Tamtam Start free

List of companies with in-house R&D in South Carolina

Tamtam tracks 70 companies with in-house R&D headquartered in South Carolina. This list ranks the 50 largest by number of employees on LinkedIn, led by Medical University of South Carolina, University of South Carolina and Clemson University. Their median headcount is 719. Half of them were founded in 1964 or later. The most common headquarters are Greenville (7), Columbia (5) and Charleston (4).

馃嚭馃嚫 South Carolina50 companiesUpdated Nov 14, 2026

These companies are primarily large institutions, including several universities and a medical center, alongside established manufacturing and technology firms. The list features major employers such as the Medical University of South Carolina, a public institution dedicated to healthcare education and research, and the University of South Carolina, a globally recognized research university. Sonoco, a manufacturer of packaging solutions, and Milliken & Company, a materials science leader, also represent significant manufacturing presence. The companies operate across diverse sectors including healthcare, education, packaging, chemicals, and industrial machinery.

A notable characteristic is the strong representation of higher education institutions, with the Medical University of South Carolina, the University of South Carolina, Clemson University, and Coastal Carolina University all appearing on the list. This indicates a significant concentration of R&D activity within academic and medical research environments in South Carolina, alongside a robust industrial base.

#CompanyIndustryHeadquarters EmployeesFounded
1
Medical University of South Carolinamusc.edu

Public institution focused on educating healthcare professionals, conducting biomedical research, and providing comprehensive healthcare services in South Carolina and beyond.

Hospitals and Health Care 馃嚭馃嚫 Charleston 15,845 1824
2
University of South Carolinasc.edu

A globally recognized research university offering 324 degree programs, top-tier research, community engagement, and numerous nationally ranked programs in South Carolina

Higher Education 馃嚭馃嚫 Columbia 13,337 1801
3
Clemson Universityclemson.edu

A historic university dedicated to academic excellence, research, and developing leaders with values of honesty, integrity, and respect

Higher Education 馃嚭馃嚫 Clemson 11,869 1889
4
Sonocosonoco.com

A leading manufacturer of consumer, industrial, healthcare, and protective packaging, creating sustainable solutions for brands worldwide to enhance products and lives

Packaging and Containers Manufacturing 馃嚭馃嚫 Hartsville 10,850 n/a
5
MilliporeSigmasigmaaldrich.com

Provides scientists with state-of-the-art tools, services, and expertise for experiments and product development, impacting life and health globally. Offers broad portfolio and integrated services.

Biotechnology Research 馃嚭馃嚫 Burlington 10,484 1668
6
Diverseysolenis.com

provides cleaning, hygiene, and infection prevention solutions with advanced chemicals, digital technologies, and services for multiple industries

Chemical Manufacturing 馃嚭馃嚫 Fort Mill 10,357 1923
7
Milliken & Companymilliken.com

Global leader in materials science creating sustainable products and solutions across textiles, chemicals, flooring, and healthcare industries.

Industrial Machinery Manufacturing 馃嚭馃嚫 Spartanburg 4,191 1865
8
JTEKT North America Corporationjtekt-na.com

Development and manufacturing of steering systems, driveline components, and bearings for automotive, industrial, and energy sectors.

Motor Vehicle Parts Manufacturing 馃嚭馃嚫 Greenville 3,851 2006
9
AFLaflglobal.com

A global manufacturer offering end-to-end solutions in fiber optic technology for energy, service provider, enterprise, and industrial markets in over 130 countries

Telecommunications 馃嚭馃嚫 Duncan 3,658 n/a
10
Coastal Carolina Universitycoastal.edu

Public university offering over 100 undergraduate and 30 graduate programs, including Ph.D. degrees, with strong marine science focus and active student life.

Higher Education 馃嚭馃嚫 Conway 3,558 1954
11
3D Systems Corporation3dsystems.com

Provides additive manufacturing solutions, including hardware, software, materials, and services, empowering customers to create products in healthcare and industrial markets.

Industrial Machinery Manufacturing 馃嚭馃嚫 Rock Hill 3,536 n/a
12
Blackbaudblackbaud.com

Software provider focused on social impact, serving nonprofits, education, and socially responsible companies with essential solutions for fundraising, financial management, and more

Software Development 馃嚭馃嚫 Charleston 3,257 n/a
13
Savannah River Nuclear Solutionssavannahrivernuclearsolutions.com

A company responsible for managing and operating the Department of Energy's Savannah River Site in South Carolina, working with Newport News Nuclear and Honeywell

Government Relations Services 馃嚭馃嚫 Aiken 3,126 2008
14
KYOCERA AVX Components Corporationkyocera-avx.com

A global manufacturer of advanced electronic components for various industries, focused on technological innovation and building a better future through quality products

Appliances, Electrical, and Electronics Manufacturing 馃嚭馃嚫 Fountain Inn 3,005 1970
15
Phillips Medisizephillipsmedisize.com

Designs and manufactures products for pharmaceutical, medtech, and in vitro diagnostic companies globally, focusing on patient-centric solutions.

Medical Equipment Manufacturing 馃嚭馃嚫 Hudson 2,893 1964
16
Zeuszeusinc.com

Specializing in polymer extrusion and catheter design, this global company partners with various industries to deliver innovative solutions and enhance lives worldwide

Plastics Manufacturing 馃嚭馃嚫 Orangeburg 1,381 1966
17
AVX Corporationkyocera-avx.com

Manufacturer and supplier of advanced electronic components, including capacitors, inductors, filters, and various innovative sensor and antenna solutions, serving multiple global markets.

Appliances, Electrical, and Electronics Manufacturing 馃嚭馃嚫 United States 1,352 n/a
18
Delineadelinea.com

Reduces identity-based risk by providing real-time, context-aware access controls for human, machine, and AI identities with unified enforcement and auditing.

Software Development 馃嚭馃嚫 San Francisco 1,341 2021
19
Sage Automotive Interiorssageautomotiveinteriors.com

A global supplier of specialty materials for automotive interiors, focusing on design, sustainability, and innovation for leading global automotive brands worldwide

Motor Vehicle Manufacturing 馃嚭馃嚫 Greenville 1,208 n/a
20
Ingevityingevity.com

This company develops and manufactures solutions for purifying, protecting, and enhancing the world through specialty chemicals, biodegradable plastics, and activated carbon products

Chemical Manufacturing 馃嚭馃嚫 North Charleston 1,054 n/a
21
Wabtec Passenger Transitwabteccorp.com

Global provider of pneumatic, electronic, and mechanical solutions for transit industry, specializing in braking equipment, controllers, couplers, and train-control systems

Railroad Equipment Manufacturing 馃嚭馃嚫 Spartanburg 924 1869
22
Savannah River National Laboratorysrnl.gov

A multidisciplinary research center solving environmental and security challenges by applying science to global security, energy, and environmental cleanup

Research Services 馃嚭馃嚫 Aiken 865 1951
23
Chicago Pneumaticcp.com

Design and manufacture construction, maintenance, and production tools and compressors tailored for specific industrial applications worldwide.

Industrial Machinery Manufacturing 馃嚭馃嚫 Rock Hill 837 1901
24
Coroplast Tape Corporationcoroplast-tape.com

Develops innovative adhesive tape products, specializing in special-purpose applications for a variety of industries, with a focus on driving success and strong relationships globally

Motor Vehicle Manufacturing 馃嚭馃嚫 Rock Hill 806 2014
25
Reliable Automatic Sprinkler Co., Inc.reliablesprinkler.com

Global manufacturer of fire protection products, specializing in innovative fire sprinklers, valves, and special systems Offers premier customer service worldwide

Wholesale Building Materials 馃嚭馃嚫 Liberty 719 1920

Want more companies than this list?

This page shows the largest ones only. Connect to Tamtam to see every company that matches, filter by size, industry or growth, and reach their decision-makers.

Get more companies, free
26
AGYagy.com

A global provider of high-performance composite solutions, specializing in high-strength and specialty glass yarns and rovings for various industries

Glass Product Manufacturing 馃嚭馃嚫 Aiken 675 n/a
27
AstenJohnsonastenjohnson.com

Global manufacturer of pulp & paper machine clothing, filaments, technical fabrics, and nonwovens for various industries, prioritizing quality, innovation, and customer relationships

Paper and Forest Product Manufacturing 馃嚭馃嚫 North Charleston 661 1790
28
Nutramax Laboratoriesnutramaxlabs.com

The company provides safe, effective products with high-quality ingredients and manufacturing standards for improved quality of life internationally

Manufacturing 馃嚭馃嚫 Lancaster 627 1992
29
Thornethorne.com

Innovative health solutions company focused on home testing, dietary education, and nutritional products, promoting good health through technology and expertise

Wellness and Fitness Services 馃嚭馃嚫 Summerville 557 n/a
30
Belimedbelimed.com

Supplier of sterilization, disinfection, and cleaning products and services for medical and surgical instruments with global presence and innovation focus.

Medical Equipment Manufacturing 馃嚭馃嚫 Ladson 551 1968
31
International Vitamin Corporationivcinc.com

Production of high-quality dietary supplements, nutritional, prescription, and OTC products for leading U.S. retailers and global contract customers.

Manufacturing 馃嚭馃嚫 Greenville 543 n/a
32
Gelnex Gelatindarlingii.com

A leading manufacturer of gelatin and collagen peptides, sourcing proteins from inspected animals and focusing on high quality, sustainability, and customer satisfaction

Food and Beverage Services 馃嚭馃嚫 Ita 528 1998
33
University of South Carolina School of Medicinesc.edu

Established in 1974, USC SOM improves South Carolinians' health by training physicians, genetic counselors, nurse anesthetists, and biomedical scientists in a nurturing environment

Higher Education 馃嚭馃嚫 Columbia 477 1977
34
Technetics Grouptechnetics.com

Design and manufacture custom-engineered seals, components, and sub-systems for extreme applications in semiconductor, aerospace, nuclear, and life sciences industries.

Industrial Machinery Manufacturing 馃嚭馃嚫 Columbia 467 n/a
35
Precision Valve Corporationprecisionglobal.com

Innovates, designs, and manufactures dispensing solutions for personal, household, food, industrial, and pharmaceutical markets, including valves, actuators, and pumps.

Packaging and Containers Manufacturing 馃嚭馃嚫 Greenville 451 1949
36
Gulbrandsen Technologiesgulbrandsentechnologies.com

Manufacturer of low-cost chemical solutions for various industries with a focus on water treatment, personal care, pigments, and electronic etchants, prioritizing customer service

Chemical Manufacturing 馃嚭馃嚫 Orangeburg 443 1984
37
Milliken Chemicalmilliken.com

Innovative solutions in plastics additives, colorants, silicones, and chemical intermediates for a sustainable future in various industries

Chemical Manufacturing 馃嚭馃嚫 Spartanburg 436 1865
38
FN America, LLCfnamerica.com

Develops and manufactures high quality reliable firearms training and support services for global military law enforcement and commercial customers from US facilities

Defense and Space Manufacturing 馃嚭馃嚫 Columbia 383 1980
39
MUSC Children's Healthmusckids.org

Specializing in pediatric clinical care and research, providing comprehensive and compassionate services in over 27 specialty areas across South Carolina

Hospitals and Health Care 馃嚭馃嚫 Charleston 376 n/a
40
Wikoffwikoff.com

A company specializing in high quality, tailor-made inks for challenging printing needs, fostering a culture of employee ownership and providing unmatched service and support worldwide

Printing Services 馃嚭馃嚫 Fort Mill 368 1956
41
AIRSYS Globalair-sys.com

A global leader in energy-saving cooling technology for data centers, telecom, medical, and semiconductor industries, prioritizing environmental sustainability and technological advancement

Mechanical Or Industrial Engineering 馃嚭馃嚫 Greer 366 1995
42
Nutra Manufacturingivcinc.com

Leader in nutritional supplements, prioritizing truth in labeling, ingredient safety, and product potency Committed to helping customers improve their lives through quality products

Pharmaceutical Manufacturing 馃嚭馃嚫 Greenville 350 n/a
43
SixAxis, LLCsixaxisllc.com

Innovative manufacturing company offering loading rack, fall protection, and safety solutions worldwide through diverse brands and software innovations

Industrial Machinery Manufacturing 馃嚭馃嚫 Andrews 328 2002
44
The Ritedose Corporationritedose.com

A leading manufacturer specializing in blow-fill-seal production of small fill volume pharmaceutical unit dose sterile and non-sterile liquids for inhalation, eyes, ears, and oral consumption

Pharmaceutical Manufacturing 馃嚭馃嚫 Columbia 323 1995
45
ORBIS Incorbisinc.net

A Veteran Owned Small Business providing engineering, technical, and consulting services to the Department of Defense with headquarters in Charleston, SC

Defense and Space Manufacturing 馃嚭馃嚫 Charleston 302 2000
46
Alltrista Plastics LLCalltrista.com

Innovative precision manufacturing company serving medical, consumer packaging, and industrial markets worldwide, focusing on design, engineering, and sustainable solutions Join us!

Plastics Manufacturing 馃嚭馃嚫 Greer 263 1973
47
Cornell Dubilier - Manufacturer of Power Capacitorscde.com

Leading global supplier of capacitors, RF filters, and advanced medtech components for industrial applications in renewable energy, electric vehicles, and aerospace

Manufacturing 馃嚭馃嚫 Liberty 238 1933
48
Clayens USclayens.com

Global leader in custom molding technologies, offering design, production, and program management services for various industries worldwide, specializing in various types of plastics

Plastics Manufacturing 馃嚭馃嚫 Greenville 227 1931
49
ITW Hartnesshartness.com

A leading provider of secondary packaging solutions, specializing in accumulation and case packing technology for various markets worldwide

Machinery Manufacturing 馃嚭馃嚫 Greenville 225 1940
50
Sage Partssageparts.com

A leading provider of replacement parts for aviation ground support equipment, offering cost-saving solutions, fast delivery, extensive catalog, online ordering, and green alternatives

Aviation and Aerospace Component Manufacturing 馃嚭馃嚫 Fountain Inn 221 1969

Turn this list into pipeline

Tamtam finds the decision-makers at every company on a list like this one, with verified emails, phone numbers and the buying signals that tell you when to reach out.

Build your own list, free

How this list is built

Every company on this list has a Tamtam company profile. The industry is the one the company gives on LinkedIn; categories such as SaaS or fintech are classified by Tamtam's AI from the company's website and LinkedIn page; and the headquarters city must match the company's own address. Companies are ranked by the number of employees on LinkedIn, and the list is refreshed every night. Classifications can be wrong, so treat the list as a starting point rather than an official ranking. Last updated Nov 14, 2026.

More company lists in South Carolina

The same list elsewhere in United States

The same list elsewhere