The 30 largest critical infrastructure operators in Indianapolis (2026 list)

These Indianapolis-based companies are critical infrastructure operators, predominantly large organizations in the hospitals and health care sector. Elevance Health serves over 118 million people with integrated health services. Indiana University Health provides comprehensive healthcare and research. USIC offers underground utility damage prevention services, and Republic Airways is a regional airline.

The data shows a strong concentration of healthcare providers, with several large hospital networks and health systems headquartered in Indianapolis. Most of these companies are well-established, with some founded in the 19th and early 20th centuries, such as Eskenazi Health (1859) and St. Vincent Health (1881).

#	Company	Industry	Headquarters	Employees	Founded
1	Elevance Health elevancehealth.com Serving over 118 million people with a digital platform and integrated health services, focusing on improving health at every stage.	Hospitals and Health Care	🇺🇸 Indianapolis	43,568	n/a
2	Indiana University Health iuhealth.org Provides comprehensive healthcare services, innovative treatments, and groundbreaking research through a partnership with Indiana University School of Medicine Prioritizes personal and professional growth	Hospitals and Health Care	🇺🇸 Indianapolis	20,779	n/a
3	Anthem, Inc.elevancehealth.com A company formerly known as Anthem, Inc has rebranded as Elevance Health Follow them on their new LinkedIn page	Hospitals and Health Care	🇺🇸 Indianapolis	19,648	n/a
4	Anthem Blue Cross and Blue Shield anthem.com Dedicated to delivering better care to members, providing greater value to customers, and helping improve the health of communities through health plans.	Insurance	🇺🇸 Indianapolis	10,425	n/a
5	Community Health Network ecommunity.com A non-profit health system in Central Indiana providing a full continuum of care through hospitals, physicians, home care, and other services	Hospitals and Health Care	🇺🇸 Indianapolis	8,889	n/a
6	USIC usicllc.com A leading provider of underground utility damage prevention services and utility solutions in the United States and Canada	Utilities	🇺🇸 Indianapolis	5,331	n/a
7	Republic Airways rjet.com A regional airline providing safe, reliable flights for major carriers with a fleet of Embraer jets and multiple bases across the US	Airlines and Aviation	🇺🇸 Indianapolis	4,334	1974
8	St. Vincent Health healthcare.ascension.org A healthcare organization operating 23 hospitals, medical practices, and clinics in central and southern Indiana, dedicated to compassionate care for all	Hospitals and Health Care	🇺🇸 Indianapolis	4,279	1881
9	Eskenazi Health eskenazihealth.edu Comprehensive healthcare provider offering primary and specialty medical services through hospital and community health centers, focusing on vulnerable populations.	Hospitals and Health Care	🇺🇸 Indianapolis	3,817	1859
10	IU Health Methodist Hospital iuhealth.org A top-ranked hospital known for quality, safety, nursing excellence, and high-quality clinical outcomes, recognized nationally by University Health Consortium and US News & World Report	Medical Practices	🇺🇸 Indianapolis	1,724	n/a
11	Indiana Department of Transportation in.gov INDOT is a transportation agency in Indiana, offering dynamic opportunities for professionals to improve infrastructure, safety, mobility, and economic growth	Truck Transportation	🇺🇸 Indianapolis	1,722	1919
12	Riley Children's Health rileychildrens.org Provider of comprehensive healthcare services for children across Indiana, with emphasis on care at Riley Hospital for Children in downtown Indianapolis	Hospitals and Health Care	🇺🇸 Indianapolis	1,492	1924
13	Franciscan St. Francis Health franciscanhealth.org A Catholic healthcare system with 14 hospital campuses in Indiana and Illinois, providing top-tier medical services and state-of-the-art facilities	Hospitals and Health Care	🇺🇸 Indianapolis	1,461	n/a
14	Indiana Department of Health health.in.gov The Indiana Department of Health provides and promotes essential public health services in the state	Wellness and Fitness Services	🇺🇸 Indianapolis	1,133	1881
15	Riley Hospital for Children rileychildrenshospital.com A hospital and healthcare company in Indianapolis, Indiana, dedicated to providing specialized care for children at Riley Hospital for Children	Hospitals and Health Care	🇺🇸 Indianapolis	974	n/a
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16	Marion County Public Health Department marionhealth.org A health department serving Marion County, Indiana for nearly a century, promoting health, preventing disease, and protecting against injuries and disabilities	Hospitals and Health Care	🇺🇸 Indianapolis	834	n/a
17	Citizens Energy Group info.citizensenergygroup.com A public trust providing clean, efficient, and reliable energy services to customers in the Indianapolis area, prioritizing customer service and community benefit	Utilities	🇺🇸 Indianapolis	778	1887
18	USPS Usps.com Indianapolis area provider of towing, auto parts, scrap metal recycling, body shop services, auto auctions, and cash for cars	Transportation, Logistics, Supply Chain and Storage	🇺🇸 Indianapolis	732	n/a
19	St.Vincent Indianapolis Hospital healthcare.ascension.org Faith-based healthcare organization committed to providing compassionate, personalized care to those in need, operating hospitals, senior living facilities, and various healthcare services nationwide	Hospitals and Health Care	🇺🇸 Indianapolis	626	n/a
20	AES Indiana aesindiana.com A company specializing in customized energy solutions, fostering innovation and collaboration to empower customer growth and achieve energy goals	Utilities	🇺🇸 Indianapolis	602	1927
21	HealthNet indyhealthnet.org HealthNet is a Federally Qualified Health Center providing high-quality medical, dental, and behavioral health care regardless of insurance status They offer various rewarding healthcare careers	Hospitals and Health Care	🇺🇸 Indianapolis	586	n/a
22	IndyGo indygo.net Operating the public transit system for the City of Indianapolis, IndyGo has 30 fixed routes with 2,708 stops and carries five million passengers annually	Urban Transit Services	🇺🇸 Indianapolis	461	1973
23	Indianapolis Airport Authority ind.com A municipal corporation operating Indiana's largest airport system in the Indianapolis area, with a $54 billion economic impact and top rankings in customer satisfaction	Airlines and Aviation	🇺🇸 Indianapolis	427	1962
24	Indiana Members Credit Union imcu.com A non-profit credit union in Indiana offering financial services including banking, loans, and online services to consumer and business members	Banking	🇺🇸 Indianapolis	374	1956
25	Federal Home Loan Bank of Indianapolis (FHLBI)fhlbi.com Provides liquidity to member financial institutions, supports housing finance, community lending, and economic development through grants and loans.	Banking	🇺🇸 Indianapolis	367	1932
26	CountryMark countrymark.com American-owned company in oil exploration, production, refining, and marketing Distributes premium fuels, lubricants, and DEF to farms, fleets, and families in the Midwest	Oil and Gas	🇺🇸 Indianapolis	342	n/a
27	The National Bank of Indianapolis nbofi.com A locally-owned bank in Indianapolis offering banking services, wealth management, and superior customer service to professionals, businesses, and nonprofits	Banking	🇺🇸 Indianapolis	341	1993
28	Indiana Farmers Insurance indianafarmers.com Established in 1877, this mutual insurance company specializes in serving the Midwest region with a focus on strong relationships and community values	Insurance	🇺🇸 Indianapolis	267	1877
29	Richard L Roudebush Vamc indianapolis.va.gov This company offers healthcare services to veterans in Central Indiana and Eastern Illinois	Mental Health Care	🇺🇸 Indianapolis	236	n/a
30	Jane Pauley Community Health Center janepauleychc.org A nonprofit health center in Central Indiana providing quality, affordable healthcare for all Offering medical, behavioral health, and dental services	Hospitals and Health Care	🇺🇸 Indianapolis	208	2009

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Every company on this list has a Tamtam company profile. The industry is the one the company gives on LinkedIn; categories such as SaaS or fintech are classified by Tamtam's AI from the company's website and LinkedIn page; and the headquarters city must match the company's own address. Companies are ranked by the number of employees on LinkedIn, and the list is refreshed every night. Classifications can be wrong, so treat the list as a starting point rather than an official ranking. Last updated Nov 11, 2026.

The 30 largest critical infrastructure operators in Indianapolis

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