The companies in Tennessee with in-house R&D are primarily large organizations, including major healthcare providers and educational institutions. HCA Healthcare, for instance, operates 186 hospitals, while Bridgestone Americas is a global leader in sustainable mobility solutions. Vanderbilt University and the University of Tennessee, Knoxville, are prominent higher education institutions. Other notable companies include Eastman, a global specialty materials company, and St. Jude Children's Research Hospital, focused on pediatric cancer research.
A significant concentration of these companies, particularly in healthcare and higher education, have their headquarters in Nashville. This suggests a hub for medical research and academic development within the state. The list also shows a mix of sectors, from manufacturing with companies like McKee Foods Corporation, known for Little Debbie snack cakes, to agriculture with Helena Agri-Enterprises, LLC.
| # | Company | Employees | |||
|---|---|---|---|---|---|
| 1 |
HCA Healthcaredpxmedcity.net
A healthcare organization with 186 hospitals and 2,300 sites, focused on providing quality care, advancing science, and impacting communities positively |
150,409 | |||
| 2 |
Bridgestone Americasbridgestoneamericas.com
Global leader in sustainable mobility solutions, manufacturing tires, rubber products, and air springs for commercial and passenger vehicles worldwide Our goal is to shape a sustainable future |
19,556 | |||
| 3 |
Vanderbilt Universityvanderbilt.edu
Top-ranked university in Nashville focusing on teaching, research, collaboration, diversity, and providing diverse career opportunities across multiple fields. |
12,700 | |||
| 4 |
Eastmaneastman.com
A global specialty materials company founded in 1920, delivering innovative products for everyday use with a focus on safety and sustainability |
10,916 | |||
| 5 |
St. Jude Children's Research Hospital - ALSACstjude.org
Fundraising and awareness efforts supporting a children's research hospital focused on curing diseases and providing free family care. |
10,579 | |||
| 6 |
University of Tennessee, Knoxvillealumni.utk.edu
A prestigious public university offering a wide range of undergraduate and graduate programs, research opportunities, and partnerships with national institutions |
9,622 | |||
| 7 |
Middle Tennessee State University (MTSU)mtsu.edu
A regional university offering superior academic programs to a diverse student population, with a focus on student success and support |
5,262 | |||
| 8 |
St. Jude Children's Research Hospitalstjude.org
A global leader in pediatric cancer research and treatment, sharing innovations worldwide to improve survival rates for children with life-threatening diseases |
5,155 | |||
| 9 |
Erlangererlanger.org
Non-profit academic medical center providing Level-One trauma, tertiary care, and specialized pediatric services across a four-state region. |
4,728 | |||
| 10 |
Centerstonecenterstone.org
Nonprofit health system providing mental health and substance use disorder treatments, including outpatient clinics, residential programs, school-based services, telehealth, and inpatient hospital care |
3,576 | |||
| 11 |
McKee Foods Corporationjobs.mckeefoods.com
The company is known for producing Little Debbie snack cakes, a leading brand in America, committed to quality products and value |
3,176 | |||
| 12 |
Helena Agri-Enterprises, LLChelenaagri.com
Agricultural and specialty products, services, and software provider with a focus on customer success through dedicated people, unique products, and technical knowledge |
2,546 | |||
| 13 |
Meharry Medical Collegemeharry.edu
An academic health center dedicated to improving health and healthcare for minority and underserved communities through education, research, and quality health services |
1,628 | |||
| 14 |
Atmus Filtration Technologiesatmus.com
Designs and manufactures premium filtration products under Fleetguard brand, serving diverse equipment applications with global reach and technology leadership. |
1,559 | |||
| 15 |
Bourns, Inc.bourns.com
Leading manufacturer, supplier automotive sensors, circuit protection, magnetic products, microelectronic modules, potentiometers, panel controls, encoders, resistive products for various markets. |
1,544 | |||
| 16 |
Smith & Wessonsmith-wesson.com
Manufacturing and designing quality firearms, related products, and training for U.S. consumers, law enforcement, and global military customers. |
1,335 | |||
| 17 |
Dura-Lineduraline.com
Manufacture and distribute HDPE conduits and accessories for telecommunications, data centers, and power markets worldwide with durable infrastructure products. |
1,282 | |||
| 18 |
Kasai North America, Inckasai-na.com
Cutting-edge automotive technology company focused on engineering, testing, and quality to achieve continuous improvement in collaboration with a global network of facilities |
1,147 | |||
| 19 |
Sarah Cannon Research Institutescri.com
A leading oncology research organization conducting community-based clinical trials, advancing therapies and enhancing trial access across the country |
975 | |||
| 20 |
Tennessee Oncologytnoncology.com
Specializing in community-based cancer care, our network of physicians offers clinical trials, diagnostic services, chemotherapy treatments, molecular diagnostics, and specialty pharmacy services |
945 | |||
| 21 | 865 | ||||
| 22 |
Wright Medicalstryker.com
Global medical device company focused on providing extremity and biologic solutions to alleviate pain and restore patient lifestyles. A recognized leader of surgical solutions. |
860 | |||
| 23 |
Revancerevance.com
Biotechnology company revolutionizing healthcare with innovative aesthetic and therapeutic solutions, prioritizing enhanced patient and physician experiences |
766 | |||
| 24 |
Haslam College of Business at the University of Tennesseehaslam.utk.edu
The company is committed to producing well-prepared students, conducting impactful research, and offering a range of business education programs |
764 | |||
| 25 |
Aegis Sciences Corporationaegislabs.com
Forensic toxicology and healthcare laboratory specializing in drug testing, consulting, medication compliance, substance abuse, and healthcare specialty testing services |
723 | |||
Want more companies than this list?This page shows the largest ones only. Connect to Tamtam to see every company that matches, filter by size, industry or growth, and reach their decision-makers. | |||||
| 26 |
AOC Formulationsaocformulations.com
A global supplier of resins and specialty materials, providing durable and versatile products through innovative solutions and unrivaled quality and service |
720 | |||
| 27 |
Franke Foodservice Systemsfranke.com
Designs and implements high-quality equipment and solutions for the quick-service restaurant and convenience store industries worldwide Specializing in turnkey facilities and large-scale rollouts |
710 | |||
| 28 |
VGTaristocrat.com
A leading developer and distributor of casino games for Class II and emerging markets, known for high-performance terminals and exciting game titles |
660 | |||
| 29 |
The Escape Gametheescapegame.com
Escape rooms and immersive team-building experiences designed and crafted by a multidisciplinary team across 30+ U.S. locations. |
649 | |||
| 30 |
SVP Worldwidesvpworldwide.com
World's largest consumer sewing machine company with premium brands, innovative technology, and global reach through manufacturing, R&D, and extensive retail network |
642 | |||
| 31 |
Stratas Foodsstratasfoods.com
A leading supplier of fats, oils, sauces, mayonnaises, and dressings for North American markets, known for product innovation and customer-focused development |
592 | |||
| 32 |
Firestone Airidefirestoneairide.com
A global leader in air spring manufacturing with over 85 years of experience, providing advanced solutions for various vehicles and industrial applications worldwide |
591 | |||
| 33 |
MicroPort Orthopedicsmicroportortho.com
A global orthopedic company focused on improving patient outcomes, provider satisfaction, and advancing knee and hip implants through innovation and superior clinical results |
549 | |||
| 34 |
Ring Container Technologiesringcontainer.com
Industry leader in PET and HDPE plastic packaging, creating durable, practical containers through innovation and collaboration with customers for superior consumer product packaging |
544 | |||
| 35 |
Elo Touch Solutionselotouch.com
A global leader in touchscreen solutions offering point of sale systems, digital signage, touch monitors, and all-in-one touch computers for various industries worldwide |
511 | |||
| 36 |
Vanderbilt University School of Medicinemedschool.vanderbilt.edu
A leading medical school with a reputation for personalized education, cutting-edge research, and fostering future leaders in healthcare through exceptional faculty and resources |
477 | |||
| 37 |
Iconexiconex.com
A global leader in manufacturing unique label solutions and affordable paper receipts to enhance transactions and improve operational efficiency in everyday commerce |
451 | |||
| 38 |
Radio Systems Corporationpetsafebrands.com
A leading manufacturer of pet products with a mission to build trusted pet brands, offering innovative solutions and fostering a collaborative, wellness-focused culture |
432 | |||
| 39 |
Shoals Technologies Groupshoals.com
A leading provider of electrical balance of systems solutions for solar, energy storage, and eMobility, improving installation efficiency and system performance globally |
419 | |||
| 40 |
Pig Improvement Company (PIC) - North Americapic.com
A global leader in swine genetics, providing healthy and productive swine genetics to pork producers worldwide for over 60 years |
416 | |||
| 41 |
SteriPack Groupsteripack.com
Contract design and manufacturing organization for healthcare industry partners. Outstanding client service, flexibility, and tailored solutions for products to market. |
411 | |||
| 42 |
Malibu Boatsmalibuboats.com
A leading manufacturer of watersports towboats with patented wake and wave technologies, offering handcrafted boats for wakeboarding, surfing, and skiing |
391 | |||
| 43 |
Heil Trailer Internationalheiltrailer.com
Global manufacturer of specialty transport trailers with a diverse product line, committed to providing high-quality, innovative solutions backed by exceptional service and ethical standards |
387 | |||
| 44 |
Crown Bakeriescrownbakeries.com
A group of dedicated bakers delivering unmatched baking expertise and customer service to foodservice, manufacturing, and retail customers across America |
379 | |||
| 45 |
PlayCoreplaycore.com
This company advances play through research, education, and partnerships to create customized play solutions for communities worldwide |
377 | |||
| 46 |
Yorozu Automotive of TN and ALyorozu-corp.co.jp
A global automotive parts manufacturer specializing in suspensions, with advanced total system for development, manufacturing, and efficient delivery worldwide |
367 | |||
| 47 |
Lochinvar, LLClochinvar.com
A leading manufacturer of high-efficiency water heaters, boilers, pool heaters, and custom packaged systems with a rich family heritage and commitment to innovation |
361 | |||
| 48 |
West Cancer Center & Research Institutewestcancercenter.org
A leading cancer center providing comprehensive adult cancer care and research, offering personalized treatments and support programs for patients and families |
355 | |||
| 49 |
MasterCraft Boat Companymastercraft.com
A leading innovator and manufacturer of premium performance sport boats, specializing in ski, wakeboard, and luxury powerboats since 1968 |
348 | |||
| 50 |
Tritiumtritiumcharging.com
Develops and manufactures advanced DC fast charging technology for electric vehicles, with a global presence and significant deployment of chargers worldwide. |
343 | |||
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How this list is built
Every company on this list has a Tamtam company profile. The industry is the one the company gives on LinkedIn; categories such as SaaS or fintech are classified by Tamtam's AI from the company's website and LinkedIn page; and the headquarters city must match the company's own address. Companies are ranked by the number of employees on LinkedIn, and the list is refreshed every night. Classifications can be wrong, so treat the list as a starting point rather than an official ranking. Last updated Nov 12, 2026.
More company lists in Tennessee
- The largest companies in Tennessee 1,551
- Hospitals and Health Care companies in Tennessee 190
- Healthcare providers in Tennessee 180
- Multinational companies in Tennessee 160
- Manufacturers in Tennessee 156
- Retail chains in Tennessee 143
- Critical infrastructure operators in Tennessee 132
- Education providers in Tennessee 125
- Financial services firms in Tennessee 84
- Professional services firms in Tennessee 80
- Hardware manufacturers in Tennessee 71
- Real Estate companies in Tennessee 68
- Companies with a mobile app in Tennessee 63
- Higher Education companies in Tennessee 62
- Public sector organisations in Tennessee 62
- Corporate groups and holding companies in Tennessee 60
- Financial Services companies in Tennessee 57
- Distributors and wholesalers in Tennessee 54
- Logistics companies in Tennessee 53
- IT Services and IT Consulting companies in Tennessee 52
- Publicly traded companies in Tennessee 51
- IT services companies in Tennessee 50
- Consulting firms in Tennessee 46
- Family-owned companies in Tennessee 45
The same list elsewhere in United States
- Companies with in-house R&D in the United States 6,796
- Companies with in-house R&D in California 1,275
- Companies with in-house R&D in Texas 442
- Companies with in-house R&D in New York State 419
- Companies with in-house R&D in Massachusetts 396
- Companies with in-house R&D in Illinois 322
- Companies with in-house R&D in Michigan 287
- Companies with in-house R&D in Ohio 277
- Companies with in-house R&D in Pennsylvania 255
- Companies with in-house R&D in New Jersey 224
- Companies with in-house R&D in Florida 221
- Companies with in-house R&D in Alabama 215
- Companies with in-house R&D in Georgia 173
- Companies with in-house R&D in Virginia 166
- Companies with in-house R&D in North Carolina 158
- Companies with in-house R&D in Wisconsin 154
- Companies with in-house R&D in Minnesota 146
- Companies with in-house R&D in Washington State 140
- Companies with in-house R&D in Colorado 113
- Companies with in-house R&D in Maryland 107
- Companies with in-house R&D in Indiana 104
- Companies with in-house R&D in New York 223
- Companies with in-house R&D in San Francisco 147
- Companies with in-house R&D in Houston 129