| # | Company | Employees |
|---|---|---|
| 1 |
Medical University of South Carolinamusc.edu
Public institution focused on educating healthcare professionals, conducting biomedical research, and providing comprehensive healthcare services in South Carolina and beyond. |
15,845 |
| 2 |
Prisma Healthcareers.prismahealth.org
largest nonprofit health system in South Carolina, serving over 1.2 million patients with quality care and improved access. |
14,555 |
| 3 |
MUSC Healthmuschealth.org
A healthcare system based in South Carolina, providing high-quality patient care, education for healthcare providers, and groundbreaking research and innovation |
5,606 |
| 4 |
Spartanburg Regional Healthcare Systemspartanburgregional.com
Comprehensive healthcare services across multiple hospital campuses, cancer care centers, outpatient surgery, trauma center, and extensive physician network. |
4,897 |
| 5 |
Lexington Healthlexhealth.com
A leading teaching hospital in South Carolina with a network of medical centers, offering a range of services including cancer treatment and cardiovascular care |
4,627 |
| 6 |
McLeod Healthmcleodhealth.org
A leading regional healthcare system with 7 hospitals and various outpatient services, dedicated to providing top-quality medical care with a focus on continuous improvement |
4,603 |
| 7 |
Greenville Health Systemprismahealth.org
The largest not-for-profit health organization in South Carolina, providing high-quality healthcare services to over 12 million patients annually |
4,097 |
| 8 |
Roper St. Francis Healthcarersfh.com
A leading healthcare provider in Charleston with 657 beds, over 90 facilities, and a network of 900 board-certified doctors offering primary care and subspecialties |
4,045 |
| 9 |
Palmetto Healthpalmettohealth.org
A leading healthcare system in the South Carolina Midlands region, providing compassionate care through six hospitals, a medical group, and training programs |
3,200 |
| 10 |
Savannah River Nuclear Solutionssavannahrivernuclearsolutions.com
A company responsible for managing and operating the Department of Energy's Savannah River Site in South Carolina, working with Newport News Nuclear and Honeywell |
3,126 |
| 11 |
Southeastern Freight Linessefl.com
Regional less-than-truckload carrier specializing in next-day service across Southeast and Southwest with extensive service centers and partner network. |
2,648 |
| 12 | 2,600 | |
| 13 |
United Communityucbi.com
Regional bank offering consumer and commercial banking products with award-winning customer service across six southeastern U.S. states. |
2,509 |
| 14 |
Self Regional Healthcareselfregional.org
An independent not-for-profit regional hospital providing acute, tertiary, cancer, neurosurgery, heart care, NICU, orthopedics, genetics, prevention/wellness services with employed physician network |
2,454 |
| 15 |
South Carolina Department of Transportationscdot.org
A government agency in South Carolina developing and maintaining transportation systems, offering careers in engineering, IT, finance, HR, communications |
1,848 |
| 16 |
SCANA Corporationscana.com
A corporation providing electricity and natural gas to homes and businesses in South Carolina, North Carolina, and Georgia, supporting economic growth and local communities for over 160 years |
1,770 |
| 17 |
Santee Coopersanteecooper.com
A leading power producer in South Carolina, providing low-cost, reliable, and environmentally responsible electricity and water services to 2 million people |
1,472 |
| 18 |
Tidelands Healthtidelandshealth.org
The largest healthcare provider in the region, dedicated to promoting wellness, preventing illness, and restoring health through hospitals and outpatient locations |
1,358 |
| 19 |
Beaufort Memorial Hospitalbmhsc.org
A leading hospital with 197 licensed beds, accredited by The Joint Commission, and a dedicated medical staff providing superior healthcare services |
1,208 |
| 20 |
Piedmont Medical Networkpiedmontmedicalcenter.com
Comprehensive medical center in Rock Hill, SC, offering advanced heart and stroke care, women and children's services, with a network of physician practices serving York County |
1,011 |
| 21 |
Shellpoint Mortgage Servicingshellpointmtg.com
Manage residential mortgage loans nationwide, collect payments, provide customer service, and deliver special servicing for credit-sensitive portfolios. |
1,011 |
| 22 |
Grand Strand Medical Center โ HCAmygrandstrandhealth.com
A leading healthcare facility providing advanced medical services to patients, including cardiac and neurosurgery, trauma care, and specialized treatment programs |
974 |
| 23 |
Hargray Communicationssparklight.com
A regional telecommunications company offering advanced Internet, TV, and phone services in South Carolina and Georgia, with a focus on technology and customer service |
944 |
| 24 |
HCA Healthcare Trident Hospitalhcahealthcarecharleston.com
A top-ranking hospital in Charleston, SC, providing exceptional trauma care and part of a healthcare system with multiple facilities |
894 |
| 25 |
SOUTH CAROLINA DEPARTMENT OF MENTAL HEALTHscdmh.org
public mental health system providing outpatient and inpatient clinical services to approximately 100,000 patients annually across South Carolina |
871 |
| 26 |
AgFirst Farm Credit Bankagfirst.com
Wholesale funding, technology, and support services to local agricultural and rural lenders across 15 states and Puerto Rico. |
848 |
| 27 |
Ob Hospitalist Groupobhg.com
Leader in providing real-time triage and hospital-based obstetric coverage to ensure consistent, timely care for pregnant patients and support for local OB/GYN physicians |
763 |
| 28 |
Comporiumcomporium.com
Provides broadband, TV, voice, wireless, smart home systems, and advertising services across the Carolinas with nearly 130 years experience. |
730 |
| 29 |
Aiken Regional Medical Centersaikenregional.com
Aiken Regional Medical Centers in South Carolina offers comprehensive healthcare services, including emergency care, surgeries, and specialized certifications, with a focus on patient safety and quality |
683 |
| 30 |
RALPH H. JOHNSON VA HEALTH CARE SYSTEMva.gov
A Veterans healthcare system located in Charleston, South Carolina, providing healthcare services to veterans in the United States |
585 |
| 31 |
Founders Federal Credit Unionfoundersfcu.com
A not-for-profit financial institution offering lifetime benefits to individuals in qualifying communities in the Carolinas, with a focus on member financial goals |
554 |
| 32 |
First Citizens Bank and Trust Company, Inc.firstcitizens.com
Financial institution offering personal, business, commercial, and wealth services nationwide, with a focus on strength, stability, innovation, and long-term thinking |
527 |
| 33 |
REV Federal Credit Unionrevfcu.com
A not-for-profit financial institution providing innovative banking solutions to enhance members' financial well-being since 1955 |
286 |
| 34 |
Proactive MDproactive-md.com
Innovative Advanced Primary Care company focused on helping people live healthier lives, reducing healthcare costs, and improving employee well-being |
264 |
| 35 |
Palmetto Electric Cooperative, Inc.palmetto.coop
Providing competitively priced energy and innovative services to members, while also offering leadership and support to the communities served |
89 |
| 36 |
South Carolina Electric & Gas Companydominionenergy.com
A company in South Carolina that provides electricity and natural gas services to businesses and residents |
79 |
| 37 |
Progress Bankucbi.com
A bank focused on fostering community connections and financial well-being for its customers |
67 |
| 38 |
Pee Dee Electric Cooperative, Inc.mpd.coop
An energy company focused on electrical safety, energy efficiency, and business development, serving members' current and future energy needs |
34 |
| 39 |
Coastal Banking Company, Inc.ffbf.com
Financial institution offering consumer and business banking services, residential mortgage lending, and Small Business Administration loans through multiple locations across Southeastern United States |
2 |
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Every company on this list has a Tamtam company profile. The industry is the one the company gives on LinkedIn; categories such as SaaS or fintech are classified by Tamtam's AI from the company's website and LinkedIn page; and the headquarters city must match the company's own address. Companies are ranked by the number of employees on LinkedIn, and the list is refreshed every night. Classifications can be wrong, so treat the list as a starting point rather than an official ranking. Last updated Oct 24, 2026.
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