These large New York State companies conduct in-house research and development. The list features major players across diverse sectors. IBM focuses on technology, infrastructure, software, and consulting, while PepsiCo is a global food and beverage innovator. Pfizer is a biopharmaceutical company developing therapies, and American Express is a globally integrated payments company. Goldman Sachs provides capital markets services and asset management, and Mastercard is a global technology company in payments.
A notable pattern is the strong presence of financial services firms, with several headquartered in New York City, including Goldman Sachs, American Express, BNY, and BlackRock. The list also shows a significant concentration of healthcare organizations like Northwell Health, Mount Sinai Health System, and NYU Langone Health, all contributing to medical research and patient care.
| # | Company | Employees | |||
|---|---|---|---|---|---|
| 1 | 335,625 | ||||
| 2 |
PepsiCopepsico.com
A global company championing innovation, creating deep connections with iconic brands, and empowering employees to make a global impact for a better world |
140,098 | |||
| 3 |
Pfizerpfizer.com
A leading biopharmaceutical company focused on research and innovation to develop therapies that improve and extend the lives of patients worldwide |
102,598 | |||
| 4 |
American Expressamericanexpress.com
A globally integrated payments company supporting customers' financial confidence, promoting commerce, and providing experiences that enrich lives and drive business success |
94,909 | |||
| 5 |
Goldman Sachsgoldmansachs.com
Global financial institution providing expert capital markets services, investment banking, and asset management for clients through partnership, integrity, and world-class operational excellence. |
76,000 | |||
| 6 | 61,367 | ||||
| 7 |
The Estée Lauder Companies Inc.elcompanies.com
A global leader in skincare, makeup, fragrance, and hair care, offering luxury brands sold in 150+ countries, with a diverse product portfolio |
60,000 | |||
| 8 |
Northwell Healthnorthwell.edu
Largest New York healthcare system with hospitals, outpatient facilities, research institutes, medical education, and extensive patient care services. |
56,405 | |||
| 9 | 55,654 | ||||
| 10 |
Mastercardmastercard.com
Global technology company in payments industry connecting and powering inclusive digital economy through safe, simple, smart transactions benefiting individuals, institutions, and businesses worldwide |
49,687 | |||
| 11 |
Compasscompass.com
Real estate technology company with a platform supporting the buying and selling process, delivering exceptional experiences for agents and clients |
35,116 | |||
| 12 |
BlackRockblackrock.com
Global asset manager and technology provider helping people invest through diverse market access and expert financial insights across more than forty countries. |
34,599 | |||
| 13 |
Colgate-Palmolivecolgatepalmolive.com
Develops, produces, distributes, and sells essential health & hygiene products and pet nutrition offerings, with a focus on sustainability and community wellbeing. |
30,816 | |||
| 14 |
Mount Sinai Health Systemmountsinai.org
Provides distinguished care, conducts transformative research, and advances biomedical education through hospitals, a medical school, and extensive ambulatory network. |
30,202 | |||
| 15 |
NYU Langone Healthjobs.nyulangone.org
World-class academic medical center with top-ranked patient care, education, and research programs, serving diverse communities with excellence and inclusive values |
29,840 | |||
| 16 |
Nielsennielsen.com
Global leader in audience insights, data, and analytics shaping media and content by understanding behaviors across all platforms, empowering clients with actionable intelligence |
29,147 | |||
| 17 |
Bloombergbloomberg.com
Global provider of real-time financial data, market information, and news, leveraging technology and analysis to support financial decision-making worldwide. |
26,832 | |||
| 18 |
Columbia Universitycolumbia.edu
A renowned leader in higher education, Columbia attracts top minds to drive academic inquiry, make groundbreaking discoveries, and serve society globally |
23,565 | |||
| 19 |
Corning Incorporatedcorning.com
Development of advanced glass, ceramics, and optical products for communications, electronics, automotive, life sciences, and display technologies. |
22,260 | |||
| 20 | 22,222 | ||||
| 21 | 22,000 | ||||
| 22 |
Ralph Laurencorporate.ralphlauren.com
Global leader in luxury lifestyle products across apparel, footwear, accessories, home, fragrances, and hospitality, inspiring timeless style and authenticity for over 50 years |
21,641 | |||
| 23 |
Memorial Sloan Kettering Cancer Centermskcc.org
Specialized teams provide personalized cancer care, conduct innovative research, and train future scientists and clinicians worldwide. |
19,653 | |||
| 24 |
Broadridgebroadridge.com
Provide technology and operations platforms supporting financial services, processing communications, enabling trading, and enhancing investor experiences worldwide. |
17,674 | |||
| 25 |
Hospital for Special Surgeryhss.edu
Academic medical center specializing in orthopedics and rheumatology with top national rankings, low complication rates, and multiple regional facilities. |
17,614 | |||
| 26 |
GE Powergepower.com
A global energy leader offering technology, solutions, and services spanning the energy value chain, serving customers in over 150 countries |
17,248 | |||
| 27 |
Regeneronregeneron.com
Develops and commercializes life-transforming medicines for serious diseases, establishing new approaches in science, manufacturing, and health. Building a future in biopharmaceuticals. |
16,874 | |||
| 28 |
L3 Technologiesl3harris.com
Develops advanced defense technologies and commercial solutions in pilot training, aviation security, night vision, weapons, maritime systems and space for worldwide deployment. |
15,734 | |||
| 29 | 15,308 | ||||
| 30 |
Moody's Corporationmoodys.com
Global risk assessment firm providing data, analytics, and insights to empower organizations in making informed decisions and managing business risks worldwide |
15,249 | |||
| 31 |
Gapgapinc.com
Iconic global retailer specializing in denim and elevated American style clothing across fourteen hundred stores worldwide with a focus on community and diversity. |
15,202 | |||
| 32 |
Synechronsynechron.com
Innovative consulting firm leveraging digital technology to deliver leading solutions in AI, digital, cloud, data, and software engineering for financial services and technology industries globally |
14,671 | |||
| 33 |
Tiffany & Co.tiffany.com
Luxury jewelry and accessories company founded in 1837, known for innovative design, fine craftsmanship, and global cultural influence Operates worldwide |
14,000 | |||
| 34 |
GlobalFoundriesgf.com
Semiconductor manufacturer offering innovative process technology solutions, design, development, and fabrication services with global presence and diverse workforce |
13,861 | |||
| 35 |
Cliniqueclinique.com
A leading skincare and makeup brand founded by dermatologists, offering clinically proven, allergy-tested solutions for remarkable skin results worldwide |
11,697 | |||
| 36 |
Montefiore Health Systemmontefiore.org
Premier academic health system providing specialized medical education, innovative research, advanced technology, and coordinated care for diverse populations. |
11,619 | |||
| 37 |
University of Rochesterrochester.edu
Private research institution providing undergraduate and graduate degrees across seven schools while operating a major health system and NCAA athletics program. |
11,592 | |||
| 38 |
Moody's Analyticsmoodys.com
Financial intelligence and analytical tools provider empowering clients to make better decisions through expertise in risk, information resources, and innovative technology solutions |
11,588 | |||
| 39 |
Datadogdatadoghq.com
Provider of essential monitoring platform for cloud applications, consolidating data from various sources to ensure optimal performance and user experience for DevOps teams |
10,888 | |||
| 40 |
Weill Cornell Medicinecareers.weill.cornell.edu
A leading medical institution in NYC, conducting cutting-edge research, providing top-notch patient care, and educating future physicians and scientists worldwide |
10,471 | |||
| 41 |
Revlonrevlon.com
A global beauty company known for high-quality cosmetics, hair care, and fragrances sold in 150 countries through various retail channels |
8,874 | |||
| 42 |
Nasdaqnasdaq.com
This company aims to advance economic progress by powering economies, creating equitable opportunities, and contributing to a sustainable world |
8,532 | |||
| 43 |
University of Rochester Medicineurmc.rochester.edu
Academic medical center providing advanced patient care, conducting disease research, and educating future healthcare professionals including doctors, dentists, and nurses. |
8,483 | |||
| 44 |
Eastman Kodak Companykodak.com
Leading global manufacturer specializing in commercial printing, advanced materials, and chemicals with extensive patents and research history. |
8,449 | |||
| 45 | 8,085 | ||||
| 46 |
MathWorksmathworks.com
Develops mathematical computing software like MATLAB and Simulink for engineers and scientists to accelerate discovery, innovation, and development, also used for teaching and research. |
8,041 | |||
| 47 |
MongoDBmongodb.com
A developer data platform empowering innovation through software and data solutions for modern applications, with a global customer base Visit mongodbcom |
8,013 | |||
| 48 |
Columbia University Irving Medical Centercuimc.columbia.edu
A leading clinical, research, and educational institution providing patient care, medical education, and public health services in northern Manhattan |
7,913 | |||
| 49 | 7,759 | ||||
| 50 |
Icahn School of Medicine at Mount Sinaiicahn.mssm.edu
A leading medical school and research institution dedicated to training, research, and patient care to advance biomedical discoveries and improve outcomes |
7,423 | |||
Want more companies than this list?This page shows the largest ones only. Connect to Tamtam to see every company that matches, filter by size, industry or growth, and reach their decision-makers. | |||||
| 51 |
Binghamton Universitybinghamton.edu
A top public university in the Northeast offering broad education, vibrant research programs, financial accessibility, diverse student body, and unique academic opportunities |
7,412 | |||
| 52 |
Fractalfractal.ai
Provides AI-powered decision-making tools and analytics services, supporting revenue growth, healthcare AI, and foundational AI research globally. |
7,024 | |||
| 53 |
Stony Brook Medicinestonybrookmedicine.edu
A leading academic medical center with health sciences schools, research, and clinical care teams delivering innovative ideas in healthcare to patients worldwide |
5,786 | |||
| 54 |
DataArtdataart.com
Global software engineering firm specializing in data-driven, cloud-native solutions, with a focus on professional growth, diversity, and employee autonomy |
5,451 | |||
| 55 |
Akums Drugs& Pharmaceuticals Ltdakums.in
Leading pharmaceutical contract development and manufacturing for diverse formulations, including oral solids, liquids, injectables, personal care, and animal healthcare solutions. |
5,173 | |||
| 56 |
Pall Corporationpall.com
Filtration, separation, and purification solutions for health, safety, environment, improving product quality, protecting assets, minimizing emissions, and advancing technology. |
5,067 | |||
| 57 |
Westchester Medical Center Health Networkwmchealth.org
Provider of advanced medical care in NY's Hudson Valley, offering Level I trauma care, organ transplants, and neurovascular procedures to 35 million residents |
4,961 | |||
| 58 |
Verifoneverifone.com
Innovative payments architects shaping powerful commerce experiences globally with a future-first approach, digital focus, and industry leadership #CommerceExperts #ProvenLeader #NewBrand |
4,702 | |||
| 59 |
Standard Industriesstandardindustries.com
A global industrial company with diverse holdings, technologies, and investments in building solutions, performance materials, logistics, real estate, and solar technology |
4,528 | |||
| 60 |
Sprinklrsprinklr.com
AI-native platform for unified customer experience management across social media, marketing, advertising, and contact center operations to provide consistent, real-time enterprise insights. |
4,424 | |||
| 61 |
Momentivemomentive.com
A global company creating high-performance silicones and specialties to improve quality of life, drive innovation, and promote sustainability worldwide |
4,399 | |||
| 62 |
Verintverint.com
The company helps brands build lasting customer relationships by connecting work, data, and experiences to deliver differentiated experiences at scale |
4,354 | |||
| 63 |
FUJIFILM Americasfujifilm.com
A diverse group of affiliate companies focused on innovation in industries such as medical, electronics, chemicals, and photography to enhance global lives |
4,327 | |||
| 64 |
Rensselaer Polytechnic Instituterpi.edu
A pioneering technological research university focused on advancing scientific and technological innovation, educating future leaders, and addressing global challenges for over 195 years |
4,257 | |||
| 65 |
Wildlife Conservation Societywcs.org
Global wildlife conservation organization protecting wilderness, oceans, and wildlife through science, on-the-ground conservation efforts, education, and partnerships in 60 countries |
4,131 | |||
| 66 |
Celoniscelonis.com
It provides a platform for visualizing and optimizing business processes using existing data, benefiting companies and the environment. |
4,012 | |||
| 67 |
Carestreamcarestream.com
Provides digital X-ray products, X-ray film for medical, non-destructive testing markets, alongside product, technical, service support globally, holding 1,000+ patents. |
3,895 | |||
| 68 |
Entrustentrust.com
Provides identity-centric security solutions, protecting people, devices, data. Fights fraud, cyber threats, secures identity lifecycle, ensures transaction confidence. Global presence, 150 countries. |
3,755 | |||
| 69 |
Long Island Universityliu.edu
Provides access to diverse higher education programs, including pharmacy, global studies, and online courses, with a focus on academic excellence and community service |
3,707 | |||
| 70 |
The D. E. Shaw Groupdeshaw.com
Global investment management firm combining quantitative tools and fundamental analysis to find returns across public and private markets through systematic and discretionary strategies. |
3,518 | |||
| 71 |
Steve Maddenstevemadden.com
Global fashion industry leader known for iconic footwear designs, including licensed and private label brands, with emphasis on retail, wholesale, licensing, and international business |
3,419 | |||
| 72 |
Curiacuriaglobal.com
Develops and manufactures biologics and small molecules, spanning discovery to commercialization, with regulatory and analytical support to accelerate life-changing therapeutics. |
3,398 | |||
| 73 |
Production Resource Groupprg.com
Global entertainment services provider delivering specialized technology, engineering, and creative solutions for theater, film, television, broadcast, concert touring, and corporate events worldwide. |
3,392 | |||
| 74 |
Brookhaven National Laboratorybnl.gov
This company delivers transformative technology and discovery science to address various challenges in energy, environment, and nuclear fields through innovative research |
3,317 | |||
| 75 |
Federal Reserve Bank of New Yorknewyorkfed.org
Implementation of monetary policy, supervision of financial institutions, international operations, and financial services within the Second Federal Reserve District. |
3,239 | |||
| 76 |
Payoneerpayoneer.com
Global partner for digital commerce, providing technology and connections for businesses worldwide to thrive in the new global economy |
3,221 | |||
| 77 | 3,147 | ||||
| 78 | 3,080 | ||||
| 79 |
Zeta Globalzetaglobal.com
Zeta is a cloud-based marketing technology company that helps brands acquire, retain, and grow customers through sophisticated AI-driven marketing solutions across various channels |
3,034 | |||
| 80 |
Diligentdiligent.com
Provides AI-powered governance, risk, and compliance SaaS solutions through a consolidated platform for practitioners and board members to manage enterprise risk. |
3,022 | |||
| 81 |
Adelphi Universityadelphi.edu
A highly awarded doctoral research university in New York, offering personalized higher learning with a focus on liberal arts, sciences, and professional training |
2,951 | |||
| 82 |
New York Institute of Technologynyit.edu
A nonprofit university offering undergraduate, graduate, and professional programs in various disciplines, with campuses worldwide and a network of alumni |
2,946 | |||
| 83 |
Peloton Interactiveonepeloton.com
Connected fitness company offering equipment, software, live and on-demand classes, apparel, and corporate wellness solutions for global members. |
2,917 | |||
| 84 |
MONTEFIORE MEDICAL CENTERcham.org
A hospital & health care company located in Bronx, New York, providing medical services and care to individuals in the community |
2,905 | |||
| 85 |
NYU Winthrop Hospitalnyulangone.org
A hospital merged with NYU Langone Health, offering updated company information, news, and job openings on their LinkedIn page |
2,880 | |||
| 86 |
Albert Einstein College of Medicineeinsteinmed.edu
Offers medical and graduate biomedical degrees, located in New York City, and is a not-for-profit, private, nonsectarian institution. |
2,873 | |||
| 87 |
SRCsrcinc.com
A not-for-profit R&D company tackling defense, environment, and intelligence challenges through innovative solutions, technology, and expertise since 1957 |
2,790 | |||
| 88 |
Arcesiumarcesium.com
A leading fintech company providing advanced data, operations, and analytics platform for financial institutions, optimizing investment lifecycle with industry-specific capabilities |
2,704 | |||
| 89 |
Levitonleviton.com
A global leader in electrical devices, lighting solutions, networking, security, home automation, and data infrastructure products for residential, commercial, and industrial needs |
2,593 | |||
| 90 | 2,536 | ||||
| 91 |
Two Sigmatwosigma.com
Quantitative investment management firm using artificial intelligence, data science, and rigorous research to capitalize on market opportunities and deliver alpha for clients. |
2,414 | |||
| 92 |
NYU Langone Hospital—Brooklynnyulangone.org
NYU Langone Hospital – Brooklyn is now part of NYU Langone Health Stay updated on company information, news, and job openings |
2,367 | |||
| 93 |
United States Military Academy at West Pointwestpoint.edu
A higher education institution based in NY, United States focused on training future military leaders at West Point Academy |
2,342 | |||
| 94 | 2,308 | ||||
| 95 |
Squarespacesquarespace.com
A design-driven platform empowering entrepreneurs worldwide to build online brands and businesses through websites, domains, ecommerce, and marketing tools |
2,206 | |||
| 96 |
Squarepointsquarepoint-capital.com
Develops quantitative investment strategies and automated trading systems leveraging data and technology to achieve high quality returns globally. |
2,188 | |||
| 97 |
PAR Technologypartech.com
Provides foodservice technology solutions including point-of-sale, digital ordering, loyalty, back-office, payments, and hardware to streamline operations and enhance guest experiences. |
2,154 | |||
| 98 |
Bassett Healthcare Networkbassett.org
An integrated health care system serving a rural region in upstate New York with hospitals, nursing facilities, health centers, and partners |
2,088 | |||
| 99 |
Patheonpatheon.com
Provides industry-leading pharma services for drug development, clinical trials, and commercial manufacturing, partnering with pharmaceutical, biotech, and life science companies globally. |
2,072 | |||
| 100 |
Viaridewithvia.com
The company specializes in developing innovative software for various organizations to improve their transportation systems and offer new digital services worldwide |
2,051 | |||
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Every company on this list has a Tamtam company profile. The industry is the one the company gives on LinkedIn; categories such as SaaS or fintech are classified by Tamtam's AI from the company's website and LinkedIn page; and the headquarters city must match the company's own address. Companies are ranked by the number of employees on LinkedIn, and the list is refreshed every night. Classifications can be wrong, so treat the list as a starting point rather than an official ranking. Last updated Nov 11, 2026.
More company lists in New York State
- The largest companies in New York State 12,432
- Multinational companies in New York State 2,216
- Financial services firms in New York State 1,272
- Financial Services companies in New York State 1,076
- SaaS companies in New York State 1,060
- Professional services firms in New York State 955
- Real Estate companies in New York State 789
- Venture capital and private equity firms in New York State 757
- Software Development companies in New York State 696
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- Subscription businesses in New York State 485
- Consulting firms in New York State 474
- Advertising Services companies in New York State 473
- IT services companies in New York State 468
- Investment Management companies in New York State 457
- Marketing and communications agencies in New York State 449
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The same list elsewhere in United States
- Companies with in-house R&D in the United States 6,796
- Companies with in-house R&D in California 1,276
- Companies with in-house R&D in Texas 442
- Companies with in-house R&D in Massachusetts 396
- Companies with in-house R&D in Illinois 322
- Companies with in-house R&D in Michigan 287
- Companies with in-house R&D in Ohio 277
- Companies with in-house R&D in Pennsylvania 255
- Companies with in-house R&D in New Jersey 224
- Companies with in-house R&D in Florida 221
- Companies with in-house R&D in Alabama 214
- Companies with in-house R&D in Georgia 173
- Companies with in-house R&D in Virginia 166
- Companies with in-house R&D in North Carolina 158
- Companies with in-house R&D in Wisconsin 154
- Companies with in-house R&D in Minnesota 146
- Companies with in-house R&D in Washington State 140
- Companies with in-house R&D in Colorado 113
- Companies with in-house R&D in Maryland 107
- Companies with in-house R&D in Indiana 104
- Companies with in-house R&D in New York 223
- Companies with in-house R&D in San Francisco 147
- Companies with in-house R&D in Houston 129
- Companies with in-house R&D in San Jose 103