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The 30 largest companies with in-house R&D in San Francisco

Tamtam tracks 147 companies with in-house R&D headquartered in San Francisco. This list ranks the 30 largest by number of employees on LinkedIn, led by Uber, Salesforce and DoorDash. Their median headcount is 8,490. Half of them were founded in 2009 or later.

๐Ÿ‡บ๐Ÿ‡ธ San Francisco30 companiesUpdated Nov 11, 2026

This selection of San Francisco companies with in-house R&D includes large corporations and mid-sized firms. The majority operate in software development, such as Salesforce, which provides customer relationship management solutions, and Databricks, offering a Data Intelligence Platform. Other notable companies include Uber, a global platform for transportation and delivery, and Levi Strauss & Co., which designs and markets denim jeans and apparel.

The data shows a concentration of companies focused on digital platforms and technology. While many are in software, there is also representation from other sectors like retail with Williams-Sonoma, Inc. and healthcare with UCSF Health. The companies listed are all headquartered in San Francisco.

#CompanyIndustryHeadquarters EmployeesFounded
1
Uberuber.com

Global platform powering flexible earnings and movement of people and things, constantly reimagining how to enable transportation and delivery services worldwide

Internet Marketplace Platforms ๐Ÿ‡บ๐Ÿ‡ธ San Francisco 160,913 n/a
2
Salesforcesalesforce.com

It provides customer relationship management solutions, integrating data, artificial intelligence, and a focus on trust to enhance customer experiences.

Software Development ๐Ÿ‡บ๐Ÿ‡ธ San Francisco 86,347 n/a
3
DoorDashcareersatdoordash.com

A tech and logistics company focused on empowering local economies through delivery services, with a mission to expand beyond food delivery

Software Development ๐Ÿ‡บ๐Ÿ‡ธ San Francisco 80,754 n/a
4
Airbnbairbnb.com

The company offers unique stays and experiences worldwide through a platform connecting hosts with guests, fostering community connections

Software Development ๐Ÿ‡บ๐Ÿ‡ธ San Francisco 72,938 2007
5
Rodan + Fieldsrodanandfields.com

A skincare company founded by dermatologists focusing on giving people the best skin and confidence, with a commitment to social impact

Manufacturing ๐Ÿ‡บ๐Ÿ‡ธ San Francisco 17,749 2000
6
Levi Strauss & Co.levistrauss.com

designs and markets iconic denim jeans and apparel brands, emphasizing sustainability, innovation, and global self-expression through fashion.

Retail Apparel and Fashion ๐Ÿ‡บ๐Ÿ‡ธ San Francisco 17,743 1853
7
Databricksdatabricks.com

It provides a Data Intelligence Platform for organizations to manage their data effectively and leverage AI for better decision-making.

Software Development ๐Ÿ‡บ๐Ÿ‡ธ San Francisco 15,896 n/a
8
Williams-Sonoma, Inc.williams-sonomainc.com

Specialty retailer offering high-quality kitchenware, furniture, and home decor through brands like Pottery Barn and West Elm across global multi-channel retail platforms.

Retail ๐Ÿ‡บ๐Ÿ‡ธ San Francisco 15,546 n/a
9
Autodeskautodesk.com

It provides software for architecture, engineering, construction, and media, enabling users to design, collaborate, and solve various challenges effectively.

Software Development ๐Ÿ‡บ๐Ÿ‡ธ San Francisco 15,378 1982
10
Pinterestpinterest.com

It is a visual inspiration platform with 482 million monthly active users, helping people search, save, and shop ideas.

Software Development ๐Ÿ‡บ๐Ÿ‡ธ San Francisco 13,766 2010
11
UCSF Healthucsfhealth.org

An integrated healthcare network with top-ranked hospitals, providing innovative patient care, advanced technology, pioneering research, and compassionate treatment across numerous specialties.

Hospitals and Health Care ๐Ÿ‡บ๐Ÿ‡ธ San Francisco 11,588 n/a
12
Deeldeel.com

Platform offering HR tools, payroll, compliance, and mobility services to help companies manage and scale international workforces efficiently.

Human Resources Services ๐Ÿ‡บ๐Ÿ‡ธ San Francisco 9,873 2019
13
OpenAIopenai.com

An AI research and deployment company focused on creating safe and beneficial general-purpose artificial intelligence for the benefit of humanity

Research Services ๐Ÿ‡บ๐Ÿ‡ธ San Francisco 9,268 2015
14
Splunksplunk.com

Providing organizations with a unified security and observability platform to ensure operational resilience in the face of digital disruptions

Software Development ๐Ÿ‡บ๐Ÿ‡ธ San Francisco 8,820 n/a
15
Docusigndocusign.com

It provides e-signature and contract lifecycle management solutions, helping businesses streamline agreement processes and unlock valuable data trapped in documents.

Software Development ๐Ÿ‡บ๐Ÿ‡ธ San Francisco 8,490 2003

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16
Genslergensler.com

Global architecture, design, and planning firm with a network of 6,000+ professionals creating positive change through impactful design across various sectors worldwide

Architecture and Planning ๐Ÿ‡บ๐Ÿ‡ธ San Francisco 8,363 1965
17
Ripplingrippling.com

Workforce management system streamlining business operations by consolidating data and applications for payroll, IT, expenses, and more into one unified platform

Software Development ๐Ÿ‡บ๐Ÿ‡ธ San Francisco 7,811 2016
18
Oktaokta.com

A platform that prioritizes identity management by offering neutrality, power, and flexibility, tailored to various industries, use cases, and support levels

Software Development ๐Ÿ‡บ๐Ÿ‡ธ San Francisco 7,522 2009
19
Cloudflarecloudflare.com

The company is a leading connectivity cloud provider, empowering organizations to enhance speed and security while reducing complexity and cost

Computer and Network Security ๐Ÿ‡บ๐Ÿ‡ธ San Francisco 7,489 2009
20
Unityunity.com

Platform providing software solutions for creating, running, and monetizing interactive real-time 2D and 3D content across devices.

Software Development ๐Ÿ‡บ๐Ÿ‡ธ San Francisco 7,154 n/a
21
Twiliotwilio.com

Platform enabling companies to build personalized customer relationships using communications and data across sales, marketing, service, and growth worldwide.

Software Development ๐Ÿ‡บ๐Ÿ‡ธ San Francisco 6,921 2008
22
Zendeskzdsk.co

It provides a customer service platform that connects brands with customers through various communication channels, enhancing customer experience globally.

Software Development ๐Ÿ‡บ๐Ÿ‡ธ San Francisco 6,874 2007
23
SoFisofi.com

Values-driven company providing modern financial products & services to help members borrow, save, spend, invest, and protect their money for financial independence

Financial Services ๐Ÿ‡บ๐Ÿ‡ธ San Francisco 6,754 2011
24
GitHubgithub.com

It serves as a global platform for developers to collaborate, build, and deliver secure software using AI-powered tools and features.

Software Development ๐Ÿ‡บ๐Ÿ‡ธ San Francisco 6,506 2008
25
Notionnotion.com

Combines product roadmaps, company wikis, and meeting notes into a single customizable workspace allowing teams to build and modify their own software tools.

Software Development ๐Ÿ‡บ๐Ÿ‡ธ San Francisco 6,434 2016
26
Squaresquareup.com

It provides integrated software and financial services to help sellers manage sales, inventory, and cash flow across various channels.

Software Development ๐Ÿ‡บ๐Ÿ‡ธ San Francisco 6,380 2009
27
Samsarasamsara.com

A pioneer in Connected Operationsโ„ข Cloud, leveraging IoT data for actionable insights to improve operations in various industries worldwide

Software Development ๐Ÿ‡บ๐Ÿ‡ธ San Francisco 5,639 2015
28
Elasticelastic.co

This company specializes in Enterprise Search, Observability, and Security solutions to enhance customer and employee experiences, ensure smooth application performance, and protect against cyber threats

Software Development ๐Ÿ‡บ๐Ÿ‡ธ San Francisco 5,089 n/a
29
Gustogusto.com

A payroll and HR platform providing benefits, insurance, and support to streamline operations for over 300,000 businesses nationwide

Software Development ๐Ÿ‡บ๐Ÿ‡ธ San Francisco 4,450 2011
30
Asanaasana.com

It empowers organizations with a comprehensive platform for managing goals, initiatives, and work execution, serving over 150,000 customers globally.

Software Development ๐Ÿ‡บ๐Ÿ‡ธ San Francisco 4,407 2008

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How this list is built

Every company on this list has a Tamtam company profile. The industry is the one the company gives on LinkedIn; categories such as SaaS or fintech are classified by Tamtam's AI from the company's website and LinkedIn page; and the headquarters city must match the company's own address. Companies are ranked by the number of employees on LinkedIn, and the list is refreshed every night. Classifications can be wrong, so treat the list as a starting point rather than an official ranking. Last updated Nov 11, 2026.

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