largely established enterprises with significant employee numbers, predominantly focused on manufacturing, technology, and healthcare. Many of the featured companies, such as Emerson, Monsanto Company, Nestlé Purina North America, and Anheuser-Busch, are deeply rooted in the state's industrial landscape.
A notable pattern among these companies is their long-standing presence; several were founded in the late 19th or early 20th centuries, indicating a history of sustained operations and development within Missouri. For example, Anheuser-Busch was founded in 1852, Emerson in 1890, and Nestlé Purina North America in 1894.
| # | Company | Employees | |||
|---|---|---|---|---|---|
| 1 |
Emersonemerson.com
A global technology and engineering company providing innovative solutions for industrial and commercial markets, driving innovation for a healthier, safer, and smarter world |
51,841 | |||
| 2 |
Amdocsamdocs.com
A global company empowers clients to innovate and create exceptional digital experiences, accelerate cloud migration, differentiate in 5G era, and enhance communication and media experiences |
34,637 | |||
| 3 |
University of Missouri-Columbiamissouri.edu
State-supported research university providing education, advancing arts, sciences, and professions, focusing on public service and economic development. |
14,879 | |||
| 4 |
Monsanto Companybayer.com
Leading in modern agriculture with a focus on seeds, plant traits, and crop protection through innovative breakthroughs for global impact |
9,303 | |||
| 5 |
Children's Mercychildrensmercy.org
Specialized pediatric healthcare provider focusing on exceptional care, innovative research, and education to improve children's health and well-being. |
8,393 | |||
| 6 |
Nestlé Purina North Americapurinajobs.com
Advances pet nutrition science, collaborates on innovation, and enriches lives of pets and owners. Builds strong teams for pet care. |
8,321 | |||
| 7 |
Anheuser-Buschanheuser-busch.com
A leading brewer in the United States with a legacy of crafting high-quality beers, supporting communities, and valuing talented employees |
7,091 | |||
| 8 |
Nidec Motor Corporationacim.nidec.com
manufacture high efficiency commercial and industrial motors, controls, and generators for applications in water treatment, mining, oil, gas, and refrigeration |
5,082 | |||
| 9 |
Copelandcopeland.com
Develop sustainable HVACR technologies for residential, commercial, and industrial spaces, ensuring cold chain integrity and global comfort. |
4,804 | |||
| 10 |
EquipmentShareequipmentshare.com
A nationwide equipment and digital solutions company empowering construction industry with technology platform, equipment rental, retail, and service solutions |
4,193 | |||
| 11 |
Sigma-Aldrichbit.ly
Providing scientists with lab materials, technologies, and services to simplify, accelerate, and improve life science research and biotech production worldwide. |
3,467 | |||
| 12 |
Missouri University of Science and Technologymst.edu
A prestigious technological research university offering degrees in engineering, science, business, IT, humanities, and education with a focus on technological literacy |
3,410 | |||
| 13 |
Hussmannhussmann.com
A global leader in providing innovative display cases and refrigeration systems, Hussmann focuses on improving food retailing with value-added solutions and services since 1906 |
3,148 | |||
| 14 |
Watlowwatlow.com
Global industrial technology company, expertise in thermal systems, providing temperature control, power control, heater technologies, and temperature sensing platforms to various industries. |
2,840 | |||
| 15 |
Par Healthparhealth.com
Manufactures generic medicines, active pharmaceutical ingredients, and sterile injectables across multiple therapeutic areas, providing essential healthcare solutions for patients and providers. |
2,196 | |||
| 16 |
SSM Health Saint Louis University Hospitalssmhealth.com
An academic medical center affiliated with Saint Louis University School of Medicine, offering cutting-edge treatments, research, and compassionate care to patients |
1,563 | |||
| 17 |
Hunter Engineering Companyhunter.com
Global leader in automotive service equipment with innovative wheel alignment systems, balancers, tire changers, inspection equipment, brake lathes, and patented features for efficient undercar service |
1,535 | |||
| 18 |
EyeCare Partnerseyecare-partners.com
EyeCare Partners is dedicated to reinventing eye care by uniting optometry and ophthalmology practices to provide high-quality, accessible, and personalized vision health solutions nationwide |
1,457 | |||
| 19 |
Silgan Plasticssilganplastics.com
Silgan Plastics offers innovative and customized packaging solutions, from design to production, to help clients achieve packaging success |
1,397 | |||
| 20 |
Herzogherzog.com
A leading industry expert in railroad construction, maintenance, and operations with in-house equipment design for data-driven operational decisions |
1,356 | |||
| 21 |
Vegetables by Bayervegetables.bayer.com
A St Louis-based food production company specializing in vegetable seeds, part of Bayer CropScience |
1,354 | |||
| 22 |
Lumerislumeris.com
Value-based care managed services operator aligning providers and payers to achieve high-quality, cost-effective care with satisfied consumers and engaged physicians |
1,149 | |||
| 23 |
Arch Resources, Inccorenaturalresources.com
Producer and exporter of metallurgical and thermal coals, operating multiple mines and marine export terminals focused on seaborne markets. |
1,136 | |||
| 24 |
Kansas City Universitykansascity.edu
A private university offering programs in osteopathic medicine, dental medicine, biosciences, and clinical psychology, known for academic excellence and hands-on learning opportunities |
1,122 | |||
| 25 |
Carbolinecarboline.com
This company offers a comprehensive range of high-performance coatings, linings, and fireproofing products, providing proven and reliable protective solutions globally for industrial and commercial markets. |
1,059 | |||
Want more companies than this list?This page shows the largest ones only. Connect to Tamtam to see every company that matches, filter by size, industry or growth, and reach their decision-makers. | |||||
| 26 |
Kansas City National Security Campuskcnsc.doe.gov
An advanced engineering and manufacturing facility dedicated to ensuring the safety and security of our country's nuclear deterrence |
1,018 | |||
| 27 | 1,010 | ||||
| 28 |
Nestlé Purina Latin America & Caribbeannestle.com
This company focuses on enhancing the lives of pets and their owners through nutritious food sourced responsibly, with a portfolio of recognized brands |
999 | |||
| 29 |
LMI Aerospace - A Member of the Sonaca Groupsonaca.com
Designing, building, and manufacturing aerospace structures, systems, and components for commercial, business, regional, and military aerospace industries. |
905 | |||
| 30 |
PROENERGYproenergyservices.com
Integrated service provider delivering cost-effective, safe, and reliable solutions to the global energy industry with offices in multiple countries |
866 | |||
| 31 |
SSM Health Cardinal Glennon Children's Hospitalssmhealth.com
A non-profit Catholic pediatric hospital providing high-quality care to children with complex conditions, located in St Louis, MO |
824 | |||
| 32 |
Saint Louis Zoostlzoo.org
A world-renowned zoo with over 16,000 animals and 500 species, focusing on animal care, wildlife conservation, research, and education |
793 | |||
| 33 |
Pretium Packagingpretiumpkg.com
Plastic container manufacturer specializing in sustainable packaging for food, beverage, healthcare, personal care, and more with custom design capabilities |
760 | |||
| 34 |
Anchor Packaginganchorpackaging.com
A leading thermoform packaging producer in North America, specializing in custom designs for foodservice industry with a focus on sustainability and innovation |
698 | |||
| 35 |
Fike Corporationfike.com
Designs and manufactures rupture discs, explosion protection, fire alarm, and suppression systems for global businesses seeking disaster prevention and safety assurance. |
692 | |||
| 36 |
SunEdison Semiconductorgw-semi.com
Global leader in semiconductor technology, providing silicon wafers for electronic devices and industrial applications, serving top chip manufacturers worldwide since 1959 |
674 | |||
| 37 |
The Doe Run Companydoerun.com
A privately held natural resources company in St Louis, USA, providing lead, copper, and zinc concentrates, with a focus on environmentally responsible mineral production and recycling |
546 | |||
| 38 |
CST Industries, Inc.cstindustries.com
Global leader in manufacturing factory coated metal storage tanks, aluminum domes, and specialty covers with a worldwide presence in various industries |
540 | |||
| 39 | 523 | ||||
| 40 |
EaglePicher Technologieseaglepicher.com
Leading producer of batteries and energetic devices. Serving mission-critical aerospace, defense, and aviation battery markets for over 80 years. Provides power solutions. |
518 | |||
| 41 |
The Gund Companythegundcompany.com
Custom engineered material solutions provider, manufacturing and fabricating parts worldwide. Material specialists offer consultative services, optimizing production for efficiency and cost reduction. |
505 | |||
| 42 |
White River Marine Groupwhiterivermg.com
The company is a leading manufacturer of fishing and recreational boats, ATVs, side-by-sides, kayaks, and provides financing solutions for outdoor recreational products |
473 | |||
| 43 |
Brewer Sciencebrewerscience.com
A global leader in developing innovative materials, processes, and equipment for cutting-edge microdevices used in electronics, specializing in advanced lithography and nanotechnology |
447 | |||
| 44 |
University of Missouri-Columbia, School of Medicinemedicine.missouri.edu
An academic health system dedicated to patient care, research, and education, serving patients from all Missouri counties and training future healthcare providers |
431 | |||
| 45 |
Schaeffer Mfg. Companyschaefferoil.com
Family-owned company delivering specialized lubricant solutions for equipment challenges, enhancing engine durability, fuel economy, and overall equipment efficiency for customers. |
431 | |||
| 46 | 423 | ||||
| 47 |
Alpha Packagingalphap.com
Manufacturer of plastic bottles and jars for various industries worldwide, offering stock and custom PET and HDPE containers in sizes up to 1 gallon |
411 | |||
| 48 |
Spartech LLCspartech.com
Develops custom engineered plastic sheet and rollstock solutions for diverse industries, offering various materials, specializing in thermoforming, medical, military, and packaging applications. |
407 | |||
| 49 |
ALTORaltorsolutions.com
Innovative company revolutionizing Life Sciences and Engineered Transport Solutions industries with extensive manufacturing and distribution network in US and Mexico |
403 | |||
| 50 |
AFB Internationalafbinternational.com
A global leader creating high-quality palatability enhancers for pet food Enhancing taste and providing essential nutrients for companion animals worldwide |
394 | |||
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How this list is built
Every company on this list has a Tamtam company profile. The industry is the one the company gives on LinkedIn; categories such as SaaS or fintech are classified by Tamtam's AI from the company's website and LinkedIn page; and the headquarters city must match the company's own address. Companies are ranked by the number of employees on LinkedIn, and the list is refreshed every night. Classifications can be wrong, so treat the list as a starting point rather than an official ranking. Last updated Nov 11, 2026.
More company lists in Missouri
- The largest companies in Missouri 1,495
- Multinational companies in Missouri 201
- Manufacturers in Missouri 162
- Retail chains in Missouri 143
- Education providers in Missouri 130
- Critical infrastructure operators in Missouri 120
- Healthcare providers in Missouri 118
- Hospitals and Health Care companies in Missouri 118
- Financial services firms in Missouri 116
- Family-owned companies in Missouri 84
- Professional services firms in Missouri 84
- Companies with a mobile app in Missouri 78
- Public sector organisations in Missouri 78
- Construction companies in Missouri 72
- Higher Education companies in Missouri 70
- IT Services and IT Consulting companies in Missouri 69
- Hardware manufacturers in Missouri 68
- IT services companies in Missouri 61
- Corporate groups and holding companies in Missouri 59
- Distributors and wholesalers in Missouri 57
- Financial Services companies in Missouri 53
- Logistics companies in Missouri 46
- Consulting firms in Missouri 43
- Contract manufacturers in Missouri 43
The same list elsewhere in United States
- Companies with in-house R&D in the United States 6,796
- Companies with in-house R&D in California 1,276
- Companies with in-house R&D in Texas 442
- Companies with in-house R&D in New York State 419
- Companies with in-house R&D in Massachusetts 396
- Companies with in-house R&D in Illinois 322
- Companies with in-house R&D in Michigan 287
- Companies with in-house R&D in Ohio 277
- Companies with in-house R&D in Pennsylvania 255
- Companies with in-house R&D in New Jersey 224
- Companies with in-house R&D in Florida 221
- Companies with in-house R&D in Alabama 214
- Companies with in-house R&D in Georgia 173
- Companies with in-house R&D in Virginia 166
- Companies with in-house R&D in North Carolina 158
- Companies with in-house R&D in Wisconsin 154
- Companies with in-house R&D in Minnesota 146
- Companies with in-house R&D in Washington State 140
- Companies with in-house R&D in Colorado 113
- Companies with in-house R&D in Maryland 107
- Companies with in-house R&D in Indiana 104
- Companies with in-house R&D in New York 223
- Companies with in-house R&D in San Francisco 147
- Companies with in-house R&D in Houston 129