The companies in Delaware with in-house R&D are primarily established firms in manufacturing, chemicals, and healthcare, alongside a significant educational institution. DuPont, a global company, focuses on essential innovations, while Solenis provides sustainable chemical solutions for water-intensive industries. W. L. Gore & Associates is a materials science company, and ChristianaCare is a leading healthcare provider.
The data shows a strong concentration of headquarters in Wilmington and Newark, indicating these cities as key hubs for research and development activities in the state. Many of these companies have a long history, with several founded in the early to mid-20th century, suggesting a mature industrial base.
| # | Company | Employees | |||
|---|---|---|---|---|---|
| 1 |
DuPontdupont.com
A global company focused on creating essential innovations, uncovering insights, and inventing a better now for a brighter future |
22,104 | |||
| 2 |
Solenissolenis.com
A global specialty chemicals producer offering sustainable solutions for water-intensive industries with a wide range of products and technologies for improving operational efficiency and environmental impact |
21,407 | |||
| 3 |
University of Delawareudel.edu
State-assisted university offering diverse courses across multiple campuses, emphasizing high research activity and extensive educational programs. |
11,445 | |||
| 4 |
W. L. Gore & Associatesgore.com
A global materials science company solving technical challenges in diverse environments, generating annual revenues of $48 billion, and improving lives |
10,358 | |||
| 5 |
ChristianaCarecareers.christianacare.org
A leading health care provider in Delaware offering value-based care to the community through hospitals, medical residents, specialized services, and awards for excellence |
9,189 | |||
| 6 |
Ashlandashland.com
This company provides additives and specialty ingredients to various consumer and industrial markets globally, focusing on innovative solutions for complex customer problems. |
5,843 | |||
| 7 |
The Chemours Companychemours.com
A company driven by chemistry, providing sustainable solutions for various industries like automotive, electronics, energy, and construction through Courageous Chemistryâ„¢ |
4,528 | |||
| 8 |
Enovisenovis.com
A medical technology company creating innovative solutions for better patient outcomes, improved workflows, and active lifestyles through collaboration with healthcare professionals |
3,892 | |||
| 9 |
Incyteincyte.com
Global biopharmaceutical company focused on discovering, developing, and commercializing innovative medicines for patients with unmet medical needs in Oncology and Inflammation & Autoimmunity. |
3,425 | |||
| 10 |
EDBenterprisedb.com
A global provider of enterprise-class software and services for harnessing the power of Postgres, offering high availability, reliability, security, and 24x7 support |
1,534 | |||
| 11 |
Phreesiaphreesia.com
Innovative technology empowering healthcare organizations to understand and engage patients for better care experiences and efficiency in managing visits |
1,497 | |||
| 12 | 1,255 | ||||
| 13 |
Chem-Aqua, Inc.chemaqua.com
A leading provider of custom water treatment solutions for boiler, cooling, and process water systems, focusing on energy efficiency and cost savings |
950 | |||
| 14 |
Amphenol Aerospaceamphenol-aerospace.com
Designs and manufactures high-quality, rugged interconnect solutions for military and commercial aerospace markets, including circular, rectangular, fiber optic connectors, and integrated systems. |
773 | |||
| 15 |
The LYCRA Companylycra.com
Innovates and produces fiber and technology solutions for global apparel and hygiene industries, focusing on comfort and lasting performance benefits for clothing across many categories. |
611 | |||
| 16 |
QPS Holdings, LLCqps.com
A global contract research organization specializing in discovery, preclinical, and clinical drug development services with a focus on bioanalytics and clinical trials |
719 | |||
Want more companies than this list?This page shows the largest ones only. Connect to Tamtam to see every company that matches, filter by size, industry or growth, and reach their decision-makers. | |||||
| 17 |
DuPontâ„¢ Spectrumâ„¢spectrumplastics.com
Leading partner in developing and manufacturing critical polymer-based components and finished devices for medical and demanding applications. |
704 | |||
| 18 |
Bel Fuse Inc.belfuse.com
Designs, manufactures, and markets products for powering, protecting, and connecting electronic circuits. A global supplier with technical innovation and cost-effective solutions. |
676 | |||
| 19 |
TA Instrumentstainstruments.com
Develops and supplies instruments for material characterization, including thermal analysis, rheology, and microcalorimetry, used for research, analysis, and quality control. |
655 | |||
| 20 |
InterDigital, Inc.interdigital.com
This company develops mobile and video technologies for devices, networks, and services globally, focusing on efficient broadband networks and advanced multimedia experiences |
600 | |||
| 21 |
Rain Carbon Incraincarbon.com
Global producer of carbon-based products and advanced materials, transforming byproducts into high-value products for industrial processes and manufactured goods worldwide |
575 | |||
| 22 |
DuPont Water Solutionsdupont.com
The company provides solutions for a sustainable energy and water future globally, assisting businesses in making real progress in every industry |
558 | |||
| 23 | 353 | ||||
| 24 |
SPI Pharmaspipharma.com
Supplies pharmaceutical industry with engineered products and innovative solutions, improving drug formulation and delivery for patient needs with functional excipients and active ingredients. |
317 | |||
| 25 |
Devartdevart.com
A database tools and native data access solutions provider with 20+ years of experience, serving thousands of customers worldwide with a focus on innovation and user support |
253 | |||
| 26 |
Laird Performance Materialslaird.com
Enables and improves signal integrity and power transmission in advanced interconnects; protects electronics, manages electromagnetic interference and heat, custom precision metal parts |
219 | |||
| 27 |
Noramconoramco.com
Global leader in manufacturing controlled substances for pharmaceutical medicines, including those for ADHD, pain, and addiction, ensuring DEA-compliant security and supply from kilos to multi-tons. |
201 | |||
| 28 |
Smart Analyticasmart-analytica.com
Specializes in data modernization, analytics, AI solutions, and secure data platform enhancement across cloud and on-premises environments. |
193 | |||
| 29 |
iZOOlogicizoologic.com
A company specializing in tailored threat intelligence, incident response, brand monitoring, and global security enforcement for leading Enterprise and Government organizations |
72 | |||
| 30 |
Versogenversogen.com
A leader in the global energy transition, using breakthrough electrolyzer technology to produce green hydrogen at scale, reducing industrial carbon emissions for a sustainable energy future |
21 | |||
| 31 | 
Millennium Microwave Corpmicrowave2000.com
An electrical/electronic manufacturing company located in Seaford, Delaware, specializing in microwave technology and products for various industries |
19 | |||
| 32 |
SHYP BV LTDshypbv.com
The company produces green hydrogen and co-products from seawater using membraneless electrolyzer systems for sustainable water, CO2 capture, and net zero goals |
2 | |||
| 33 |
THERAONCOtheraonco.com
A cutting-edge company utilizing modified sugars to deliver targeted anti-cancer payloads to tumor cells through innovative click chemistry technology |
1 | |||
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How this list is built
Every company on this list has a Tamtam company profile. The industry is the one the company gives on LinkedIn; categories such as SaaS or fintech are classified by Tamtam's AI from the company's website and LinkedIn page; and the headquarters city must match the company's own address. Companies are ranked by the number of employees on LinkedIn, and the list is refreshed every night. Classifications can be wrong, so treat the list as a starting point rather than an official ranking. Last updated Nov 11, 2026.
More company lists in Delaware
- The largest companies in Delaware 579
- IT Services and IT Consulting companies in Delaware 108
- Multinational companies in Delaware 106
- SaaS companies in Delaware 103
- IT services companies in Delaware 93
- Software Development companies in Delaware 83
- AI companies in Delaware 42
- Technology, Information and Internet companies in Delaware 39
- Professional services firms in Delaware 35
- AI-native companies in Delaware 33
- Manufacturers in Delaware 33
- Financial Services companies in Delaware 30
- AI consultancies and service providers in Delaware 28
- Consulting firms in Delaware 27
- Education providers in Delaware 27
- Subscription businesses in Delaware 27
The same list elsewhere in United States
- Companies with in-house R&D in the United States 6,796
- Companies with in-house R&D in California 1,276
- Companies with in-house R&D in Texas 442
- Companies with in-house R&D in New York State 419
- Companies with in-house R&D in Massachusetts 396
- Companies with in-house R&D in Illinois 322
- Companies with in-house R&D in Michigan 287
- Companies with in-house R&D in Ohio 277
- Companies with in-house R&D in Pennsylvania 255
- Companies with in-house R&D in New Jersey 224
- Companies with in-house R&D in Florida 221
- Companies with in-house R&D in Alabama 214
- Companies with in-house R&D in Georgia 173
- Companies with in-house R&D in Virginia 166
- Companies with in-house R&D in North Carolina 158
- Companies with in-house R&D in Wisconsin 154
- Companies with in-house R&D in Minnesota 146
- Companies with in-house R&D in Washington State 140
- Companies with in-house R&D in Colorado 113
- Companies with in-house R&D in Maryland 107
- Companies with in-house R&D in Indiana 104
- Companies with in-house R&D in New York 223
- Companies with in-house R&D in San Francisco 147
- Companies with in-house R&D in Houston 129