These companies are primarily large institutions, including several universities and a medical center, alongside established manufacturing and technology firms. The list features major employers such as the Medical University of South Carolina, a public institution dedicated to healthcare education and research, and the University of South Carolina, a globally recognized research university. Sonoco, a manufacturer of packaging solutions, and Milliken & Company, a materials science leader, also represent significant manufacturing presence. The companies operate across diverse sectors including healthcare, education, packaging, chemicals, and industrial machinery.
A notable characteristic is the strong representation of higher education institutions, with the Medical University of South Carolina, the University of South Carolina, Clemson University, and Coastal Carolina University all appearing on the list. This indicates a significant concentration of R&D activity within academic and medical research environments in South Carolina, alongside a robust industrial base.
| # | Company | Employees | |||
|---|---|---|---|---|---|
| 1 |
Medical University of South Carolinamusc.edu
Public institution focused on educating healthcare professionals, conducting biomedical research, and providing comprehensive healthcare services in South Carolina and beyond. |
15,845 | |||
| 2 |
University of South Carolinasc.edu
A globally recognized research university offering 324 degree programs, top-tier research, community engagement, and numerous nationally ranked programs in South Carolina |
13,337 | |||
| 3 |
Clemson Universityclemson.edu
A historic university dedicated to academic excellence, research, and developing leaders with values of honesty, integrity, and respect |
11,869 | |||
| 4 |
Sonocosonoco.com
A leading manufacturer of consumer, industrial, healthcare, and protective packaging, creating sustainable solutions for brands worldwide to enhance products and lives |
10,850 | |||
| 5 |
MilliporeSigmasigmaaldrich.com
Provides scientists with state-of-the-art tools, services, and expertise for experiments and product development, impacting life and health globally. Offers broad portfolio and integrated services. |
10,484 | |||
| 6 |
Diverseysolenis.com
provides cleaning, hygiene, and infection prevention solutions with advanced chemicals, digital technologies, and services for multiple industries |
10,357 | |||
| 7 |
Milliken & Companymilliken.com
Global leader in materials science creating sustainable products and solutions across textiles, chemicals, flooring, and healthcare industries. |
4,191 | |||
| 8 |
JTEKT North America Corporationjtekt-na.com
Development and manufacturing of steering systems, driveline components, and bearings for automotive, industrial, and energy sectors. |
3,851 | |||
| 9 |
AFLaflglobal.com
A global manufacturer offering end-to-end solutions in fiber optic technology for energy, service provider, enterprise, and industrial markets in over 130 countries |
3,658 | |||
| 10 |
Coastal Carolina Universitycoastal.edu
Public university offering over 100 undergraduate and 30 graduate programs, including Ph.D. degrees, with strong marine science focus and active student life. |
3,558 | |||
| 11 |
3D Systems Corporation3dsystems.com
Provides additive manufacturing solutions, including hardware, software, materials, and services, empowering customers to create products in healthcare and industrial markets. |
3,536 | |||
| 12 |
Blackbaudblackbaud.com
Software provider focused on social impact, serving nonprofits, education, and socially responsible companies with essential solutions for fundraising, financial management, and more |
3,257 | |||
| 13 |
Savannah River Nuclear Solutionssavannahrivernuclearsolutions.com
A company responsible for managing and operating the Department of Energy's Savannah River Site in South Carolina, working with Newport News Nuclear and Honeywell |
3,126 | |||
| 14 |
KYOCERA AVX Components Corporationkyocera-avx.com
A global manufacturer of advanced electronic components for various industries, focused on technological innovation and building a better future through quality products |
3,005 | |||
| 15 |
Phillips Medisizephillipsmedisize.com
Designs and manufactures products for pharmaceutical, medtech, and in vitro diagnostic companies globally, focusing on patient-centric solutions. |
2,893 | |||
| 16 |
Zeuszeusinc.com
Specializing in polymer extrusion and catheter design, this global company partners with various industries to deliver innovative solutions and enhance lives worldwide |
1,381 | |||
| 17 |
AVX Corporationkyocera-avx.com
Manufacturer and supplier of advanced electronic components, including capacitors, inductors, filters, and various innovative sensor and antenna solutions, serving multiple global markets. |
1,352 | |||
| 18 |
Delineadelinea.com
Reduces identity-based risk by providing real-time, context-aware access controls for human, machine, and AI identities with unified enforcement and auditing. |
1,341 | |||
| 19 |
Sage Automotive Interiorssageautomotiveinteriors.com
A global supplier of specialty materials for automotive interiors, focusing on design, sustainability, and innovation for leading global automotive brands worldwide |
1,208 | |||
| 20 |
Ingevityingevity.com
This company develops and manufactures solutions for purifying, protecting, and enhancing the world through specialty chemicals, biodegradable plastics, and activated carbon products |
1,054 | |||
| 21 |
Wabtec Passenger Transitwabteccorp.com
Global provider of pneumatic, electronic, and mechanical solutions for transit industry, specializing in braking equipment, controllers, couplers, and train-control systems |
924 | |||
| 22 |
Savannah River National Laboratorysrnl.gov
A multidisciplinary research center solving environmental and security challenges by applying science to global security, energy, and environmental cleanup |
865 | |||
| 23 |
Chicago Pneumaticcp.com
Design and manufacture construction, maintenance, and production tools and compressors tailored for specific industrial applications worldwide. |
837 | |||
| 24 |
Coroplast Tape Corporationcoroplast-tape.com
Develops innovative adhesive tape products, specializing in special-purpose applications for a variety of industries, with a focus on driving success and strong relationships globally |
806 | |||
| 25 |
Reliable Automatic Sprinkler Co., Inc.reliablesprinkler.com
Global manufacturer of fire protection products, specializing in innovative fire sprinklers, valves, and special systems Offers premier customer service worldwide |
719 | |||
Want more companies than this list?This page shows the largest ones only. Connect to Tamtam to see every company that matches, filter by size, industry or growth, and reach their decision-makers. | |||||
| 26 | 675 | ||||
| 27 |
AstenJohnsonastenjohnson.com
Global manufacturer of pulp & paper machine clothing, filaments, technical fabrics, and nonwovens for various industries, prioritizing quality, innovation, and customer relationships |
661 | |||
| 28 |
Nutramax Laboratoriesnutramaxlabs.com
The company provides safe, effective products with high-quality ingredients and manufacturing standards for improved quality of life internationally |
627 | |||
| 29 |
Thornethorne.com
Innovative health solutions company focused on home testing, dietary education, and nutritional products, promoting good health through technology and expertise |
557 | |||
| 30 |
Belimedbelimed.com
Supplier of sterilization, disinfection, and cleaning products and services for medical and surgical instruments with global presence and innovation focus. |
551 | |||
| 31 |
International Vitamin Corporationivcinc.com
Production of high-quality dietary supplements, nutritional, prescription, and OTC products for leading U.S. retailers and global contract customers. |
543 | |||
| 32 |
Gelnex Gelatindarlingii.com
A leading manufacturer of gelatin and collagen peptides, sourcing proteins from inspected animals and focusing on high quality, sustainability, and customer satisfaction |
528 | |||
| 33 |
University of South Carolina School of Medicinesc.edu
Established in 1974, USC SOM improves South Carolinians' health by training physicians, genetic counselors, nurse anesthetists, and biomedical scientists in a nurturing environment |
477 | |||
| 34 |
Technetics Grouptechnetics.com
Design and manufacture custom-engineered seals, components, and sub-systems for extreme applications in semiconductor, aerospace, nuclear, and life sciences industries. |
467 | |||
| 35 |
Precision Valve Corporationprecisionglobal.com
Innovates, designs, and manufactures dispensing solutions for personal, household, food, industrial, and pharmaceutical markets, including valves, actuators, and pumps. |
451 | |||
| 36 |
Gulbrandsen Technologiesgulbrandsentechnologies.com
Manufacturer of low-cost chemical solutions for various industries with a focus on water treatment, personal care, pigments, and electronic etchants, prioritizing customer service |
443 | |||
| 37 |
Milliken Chemicalmilliken.com
Innovative solutions in plastics additives, colorants, silicones, and chemical intermediates for a sustainable future in various industries |
436 | |||
| 38 |
FN America, LLCfnamerica.com
Develops and manufactures high quality reliable firearms training and support services for global military law enforcement and commercial customers from US facilities |
383 | |||
| 39 |
MUSC Children's Healthmusckids.org
Specializing in pediatric clinical care and research, providing comprehensive and compassionate services in over 27 specialty areas across South Carolina |
376 | |||
| 40 |
Wikoffwikoff.com
A company specializing in high quality, tailor-made inks for challenging printing needs, fostering a culture of employee ownership and providing unmatched service and support worldwide |
368 | |||
| 41 |
AIRSYS Globalair-sys.com
A global leader in energy-saving cooling technology for data centers, telecom, medical, and semiconductor industries, prioritizing environmental sustainability and technological advancement |
366 | |||
| 42 |
Nutra Manufacturingivcinc.com
Leader in nutritional supplements, prioritizing truth in labeling, ingredient safety, and product potency Committed to helping customers improve their lives through quality products |
350 | |||
| 43 |
SixAxis, LLCsixaxisllc.com
Innovative manufacturing company offering loading rack, fall protection, and safety solutions worldwide through diverse brands and software innovations |
328 | |||
| 44 |
The Ritedose Corporationritedose.com
A leading manufacturer specializing in blow-fill-seal production of small fill volume pharmaceutical unit dose sterile and non-sterile liquids for inhalation, eyes, ears, and oral consumption |
323 | |||
| 45 |
ORBIS Incorbisinc.net
A Veteran Owned Small Business providing engineering, technical, and consulting services to the Department of Defense with headquarters in Charleston, SC |
302 | |||
| 46 |
Alltrista Plastics LLCalltrista.com
Innovative precision manufacturing company serving medical, consumer packaging, and industrial markets worldwide, focusing on design, engineering, and sustainable solutions Join us! |
263 | |||
| 47 |
Cornell Dubilier - Manufacturer of Power Capacitorscde.com
Leading global supplier of capacitors, RF filters, and advanced medtech components for industrial applications in renewable energy, electric vehicles, and aerospace |
238 | |||
| 48 |
Clayens USclayens.com
Global leader in custom molding technologies, offering design, production, and program management services for various industries worldwide, specializing in various types of plastics |
227 | |||
| 49 |
ITW Hartnesshartness.com
A leading provider of secondary packaging solutions, specializing in accumulation and case packing technology for various markets worldwide |
225 | |||
| 50 |
Sage Partssageparts.com
A leading provider of replacement parts for aviation ground support equipment, offering cost-saving solutions, fast delivery, extensive catalog, online ordering, and green alternatives |
221 | |||
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Every company on this list has a Tamtam company profile. The industry is the one the company gives on LinkedIn; categories such as SaaS or fintech are classified by Tamtam's AI from the company's website and LinkedIn page; and the headquarters city must match the company's own address. Companies are ranked by the number of employees on LinkedIn, and the list is refreshed every night. Classifications can be wrong, so treat the list as a starting point rather than an official ranking. Last updated Nov 14, 2026.
More company lists in South Carolina
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- Construction companies in South Carolina 29
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The same list elsewhere in United States
- Companies with in-house R&D in the United States 6,794
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- Companies with in-house R&D in New York State 417
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- Companies with in-house R&D in Washington State 140
- Companies with in-house R&D in Colorado 112
- Companies with in-house R&D in Maryland 107
- Companies with in-house R&D in Indiana 104
- Companies with in-house R&D in New York 223
- Companies with in-house R&D in San Francisco 147
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