| # | Company | Employees |
|---|---|---|
| 1 |
Medical University of South Carolinamusc.edu
Public institution focused on educating healthcare professionals, conducting biomedical research, and providing comprehensive healthcare services in South Carolina and beyond. |
15,845 |
| 2 |
Prisma Healthcareers.prismahealth.org
largest nonprofit health system in South Carolina, serving over 1.2 million patients with quality care and improved access. |
14,555 |
| 3 |
MUSC Healthmuschealth.org
A healthcare system based in South Carolina, providing high-quality patient care, education for healthcare providers, and groundbreaking research and innovation |
5,606 |
| 4 |
Spartanburg Regional Healthcare Systemspartanburgregional.com
Comprehensive healthcare services across multiple hospital campuses, cancer care centers, outpatient surgery, trauma center, and extensive physician network. |
4,897 |
| 5 |
Lexington Healthlexhealth.com
A leading teaching hospital in South Carolina with a network of medical centers, offering a range of services including cancer treatment and cardiovascular care |
4,627 |
| 6 |
McLeod Healthmcleodhealth.org
A leading regional healthcare system with 7 hospitals and various outpatient services, dedicated to providing top-quality medical care with a focus on continuous improvement |
4,603 |
| 7 |
Greenville Health Systemprismahealth.org
The largest not-for-profit health organization in South Carolina, providing high-quality healthcare services to over 12 million patients annually |
4,097 |
| 8 |
Roper St. Francis Healthcarersfh.com
A leading healthcare provider in Charleston with 657 beds, over 90 facilities, and a network of 900 board-certified doctors offering primary care and subspecialties |
4,045 |
| 9 |
Palmetto Healthpalmettohealth.org
A leading healthcare system in the South Carolina Midlands region, providing compassionate care through six hospitals, a medical group, and training programs |
3,200 |
| 10 | 2,600 | |
| 11 |
Self Regional Healthcareselfregional.org
An independent not-for-profit regional hospital providing acute, tertiary, cancer, neurosurgery, heart care, NICU, orthopedics, genetics, prevention/wellness services with employed physician network |
2,454 |
| 12 |
Crossroadscrossroadstreatmentcenters.com
A behavioral healthcare company offering medication-assisted treatment, hepatitis C services, toxicology screening, and digital health screens to improve health outcomes and equity |
1,513 |
| 13 |
Tidelands Healthtidelandshealth.org
The largest healthcare provider in the region, dedicated to promoting wellness, preventing illness, and restoring health through hospitals and outpatient locations |
1,358 |
| 14 |
Beaufort Memorial Hospitalbmhsc.org
A leading hospital with 197 licensed beds, accredited by The Joint Commission, and a dedicated medical staff providing superior healthcare services |
1,208 |
| 15 |
Piedmont Medical Networkpiedmontmedicalcenter.com
Comprehensive medical center in Rock Hill, SC, offering advanced heart and stroke care, women and children's services, with a network of physician practices serving York County |
1,011 |
| 16 |
Grand Strand Medical Center โ HCAmygrandstrandhealth.com
A leading healthcare facility providing advanced medical services to patients, including cardiac and neurosurgery, trauma care, and specialized treatment programs |
974 |
| 17 |
Medical Services of Americamsahealthcare.com
Comprehensive provider of home healthcare services including hospice, medical equipment, diabetic supplies, respiratory services, and non-medical care, all managed by qualified professionals |
944 |
| 18 |
HCA Healthcare Trident Hospitalhcahealthcarecharleston.com
A top-ranking hospital in Charleston, SC, providing exceptional trauma care and part of a healthcare system with multiple facilities |
894 |
| 19 |
SOUTH CAROLINA DEPARTMENT OF MENTAL HEALTHscdmh.org
public mental health system providing outpatient and inpatient clinical services to approximately 100,000 patients annually across South Carolina |
871 |
| 20 |
Agape Care Groupagapecaregroup.com
A regional leader in hospice and palliative care serving nearly 3,700 patients with 1,500 employees providing compassionate support and care |
855 |
| 21 |
Ob Hospitalist Groupobhg.com
Leader in providing real-time triage and hospital-based obstetric coverage to ensure consistent, timely care for pregnant patients and support for local OB/GYN physicians |
763 |
| 22 |
Your Healthyourhealth.org
Providing health services in the comfort of your own home, at physicians' offices, and through telehealth to help you feel better |
741 |
| 23 |
Aiken Regional Medical Centersaikenregional.com
Aiken Regional Medical Centers in South Carolina offers comprehensive healthcare services, including emergency care, surgeries, and specialized certifications, with a focus on patient safety and quality |
683 |
| 24 |
UCI Medical Affiliatesucimedinc.com
Provides management services for various medical centers in South Carolina, offering urgent care, specialty practices, and physical therapy to patients |
633 |
| 25 |
RALPH H. JOHNSON VA HEALTH CARE SYSTEMva.gov
A Veterans healthcare system located in Charleston, South Carolina, providing healthcare services to veterans in the United States |
585 |
| 26 |
Harmony Senior Servicesharmonyseniorservices.com
Fully-integrated management services company specializing in senior housing industry, offering unique care strategies and a continuum of care for senior residents |
578 |
| 27 |
Proactive MDproactive-md.com
Innovative Advanced Primary Care company focused on helping people live healthier lives, reducing healthcare costs, and improving employee well-being |
264 |
Turn this list into pipeline
Tamtam finds the decision-makers at every company on a list like this one, with verified emails, phone numbers and the buying signals that tell you when to reach out.
How this list is built
Every company on this list has a Tamtam company profile. The industry is the one the company gives on LinkedIn; categories such as SaaS or fintech are classified by Tamtam's AI from the company's website and LinkedIn page; and the headquarters city must match the company's own address. Companies are ranked by the number of employees on LinkedIn, and the list is refreshed every night. Classifications can be wrong, so treat the list as a starting point rather than an official ranking. Last updated Oct 24, 2026.
More company lists in South Carolina
- The largest companies in South Carolina 795
- Hospitals and Health Care companies in South Carolina 56
- Education providers in South Carolina 55
- Higher Education companies in South Carolina 50
- Public sector organisations in South Carolina 47
- Financial services firms in South Carolina 43
- Manufacturers in South Carolina 43
- Financial Services companies in South Carolina 40
- Critical infrastructure operators in South Carolina 39
- Retail chains in South Carolina 39
- Government Administration companies in South Carolina 31
- Construction companies in South Carolina 28
- IT Services and IT Consulting companies in South Carolina 28
- Real Estate companies in South Carolina 26
- Education Administration Programs companies in South Carolina 25
The same list elsewhere in United States
- Healthcare providers in the United States 3,019
- Healthcare providers in California 277
- Healthcare providers in New York State 261
- Healthcare providers in Texas 221
- Healthcare providers in Florida 184
- Healthcare providers in Illinois 140
- Healthcare providers in Pennsylvania 139
- Healthcare providers in Massachusetts 108
- Healthcare providers in Tennessee 96
- Healthcare providers in Ohio 90
- Healthcare providers in New Jersey 77
- Healthcare providers in Michigan 76
- Healthcare providers in North Carolina 75
- Healthcare providers in Washington State 73
- Healthcare providers in Georgia 70
- Healthcare providers in Missouri 70
- Healthcare providers in Alabama 66
- Healthcare providers in Maryland 66
- Healthcare providers in Colorado 65
- Healthcare providers in Minnesota 65
- Healthcare providers in Arizona 63
- Healthcare providers in Virginia 63
- Healthcare providers in Indiana 61
- Healthcare providers in New York 95