This selection of San Francisco companies with in-house R&D includes large corporations and mid-sized firms. The majority operate in software development, such as Salesforce, which provides customer relationship management solutions, and Databricks, offering a Data Intelligence Platform. Other notable companies include Uber, a global platform for transportation and delivery, and Levi Strauss & Co., which designs and markets denim jeans and apparel.
The data shows a concentration of companies focused on digital platforms and technology. While many are in software, there is also representation from other sectors like retail with Williams-Sonoma, Inc. and healthcare with UCSF Health. The companies listed are all headquartered in San Francisco.
| # | Company | Employees | |||
|---|---|---|---|---|---|
| 1 | 160,913 | ||||
| 2 |
Salesforcesalesforce.com
It provides customer relationship management solutions, integrating data, artificial intelligence, and a focus on trust to enhance customer experiences. |
86,347 | |||
| 3 |
DoorDashcareersatdoordash.com
A tech and logistics company focused on empowering local economies through delivery services, with a mission to expand beyond food delivery |
80,754 | |||
| 4 |
Airbnbairbnb.com
The company offers unique stays and experiences worldwide through a platform connecting hosts with guests, fostering community connections |
72,938 | |||
| 5 |
Rodan + Fieldsrodanandfields.com
A skincare company founded by dermatologists focusing on giving people the best skin and confidence, with a commitment to social impact |
17,749 | |||
| 6 |
Levi Strauss & Co.levistrauss.com
designs and markets iconic denim jeans and apparel brands, emphasizing sustainability, innovation, and global self-expression through fashion. |
17,743 | |||
| 7 |
Databricksdatabricks.com
It provides a Data Intelligence Platform for organizations to manage their data effectively and leverage AI for better decision-making. |
15,896 | |||
| 8 |
Williams-Sonoma, Inc.williams-sonomainc.com
Specialty retailer offering high-quality kitchenware, furniture, and home decor through brands like Pottery Barn and West Elm across global multi-channel retail platforms. |
15,546 | |||
| 9 |
Autodeskautodesk.com
It provides software for architecture, engineering, construction, and media, enabling users to design, collaborate, and solve various challenges effectively. |
15,378 | |||
| 10 |
Pinterestpinterest.com
It is a visual inspiration platform with 482 million monthly active users, helping people search, save, and shop ideas. |
13,766 | |||
| 11 |
UCSF Healthucsfhealth.org
An integrated healthcare network with top-ranked hospitals, providing innovative patient care, advanced technology, pioneering research, and compassionate treatment across numerous specialties. |
11,588 | |||
| 12 | 9,873 | ||||
| 13 |
OpenAIopenai.com
An AI research and deployment company focused on creating safe and beneficial general-purpose artificial intelligence for the benefit of humanity |
9,268 | |||
| 14 |
Splunksplunk.com
Providing organizations with a unified security and observability platform to ensure operational resilience in the face of digital disruptions |
8,820 | |||
| 15 |
Docusigndocusign.com
It provides e-signature and contract lifecycle management solutions, helping businesses streamline agreement processes and unlock valuable data trapped in documents. |
8,490 | |||
Want more companies than this list?This page shows the largest ones only. Connect to Tamtam to see every company that matches, filter by size, industry or growth, and reach their decision-makers. | |||||
| 16 |
Genslergensler.com
Global architecture, design, and planning firm with a network of 6,000+ professionals creating positive change through impactful design across various sectors worldwide |
8,363 | |||
| 17 |
Ripplingrippling.com
Workforce management system streamlining business operations by consolidating data and applications for payroll, IT, expenses, and more into one unified platform |
7,811 | |||
| 18 | 7,522 | ||||
| 19 |
Cloudflarecloudflare.com
The company is a leading connectivity cloud provider, empowering organizations to enhance speed and security while reducing complexity and cost |
7,489 | |||
| 20 | 7,154 | ||||
| 21 |
Twiliotwilio.com
Platform enabling companies to build personalized customer relationships using communications and data across sales, marketing, service, and growth worldwide. |
6,921 | |||
| 22 | 6,874 | ||||
| 23 | 6,754 | ||||
| 24 |
GitHubgithub.com
It serves as a global platform for developers to collaborate, build, and deliver secure software using AI-powered tools and features. |
6,506 | |||
| 25 |
Notionnotion.com
Combines product roadmaps, company wikis, and meeting notes into a single customizable workspace allowing teams to build and modify their own software tools. |
6,434 | |||
| 26 |
Squaresquareup.com
It provides integrated software and financial services to help sellers manage sales, inventory, and cash flow across various channels. |
6,380 | |||
| 27 |
Samsarasamsara.com
A pioneer in Connected Operationsโข Cloud, leveraging IoT data for actionable insights to improve operations in various industries worldwide |
5,639 | |||
| 28 |
Elasticelastic.co
This company specializes in Enterprise Search, Observability, and Security solutions to enhance customer and employee experiences, ensure smooth application performance, and protect against cyber threats |
5,089 | |||
| 29 | 4,450 | ||||
| 30 | 4,407 | ||||
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How this list is built
Every company on this list has a Tamtam company profile. The industry is the one the company gives on LinkedIn; categories such as SaaS or fintech are classified by Tamtam's AI from the company's website and LinkedIn page; and the headquarters city must match the company's own address. Companies are ranked by the number of employees on LinkedIn, and the list is refreshed every night. Classifications can be wrong, so treat the list as a starting point rather than an official ranking. Last updated Nov 11, 2026.
More company lists in San Francisco
- The largest companies in San Francisco 2,410
- SaaS companies in San Francisco 783
- Software Development companies in San Francisco 656
- AI companies in San Francisco 455
- Multinational companies in San Francisco 446
- Subscription businesses in San Francisco 323
- Venture capital and private equity firms in San Francisco 321
- AI-native companies in San Francisco 270
- Venture Capital and Private Equity Principals companies in San Francisco 267
- Companies with a mobile app in San Francisco 238
- Venture-backed startups in San Francisco 227
- Technology, Information and Internet companies in San Francisco 214
- Financial Services companies in San Francisco 149
- IT Services and IT Consulting companies in San Francisco 130
- Professional services firms in San Francisco 130
- Data and analytics companies in San Francisco 115
- Financial services firms in San Francisco 109
- Online-only businesses in San Francisco 95
- Consulting firms in San Francisco 88
- Education providers in San Francisco 86
- Fintech companies in San Francisco 86
- IT services companies in San Francisco 78
- Online marketplaces in San Francisco 72
- E-commerce companies in San Francisco 67
The same list elsewhere in United States
- Companies with in-house R&D in the United States 6,796
- Companies with in-house R&D in California 1,276
- Companies with in-house R&D in Texas 442
- Companies with in-house R&D in New York State 419
- Companies with in-house R&D in Massachusetts 396
- Companies with in-house R&D in Illinois 322
- Companies with in-house R&D in Michigan 287
- Companies with in-house R&D in Ohio 277
- Companies with in-house R&D in Pennsylvania 255
- Companies with in-house R&D in New Jersey 224
- Companies with in-house R&D in Florida 221
- Companies with in-house R&D in Alabama 214
- Companies with in-house R&D in Georgia 173
- Companies with in-house R&D in Virginia 166
- Companies with in-house R&D in North Carolina 158
- Companies with in-house R&D in Wisconsin 154
- Companies with in-house R&D in Minnesota 146
- Companies with in-house R&D in Washington State 140
- Companies with in-house R&D in Colorado 113
- Companies with in-house R&D in Maryland 107
- Companies with in-house R&D in Indiana 104
- Companies with in-house R&D in New York 223
- Companies with in-house R&D in Houston 129
- Companies with in-house R&D in San Jose 103