28 leading critical infrastructure operators in Mississippi (2026 list)

#	Company	Industry	Headquarters	Employees	Founded
1	University of Mississippi Medical Center umc.edu A leading academic medical center in Mississippi, providing education, research, and high-quality healthcare services to improve health and eliminate disparities	Hospitals and Health Care	🇺🇸 Jackson	6,962	1955
2	Hancock Whitney hancockwhitney.com An institution with over a century of experience offering a wide range of financial products and services focused on helping clients achieve their goals	Banking	🇺🇸 Gulfport	4,852	1899
3	Cadence Bank cadencebank.com A regional banking franchise offering a full range of banking and financial services, including consumer and business banking, lending, wealth management, and insurance	Banking	🇺🇸 Tupelo	3,431	n/a
4	North Mississippi Health Services nmhs.net Health care system serving 24 counties in north Mississippi and northwest Alabama, offering acute diagnostic and therapeutic services, primary and specialty clinics, managed care plans, and more	Hospitals and Health Care	🇺🇸 Tupelo	3,167	n/a
5	North Mississippi Medical Center nmhs.net A healthcare organization serving 24 counties in north Mississippi and northwest Alabama, offering diagnostic, therapeutic, and managed care services with a focus on quality and cost-effectiveness	Hospitals and Health Care	🇺🇸 Tupelo	2,316	n/a
6	Trustmark Bank trustmark.com Provides banking and financial solutions across multiple states including Alabama, Florida, Georgia, Mississippi, Tennessee, and Texas.	Banking	🇺🇸 Jackson	2,190	1889
7	Renasant Bank renasantbank.com A financial services institution with $173 billion in assets, operating 195 offices in the Southeast, offering banking, lending, wealth management, and insurance services	Banking	🇺🇸 Tupelo	2,053	1904
8	Forrest Health forresthealth.org Healthcare organization in south Mississippi with flagship hospital and multiple facilities, focused on quality patient care and creating a compassionate work environment for staff	Hospitals and Health Care	🇺🇸 Hattiesburg	1,905	1952
9	Singing River Health System singingriverhealthsystem.com Comprehensive healthcare provider in South Mississippi with three hospitals, primary care clinics, specialties, and community benefit programs, employing over 3,000 team members	Hospitals and Health Care	🇺🇸 Ocean Springs	1,808	1931
10	BancorpSouth bancorpsouth.com A regional banking division provides relationship-focused financial services, innovative banking solutions, and community support with honesty, integrity, and value	Banking	🇺🇸 Tupelo	1,807	n/a
11	Memorial Hospital at Gulfport wearememorial.com Not-for-profit healthcare system with comprehensive services including trauma care, surgical centers, specialty clinics, and advanced medical technology	Hospitals and Health Care	🇺🇸 Gulfport	1,753	1946
12	C Spire cspire.com A technology provider offering ultra-fast 5G wireless services, high-speed fiber internet, and cutting-edge business solutions to enhance the user experience Apply now	Telecommunications	🇺🇸 Ridgeland	1,671	1988
13	St. Dominic Hospital stdom.com This company blends high-tech services with high-touch care to provide healing with advanced technology and skilled healthcare professionals while prioritizing patient needs	Hospitals and Health Care	🇺🇸 Jackson	1,608	1946
14	Forrest General Hospital forresthealth.org A leading medical facility in South Mississippi offering a wide range of services including trauma care, behavioral health, rehabilitation, hospice, and long-term acute care	Hospitals and Health Care	🇺🇸 Hattiesburg	1,527	1952
15	Hattiesburg Clinic, PA hattiesburgclinic.com A medical practice that provides high quality, patient-centered healthcare with a focus on commitment, compassion, fairness, integrity, respect, and innovation	Medical Practices	🇺🇸 Hattiesburg	1,196	1963
16	Catawba Valley Health System catawbavalleyhealth.org Providing high-quality healthcare services and supporting organizations to improve community health in Catawba Valley through compassion and innovation	Hospitals and Health Care	🇺🇸 Hickory	1,115	1968
17	Ergon Inc.ergon.com A well-established, family-owned organization in the petroleum industry providing reliable supply, quality products, and exceptional customer service worldwide for over 60 years	Oil and Gas	🇺🇸 Flowood	950	1954
18	South Central Regional Medical Center scrmc.com A not-for-profit hospital in Laurel, MS providing excellent healthcare services to residents in South Central Mississippi with 80 physicians and over 2,100 employees	Hospitals and Health Care	🇺🇸 Laurel	692	1952
19	Mississippi State Hospital msh.ms.gov A publicly funded psychiatric treatment facility in Mississippi, offering various services including acute and continued treatment, forensic, and substance use services	Hospitals and Health Care	🇺🇸 Whitfield	681	1855
20	Keesler Federal Credit Union kfcu.org A dynamic, financially strong credit union serving over 300,000 members with $4 billion in assets across Mississippi Gulf Coast, Mobile, New Orleans, and more	Financial Services	🇺🇸 Biloxi	656	1947
21	Magnolia Regional Health Center mrhc.org A 200-bed acute care community hospital in Mississippi, jointly owned by the City of Corinth and Alcorn County, offering various medical services and employing over 1,500 people	Hospitals and Health Care	🇺🇸 Corinth	626	1965
22	Mississippi Baptist Health Systems baptistonline.org A Christian healing ministry focused on providing quality care, recognized for excellence, with employees committed to high standards of performance	Hospitals and Health Care	🇺🇸 Jackson	601	1908
23	Mississippi Power mississippipower.com A company providing safe, reliable, and affordable energy to over 191,000 customers in southeast Mississippi, along with community wellness support	Utilities	🇺🇸 Gulfport	601	1925
24	Ochsner Rush Health ochsnerrush.org A non-profit healthcare system serving east Mississippi and west Alabama, dedicated to healing, leading, educating, and innovating in local communities	Hospitals and Health Care	🇺🇸 Meridian	562	1915
25	BankFirst Financial Services bankfirstfs.com A long-standing bank committed to excellence in financial products, social responsibility, and fostering a positive workplace culture to support community growth	Banking	🇺🇸 Columbus	303	1888
26	Bolivar Medical Center bolivarmedical.com A hospital committed to delivering high-quality patient care, supporting physicians, creating excellent workplaces, strengthening community roles, and ensuring fiscal responsibility	Hospitals and Health Care	🇺🇸 Cleveland	148	1962
27	Southern Pine Electric southernpine.coop Providing reliable and affordable electric energy to enhance the quality of life for members and community in a large service area	Utilities	🇺🇸 Taylorsville	83	1938
28	Farmers & Merchants Bank (Baldwyn, MS)fmbms.com A financial institution offering banking services to individuals and businesses, providing a variety of products and tailored financial solutions	Banking	🇺🇸 Baldwyn	12	1941

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Every company on this list has a Tamtam company profile. The industry is the one the company gives on LinkedIn; categories such as SaaS or fintech are classified by Tamtam's AI from the company's website and LinkedIn page; and the headquarters city must match the company's own address. Companies are ranked by the number of employees on LinkedIn, and the list is refreshed every night. Classifications can be wrong, so treat the list as a starting point rather than an official ranking. Last updated Oct 24, 2026.

28 leading critical infrastructure operators in Mississippi

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