This selection of companies with in-house R&D in Philadelphia is dominated by large organizations in healthcare and education. Among the prominent names are Comcast, offering broadband and entertainment, the University of Pennsylvania, an Ivy League institution, Penn Medicine, a leading academic medical center, and Children's Hospital of Philadelphia, specializing in pediatric care. FMC Corporation, focused on agricultural chemicals, and Axalta, a provider of performance coatings, also feature. These companies, each with thousands of employees, represent significant established entities.
The data reveals a strong concentration of institutions founded in the late 19th and early 20th centuries, such as Temple University (1884), FMC Corporation (1883), and Drexel University (1891). However, the list also includes newer companies like Axalta (2013) and Clario (1972), indicating a mix of long-standing establishments and more recently founded firms contributing to the R&D landscape in Philadelphia.
| # | Company | Employees | |||
|---|---|---|---|---|---|
| 1 |
Comcastcomcast.com
Delivering broadband, mobile, and video products, along with entertainment, sports, news, and theme park experiences; driven by passionate creators and innovators |
189,000 | |||
| 2 |
University of Pennsylvaniaupenn.edu
Renowned Ivy League university with 12 schools offering a wide range of programs including arts, sciences, engineering, business, and medicine |
22,558 | |||
| 3 |
Penn Medicine, University of Pennsylvania Health Systempennmedicine.org
Leading academic medical center combining cutting-edge research, comprehensive patient care, and education to improve health and transform lives regionally. |
21,979 | |||
| 4 |
Children's Hospital of Philadelphiachop.edu
Specialized pediatric hospital providing exceptional patient care, pioneering medical research, and training future pediatric healthcare professionals. |
18,042 | |||
| 5 |
Temple Universitytemple.edu
A top-tier research institution in a vibrant city, offering diverse degree programs to prepare future leaders for impactful careers |
13,124 | |||
| 6 |
FMC Corporationfmc.com
The company is dedicated to innovating sustainable technologies to protect crops, support farmers, and tackle agriculture's challenges using science |
11,986 | |||
| 7 |
Axaltaaxalta.com
A global provider of performance coatings for industrial, automotive, and refinish applications, focused on innovation for a sustainable future |
7,744 | |||
| 8 |
Drexel Universitydrexel.edu
Academically comprehensive urban research university with a globally engaged community and a premier cooperative education program nationwide. |
7,580 | |||
| 9 |
Clarioclario.com
A leading healthcare research and technology company providing expertise and technology for advancing clinical trials in various therapeutic areas worldwide |
7,151 | |||
| 10 |
Temple Health – Temple University Health Systemtemplehealth.org
Temple Health provides advanced research and clinical care, offering innovative treatments through renowned physicians, nurses, and researchers in various medical facilities and practices |
5,770 | |||
| 11 |
Thomas Jefferson Universityjefferson.edu
University focused on innovative health education, interdisciplinary learning, expert faculty collaboration, and redefining possibilities in health, education, and discovery. |
5,700 | |||
| 12 |
PCI Pharma Servicespci.com
Provides world-class solutions for drug development, manufacturing, advanced drug delivery, clinical trials, and commercial packaging, delivering life-changing therapies globally. |
4,795 | |||
| 13 |
Carpenter Technology Corporationcarpentertechnology.com
Producer and distributor of premium specialty alloys and advanced materials for aerospace, transportation, medical, energy, and additive manufacturing applications. |
3,271 | |||
| 14 |
Fox Chase Cancer Centerfoxchase.org
Dedicated cancer hospital with expert multidisciplinary teams advancing prevention, diagnosis, treatment, and survivorship through pioneering research and clinical care. |
2,146 | |||
| 15 |
Drexel University College of Medicinedrexel.edu
A prestigious medical school offering MD and graduate programs, committed to diversity and excellence in medical education and research |
1,935 | |||
Want more companies than this list?This page shows the largest ones only. Connect to Tamtam to see every company that matches, filter by size, industry or growth, and reach their decision-makers. | |||||
| 16 |
Spark Therapeutics, Inc.sparktx.com
Leading gene therapy company focused on treating inherited diseases through innovative science, integrated expertise, and commitment to accelerating healthcare transformation globally |
1,035 | |||
| 17 |
Temple University - Lewis Katz School of Medicinetemple.edu
Leading medical school offering humanistic education, top clinical training, and groundbreaking research, recognized internationally, honored nationally, and essential locally |
1,015 | |||
| 18 |
Federal Reserve Bank of Philadelphiaphiladelphiafed.org
Implement monetary policy, supervise banks, provide financial services to institutions and government One of 12 regional Reserve Banks in Federal Reserve System |
852 | |||
| 19 |
Cardone Industriescardone.com
A global supplier of remanufactured and new automotive parts for cars and trucks, with over 50 years of experience in delivering high-quality products |
785 | |||
| 20 |
Naval Surface Warfare Center Philadelphia Divisionnavsea.navy.mil
Specializing in naval machinery research, development, cybersecurity, and engineering, providing technical expertise for the Navy's fleet support and innovation |
768 | |||
| 21 | 733 | ||||
| 22 |
AgroFreshagrofresh.com
AgroFresh empowers fresh produce businesses with science-based solutions to enhance quality, extend shelf life, prevent food waste, and preserve resources |
726 | |||
| 23 |
Adare Pharma Solutionsadarepharmasolutions.com
providing end-to-end integrated services from product development to commercial manufacturing and packaging with expertise in oral dosage forms and specialized technology platforms. |
597 | |||
| 24 |
Wills Eye Hospitalwillseye.org
A global leader in eye disease treatment, providing top-notch care, cutting-edge technology, and advanced surgical capabilities to patients worldwide since 1832 |
556 | |||
| 25 |
University of Pennsylvania Graduate School of Educationgse.upenn.edu
A pioneer in education research, innovation, and leadership development, offering top-ranked graduate programs and a diverse, inclusive community of professionals |
443 | |||
| 26 |
University of Pennsylvania School of Veterinary Medicinevet.upenn.edu
Innovative approach to veterinary medicine, providing medical treatments, public health vigilance, and education on animal and human health connections |
377 | |||
| 27 |
Tastepoint by IFFtastepoint.com
Tastepoint blends passion and technology to provide innovative taste solutions, creating delightful experiences for customers and consumers |
375 | |||
| 28 |
Penn Dental Medicinedental.upenn.edu
Private, Ivy-League institution with a history deeply rooted in forging precedents in dental education, research, and patient care. Dentistry taught as a specialty of medicine. |
312 | |||
| 29 |
Sidney Kimmel Comprehensive Cancer Center at Jeffersonjeffersonhealth.org
A leading cancer center focused on research, patient care, and education in Greater Philadelphia, striving to improve lives through innovation and breakthroughs #CancerCure |
244 | |||
| 30 |
Kingsbury, Inc.®kingsbury.com
A legacy company known for innovative fluid film bearings and tailored solutions for industrial applications, focusing on quality, sustainability, and customer satisfaction |
229 | |||
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How this list is built
Every company on this list has a Tamtam company profile. The industry is the one the company gives on LinkedIn; categories such as SaaS or fintech are classified by Tamtam's AI from the company's website and LinkedIn page; and the headquarters city must match the company's own address. Companies are ranked by the number of employees on LinkedIn, and the list is refreshed every night. Classifications can be wrong, so treat the list as a starting point rather than an official ranking. Last updated Nov 12, 2026.
More company lists in Philadelphia
- The largest companies in Philadelphia 552
- Multinational companies in Philadelphia 76
- Education providers in Philadelphia 72
- Professional services firms in Philadelphia 72
- Healthcare providers in Philadelphia 60
- Retail chains in Philadelphia 51
- Critical infrastructure operators in Philadelphia 41
- Financial services firms in Philadelphia 38
- Hospitals and Health Care companies in Philadelphia 38
- Higher Education companies in Philadelphia 35
- Consulting firms in Philadelphia 34
- Hotel and hospitality groups in Philadelphia 28
The same list elsewhere in United States
- Companies with in-house R&D in the United States 6,796
- Companies with in-house R&D in California 1,275
- Companies with in-house R&D in Texas 442
- Companies with in-house R&D in New York State 419
- Companies with in-house R&D in Massachusetts 396
- Companies with in-house R&D in Illinois 322
- Companies with in-house R&D in Michigan 287
- Companies with in-house R&D in Ohio 277
- Companies with in-house R&D in Pennsylvania 255
- Companies with in-house R&D in New Jersey 224
- Companies with in-house R&D in Florida 221
- Companies with in-house R&D in Alabama 215
- Companies with in-house R&D in Georgia 173
- Companies with in-house R&D in Virginia 166
- Companies with in-house R&D in North Carolina 158
- Companies with in-house R&D in Wisconsin 154
- Companies with in-house R&D in Minnesota 146
- Companies with in-house R&D in Washington State 140
- Companies with in-house R&D in Colorado 113
- Companies with in-house R&D in Maryland 107
- Companies with in-house R&D in Indiana 104
- Companies with in-house R&D in New York 223
- Companies with in-house R&D in San Francisco 147
- Companies with in-house R&D in Houston 129