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Top 39 critical infrastructure operators in South Carolina

Tamtam tracks 39 critical infrastructure operators headquartered in South Carolina. This list ranks all of them by number of employees on LinkedIn, led by Medical University of South Carolina, Prisma Health and MUSC Health. Their median headcount is 1,011. Half of them were founded in 1944 or later. The most common headquarters are Greenville (7), Charleston (5) and Columbia (5).

๐Ÿ‡บ๐Ÿ‡ธ South Carolina39 companiesUpdated Oct 24, 2026
#CompanyIndustryHeadquarters EmployeesFounded
1
Medical University of South Carolinamusc.edu

Public institution focused on educating healthcare professionals, conducting biomedical research, and providing comprehensive healthcare services in South Carolina and beyond.

Hospitals and Health Care ๐Ÿ‡บ๐Ÿ‡ธ Charleston 15,845 1824
2
Prisma Healthcareers.prismahealth.org

largest nonprofit health system in South Carolina, serving over 1.2 million patients with quality care and improved access.

Hospitals and Health Care ๐Ÿ‡บ๐Ÿ‡ธ Greenville 14,555 2017
3
MUSC Healthmuschealth.org

A healthcare system based in South Carolina, providing high-quality patient care, education for healthcare providers, and groundbreaking research and innovation

Hospitals and Health Care ๐Ÿ‡บ๐Ÿ‡ธ Charleston 5,606 1824
4
Spartanburg Regional Healthcare Systemspartanburgregional.com

Comprehensive healthcare services across multiple hospital campuses, cancer care centers, outpatient surgery, trauma center, and extensive physician network.

Hospitals and Health Care ๐Ÿ‡บ๐Ÿ‡ธ Spartanburg 4,897 1921
5
Lexington Healthlexhealth.com

A leading teaching hospital in South Carolina with a network of medical centers, offering a range of services including cancer treatment and cardiovascular care

Hospitals and Health Care ๐Ÿ‡บ๐Ÿ‡ธ West Columbia 4,627 1971
6
McLeod Healthmcleodhealth.org

A leading regional healthcare system with 7 hospitals and various outpatient services, dedicated to providing top-quality medical care with a focus on continuous improvement

Hospitals and Health Care ๐Ÿ‡บ๐Ÿ‡ธ Florence 4,603 1906
7
Greenville Health Systemprismahealth.org

The largest not-for-profit health organization in South Carolina, providing high-quality healthcare services to over 12 million patients annually

Hospitals and Health Care ๐Ÿ‡บ๐Ÿ‡ธ Greenville 4,097 1912
8
Roper St. Francis Healthcarersfh.com

A leading healthcare provider in Charleston with 657 beds, over 90 facilities, and a network of 900 board-certified doctors offering primary care and subspecialties

Hospitals and Health Care ๐Ÿ‡บ๐Ÿ‡ธ Charleston 4,045 1829
9
Palmetto Healthpalmettohealth.org

A leading healthcare system in the South Carolina Midlands region, providing compassionate care through six hospitals, a medical group, and training programs

Hospitals and Health Care ๐Ÿ‡บ๐Ÿ‡ธ Columbia 3,200 1998
10
Savannah River Nuclear Solutionssavannahrivernuclearsolutions.com

A company responsible for managing and operating the Department of Energy's Savannah River Site in South Carolina, working with Newport News Nuclear and Honeywell

Government Relations Services ๐Ÿ‡บ๐Ÿ‡ธ Aiken 3,126 2008
11
Southeastern Freight Linessefl.com

Regional less-than-truckload carrier specializing in next-day service across Southeast and Southwest with extensive service centers and partner network.

Truck Transportation ๐Ÿ‡บ๐Ÿ‡ธ Lexington 2,648 1950
12
AnMedanmed.org

Leading not-for-profit health system in South Carolina, with focus on employee development and community collaboration to optimize patient care and staff wellness

Hospitals and Health Care ๐Ÿ‡บ๐Ÿ‡ธ Anderson 2,600 1908
13
United Communityucbi.com

Regional bank offering consumer and commercial banking products with award-winning customer service across six southeastern U.S. states.

Banking ๐Ÿ‡บ๐Ÿ‡ธ Greenville 2,509 1950
14
Self Regional Healthcareselfregional.org

An independent not-for-profit regional hospital providing acute, tertiary, cancer, neurosurgery, heart care, NICU, orthopedics, genetics, prevention/wellness services with employed physician network

Hospitals and Health Care ๐Ÿ‡บ๐Ÿ‡ธ Greenwood 2,454 1951
15
South Carolina Department of Transportationscdot.org

A government agency in South Carolina developing and maintaining transportation systems, offering careers in engineering, IT, finance, HR, communications

Civil Engineering ๐Ÿ‡บ๐Ÿ‡ธ Columbia 1,848 n/a
16
SCANA Corporationscana.com

A corporation providing electricity and natural gas to homes and businesses in South Carolina, North Carolina, and Georgia, supporting economic growth and local communities for over 160 years

Utilities ๐Ÿ‡บ๐Ÿ‡ธ Cayce 1,770 n/a
17
Santee Coopersanteecooper.com

A leading power producer in South Carolina, providing low-cost, reliable, and environmentally responsible electricity and water services to 2 million people

Utilities ๐Ÿ‡บ๐Ÿ‡ธ Moncks Corner 1,472 1934
18
Tidelands Healthtidelandshealth.org

The largest healthcare provider in the region, dedicated to promoting wellness, preventing illness, and restoring health through hospitals and outpatient locations

Hospitals and Health Care ๐Ÿ‡บ๐Ÿ‡ธ Georgetown 1,358 n/a
19
Beaufort Memorial Hospitalbmhsc.org

A leading hospital with 197 licensed beds, accredited by The Joint Commission, and a dedicated medical staff providing superior healthcare services

Hospitals and Health Care ๐Ÿ‡บ๐Ÿ‡ธ Beaufort 1,208 1944
20
Piedmont Medical Networkpiedmontmedicalcenter.com

Comprehensive medical center in Rock Hill, SC, offering advanced heart and stroke care, women and children's services, with a network of physician practices serving York County

Hospitals and Health Care ๐Ÿ‡บ๐Ÿ‡ธ Rock Hill 1,011 1983
21
Shellpoint Mortgage Servicingshellpointmtg.com

Manage residential mortgage loans nationwide, collect payments, provide customer service, and deliver special servicing for credit-sensitive portfolios.

Financial Services ๐Ÿ‡บ๐Ÿ‡ธ Greenville 1,011 2014
22
Grand Strand Medical Center โ€“ HCAmygrandstrandhealth.com

A leading healthcare facility providing advanced medical services to patients, including cardiac and neurosurgery, trauma care, and specialized treatment programs

Hospitals and Health Care ๐Ÿ‡บ๐Ÿ‡ธ Myrtle Beach 974 n/a
23
Hargray Communicationssparklight.com

A regional telecommunications company offering advanced Internet, TV, and phone services in South Carolina and Georgia, with a focus on technology and customer service

Telecommunications ๐Ÿ‡บ๐Ÿ‡ธ Hilton Head Island 944 n/a
24
HCA Healthcare Trident Hospitalhcahealthcarecharleston.com

A top-ranking hospital in Charleston, SC, providing exceptional trauma care and part of a healthcare system with multiple facilities

Hospitals and Health Care ๐Ÿ‡บ๐Ÿ‡ธ Charleston 894 1975
25
SOUTH CAROLINA DEPARTMENT OF MENTAL HEALTHscdmh.org

public mental health system providing outpatient and inpatient clinical services to approximately 100,000 patients annually across South Carolina

Mental Health Care ๐Ÿ‡บ๐Ÿ‡ธ Columbia 871 1821
26
AgFirst Farm Credit Bankagfirst.com

Wholesale funding, technology, and support services to local agricultural and rural lenders across 15 states and Puerto Rico.

Banking ๐Ÿ‡บ๐Ÿ‡ธ Columbia 848 1916
27
Ob Hospitalist Groupobhg.com

Leader in providing real-time triage and hospital-based obstetric coverage to ensure consistent, timely care for pregnant patients and support for local OB/GYN physicians

Hospitals and Health Care ๐Ÿ‡บ๐Ÿ‡ธ Greenville 763 2006
28
Comporiumcomporium.com

Provides broadband, TV, voice, wireless, smart home systems, and advertising services across the Carolinas with nearly 130 years experience.

Telecommunications ๐Ÿ‡บ๐Ÿ‡ธ Rock Hill 730 1894
29
Aiken Regional Medical Centersaikenregional.com

Aiken Regional Medical Centers in South Carolina offers comprehensive healthcare services, including emergency care, surgeries, and specialized certifications, with a focus on patient safety and quality

Hospitals and Health Care ๐Ÿ‡บ๐Ÿ‡ธ Aiken 683 1917
30
RALPH H. JOHNSON VA HEALTH CARE SYSTEMva.gov

A Veterans healthcare system located in Charleston, South Carolina, providing healthcare services to veterans in the United States

Hospitals and Health Care ๐Ÿ‡บ๐Ÿ‡ธ Charleston 585 n/a
31
Founders Federal Credit Unionfoundersfcu.com

A not-for-profit financial institution offering lifetime benefits to individuals in qualifying communities in the Carolinas, with a focus on member financial goals

Banking ๐Ÿ‡บ๐Ÿ‡ธ Lancaster 554 1950
32
First Citizens Bank and Trust Company, Inc.firstcitizens.com

Financial institution offering personal, business, commercial, and wealth services nationwide, with a focus on strength, stability, innovation, and long-term thinking

Financial Services ๐Ÿ‡บ๐Ÿ‡ธ Columbia 527 1898
33
REV Federal Credit Unionrevfcu.com

A not-for-profit financial institution providing innovative banking solutions to enhance members' financial well-being since 1955

Financial Services ๐Ÿ‡บ๐Ÿ‡ธ Summerville 286 1955
34
Proactive MDproactive-md.com

Innovative Advanced Primary Care company focused on helping people live healthier lives, reducing healthcare costs, and improving employee well-being

Hospitals and Health Care ๐Ÿ‡บ๐Ÿ‡ธ Greenville 264 2016
35
Palmetto Electric Cooperative, Inc.palmetto.coop

Providing competitively priced energy and innovative services to members, while also offering leadership and support to the communities served

Utilities ๐Ÿ‡บ๐Ÿ‡ธ Ridgeland 89 1940
36
South Carolina Electric & Gas Companydominionenergy.com

A company in South Carolina that provides electricity and natural gas services to businesses and residents

Utilities ๐Ÿ‡บ๐Ÿ‡ธ Cayce 79 1923
37
Progress Bankucbi.com

A bank focused on fostering community connections and financial well-being for its customers

Banking ๐Ÿ‡บ๐Ÿ‡ธ Greenville 67 2008
38
Pee Dee Electric Cooperative, Inc.mpd.coop

An energy company focused on electrical safety, energy efficiency, and business development, serving members' current and future energy needs

Utilities ๐Ÿ‡บ๐Ÿ‡ธ Darlington 34 1939
39
Coastal Banking Company, Inc.ffbf.com

Financial institution offering consumer and business banking services, residential mortgage lending, and Small Business Administration loans through multiple locations across Southeastern United States

Banking ๐Ÿ‡บ๐Ÿ‡ธ Beaufort 2 1999

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How this list is built

Every company on this list has a Tamtam company profile. The industry is the one the company gives on LinkedIn; categories such as SaaS or fintech are classified by Tamtam's AI from the company's website and LinkedIn page; and the headquarters city must match the company's own address. Companies are ranked by the number of employees on LinkedIn, and the list is refreshed every night. Classifications can be wrong, so treat the list as a starting point rather than an official ranking. Last updated Oct 24, 2026.

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