These Durham-based companies are predominantly large organizations specializing in healthcare, higher education, and technology. Many are significant employers, reflecting a focus on research and development. Key entities include IQVIA, which provides clinical research and healthcare intelligence; Duke University, a private research university; FHI 360, a nonprofit advancing global equity and well-being; and Avalara, offering an AI platform for global tax and compliance.
A notable characteristic is the strong presence of academic and healthcare institutions. Duke University, Duke University Health System, and Duke University Hospital collectively form a substantial cluster, indicating a deep integration of medical research, education, and patient care within the local economy.
| # | Company | Employees | |||
|---|---|---|---|---|---|
| 1 | 80,633 | ||||
| 2 |
Duke Universityduke.edu
Private research university offering undergraduate, graduate, and professional education with strong emphasis on research and academic excellence. |
16,307 | |||
| 3 |
Duke University Health Systemdukehealth.org
Academic health system focused on innovative research, education, evidence-based medicine, community health improvement, and eliminating health disparities globally and locally. |
12,096 | |||
| 4 |
FHI 360fhi360.org
Nonprofit organization advancing equity, health, and well-being worldwide through research, resources, and locally led, data-driven solutions. |
8,644 | |||
| 5 |
University of New Hampshireunh.edu
Public research university offering undergraduate and graduate programs, engaging in teaching, research, creative expression, and community service. |
6,952 | |||
| 6 |
Avalaraavalara.com
Provides an agentic AI platform for global tax and compliance, automating calculations, return filings, and exemption certificate management for businesses worldwide. |
5,649 | |||
| 7 |
Duke University Hospital
A leading academic medical center known for exceptional care, groundbreaking research, and commitment to improving the health of individuals and communities |
3,704 | |||
| 8 |
Duke University School of Medicinemedschool.duke.edu
Leading medical school with a focus on interdisciplinary collaboration, research, and innovation to improve human health locally and globally |
2,542 | |||
| 9 |
Toshiba Global Commerce Solutionscommerce.toshiba.com
Global leader in retail store technology, providing integrated in-store solutions that enhance customer engagement, transform the in-store experience, and accelerate digital transformation |
2,537 | |||
| 10 |
Wolfspeedwolfspeed.com
Global leader in Silicon Carbide technology for over 30 years, enabling breakthroughs in electric vehicles, 5G, renewable energy, aerospace, and defense industries |
2,460 | |||
| 11 |
KBI Biopharmakbibiopharma.com
Provides fully-integrated, accelerated drug development and biomanufacturing services to pharmaceutical and biotechnology companies globally with world-class analytical capabilities. |
1,694 | |||
| 12 |
Creewolfspeed.com
Specializing in Silicon Carbide technology, we provide cutting-edge solutions and innovations Follow us at Wolfspeed, Inc for the latest updates |
1,658 | |||
| 13 |
JAGGAERjaggaer.com
It provides enterprise procurement and supplier collaboration solutions, enhancing decision-making and automating processes for organizations globally, with proven expertise. |
1,474 | |||
Want more companies than this list?This page shows the largest ones only. Connect to Tamtam to see every company that matches, filter by size, industry or growth, and reach their decision-makers. | |||||
| 14 |
Q² Solutionslabs.iqvia.com
Company undergoing rebranding and transition from Q² Solutions to IQVIA Laboratories, directing audience to new website and LinkedIn. |
1,181 | |||
| 15 |
Duke Clinical Research Institutedcri.org
A global leader in clinical research, conducting groundbreaking trials, managing patient registries, and publishing impactful research to improve healthcare quality |
1,009 | |||
| 16 |
Duke University Pratt School of Engineeringpratt.duke.edu
A top-ranked engineering school providing rigorous education, research, and societal impact to cultivate purposeful and impactful lives for students |
638 | |||
| 17 |
SMT (SportsMEDIA Technology)smt.com
Provider of advanced technology and services for sports broadcasts, events, and entertainment, offering a wide range of innovative solutions to enhance productions |
636 | |||
| 18 |
BioCryst Pharmaceuticals, Inc.biocryst.com
Development of oral small-molecule and protein therapeutics targeting hereditary angioedema and other rare, difficult-to-treat diseases worldwide. |
613 | |||
| 19 |
Duke Cancer Institutedukecancerinstitute.org
A collaborative and innovative cancer institute at a renowned university and medical center, creating breakthroughs and transforming possibilities in cancer care |
374 | |||
| 20 |
MedPharmmedpharm.com
Supports companies navigating the complexity of topical and transdermal drug development and manufacturing, from formulation and preclinical research to clinical trial supply and commercial manufacturing. |
285 | |||
| 21 |
Solysticsolystic.com
Provides end-to-end automation solutions for mail, express, parcels, e-commerce, and retail industries, focusing on sorting, distribution, and intralogistics processes. |
258 | |||
| 22 |
The Duke Human Vaccine Institutedhvi.duke.edu
A leader in infectious disease research, DHVI focuses on developing vaccines, diagnostics, and therapeutics to address global health challenges and disparities |
184 | |||
| 23 |
Gilero, A Sanner Group Companygilero.com
Offering end-to-end design, development, and manufacturing for medical devices and pharmaceutical products, specializing in a variety of areas for client needs |
154 | |||
| 24 |
Smart Wires Inc.smartwires.com
Global provider of grid enhancing technology and services helping utilities unlock capacity, solve critical issues, and create flexible, reliable, affordable power grids. |
95 | |||
| 25 |
Sipcam Agro USAsipcam.com
A global leader in agrotechnology, specializing in the development, production, and marketing of plant protection products for agriculture, turfgrass, and ornamental markets |
61 | |||
| 26 |
Nocturnalnocturnalpd.com
A boutique firm specializing in accelerating medical device commercialization for class II and III devices through expertise, unique engagement model, and result-based pricing |
32 | |||
| 27 |
StrideBio, Incstridebio.com
A gene therapy company creating innovative genetic medicines to treat rare diseases, improving AAV vectors for enhanced efficacy and manufacturability at scale |
4 | |||
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How this list is built
Every company on this list has a Tamtam company profile. The industry is the one the company gives on LinkedIn; categories such as SaaS or fintech are classified by Tamtam's AI from the company's website and LinkedIn page; and the headquarters city must match the company's own address. Companies are ranked by the number of employees on LinkedIn, and the list is refreshed every night. Classifications can be wrong, so treat the list as a starting point rather than an official ranking. Last updated Nov 11, 2026.
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