| # | Company | Employees |
|---|---|---|
| 1 |
O'Reilly Auto Partsoreillyauto.com
A leading retailer in the automotive aftermarket industry with over 6,000+ locations, committed to serving customers, community, and team members |
84,000 |
| 2 |
Enterprise Mobilityenterprisemobility.com
Provides comprehensive mobility solutions worldwide, focusing on innovative, accessible, efficient, and sustainable transportation for people and goods. |
70,005 |
| 3 |
Ascensionhealthcare.ascension.org
A faith-based healthcare organization focused on providing compassionate care to those in need across the US through various services and programs |
66,381 |
| 4 |
Emersonemerson.com
A global technology and engineering company providing innovative solutions for industrial and commercial markets, driving innovation for a healthier, safer, and smarter world |
51,841 |
| 5 |
Edward Jonesedwardjones.com
Provides personalized financial advisory and investment services through a large network of advisors to help clients achieve financial goals. |
45,845 |
| 6 |
Panera Breadpanerabread.com
Fresh bakery foodservice offering freshly baked breads, pastries, and clean food with omni-channel ordering and community focus. |
39,768 |
| 7 |
Centene Corporationcentene.com
Providing affordable, high-quality healthcare plans for Medicaid, Medicare, and marketplace members, focusing on under-insured and uninsured individuals nationwide. |
36,022 |
| 8 |
Amdocsamdocs.com
A global company empowers clients to innovate and create exceptional digital experiences, accelerate cloud migration, differentiate in 5G era, and enhance communication and media experiences |
34,637 |
| 9 |
Enterpriseenterprisemobility.com
Provides car rental services globally through multiple brands, offering employment opportunities and vehicle access in many countries. |
32,638 |
| 10 | 30,240 | |
| 11 |
BJC Healthbjc.org
One of the largest nonprofit health care organizations in the US, focused on providing a wide range of healthcare services in St Louis and southern Illinois regions |
29,641 |
| 12 |
Advantage Solutionsyouradv.com
Provider of outsourced sales and marketing services including retail merchandising, digital commerce, sampling, and omnichannel marketing for consumer goods companies. |
27,762 |
| 13 |
University of Missouri Systemumsystem.edu
A prestigious public research institution in Missouri, promoting education, research, and service to serve the state, nation, and beyond |
26,615 |
| 14 | 26,107 | |
| 15 |
SSM Healthssmhealth.com
Provides innovative, sustainable, and compassionate Catholic healthcare services including hospitals, physician offices, home care, hospice, pharmacy, and insurance. |
20,202 |
| 16 |
Wal Mart Corporation
This company provides access to Walmart executive speeches, financial reports, press releases, photos, videos, and interactive global location map |
19,478 |
| 17 |
Washington University in St. Louiswashu.edu
Private university focusing on teaching, research, and fostering knowledge creation while engaging with a diverse, multicultural community. |
18,070 |
| 18 |
Hallmark Cardscareers.hallmark.com
Family-owned global business creating emotionally connected world through greeting cards, gifts, media networks, real estate development, and art products for children worldwide |
17,388 |
| 19 |
Burns & McDonnellburnsmcd.com
Engineering, construction, architecture, planning, and community engagement with a strong ownership mentality and commitment to client success and safety. |
16,200 |
| 20 |
H&R Blockhrblock.com
H&R Block provides tax preparation services worldwide, focusing on building long-lasting relationships through care, innovation, and a people-first approach |
16,116 |
| 21 |
Wells Fargo Advisorswellsfargoadvisors.com
Financial advisors providing professional investment guidance and wealth management services across fifty states to help clients achieve long-term success through complex planning. |
14,935 |
| 22 |
University of Missouri-Columbiamissouri.edu
State-supported research university providing education, advancing arts, sciences, and professions, focusing on public service and economic development. |
14,879 |
| 23 |
State of Missourimo.gov
State government employment offering diverse career paths focused on public service, community protection, natural resource management, and personal growth opportunities. |
12,461 |
| 24 |
Express Scripts Pharmacy Benefit Servicesevernorth.com
Creation and management of prescription benefit programs aimed at reducing costs for members, health plans, employers, and agencies. |
12,361 |
| 25 |
Cerner Corporationlinkedin.com
A recent acquisition deal between two tech giants, involving an all-cash tender offer for a healthcare technology company Visit oraclecom for details |
11,256 |
| 26 |
World Wide Technologywwt.com
Combining strategy and execution to deliver practical, complex technology solutions globally, helping organizations accelerate growth and achieve future goals. |
10,235 |
| 27 |
Bass Pro Shopsbasspro.com
Premier outdoor and conservation company offering destination retail, boats, resorts, and nature experiences, all while promoting conservation and community impact |
10,126 |
| 28 |
Caleres, Inc.jobs.caleres.com
This company is a global footwear brand portfolio with diverse offerings, including famous labels like Sam Edelman and Naturalizer, focusing on consumer-driven innovation and quality craftsmanship |
9,313 |
| 29 |
Monsanto Companybayer.com
Leading in modern agriculture with a focus on seeds, plant traits, and crop protection through innovative breakthroughs for global impact |
9,303 |
| 30 |
Jack Henryjackhenry.com
provides technology and services to community banks and credit unions, enabling innovation, integration with fintechs, and financial health improvement |
8,477 |
| 31 |
Children's Mercychildrensmercy.org
Specialized pediatric healthcare provider focusing on exceptional care, innovative research, and education to improve children's health and well-being. |
8,393 |
| 32 |
Nestlรฉ Purina North Americapurinajobs.com
Advances pet nutrition science, collaborates on innovation, and enriches lives of pets and owners. Builds strong teams for pet care. |
8,321 |
| 33 |
Graybargraybar.com
A Fortune 500 employee-owned corporation distributes electrical, communications, and networking products, offering supply chain management and logistics services to customers |
8,118 |
| 34 |
Saint Louis Universityslu.edu
A Jesuit, Catholic university in St Louis, MO offering top research programs Oldest university in the West, with a campus in Madrid, Spain |
7,855 |
| 35 |
Save A Lotsavealot.com
Discount grocery store chain founded in 1977, offering quality and value to local families through private label brands, national products, and fresh produce |
7,523 |
| 36 |
Washington University School of Medicine in St. Louismedicine.washu.edu
A prestigious medical school renowned for patient care, research, and education, offering top-ranked programs in medicine, science, and healthcare fields |
7,517 |
| 37 |
Stifel Financial Corp.stifel.com
Providing brokerage, trading, investment banking, advisory, and trust services to individuals, businesses, and municipalities across the U.S. |
7,384 |
| 38 |
Anheuser-Buschanheuser-busch.com
A leading brewer in the United States with a legacy of crafting high-quality beers, supporting communities, and valuing talented employees |
7,091 |
| 39 |
Saint Luke'ssaintlukeskc.org
A faith-based health system providing excellence in healthcare services, including specialized programs and hospitals across the Kansas City region |
6,749 |
| 40 |
Barnes-Jewish Hospitalbarnesjewish.org
Flagship hospital of BJC HealthCare offering advanced cancer treatment through the only National Cancer Institute-designated Comprehensive Cancer Center in Missouri. |
6,733 |
| 41 |
McCarthy Building Companies, Inc.mccarthy.com
A long-standing American construction company specializing in building essential projects nationwide, with a commitment to quality, safety, diversity, and equitable pay practices |
6,263 |
| 42 |
Premium Retail Servicespremiumretail.com
A leading company in the US and Canada helps brands develop winning retail strategies, train associates, engage customers, and drive sales growth |
6,209 |
| 43 |
Energizer Holdingsenergizerholdings.com
A global organization creating innovative products to improve lives, focused on serving customers, driving revenue, and delivering long-term value |
6,098 |
| 44 |
Varsity Tutors, a Nerdy Companyvarsitytutors.com
A leading online learning platform leveraging technology to connect learners with experts across a wide range of subjects and formats |
5,970 |
| 45 |
TCScalltcs.com
The company provides communication solutions like VOIP, cloud-based phone systems, collaboration software, managed services, and branding solutions to enhance business connectivity |
5,803 |
| 46 |
Wellcare Medicarewellcare.com
A company based in Tampa providing government-sponsored managed care services to families, children, seniors, and individuals with complex medical needs nationwide |
5,306 |
| 47 |
Magellan Healthmagellanhealth.com
management of complex health areas using technology and personal relationships, serving health plans, employers, unions, military, and government agencies |
5,096 |
| 48 |
Missouri State Universitymissouristate.edu
The company focuses on community engagement, ethical leadership, and cultural competence as part of Missouri State's public affairs mission |
5,090 |
| 49 |
Nidec Motor Corporationacim.nidec.com
manufacture high efficiency commercial and industrial motors, controls, and generators for applications in water treatment, mining, oil, gas, and refrigeration |
5,082 |
| 50 |
Commerce Bankcommercebank.com
A regional bank offering a full range of financial services, including banking, loans, credit cards, and wealth management, focused on customer relationships and community support |
5,058 |
| 51 |
St. Luke's Hospitalstlukes-stl.com
An independent, nonprofit healthcare provider offering personalized healthcare services at multiple locations in the St Louis area, focused on improving quality of life |
4,878 |
| 52 |
University of Missouri-Kansas Cityumkc.edu
A public research university in Kansas City offering over 125 academic programs and professional schools, preparing students for success in their community |
4,869 |
| 53 |
JE Dunn Constructionjedunn.com
A leading general building contractor in the USA, prioritizing authentic partnerships, community involvement, and delivering results that exceed expectations |
4,860 |
| 54 |
CoxHealthcoxhealth.com
A leading healthcare provider in southwest Missouri with six hospitals, 80+ clinics, 5 ERs, and 13,000+ employees dedicated to improving community health |
4,842 |
| 55 |
Copelandcopeland.com
Develop sustainable HVACR technologies for residential, commercial, and industrial spaces, ensuring cold chain integrity and global comfort. |
4,804 |
| 56 |
Leggett & Plattleggett.com
Designing and manufacturing innovative products and components for bedding, furniture, seating, homes, offices, airplanes, and automobiles worldwide. |
4,601 |
| 57 |
Reinsurance Group of America, Incorporatedrgare.com
Global leader in life and health reinsurance providing financial solutions to manage risk, optimize capital, and ensure financial protection accessibility. |
4,444 |
| 58 |
Barry-Wehmillerbarrywehmiller.com
The company is dedicated to improving the lives of its global team through meaningful work, care, compassion, and personal growth initiatives |
4,395 |
| 59 |
Perficientperficient.com
Global consultancy specializing in digital transformation for large enterprises, offering strategy, creative, and technology solutions to drive business growth and success |
4,362 |
| 60 |
Shelter Insurance Companiesshelterinsurance.com
Property and casualty insurance provider offering auto, home, life, renters, farm, business, and specialty insurance products across multiple states. |
4,253 |
| 61 |
EquipmentShareequipmentshare.com
A nationwide equipment and digital solutions company empowering construction industry with technology platform, equipment rental, retail, and service solutions |
4,193 |
| 62 |
Emerson Commercial & Residential Solutions
A company formerly known as Emerson Commercial and Residential Solutions now operates as Copeland, specializing in commercial and residential solutions |
4,189 |
| 63 |
Prime Inc.primeinc.com
A successful transportation company offering refrigerated, flatbed, tanker, and intermodal services with a focus on safety, reliability, and employee satisfaction |
4,147 |
| 64 |
Belden Inc.belden.com
Connecting information and intelligence to simplify, secure, and enhance the digital journey for customers transforming the way the world works |
4,091 |
| 65 |
Pi Beta Phi Fraternity for Womenpibetaphi.org
An organization established in 1867, empowering women through a fraternity, foundation, and housing corporation, with over 300,000 members |
3,846 |
| 66 | 3,682 | |
| 67 |
Special School District of St. Louis Countyssdmo.org
provides special education and career technical education to students across multiple schools and programs within St. Louis County |
3,661 |
| 68 |
Accredo Specialty Pharmacyaccredo.com
specialty pharmacy providing personalized care and medication management for patients with chronic, complex, and rare conditions through expert clinical teams |
3,599 |
| 69 |
Build-A-Bear Workshopbuildabear.com
A beloved brand offering unique retail and entertainment experiences through customizable furry friend creations in over 400 worldwide locations |
3,522 |
| 70 |
Sigma-Aldrichbit.ly
Providing scientists with lab materials, technologies, and services to simplify, accelerate, and improve life science research and biotech production worldwide. |
3,467 |
| 71 |
Missouri University of Science and Technologymst.edu
A prestigious technological research university offering degrees in engineering, science, business, IT, humanities, and education with a focus on technological literacy |
3,410 |
| 72 |
Enterprise Fleet Managementefleets.com
A family-owned enterprise managing nearly a million vehicles in the US and Canada, offering fleet management services for businesses and organizations |
3,409 |
| 73 |
Veterans United Home Loansveteransunited.com
Providing personalized VA home loan services and abundant information to veterans, military members, and their families across the U.S. |
3,372 |
| 74 |
Maritzmaritz.com
A behavioral science-driven company solving business challenges for Fortune 500 clients through research, incentives, rewards, experience design, and events services and solutions |
3,349 |
| 75 |
Webster Universitywebster.edu
A global network of faculty, staff, students, and alumni focused on high-quality learning experiences for global citizenship and individual excellence |
3,249 |
| 76 |
University of Missouri-Saint Louisumsl.edu
A public research university offering diverse learning experiences, leadership opportunities, and high-ranking programs to a large student body in St Louis |
3,152 |
| 77 |
Hussmannhussmann.com
A global leader in providing innovative display cases and refrigeration systems, Hussmann focuses on improving food retailing with value-added solutions and services since 1906 |
3,148 |
| 78 |
Whelan Securitygarda.com
Industry-leading contract security company in the US, providing quality services to diverse clients and seeking talented individuals for security officer positions |
3,133 |
| 79 |
Peabody Energypeabodyenergy.com
Leading coal producer supplying essential materials for affordable energy generation and steel manufacturing with a strong focus on sustainability. |
3,106 |
| 80 |
JCI (Junior Chamber International)jci.cc
Empowering young people worldwide through projects, events, training, and programs to develop leadership and community impact skills. |
2,970 |
| 81 |
University of Missouri Health Caremuhealth.org
A premier academic medical center in Missouri offering a full spectrum of care, from primary to specialized treatment for severe illnesses and injuries |
2,962 |
| 82 |
Giancarlo Spaggiari Ingegnere - Studio Professionalegsistudio.it
The company provides independent evaluation services in various sectors including real estate, infrastructure, urban planning, workplace accidents, energy efficiency, and more |
2,945 |
| 83 |
University Health KCuniversityhealthkc.org
Academic health system offering acute care, behavioral health, primary care, specialty clinics, trauma services, and teaching medical professionals. |
2,929 |
| 84 |
Springfield Missouri Public Schoolssps.org
Leading public school district in Missouri, offering academic excellence to over 25,000 students through diverse programs including IB, WOLF, and Middle College |
2,901 |
| 85 |
Central Bankcentralbank.net
Privately held bank serving multiple states with community-focused banking, advanced technology, local lending decisions, and extensive ATM network. |
2,885 |
| 86 |
Watlowwatlow.com
Global industrial technology company, expertise in thermal systems, providing temperature control, power control, heater technologies, and temperature sensing platforms to various industries. |
2,840 |
| 87 |
St. Louis Community Collegestlcc.edu
St Louis Community College offers opportunities for individuals to pursue education, career changes, skill updates, or personal growth Find your place today! |
2,835 |
| 88 |
Saint Louis Public Schoolsslps.org
Providing quality education to students in the St Louis region, aiming to become a national leader in student achievement and teacher quality |
2,721 |
| 89 |
Drury Hotelsjobs.druryhotels.com
Drury Hotels offers a supportive family-like environment with a focus on exceptional customer service, employee well-being, and growth opportunities in the hospitality industry |
2,664 |
| 90 |
University of Central Missouriucmo.edu
A public university that transforms students into lifelong learners, providing hands-on learning opportunities and preparing them for success in various fields |
2,656 |
| 91 |
St. Louis Children's Hospitalstlouischildrens.org
A leading pediatric teaching hospital offering comprehensive medical care, education, and injury-prevention programs with a team dedicated to children's well-being |
2,635 |
| 92 |
City of Kansas City, MOkcmo.gov
Official page representing a city in Missouri, providing information and updates about services, events, and initiatives within the community |
2,494 |
| 93 |
St. Louis Countystlouiscountymo.gov
A diverse and populous county in Missouri known for its economic vitality, parks, education system, and local government services |
2,482 |
| 94 |
Core & Maincoreandmain.com
Leading specialized distributor focused on water, wastewater, storm drainage, and fire protection products nationwide, providing solutions to municipalities, water companies, and contractors |
2,479 |
| 95 |
Hair Saloonยฎhairsaloon.com
Premium hair cutting franchise offering comfort, convenience, and perfect haircuts for men inspired by reinventing the traditional neighborhood barbershop with an Honorable Rebellion Among Menยฎ |
2,476 |
| 96 |
LaborMAX Staffinglabormax.net
A privately owned staffing agency providing quality pre-screened contingent workers to meet diverse customer needs with exceptional service since 2002 |
2,420 |
| 97 |
Kansas City Public Schoolskcpublicschools.org
This organization provides education to nearly 16,690 children in Kansas City with a focus on preparing students for higher education and successful careers |
2,358 |
| 98 |
North Kansas City Hospitalnkch.org
A leading healthcare provider in the Northland with a focus on providing quality care, a wide range of medical services, and community wellness programs |
2,287 |
| 99 |
MTM Healthmtm-inc.net
Healthcare and transportation management company providing innovative solutions to access healthcare, increase independence, and connect community resources efficiently and cost-effectively |
2,271 |
| 100 |
Suddenlink Communicationsoptimum.com
The company is a leading cable operator in the US, providing information, communication, and entertainment services to residential and commercial customers in multiple states |
2,260 |
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How this list is built
Every company on this list has a Tamtam company profile. The industry is the one the company gives on LinkedIn; categories such as SaaS or fintech are classified by Tamtam's AI from the company's website and LinkedIn page; and the headquarters city must match the company's own address. Companies are ranked by the number of employees on LinkedIn, and the list is refreshed every night. Classifications can be wrong, so treat the list as a starting point rather than an official ranking. Last updated Oct 24, 2026.
More company lists in Missouri
- Hospitals and Health Care companies in Missouri 118
- Retail chains in Missouri 103
- Financial services firms in Missouri 85
- Critical infrastructure operators in Missouri 76
- Education providers in Missouri 70
- Healthcare providers in Missouri 70
- Higher Education companies in Missouri 70
- Manufacturers in Missouri 67
- Construction companies in Missouri 60
- IT Services and IT Consulting companies in Missouri 59
- Public sector organisations in Missouri 51
- Financial Services companies in Missouri 50
- Family-owned companies in Missouri 47
- Insurance companies in Missouri 40
- Truck Transportation companies in Missouri 36
- IT services companies in Missouri 36
- Contract manufacturers in Missouri 35
- Distributors and wholesalers in Missouri 34
- Non-profit Organizations companies in Missouri 33
- Primary and Secondary Education companies in Missouri 33
- Machinery Manufacturing companies in Missouri 31
- Food and Beverage Services companies in Missouri 30
- Retail companies in Missouri 29
- Banking companies in Missouri 28
The same list elsewhere in United States
- The largest companies in the United States 91,669
- The largest companies in California 12,813
- The largest companies in New York State 10,485
- The largest companies in Texas 8,086
- The largest companies in Florida 4,945
- The largest companies in Illinois 4,175
- The largest companies in Pennsylvania 3,110
- The largest companies in Massachusetts 3,093
- The largest companies in Georgia 2,632
- The largest companies in Ohio 2,618
- The largest companies in New Jersey 2,569
- The largest companies in Virginia 2,503
- The largest companies in Michigan 2,346
- The largest companies in North Carolina 2,174
- The largest companies in Alabama 1,806
- The largest companies in Washington State 1,785
- The largest companies in Colorado 1,774
- The largest companies in Minnesota 1,700
- The largest companies in Maryland 1,527
- The largest companies in Wisconsin 1,482
- The largest companies in New York 6,920
- The largest companies in San Francisco 2,030
- The largest companies in Houston 1,791
- The largest companies in Chicago 1,668